GREMLIN Database
DUF3632 - Protein of unknown function (DUF3632)
PFAM: PF12311 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 175 (172)
Sequences: 580 (508)
Seq/√Len: 38.7
META: 0.181

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_W75_N4.1381.00
102_E167_R4.0871.00
101_L174_R3.8231.00
127_I131_G3.1871.00
93_A134_L3.1601.00
15_Q80_R3.1151.00
16_D80_R2.9601.00
124_A175_L2.8661.00
123_A175_L2.7361.00
53_L78_L2.6921.00
21_L24_A2.6671.00
15_Q73_N2.6481.00
127_I175_L2.6441.00
49_F81_L2.5671.00
48_L51_A2.4411.00
168_W171_W2.2531.00
9_K42_L2.1860.99
12_P15_Q1.9580.99
43_W47_P1.9360.98
167_R170_F1.9050.98
41_R45_D1.8880.98
95_W98_R1.8270.98
76_A125_Q1.7530.97
92_Y96_A1.7410.97
120_V124_A1.7310.97
72_L125_Q1.6950.96
102_E170_F1.6710.96
162_G167_R1.6550.96
116_L121_P1.6310.95
170_F174_R1.6070.95
94_L163_F1.5640.94
72_L121_P1.5500.94
167_R171_W1.5240.93
98_R102_E1.4840.93
123_A126_W1.4530.92
156_G159_L1.4210.91
92_Y95_W1.3970.90
79_A130_A1.3460.88
127_I168_W1.3430.88
138_S163_F1.3160.87
19_V84_A1.3120.87
165_P173_E1.3010.87
8_A77_F1.2920.86
164_S174_R1.2770.85
122_A125_Q1.2720.85
75_N92_Y1.2680.85
54_R98_R1.2510.84
93_A126_W1.2330.83
134_L163_F1.2250.83
11_I15_Q1.2070.82
19_V53_L1.1950.81
8_A73_N1.1920.81
125_Q129_Y1.1870.81
54_R92_Y1.1770.80
5_I52_D1.1740.80
91_L95_W1.1680.80
54_R95_W1.1620.80
13_Y129_Y1.1510.79
160_W170_F1.1480.79
21_L164_S1.1410.78
84_A137_L1.1350.78
94_L162_G1.1300.78
29_P32_G1.1250.77
1_W47_P1.1220.77
4_I13_Y1.1190.77
80_R83_A1.1150.77
2_D6_D1.1120.76
169_E173_E1.1060.76
39_G97_L1.1050.76
94_L154_G1.1040.76
45_D55_E1.0980.76
10_Q13_Y1.0970.75
15_Q76_A1.0950.75
49_F92_Y1.0930.75
167_R174_R1.0810.74
45_D70_R1.0770.74
6_D9_K1.0770.74
139_E173_E1.0760.74
24_A75_N1.0740.74
116_L170_F1.0680.73
73_N77_F1.0670.73
171_W175_L1.0670.73
75_N78_L1.0660.73
33_G36_T1.0600.73
116_L120_V1.0350.71
20_D84_A1.0290.71
159_L170_F1.0220.70
22_L46_L1.0130.69
8_A18_L1.0100.69
118_A129_Y1.0030.69
135_Y138_S0.9940.68
47_P125_Q0.9920.68
59_D97_L0.9920.68
5_I78_L0.9860.67
82_T160_W0.9760.67
118_A138_S0.9660.66
28_D31_T0.9520.65
57_W61_S0.9440.64
79_A126_W0.9420.64
57_W62_E0.9390.63
25_L85_G0.9390.63
4_I92_Y0.9360.63
95_W110_E0.9100.61
8_A175_L0.9010.60
113_G158_P0.9000.60
74_L78_L0.8950.60
1_W46_L0.8940.60
121_P125_Q0.8920.59
12_P130_A0.8840.59
121_P174_R0.8820.59
4_I128_L0.8760.58
76_A175_L0.8710.58
46_L49_F0.8660.57
124_A168_W0.8650.57
82_T90_S0.8610.57
171_W174_R0.8490.56
48_L53_L0.8420.55
69_A172_K0.8230.53
115_V119_L0.8210.53
19_V60_D0.8200.53
52_D55_E0.8180.53
9_K27_E0.8140.53
166_E169_E0.8120.52
43_W46_L0.8080.52
82_T89_D0.8010.51
7_A15_Q0.7960.51
22_L171_W0.7940.51
43_W82_T0.7880.50
96_A122_A0.7800.49
2_D21_L0.7740.49
5_I9_K0.7730.49
93_A102_E0.7660.48
121_P126_W0.7660.48
13_Y80_R0.7640.48
24_A142_E0.7630.48
90_S163_F0.7620.48
78_L82_T0.7560.47
61_S65_A0.7550.47
79_A167_R0.7430.46
75_N126_W0.7420.46
116_L139_E0.7380.46
22_L36_T0.7380.46
4_I82_T0.7350.45
163_F166_E0.7300.45
22_L42_L0.7170.44
130_A163_F0.7150.44
24_A119_L0.7130.43
46_L55_E0.7130.43
50_G166_E0.7020.42
20_D23_L0.7020.42
116_L129_Y0.6970.42
13_Y125_Q0.6930.42
100_A167_R0.6910.42
14_S21_L0.6900.41
62_E115_V0.6890.41
141_G157_G0.6840.41
23_L85_G0.6790.40
74_L116_L0.6730.40
26_R126_W0.6730.40
1_W164_S0.6720.40
69_A72_L0.6710.40
9_K125_Q0.6700.40
101_L161_K0.6690.40
1_W172_K0.6660.39
90_S97_L0.6650.39
3_L135_Y0.6640.39
55_E92_Y0.6520.38
154_G157_G0.6460.38
41_R159_L0.6430.37
93_A167_R0.6420.37
46_L101_L0.6410.37
79_A171_W0.6370.37
41_R135_Y0.6350.37
51_A55_E0.6350.37
55_E88_D0.6350.37
22_L125_Q0.6350.37
21_L25_L0.6330.37
117_D120_V0.6270.36
151_G154_G0.6220.36
108_E111_E0.6210.36
110_E113_G0.6210.36
50_G54_R0.6210.36
95_W102_E0.6200.35
53_L79_A0.6200.35
66_E82_T0.6190.35
17_R165_P0.6190.35
68_A114_E0.6180.35
16_D87_C0.6170.35
46_L120_V0.6130.35
152_R156_G0.6130.35
2_D93_A0.6120.35
17_R44_S0.6110.35
56_A69_A0.6070.34
21_L121_P0.6050.34
82_T126_W0.6010.34
41_R100_A0.6000.34
93_A125_Q0.6000.34
42_L134_L0.5990.34
146_P149_G0.5980.34
61_S75_N0.5970.34
55_E67_S0.5960.33
24_A27_E0.5950.33
5_I77_F0.5950.33
114_E175_L0.5900.33
21_L87_C0.5900.33
161_K164_S0.5900.33
140_E143_D0.5890.33
127_I134_L0.5880.33
131_G135_Y0.5880.33
73_N152_R0.5870.33
25_L38_D0.5860.33
71_W122_A0.5830.32
118_A128_L0.5820.32
36_T48_L0.5770.32
91_L154_G0.5760.32
99_D130_A0.5760.32
1_W167_R0.5740.32
56_A173_E0.5710.32
72_L168_W0.5610.31
63_A67_S0.5610.31
160_W164_S0.5530.30
81_L91_L0.5520.30
23_L27_E0.5510.30
6_D70_R0.5500.30
30_E35_L0.5500.30
24_A52_D0.5480.30
14_S17_R0.5470.30
81_L163_F0.5470.30
14_S129_Y0.5460.30
136_E165_P0.5460.30
26_R80_R0.5460.30
49_F165_P0.5440.29
124_A128_L0.5430.29
22_L27_E0.5420.29
71_W93_A0.5380.29
106_D166_E0.5360.29
39_G47_P0.5320.29
113_G151_G0.5310.28
134_L155_R0.5300.28
20_D129_Y0.5290.28
76_A129_Y0.5290.28
83_A94_L0.5280.28
73_N138_S0.5260.28
97_L101_L0.5250.28
26_R46_L0.5240.28
134_L156_G0.5230.28
83_A163_F0.5210.28
72_L172_K0.5210.28
83_A91_L0.5180.28
85_G92_Y0.5130.27
5_I71_W0.5120.27
129_Y136_E0.5060.27
51_A166_E0.5030.26
68_A122_A0.5030.26
74_L139_E0.5030.26
38_D49_F0.5010.26
23_L33_G0.5010.26
97_L127_I0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4c9bB 1 0.8 5 0.939 Contact Map
1h2vC 1 0.8629 4.3 0.941 Contact Map
1s4kA 2 0.4229 4.1 0.942 Contact Map
4chkA 2 0.2114 3.1 0.945 Contact Map
1y9bA 4 0.1314 2.9 0.946 Contact Map
4a4aA 1 0.76 2.2 0.949 Contact Map
1hlbA 1 0.4457 2 0.951 Contact Map
4a14A 1 0.3371 1.9 0.951 Contact Map
4cekA 1 0.8686 1.8 0.951 Contact Map
2nszA 1 0.48 1.8 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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