GREMLIN Database
DUF3619 - Protein of unknown function (DUF3619)
PFAM: PF12279 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 131 (125)
Sequences: 3153 (2416)
Seq/√Len: 216.1
META: 0.926

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_A10_A4.1711.00
26_E29_R3.3051.00
34_Q37_A2.9611.00
34_Q38_R2.9171.00
29_R33_E2.5181.00
52_L55_A2.3341.00
48_P52_L2.1881.00
118_D121_L2.1741.00
123_P126_Q2.0671.00
5_F9_I2.0601.00
10_A14_D1.9861.00
12_R15_E1.9681.00
7_R10_A1.9661.00
56_G59_G1.8571.00
20_L25_A1.8241.00
54_L58_G1.7731.00
50_P54_L1.6971.00
12_R16_G1.6611.00
57_A60_A1.6591.00
90_G94_W1.6211.00
4_R7_R1.6111.00
52_L56_G1.6101.00
8_R11_A1.5621.00
3_D7_R1.5281.00
58_G61_L1.5241.00
15_E19_D1.5231.00
22_A30_A1.5131.00
116_P119_A1.4911.00
54_L57_A1.4901.00
3_D6_A1.4451.00
103_L108_A1.4371.00
84_L87_G1.4141.00
119_A122_D1.3911.00
126_Q130_K1.3871.00
7_R14_D1.3721.00
110_L117_P1.3321.00
55_A59_G1.3271.00
30_A34_Q1.3241.00
53_A56_G1.3211.00
90_G93_Y1.2731.00
54_L59_G1.2711.00
92_Q96_Q1.2641.00
44_P47_A1.2431.00
7_R11_A1.2421.00
115_L120_Y1.2191.00
115_L119_A1.1971.00
20_L24_T1.1941.00
48_P51_A1.1851.00
70_S74_R1.1821.00
52_L57_A1.1801.00
59_G62_T1.1721.00
106_I109_A1.1671.00
69_G73_R1.1321.00
21_P24_T1.1211.00
79_L86_A1.1211.00
70_S73_R1.0971.00
47_A51_A1.0721.00
50_P55_A1.0721.00
17_A20_L1.0701.00
112_T130_K1.0561.00
63_L67_G1.0381.00
4_R11_A1.0291.00
72_W75_L1.0261.00
46_R54_L1.0201.00
50_P56_G1.0111.00
4_R8_R1.0101.00
30_A33_E0.9821.00
50_P53_A0.9791.00
37_A40_R0.9751.00
54_L61_L0.9671.00
21_P26_E0.9581.00
81_L85_V0.9521.00
117_P126_Q0.9401.00
26_E30_A0.9330.99
121_L126_Q0.9300.99
75_L78_L0.9260.99
49_A52_L0.9230.99
123_P127_A0.9060.99
80_P84_L0.8970.99
77_S82_L0.8870.99
55_A61_L0.8790.99
3_D10_A0.8740.99
46_R56_G0.8650.99
115_L126_Q0.8650.99
53_A57_A0.8640.99
109_A113_D0.8630.99
23_D30_A0.8540.99
96_Q100_A0.8490.99
22_A26_E0.8400.99
127_A130_K0.8360.99
79_L82_L0.8310.99
87_G91_I0.8280.99
72_W77_S0.8230.99
71_W74_R0.8120.99
56_G61_L0.8080.99
52_L59_G0.8050.98
46_R50_P0.8020.98
30_A37_A0.8020.98
93_Y97_D0.7990.98
91_I95_Q0.7900.98
45_A51_A0.7830.98
76_R80_P0.7820.98
56_G60_A0.7810.98
44_P51_A0.7770.98
80_P91_I0.7740.98
114_D120_Y0.7700.98
105_E120_Y0.7620.98
123_P128_W0.7610.98
46_R49_A0.7560.98
44_P48_P0.7470.98
120_Y125_F0.7360.97
46_R53_A0.7340.97
55_A58_G0.7340.97
38_R41_P0.7290.97
21_P25_A0.7260.97
95_Q99_R0.7150.97
53_A58_G0.7150.97
93_Y100_A0.7130.97
58_G63_L0.7090.97
81_L87_G0.6980.96
45_A49_A0.6970.96
121_L127_A0.6880.96
48_P54_L0.6860.96
23_D26_E0.6850.96
101_A110_L0.6850.96
111_L116_P0.6800.96
22_A29_R0.6780.96
71_W78_L0.6700.95
52_L58_G0.6660.95
57_A61_L0.6660.95
2_E74_R0.6620.95
100_A104_A0.6600.95
68_G73_R0.6570.95
89_V92_Q0.6540.95
38_R93_Y0.6540.95
80_P83_A0.6480.94
14_D17_A0.6470.94
51_A58_G0.6450.94
26_E88_L0.6430.94
90_G105_E0.6390.94
84_L88_L0.6310.94
53_A61_L0.6260.93
33_E37_A0.6230.93
76_R79_L0.6230.93
75_L79_L0.6220.93
114_D118_D0.6170.93
77_S80_P0.6150.93
117_P123_P0.6100.92
55_A63_L0.6060.92
104_A124_G0.6060.92
49_A58_G0.6030.92
10_A16_G0.6020.92
82_L85_V0.5940.91
69_G72_W0.5890.91
109_A112_T0.5880.91
68_G72_W0.5870.91
104_A109_A0.5860.91
76_R128_W0.5860.91
78_L82_L0.5830.91
97_D130_K0.5780.90
88_L108_A0.5770.90
57_A62_T0.5760.90
121_L128_W0.5740.90
115_L122_D0.5740.90
102_E127_A0.5690.90
91_I120_Y0.5630.89
48_P59_G0.5620.89
33_E106_I0.5560.89
111_L119_A0.5440.87
118_D123_P0.5420.87
86_A90_G0.5360.87
97_D101_A0.5350.87
95_Q110_L0.5350.87
123_P130_K0.5270.86
111_L114_D0.5230.85
107_D111_L0.5190.85
76_R81_L0.5170.85
74_R81_L0.5170.85
79_L84_L0.5140.84
46_R52_L0.5110.84
47_A54_L0.5090.84
106_I126_Q0.5060.83
103_L130_K0.5050.83
52_L60_A0.5020.83
31_A35_A0.5010.83
22_A27_R0.5000.83
21_P29_R0.5000.83
124_G127_A0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hy7A 1 0.313 5 0.929 Contact Map
3jz0A 2 0.458 5 0.929 Contact Map
2pbeA 1 0.3893 4.5 0.93 Contact Map
1oahA 2 0.1832 3.6 0.934 Contact Map
1rijA 1 0.0916 3.1 0.936 Contact Map
3ne5A 3 0.4885 3 0.936 Contact Map
4mqvB 1 0.1985 3 0.936 Contact Map
2kbwB 1 0.2214 2.9 0.937 Contact Map
3c18A 2 0.4962 2.5 0.939 Contact Map
3dzcA 2 0.3359 2.5 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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