GREMLIN Database
DUF3631 - Protein of unknown function (DUF3631)
PFAM: PF12307 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 183 (180)
Sequences: 5805 (5141)
Seq/√Len: 383.2
META: 0.928

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
160_T169_K4.1151.00
160_T167_T3.6611.00
159_K172_R2.7981.00
60_W82_A2.7361.00
68_D79_R2.5691.00
118_S168_A2.4781.00
73_D77_R2.4761.00
72_G75_P2.4471.00
162_R167_T2.4001.00
98_G154_F2.2821.00
119_S144_A2.2641.00
178_D182_R2.2171.00
160_T168_A2.1521.00
119_S123_L2.0901.00
76_E80_A2.0551.00
159_K175_D2.0351.00
123_L127_V1.9801.00
127_V141_P1.8841.00
5_R11_V1.8841.00
32_R36_D1.8491.00
142_L147_L1.8481.00
116_R172_R1.8461.00
120_A144_A1.8251.00
68_D75_P1.8211.00
105_I122_L1.7981.00
173_R177_E1.7721.00
129_L132_R1.7491.00
104_D132_R1.7341.00
25_P29_K1.7341.00
118_S163_I1.7211.00
108_V125_A1.6781.00
37_N40_A1.6661.00
173_R180_W1.6521.00
146_Q150_L1.5951.00
116_R161_I1.5701.00
31_A35_A1.5611.00
100_R132_R1.5461.00
52_L82_A1.5281.00
17_R61_E1.5041.00
125_A128_A1.5011.00
105_I176_F1.4931.00
45_D61_E1.4831.00
51_G83_V1.4651.00
64_L78_A1.4651.00
6_A9_E1.4561.00
108_V122_L1.4531.00
123_L144_A1.4411.00
48_M57_A1.4381.00
117_L122_L1.4211.00
75_P79_R1.3951.00
142_L146_Q1.3891.00
177_E181_A1.3521.00
13_R57_A1.3401.00
39_E42_R1.3231.00
15_R61_E1.3161.00
163_I168_A1.3031.00
60_W86_S1.3011.00
74_W77_R1.3001.00
118_S121_D1.2941.00
112_G125_A1.2711.00
123_L147_L1.2701.00
56_A86_S1.2651.00
156_I176_F1.2511.00
6_A181_A1.2411.00
172_R175_D1.2351.00
24_A28_R1.2261.00
120_A124_E1.2201.00
145_R149_R1.2171.00
53_N56_A1.2091.00
19_D23_L1.1971.00
156_I179_A1.1961.00
5_R54_D1.1801.00
33_W37_N1.1491.00
38_A41_L1.1471.00
130_E144_A1.1231.00
37_N69_L1.1231.00
121_D125_A1.1221.00
52_L56_A1.1181.00
119_S148_A1.1141.00
116_R163_I1.0861.00
163_I166_G1.0701.00
48_M64_L1.0691.00
100_R103_A1.0591.00
123_L142_L1.0591.00
104_D129_L1.0501.00
70_A74_W1.0431.00
176_F180_W1.0381.00
107_D129_L1.0361.00
82_A86_S1.0291.00
124_E128_A1.0291.00
98_G150_L1.0261.00
3_R178_D1.0251.00
108_V117_L1.0171.00
148_A158_P1.0071.00
149_R152_K0.9971.00
9_E182_R0.9931.00
109_F117_L0.9911.00
30_L34_A0.9761.00
98_G153_P0.9681.00
100_R133_P0.9681.00
131_E158_P0.9641.00
38_A42_R0.9631.00
3_R9_E0.9611.00
161_I172_R0.9441.00
73_D76_E0.9411.00
109_F173_R0.9391.00
127_V135_A0.9371.00
28_R36_D0.9371.00
174_A177_E0.9251.00
106_R110_D0.9251.00
131_E145_R0.9241.00
25_P28_R0.9231.00
24_A27_R0.9191.00
177_E180_W0.9071.00
28_R32_R0.9071.00
106_R180_W0.9041.00
5_R10_K0.9041.00
51_G57_A0.8981.00
49_P57_A0.8981.00
21_P24_A0.8951.00
14_F19_D0.8951.00
13_R61_E0.8891.00
150_L153_P0.8881.00
20_E24_A0.8761.00
137_R146_Q0.8761.00
52_L86_S0.8731.00
119_S158_P0.8571.00
120_A168_A0.8511.00
114_A125_A0.8451.00
121_D124_E0.8441.00
29_K32_R0.8321.00
15_R58_D0.8301.00
143_T146_Q0.8191.00
161_I169_K0.8131.00
109_F180_W0.8061.00
162_R165_G0.8051.00
37_N41_L0.8031.00
118_S167_T0.8021.00
67_A78_A0.7951.00
161_I170_G0.7941.00
54_D57_A0.7921.00
104_D134_W0.7891.00
80_A84_A0.7781.00
41_L69_L0.7751.00
21_P25_P0.7691.00
148_A171_Y0.7661.00
108_V129_L0.7651.00
67_A71_G0.7611.00
137_R143_T0.7561.00
16_R20_E0.7551.00
46_P68_D0.7531.00
64_L82_A0.7481.00
110_D173_R0.7481.00
103_A106_R0.7451.00
99_V154_F0.7441.00
71_G74_W0.7401.00
158_P169_K0.7381.00
152_K157_K0.7381.00
44_A68_D0.7371.00
100_R104_D0.7361.00
111_E125_A0.7341.00
64_L68_D0.7321.00
23_L59_N0.7291.00
17_R45_D0.7201.00
64_L79_R0.7201.00
13_R58_D0.7181.00
20_E23_L0.7161.00
136_E141_P0.7141.00
136_E143_T0.7101.00
103_A107_D0.7091.00
95_E103_A0.7081.00
127_V142_L0.7001.00
136_E140_K0.6960.99
161_I167_T0.6930.99
145_R148_A0.6870.99
107_D111_E0.6870.99
126_L134_W0.6830.99
145_R152_K0.6790.99
39_E43_D0.6760.99
95_E99_V0.6720.99
14_F23_L0.6710.99
161_I168_A0.6690.99
117_L125_A0.6690.99
102_L106_R0.6680.99
118_S166_G0.6670.99
53_N89_A0.6620.99
119_S170_G0.6580.99
44_A65_A0.6550.99
27_R31_A0.6510.99
22_E25_P0.6470.99
34_A37_N0.6460.99
101_L126_L0.6440.99
137_R141_P0.6400.99
162_R166_G0.6390.99
48_M51_G0.6360.99
53_N86_S0.6350.99
140_K143_T0.6320.99
56_A82_A0.6300.99
136_E139_G0.6280.99
81_A85_L0.6240.99
40_A69_L0.6170.99
26_L29_K0.6170.99
13_R54_D0.6170.99
136_E146_Q0.6160.99
23_L27_R0.6150.99
131_E135_A0.6140.99
140_K146_Q0.6100.99
104_D126_L0.6060.99
79_R83_V0.6000.98
105_I108_V0.5990.98
105_I180_W0.5990.98
67_A75_P0.5960.98
165_G168_A0.5950.98
97_L133_P0.5950.98
29_K36_D0.5920.98
28_R31_A0.5910.98
20_E27_R0.5900.98
44_A69_L0.5900.98
13_R48_M0.5880.98
31_A34_A0.5880.98
139_G143_T0.5860.98
101_L104_D0.5850.98
57_A61_E0.5830.98
115_D172_R0.5800.98
56_A59_N0.5800.98
15_R57_A0.5670.98
19_D25_P0.5650.98
54_D59_N0.5650.98
3_R6_A0.5590.98
97_L146_Q0.5570.98
164_G167_T0.5530.97
97_L137_R0.5530.97
19_D22_E0.5520.97
46_P65_A0.5470.97
112_G121_D0.5450.97
139_G142_L0.5430.97
138_R141_P0.5420.97
52_L57_A0.5370.97
114_A117_L0.5360.97
116_R160_T0.5360.97
77_R80_A0.5350.97
117_L121_D0.5340.97
40_A43_D0.5330.97
127_V146_Q0.5290.97
41_L65_A0.5280.97
35_A38_A0.5260.97
5_R53_N0.5250.96
158_P171_Y0.5230.96
137_R142_L0.5230.96
115_D173_R0.5180.96
6_A182_R0.5180.96
95_E100_R0.5170.96
5_R9_E0.5150.96
114_A121_D0.5150.96
162_R168_A0.5130.96
163_I167_T0.5090.96
16_R19_D0.5090.96
137_R150_L0.5090.96
65_A68_D0.5080.96
110_D113_G0.5070.96
26_L30_L0.5060.96
58_D61_E0.5060.96
104_D107_D0.5060.96
42_R45_D0.5050.96
5_R13_R0.5040.96
17_R23_L0.5030.96
47_E68_D0.5030.96
112_G117_L0.5020.95
122_L126_L0.5000.95
158_P170_G0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cuqA 1 0.8033 16.1 0.931 Contact Map
2ahqA 1 0.3607 13 0.933 Contact Map
3mklA 1 0.4153 9 0.938 Contact Map
3oouA 1 0.388 8.7 0.938 Contact Map
2wujA 2 0.1639 8.3 0.939 Contact Map
4ociA 2 0.3934 8.2 0.939 Contact Map
4csrA 1 0.459 7.3 0.941 Contact Map
1bl0A 1 0.3934 6.9 0.941 Contact Map
1jbwA 1 0.3333 6.6 0.942 Contact Map
1m45A 1 0.3934 6.5 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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