GREMLIN Database
IMCp - Inner membrane complex protein
PFAM: PF12314 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 94 (82)
Sequences: 620 (527)
Seq/√Len: 58.2
META: 0.755

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_Q77_Q3.3911.00
80_E84_E3.2011.00
42_E46_I2.9221.00
66_E72_E2.7621.00
35_V38_P2.3541.00
27_Q75_Q2.2041.00
10_E58_E2.0981.00
20_E24_E1.8260.99
60_P64_V1.7660.99
14_P28_V1.6810.99
32_E80_E1.6610.99
14_P62_V1.6150.99
24_E49_K1.5980.99
68_E72_E1.5820.99
58_E61_K1.5700.98
63_E76_V1.5020.98
3_E7_V1.4820.98
31_V45_K1.4700.98
71_V75_Q1.4360.97
6_E31_V1.4060.97
13_K35_V1.3760.96
22_I70_I1.3350.96
10_E13_K1.3300.96
3_E19_V1.3120.95
78_T84_E1.2650.94
20_E32_E1.2440.94
18_T24_E1.2290.93
77_Q81_R1.2060.93
15_V42_E1.1440.91
12_P21_K1.1430.91
23_V26_P1.1400.90
6_E54_E1.1380.90
81_R84_E1.1360.90
6_E29_Q1.1160.89
21_K36_E1.1120.89
7_V55_V1.1070.89
59_V82_I1.1010.89
21_K71_V1.0890.88
11_V79_V1.0860.88
49_K72_E1.0730.87
8_V56_V1.0700.87
36_E39_Q1.0610.87
33_K67_V1.0280.85
8_V54_E1.0260.85
17_Q41_Q1.0100.84
18_T66_E0.9990.83
41_Q46_I0.9870.83
69_K73_V0.9570.81
40_V44_E0.9560.81
36_E61_K0.9470.80
24_E72_E0.9460.80
32_E46_I0.9450.80
77_Q80_E0.9050.77
69_K81_R0.8970.76
30_Y34_I0.8950.76
21_K44_E0.8870.75
19_V67_V0.8830.75
9_R48_P0.8720.74
67_V71_V0.8580.73
39_Q53_Q0.8510.72
32_E44_E0.8500.72
78_T81_R0.8440.72
38_P68_E0.8390.71
17_Q48_P0.8360.71
18_T51_E0.8080.68
26_P37_V0.8060.68
9_R16_V0.8060.68
8_V12_P0.8040.68
8_V14_P0.7940.67
36_E57_R0.7880.66
30_Y82_I0.7840.66
55_V65_Q0.7780.65
50_V54_E0.7700.65
4_V36_E0.7480.62
26_P39_Q0.7430.62
28_V33_K0.7400.62
29_Q51_E0.7340.61
16_V24_E0.7280.60
7_V25_V0.6970.57
6_E39_Q0.6950.57
25_V71_V0.6910.56
79_V83_V0.6860.56
30_Y55_V0.6850.56
47_V73_V0.6830.55
42_E45_K0.6730.54
19_V49_K0.6720.54
20_E68_E0.6710.54
25_V45_K0.6710.54
24_E43_V0.6610.53
34_I43_V0.6590.53
42_E51_E0.6440.51
5_Q25_V0.6220.49
3_E15_V0.6180.48
58_E62_V0.6160.48
44_E58_E0.6110.48
4_V12_P0.6000.46
19_V23_V0.5920.45
10_E51_E0.5870.45
29_Q56_V0.5830.44
22_I66_E0.5810.44
40_V61_K0.5810.44
26_P36_E0.5810.44
21_K33_K0.5800.44
27_Q43_V0.5670.43
68_E74_P0.5660.43
8_V15_V0.5650.42
76_V81_R0.5640.42
57_R78_T0.5560.42
66_E75_Q0.5520.41
10_E22_I0.5520.41
48_P60_P0.5490.41
78_T82_I0.5460.40
57_R60_P0.5360.39
12_P60_P0.5300.39
19_V43_V0.5300.39
75_Q78_T0.5220.38
34_I56_V0.5140.37
3_E51_E0.5060.36
60_P81_R0.5050.36
33_K41_Q0.5040.36
18_T44_E0.5030.36
16_V48_P0.5020.36
3_E42_E0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1k6dA 2 0.3936 0.4 0.935 Contact Map
1wirA 1 0.3404 0.3 0.944 Contact Map
1pp5A 1 0.0957 0.2 0.949 Contact Map
4xk8F 1 0.4149 0.2 0.951 Contact Map
4pl8H 1 0.0745 0.2 0.951 Contact Map
4g97A 1 0.3191 0.2 0.952 Contact Map
1ea0A 1 0.3936 0.2 0.956 Contact Map
1eexB 1 0.3298 0.2 0.957 Contact Map
3lufA 2 0.234 0.2 0.957 Contact Map
3vrpA 1 0.3085 0.2 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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