GREMLIN Database
DUF3623 - Protein of unknown function (DUF3623)
PFAM: PF12291 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 255 (251)
Sequences: 1153 (915)
Seq/√Len: 57.8
META: 0.84

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_L137_G4.8481.00
50_G69_C4.1971.00
13_F17_F3.2671.00
57_D62_G3.1691.00
136_V217_G3.1191.00
121_T141_F3.0151.00
82_L148_R2.9301.00
195_T233_W2.8681.00
192_T233_W2.8671.00
198_A226_A2.7501.00
77_H121_T2.7411.00
126_V138_L2.6751.00
79_L83_T2.6361.00
10_F68_T2.6321.00
187_F233_W2.6301.00
95_P106_R2.6151.00
98_A103_R2.6021.00
82_L111_I2.4861.00
103_R106_R2.4261.00
157_L186_L2.4091.00
143_V221_L2.3311.00
135_Q138_L2.2631.00
54_S66_A2.2251.00
108_V112_L2.1551.00
51_L125_L1.9841.00
172_A175_K1.9471.00
47_A69_C1.9321.00
198_A229_L1.9271.00
184_N188_P1.9131.00
192_T195_T1.8871.00
41_T76_W1.8681.00
108_V149_L1.8320.99
81_F111_I1.8110.99
194_A229_L1.7770.99
111_I148_R1.7750.99
37_L80_A1.7750.99
165_E242_A1.7220.99
202_V222_A1.7080.99
105_R109_Q1.7050.99
116_L120_A1.7010.99
122_A141_F1.6790.99
7_P64_Y1.6390.99
98_A106_R1.6320.99
191_V233_W1.6210.99
151_A235_L1.5840.98
63_A213_F1.5840.98
32_T36_S1.5670.98
187_F195_T1.5570.98
187_F192_T1.5380.98
56_G133_P1.5070.98
181_R184_N1.4940.98
143_V225_L1.4580.97
111_I178_F1.4530.97
78_E148_R1.4530.97
241_D248_A1.4520.97
55_A133_P1.4500.97
14_L71_L1.4380.97
94_C98_A1.4350.97
18_S22_I1.4210.97
209_G212_P1.4190.97
4_Y7_P1.4140.97
196_A200_L1.4140.97
11_A220_L1.4110.97
187_F191_V1.4060.97
37_L85_W1.3920.97
155_L235_L1.3900.97
90_R109_Q1.3860.96
82_L178_F1.3610.96
110_T177_Y1.3580.96
47_A72_L1.3580.96
55_A129_T1.3460.96
153_L186_L1.3380.96
126_V130_W1.3290.95
77_H141_F1.2880.95
94_C106_R1.2860.95
80_A118_L1.2820.95
213_F217_G1.2770.94
35_W38_L1.2640.94
218_F221_L1.2500.94
82_L152_K1.2480.94
44_L121_T1.2470.94
36_S83_T1.2450.94
147_M228_A1.2390.93
196_A199_A1.2300.93
81_F149_L1.2240.93
70_A118_L1.2220.93
90_R106_R1.2180.93
148_R152_K1.2140.93
143_V228_A1.2090.93
102_R105_R1.1960.92
66_A217_G1.1820.92
211_T214_E1.1780.92
157_L188_P1.1740.91
22_I75_G1.1700.91
122_A142_L1.1620.91
215_A219_T1.1560.91
56_G132_A1.1470.90
186_L190_S1.1450.90
68_T72_L1.1410.90
66_A137_G1.1250.90
233_W236_V1.1250.90
62_G65_L1.1220.89
234_F239_L1.1140.89
248_A251_S1.1070.89
221_L225_L1.0990.88
80_A85_W1.0870.88
198_A202_V1.0840.88
17_F20_G1.0770.87
18_S71_L1.0610.87
183_M186_L1.0560.86
10_F14_L1.0540.86
106_R110_T1.0460.86
81_F178_F1.0400.86
22_I83_T1.0310.85
139_W218_F1.0260.85
148_R155_L1.0240.85
225_L229_L1.0220.85
26_D169_E1.0200.84
104_F108_V1.0200.84
110_T174_L1.0190.84
222_A226_A1.0120.84
108_V119_L1.0040.83
15_W19_T1.0000.83
164_E180_R0.9980.83
125_L141_F0.9920.83
157_L184_N0.9910.83
149_L163_N0.9900.83
65_L69_C0.9880.83
40_A79_L0.9750.82
41_T44_L0.9740.82
29_P32_T0.9710.81
111_I149_L0.9670.81
200_L203_E0.9620.81
149_L178_F0.9550.80
14_L68_T0.9550.80
139_W197_A0.9550.80
44_L73_V0.9480.80
58_T62_G0.9420.79
197_A225_L0.9410.79
59_S62_G0.9410.79
72_L75_G0.9400.79
102_R106_R0.9350.79
89_P112_L0.9330.79
160_P184_N0.9310.79
78_E82_L0.9310.79
98_A102_R0.9260.78
4_Y219_T0.9200.78
151_A155_L0.9140.77
28_L32_T0.9120.77
149_L155_L0.9110.77
202_V226_A0.9060.77
66_A136_V0.9020.76
80_A86_I0.8980.76
27_R251_S0.8950.76
39_G42_V0.8890.75
61_A65_L0.8880.75
230_L234_F0.8820.75
23_L155_L0.8810.75
37_L41_T0.8790.74
8_A223_T0.8780.74
103_R176_S0.8780.74
81_F166_F0.8650.73
198_A225_L0.8610.73
46_A50_G0.8590.73
26_D29_P0.8590.73
149_L160_P0.8590.73
103_R177_Y0.8580.73
118_L178_F0.8580.73
147_M225_L0.8530.72
24_Y27_R0.8530.72
239_L242_A0.8490.72
35_W39_G0.8450.72
77_H149_L0.8400.71
47_A75_G0.8380.71
82_L118_L0.8360.71
213_F216_V0.8350.71
240_P246_R0.8300.70
155_L163_N0.8290.70
26_D32_T0.8290.70
30_R170_H0.8150.69
119_L145_W0.8080.68
28_L35_W0.8030.68
170_H235_L0.8030.68
60_V216_V0.7990.67
75_G79_L0.7970.67
154_N159_V0.7970.67
200_L204_R0.7970.67
14_L18_S0.7960.67
103_R109_Q0.7960.67
146_V193_A0.7950.67
41_T45_A0.7950.67
137_G142_L0.7910.66
163_N166_F0.7890.66
154_N190_S0.7880.66
155_L171_L0.7840.66
130_W138_L0.7800.65
217_G221_L0.7740.65
191_V195_T0.7730.65
166_F249_L0.7600.63
160_P236_V0.7580.63
167_L178_F0.7560.63
225_L228_A0.7560.63
150_S232_H0.7540.63
59_S213_F0.7530.63
98_A177_Y0.7490.62
182_P185_L0.7390.61
20_G247_W0.7360.61
161_N184_N0.7340.61
40_A44_L0.7300.60
81_F163_N0.7270.60
50_G65_L0.7260.60
31_R49_W0.7230.59
48_L73_V0.7210.59
212_P215_A0.7180.59
150_S190_S0.7180.59
36_S79_L0.7090.58
167_L175_K0.7090.58
50_G71_L0.7070.58
28_L33_F0.7050.58
125_L132_A0.7050.58
129_T135_Q0.7040.57
82_L155_L0.6960.57
127_A130_W0.6940.56
111_I152_K0.6920.56
57_D61_A0.6910.56
106_R177_Y0.6890.56
118_L141_F0.6880.56
147_M194_A0.6870.56
197_A228_A0.6870.56
160_P241_D0.6870.56
199_A203_E0.6870.56
73_V125_L0.6860.55
201_L225_L0.6860.55
153_L157_L0.6850.55
48_L128_L0.6830.55
16_W19_T0.6820.55
77_H117_A0.6810.55
50_G54_S0.6800.55
241_D250_P0.6780.55
46_A197_A0.6780.55
77_H80_A0.6770.54
118_L148_R0.6700.54
210_A215_A0.6690.54
169_E172_A0.6690.54
104_F157_L0.6630.53
196_A203_E0.6630.53
76_W166_F0.6600.53
111_I177_Y0.6570.52
160_P186_L0.6560.52
81_F91_R0.6530.52
54_S118_L0.6490.51
22_I33_F0.6480.51
53_A65_L0.6470.51
94_C97_G0.6460.51
201_L222_A0.6460.51
183_M188_P0.6450.51
185_L192_T0.6430.51
22_I122_A0.6390.50
161_N166_F0.6350.50
108_V113_Y0.6350.50
189_V193_A0.6340.50
33_F83_T0.6320.50
8_A235_L0.6320.50
91_R173_Y0.6290.49
51_L73_V0.6290.49
226_A250_P0.6270.49
75_G144_L0.6260.49
112_L119_L0.6260.49
151_A228_A0.6250.49
83_T170_H0.6240.49
106_R109_Q0.6240.49
190_S229_L0.6210.48
121_T125_L0.6200.48
162_L166_F0.6200.48
48_L52_A0.6180.48
26_D36_S0.6160.48
53_A185_L0.6130.47
77_H118_L0.6110.47
123_L207_A0.6100.47
226_A235_L0.6070.47
5_A12_L0.6030.46
29_P33_F0.6020.46
230_L237_L0.6020.46
184_N190_S0.6010.46
7_P175_K0.5980.46
51_L129_T0.5980.46
48_L124_A0.5960.46
95_P103_R0.5960.46
55_A125_L0.5950.45
24_Y36_S0.5940.45
110_T171_L0.5940.45
12_L220_L0.5920.45
125_L137_G0.5910.45
13_F50_G0.5900.45
16_W20_G0.5900.45
70_A73_V0.5890.45
63_A216_V0.5890.45
78_E118_L0.5880.45
248_A252_R0.5860.44
111_I118_L0.5850.44
77_H125_L0.5780.44
52_A55_A0.5770.44
198_A222_A0.5750.43
101_W105_R0.5710.43
32_T35_W0.5710.43
37_L79_L0.5710.43
22_I80_A0.5690.43
8_A11_A0.5680.43
91_R113_Y0.5680.43
104_F156_F0.5650.42
239_L243_A0.5640.42
113_Y118_L0.5620.42
75_G155_L0.5620.42
89_P113_Y0.5590.42
80_A180_R0.5560.41
161_N183_M0.5550.41
122_A126_V0.5540.41
50_G53_A0.5530.41
149_L241_D0.5530.41
54_S165_E0.5520.41
151_A225_L0.5520.41
228_A235_L0.5510.41
148_R178_F0.5500.41
22_I235_L0.5500.41
17_F21_A0.5440.40
119_L123_L0.5430.40
54_S69_C0.5430.40
149_L152_K0.5430.40
111_I167_L0.5420.40
76_W171_L0.5420.40
200_L218_F0.5400.40
33_F36_S0.5390.39
77_H173_Y0.5380.39
90_R177_Y0.5370.39
82_L146_V0.5370.39
201_L218_F0.5370.39
80_A111_I0.5370.39
171_L186_L0.5370.39
114_H171_L0.5340.39
58_T213_F0.5330.39
194_A225_L0.5310.39
21_A24_Y0.5300.39
23_L143_V0.5290.38
208_A212_P0.5280.38
47_A71_L0.5270.38
82_L149_L0.5250.38
48_L127_A0.5240.38
17_F139_W0.5240.38
11_A67_F0.5200.37
113_Y159_V0.5200.37
130_W135_Q0.5190.37
155_L194_A0.5180.37
218_F225_L0.5170.37
237_L242_A0.5160.37
95_P177_Y0.5160.37
187_F236_V0.5150.37
70_A78_E0.5140.37
162_L236_V0.5120.37
27_R252_R0.5110.37
105_R189_V0.5110.37
184_N236_V0.5090.36
104_F217_G0.5090.36
141_F194_A0.5090.36
67_F140_T0.5080.36
243_A248_A0.5080.36
21_A42_V0.5070.36
39_G189_V0.5050.36
75_G186_L0.5050.36
169_E252_R0.5050.36
16_W23_L0.5030.36
22_I26_D0.5020.36
129_T156_F0.5010.36
234_F241_D0.5010.36
14_L137_G0.5010.36
53_A96_P0.5000.35
25_L36_S0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bg9C 1 0.5882 6.7 0.974 Contact Map
4xk8J 1 0.1529 4.2 0.976 Contact Map
4kt0J 1 0.1569 2.8 0.978 Contact Map
1jb0J 1 0.1608 2.4 0.979 Contact Map
1zsgB 1 0.0863 2.2 0.979 Contact Map
3m73A 3 0.349 2.2 0.979 Contact Map
1eyoA 1 0.1176 2 0.98 Contact Map
2lonA 1 0.3451 1.9 0.98 Contact Map
2m67A 1 0.3059 1.9 0.98 Contact Map
4b19A 1 0.1059 1.8 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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