DUF3623 - PFAM28P - GREMLIN Contacts

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DUF3623 - Protein of unknown function (DUF3623)

PFAM:	PF12291	Sequences: MSSYALPALFALFLWWFSTGAILYLDRLPRRTFRWSLLGATVLLAAALWGLAASAGDTSVAGAYLAFTCALLVWGWHELAFLTGWITGPRRTPCPPGARGWRRFRRAVQTILYHELALLATALALVALTWGAPNQVGLWTFLVLWVMRLSAKLNLFLGVPNLNEEFLPEHLAYLKSYFRRRPMNLLFPVSVTAATAAAALLVERALAAGATPFEAVGFTLLATLLALALLEHWFLVLPLPDAALWRWALPSRKRP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	255 (251)
Sequences:	1153 (915)
Seq/√Len:	57.8
META:	0.84

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
51_L	137_G	4.848	1.00
50_G	69_C	4.197	1.00
13_F	17_F	3.267	1.00
57_D	62_G	3.169	1.00
136_V	217_G	3.119	1.00
121_T	141_F	3.015	1.00
82_L	148_R	2.930	1.00
195_T	233_W	2.868	1.00
192_T	233_W	2.867	1.00
198_A	226_A	2.750	1.00
77_H	121_T	2.741	1.00
126_V	138_L	2.675	1.00
79_L	83_T	2.636	1.00
10_F	68_T	2.632	1.00
187_F	233_W	2.630	1.00
95_P	106_R	2.615	1.00
98_A	103_R	2.602	1.00
82_L	111_I	2.486	1.00
103_R	106_R	2.426	1.00
157_L	186_L	2.409	1.00
143_V	221_L	2.331	1.00
135_Q	138_L	2.263	1.00
54_S	66_A	2.225	1.00
108_V	112_L	2.155	1.00
51_L	125_L	1.984	1.00
172_A	175_K	1.947	1.00
47_A	69_C	1.932	1.00
198_A	229_L	1.927	1.00
184_N	188_P	1.913	1.00
192_T	195_T	1.887	1.00
41_T	76_W	1.868	1.00
108_V	149_L	1.832	0.99
81_F	111_I	1.811	0.99
194_A	229_L	1.777	0.99
111_I	148_R	1.775	0.99
37_L	80_A	1.775	0.99
165_E	242_A	1.722	0.99
202_V	222_A	1.708	0.99
105_R	109_Q	1.705	0.99
116_L	120_A	1.701	0.99
122_A	141_F	1.679	0.99
7_P	64_Y	1.639	0.99
98_A	106_R	1.632	0.99
191_V	233_W	1.621	0.99
151_A	235_L	1.584	0.98
63_A	213_F	1.584	0.98
32_T	36_S	1.567	0.98
187_F	195_T	1.557	0.98
187_F	192_T	1.538	0.98
56_G	133_P	1.507	0.98
181_R	184_N	1.494	0.98
143_V	225_L	1.458	0.97
111_I	178_F	1.453	0.97
78_E	148_R	1.453	0.97
241_D	248_A	1.452	0.97
55_A	133_P	1.450	0.97
14_L	71_L	1.438	0.97
94_C	98_A	1.435	0.97
18_S	22_I	1.421	0.97
209_G	212_P	1.419	0.97
4_Y	7_P	1.414	0.97
196_A	200_L	1.414	0.97
11_A	220_L	1.411	0.97
187_F	191_V	1.406	0.97
37_L	85_W	1.392	0.97
155_L	235_L	1.390	0.97
90_R	109_Q	1.386	0.96
82_L	178_F	1.361	0.96
110_T	177_Y	1.358	0.96
47_A	72_L	1.358	0.96
55_A	129_T	1.346	0.96
153_L	186_L	1.338	0.96
126_V	130_W	1.329	0.95
77_H	141_F	1.288	0.95
94_C	106_R	1.286	0.95
80_A	118_L	1.282	0.95
213_F	217_G	1.277	0.94
35_W	38_L	1.264	0.94
218_F	221_L	1.250	0.94
82_L	152_K	1.248	0.94
44_L	121_T	1.247	0.94
36_S	83_T	1.245	0.94
147_M	228_A	1.239	0.93
196_A	199_A	1.230	0.93
81_F	149_L	1.224	0.93
70_A	118_L	1.222	0.93
90_R	106_R	1.218	0.93
148_R	152_K	1.214	0.93
143_V	228_A	1.209	0.93
102_R	105_R	1.196	0.92
66_A	217_G	1.182	0.92
211_T	214_E	1.178	0.92
157_L	188_P	1.174	0.91
22_I	75_G	1.170	0.91
122_A	142_L	1.162	0.91
215_A	219_T	1.156	0.91
56_G	132_A	1.147	0.90
186_L	190_S	1.145	0.90
68_T	72_L	1.141	0.90
66_A	137_G	1.125	0.90
233_W	236_V	1.125	0.90
62_G	65_L	1.122	0.89
234_F	239_L	1.114	0.89
248_A	251_S	1.107	0.89
221_L	225_L	1.099	0.88
80_A	85_W	1.087	0.88
198_A	202_V	1.084	0.88
17_F	20_G	1.077	0.87
18_S	71_L	1.061	0.87
183_M	186_L	1.056	0.86
10_F	14_L	1.054	0.86
106_R	110_T	1.046	0.86
81_F	178_F	1.040	0.86
22_I	83_T	1.031	0.85
139_W	218_F	1.026	0.85
148_R	155_L	1.024	0.85
225_L	229_L	1.022	0.85
26_D	169_E	1.020	0.84
104_F	108_V	1.020	0.84
110_T	174_L	1.019	0.84
222_A	226_A	1.012	0.84
108_V	119_L	1.004	0.83
15_W	19_T	1.000	0.83
164_E	180_R	0.998	0.83
125_L	141_F	0.992	0.83
157_L	184_N	0.991	0.83
149_L	163_N	0.990	0.83
65_L	69_C	0.988	0.83
40_A	79_L	0.975	0.82
41_T	44_L	0.974	0.82
29_P	32_T	0.971	0.81
111_I	149_L	0.967	0.81
200_L	203_E	0.962	0.81
149_L	178_F	0.955	0.80
14_L	68_T	0.955	0.80
139_W	197_A	0.955	0.80
44_L	73_V	0.948	0.80
58_T	62_G	0.942	0.79
197_A	225_L	0.941	0.79
59_S	62_G	0.941	0.79
72_L	75_G	0.940	0.79
102_R	106_R	0.935	0.79
89_P	112_L	0.933	0.79
160_P	184_N	0.931	0.79
78_E	82_L	0.931	0.79
98_A	102_R	0.926	0.78
4_Y	219_T	0.920	0.78
151_A	155_L	0.914	0.77
28_L	32_T	0.912	0.77
149_L	155_L	0.911	0.77
202_V	226_A	0.906	0.77
66_A	136_V	0.902	0.76
80_A	86_I	0.898	0.76
27_R	251_S	0.895	0.76
39_G	42_V	0.889	0.75
61_A	65_L	0.888	0.75
230_L	234_F	0.882	0.75
23_L	155_L	0.881	0.75
37_L	41_T	0.879	0.74
8_A	223_T	0.878	0.74
103_R	176_S	0.878	0.74
81_F	166_F	0.865	0.73
198_A	225_L	0.861	0.73
46_A	50_G	0.859	0.73
26_D	29_P	0.859	0.73
149_L	160_P	0.859	0.73
103_R	177_Y	0.858	0.73
118_L	178_F	0.858	0.73
147_M	225_L	0.853	0.72
24_Y	27_R	0.853	0.72
239_L	242_A	0.849	0.72
35_W	39_G	0.845	0.72
77_H	149_L	0.840	0.71
47_A	75_G	0.838	0.71
82_L	118_L	0.836	0.71
213_F	216_V	0.835	0.71
240_P	246_R	0.830	0.70
155_L	163_N	0.829	0.70
26_D	32_T	0.829	0.70
30_R	170_H	0.815	0.69
119_L	145_W	0.808	0.68
28_L	35_W	0.803	0.68
170_H	235_L	0.803	0.68
60_V	216_V	0.799	0.67
75_G	79_L	0.797	0.67
154_N	159_V	0.797	0.67
200_L	204_R	0.797	0.67
14_L	18_S	0.796	0.67
103_R	109_Q	0.796	0.67
146_V	193_A	0.795	0.67
41_T	45_A	0.795	0.67
137_G	142_L	0.791	0.66
163_N	166_F	0.789	0.66
154_N	190_S	0.788	0.66
155_L	171_L	0.784	0.66
130_W	138_L	0.780	0.65
217_G	221_L	0.774	0.65
191_V	195_T	0.773	0.65
166_F	249_L	0.760	0.63
160_P	236_V	0.758	0.63
167_L	178_F	0.756	0.63
225_L	228_A	0.756	0.63
150_S	232_H	0.754	0.63
59_S	213_F	0.753	0.63
98_A	177_Y	0.749	0.62
182_P	185_L	0.739	0.61
20_G	247_W	0.736	0.61
161_N	184_N	0.734	0.61
40_A	44_L	0.730	0.60
81_F	163_N	0.727	0.60
50_G	65_L	0.726	0.60
31_R	49_W	0.723	0.59
48_L	73_V	0.721	0.59
212_P	215_A	0.718	0.59
150_S	190_S	0.718	0.59
36_S	79_L	0.709	0.58
167_L	175_K	0.709	0.58
50_G	71_L	0.707	0.58
28_L	33_F	0.705	0.58
125_L	132_A	0.705	0.58
129_T	135_Q	0.704	0.57
82_L	155_L	0.696	0.57
127_A	130_W	0.694	0.56
111_I	152_K	0.692	0.56
57_D	61_A	0.691	0.56
106_R	177_Y	0.689	0.56
118_L	141_F	0.688	0.56
147_M	194_A	0.687	0.56
197_A	228_A	0.687	0.56
160_P	241_D	0.687	0.56
199_A	203_E	0.687	0.56
73_V	125_L	0.686	0.55
201_L	225_L	0.686	0.55
153_L	157_L	0.685	0.55
48_L	128_L	0.683	0.55
16_W	19_T	0.682	0.55
77_H	117_A	0.681	0.55
50_G	54_S	0.680	0.55
241_D	250_P	0.678	0.55
46_A	197_A	0.678	0.55
77_H	80_A	0.677	0.54
118_L	148_R	0.670	0.54
210_A	215_A	0.669	0.54
169_E	172_A	0.669	0.54
104_F	157_L	0.663	0.53
196_A	203_E	0.663	0.53
76_W	166_F	0.660	0.53
111_I	177_Y	0.657	0.52
160_P	186_L	0.656	0.52
81_F	91_R	0.653	0.52
54_S	118_L	0.649	0.51
22_I	33_F	0.648	0.51
53_A	65_L	0.647	0.51
94_C	97_G	0.646	0.51
201_L	222_A	0.646	0.51
183_M	188_P	0.645	0.51
185_L	192_T	0.643	0.51
22_I	122_A	0.639	0.50
161_N	166_F	0.635	0.50
108_V	113_Y	0.635	0.50
189_V	193_A	0.634	0.50
33_F	83_T	0.632	0.50
8_A	235_L	0.632	0.50
91_R	173_Y	0.629	0.49
51_L	73_V	0.629	0.49
226_A	250_P	0.627	0.49
75_G	144_L	0.626	0.49
112_L	119_L	0.626	0.49
151_A	228_A	0.625	0.49
83_T	170_H	0.624	0.49
106_R	109_Q	0.624	0.49
190_S	229_L	0.621	0.48
121_T	125_L	0.620	0.48
162_L	166_F	0.620	0.48
48_L	52_A	0.618	0.48
26_D	36_S	0.616	0.48
53_A	185_L	0.613	0.47
77_H	118_L	0.611	0.47
123_L	207_A	0.610	0.47
226_A	235_L	0.607	0.47
5_A	12_L	0.603	0.46
29_P	33_F	0.602	0.46
230_L	237_L	0.602	0.46
184_N	190_S	0.601	0.46
7_P	175_K	0.598	0.46
51_L	129_T	0.598	0.46
48_L	124_A	0.596	0.46
95_P	103_R	0.596	0.46
55_A	125_L	0.595	0.45
24_Y	36_S	0.594	0.45
110_T	171_L	0.594	0.45
12_L	220_L	0.592	0.45
125_L	137_G	0.591	0.45
13_F	50_G	0.590	0.45
16_W	20_G	0.590	0.45
70_A	73_V	0.589	0.45
63_A	216_V	0.589	0.45
78_E	118_L	0.588	0.45
248_A	252_R	0.586	0.44
111_I	118_L	0.585	0.44
77_H	125_L	0.578	0.44
52_A	55_A	0.577	0.44
198_A	222_A	0.575	0.43
101_W	105_R	0.571	0.43
32_T	35_W	0.571	0.43
37_L	79_L	0.571	0.43
22_I	80_A	0.569	0.43
8_A	11_A	0.568	0.43
91_R	113_Y	0.568	0.43
104_F	156_F	0.565	0.42
239_L	243_A	0.564	0.42
113_Y	118_L	0.562	0.42
75_G	155_L	0.562	0.42
89_P	113_Y	0.559	0.42
80_A	180_R	0.556	0.41
161_N	183_M	0.555	0.41
122_A	126_V	0.554	0.41
50_G	53_A	0.553	0.41
149_L	241_D	0.553	0.41
54_S	165_E	0.552	0.41
151_A	225_L	0.552	0.41
228_A	235_L	0.551	0.41
148_R	178_F	0.550	0.41
22_I	235_L	0.550	0.41
17_F	21_A	0.544	0.40
119_L	123_L	0.543	0.40
54_S	69_C	0.543	0.40
149_L	152_K	0.543	0.40
111_I	167_L	0.542	0.40
76_W	171_L	0.542	0.40
200_L	218_F	0.540	0.40
33_F	36_S	0.539	0.39
77_H	173_Y	0.538	0.39
90_R	177_Y	0.537	0.39
82_L	146_V	0.537	0.39
201_L	218_F	0.537	0.39
80_A	111_I	0.537	0.39
171_L	186_L	0.537	0.39
114_H	171_L	0.534	0.39
58_T	213_F	0.533	0.39
194_A	225_L	0.531	0.39
21_A	24_Y	0.530	0.39
23_L	143_V	0.529	0.38
208_A	212_P	0.528	0.38
47_A	71_L	0.527	0.38
82_L	149_L	0.525	0.38
48_L	127_A	0.524	0.38
17_F	139_W	0.524	0.38
11_A	67_F	0.520	0.37
113_Y	159_V	0.520	0.37
130_W	135_Q	0.519	0.37
155_L	194_A	0.518	0.37
218_F	225_L	0.517	0.37
237_L	242_A	0.516	0.37
95_P	177_Y	0.516	0.37
187_F	236_V	0.515	0.37
70_A	78_E	0.514	0.37
162_L	236_V	0.512	0.37
27_R	252_R	0.511	0.37
105_R	189_V	0.511	0.37
184_N	236_V	0.509	0.36
104_F	217_G	0.509	0.36
141_F	194_A	0.509	0.36
67_F	140_T	0.508	0.36
243_A	248_A	0.508	0.36
21_A	42_V	0.507	0.36
39_G	189_V	0.505	0.36
75_G	186_L	0.505	0.36
169_E	252_R	0.505	0.36
16_W	23_L	0.503	0.36
22_I	26_D	0.502	0.36
129_T	156_F	0.501	0.36
234_F	241_D	0.501	0.36
14_L	137_G	0.501	0.36
53_A	96_P	0.500	0.35
25_L	36_S	0.500	0.35

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2bg9C	1	0.5882	6.7	0.974	Contact Map
4xk8J	1	0.1529	4.2	0.976	Contact Map
4kt0J	1	0.1569	2.8	0.978	Contact Map
1jb0J	1	0.1608	2.4	0.979	Contact Map
1zsgB	1	0.0863	2.2	0.979	Contact Map
3m73A	3	0.349	2.2	0.979	Contact Map
1eyoA	1	0.1176	2	0.98	Contact Map
2lonA	1	0.3451	1.9	0.98	Contact Map
2m67A	1	0.3059	1.9	0.98	Contact Map
4b19A	1	0.1059	1.8	0.98	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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