GREMLIN Database
DUF3617 - Protein of unknown function (DUF3617)
PFAM: PF12276 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 157 (145)
Sequences: 10057 (8223)
Seq/√Len: 682.9
META: 0.943

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_L64_K3.5591.00
69_P73_D3.1301.00
91_D102_D2.9441.00
31_E150_K2.8061.00
151_R154_A2.7591.00
122_G125_A2.7191.00
31_E64_K2.7131.00
102_D113_T2.6641.00
131_T144_T2.5551.00
31_E62_T2.4701.00
102_D115_E2.4201.00
35_T146_T2.0911.00
128_G147_I2.0751.00
100_T117_E2.0571.00
26_K151_R2.0011.00
26_K123_D1.9381.00
121_T125_A1.8661.00
131_T142_T1.8451.00
26_K124_S1.8381.00
33_T62_T1.8011.00
90_T102_D1.7901.00
98_T119_T1.7621.00
45_P48_Q1.6811.00
129_T146_T1.6301.00
27_P69_P1.5971.00
129_T144_T1.5621.00
94_R99_V1.5581.00
90_T104_V1.5361.00
32_I149_G1.5211.00
31_E152_L1.5101.00
15_A18_A1.5001.00
33_T148_T1.4961.00
101_W116_A1.4771.00
70_E73_D1.4541.00
100_T115_E1.4501.00
93_K100_T1.4491.00
64_K152_L1.4421.00
106_G109_G1.4361.00
133_T142_T1.4341.00
75_P78_P1.4151.00
37_E144_T1.3871.00
69_P72_A1.3811.00
18_A21_A1.3791.00
74_K77_A1.3621.00
67_L72_A1.2831.00
35_T60_P1.2741.00
104_V113_T1.2601.00
68_T71_D1.2521.00
29_L152_L1.2471.00
74_K78_P1.2071.00
89_V103_M1.1951.00
10_L14_A1.1931.00
39_E42_P1.1871.00
98_T117_E1.1811.00
127_T148_T1.1371.00
27_P72_A1.1311.00
92_V99_V1.1151.00
91_D100_T1.1041.00
14_A17_A1.0851.00
8_A11_A1.0851.00
65_Q71_D1.0771.00
35_T148_T1.0771.00
36_M145_M1.0731.00
39_E43_G1.0671.00
77_A80_F1.0591.00
38_Q42_P1.0521.00
103_M114_G1.0451.00
25_I67_L1.0431.00
15_A19_A1.0281.00
68_T72_A1.0271.00
125_A148_T1.0211.00
120_F125_A1.0201.00
16_A19_A1.0131.00
121_T124_S1.0101.00
78_P81_A1.0101.00
32_I65_Q1.0041.00
121_T127_T1.0031.00
133_T140_P0.9961.00
76_M79_L0.9911.00
6_L9_L0.9821.00
101_W114_G0.9771.00
104_V111_T0.9621.00
110_G114_G0.9611.00
17_A21_A0.9501.00
32_I147_I0.9491.00
10_L13_A0.9481.00
7_A10_L0.9421.00
112_G116_A0.9181.00
106_G111_T0.9171.00
120_F124_S0.9111.00
127_T146_T0.9051.00
37_E146_T0.9031.00
14_A19_A0.8871.00
70_E74_K0.8781.00
135_T140_P0.8781.00
14_A18_A0.8711.00
89_V92_V0.8631.00
76_M80_F0.8591.00
88_T104_V0.8521.00
34_T145_M0.8321.00
26_K154_A0.8291.00
12_L15_A0.8291.00
32_I63_S0.8251.00
9_L13_A0.8181.00
44_M48_Q0.8041.00
33_T60_P0.8001.00
6_L10_L0.7991.00
72_A76_M0.7921.00
17_A20_A0.7851.00
12_L16_A0.7851.00
94_R97_N0.7851.00
115_E131_T0.7791.00
75_P82_G0.7761.00
118_G122_G0.7761.00
134_G141_M0.7661.00
128_G132_M0.7591.00
107_G110_G0.7581.00
72_A75_P0.7581.00
119_T122_G0.7561.00
77_A81_A0.7521.00
15_A20_A0.7511.00
99_V120_F0.7491.00
130_M147_I0.7431.00
14_A20_A0.7411.00
78_P82_G0.7391.00
13_A17_A0.7371.00
125_A149_G0.7331.00
16_A21_A0.7271.00
32_I126_Y0.7241.00
126_Y135_T0.7151.00
95_S98_T0.7091.00
11_A15_A0.7081.00
34_T63_S0.7061.00
126_Y149_G0.7041.00
8_A12_L0.7021.00
5_L9_L0.7021.00
136_G139_Q0.7011.00
117_E129_T0.6961.00
38_Q41_M0.6951.00
9_L12_L0.6851.00
40_Q43_G0.6831.00
33_T150_K0.6811.00
74_K80_F0.6801.00
126_Y130_M0.6781.00
7_A11_A0.6781.00
15_A21_A0.6751.00
79_L82_G0.6731.00
153_G156_C0.6711.00
16_A20_A0.6631.00
137_G141_M0.6631.00
115_E129_T0.6541.00
13_A20_A0.6521.00
89_V101_W0.6511.00
134_G140_P0.6501.00
112_G132_M0.6471.00
87_C105_C0.6461.00
30_W124_S0.6441.00
118_G124_S0.6411.00
13_A19_A0.6411.00
5_L8_A0.6371.00
36_M143_M0.6321.00
67_L71_D0.6291.00
95_S100_T0.6291.00
25_I28_G0.6251.00
135_T138_G0.6231.00
126_Y134_G0.6231.00
27_P151_R0.6231.00
41_M44_M0.6221.00
118_G123_D0.6201.00
97_N119_T0.6151.00
86_D107_G0.6121.00
74_K79_L0.6121.00
42_P45_P0.6111.00
68_T73_D0.6081.00
116_A128_G0.5991.00
48_Q55_M0.5981.00
30_W149_G0.5971.00
108_G112_G0.5961.00
25_I65_Q0.5911.00
41_M45_P0.5891.00
128_G134_G0.5781.00
92_V102_D0.5771.00
118_G147_I0.5751.00
6_L11_A0.5701.00
119_T127_T0.5611.00
133_T138_G0.5581.00
94_R98_T0.5551.00
22_A25_I0.5541.00
130_M145_M0.5531.00
107_G112_G0.5511.00
91_D96_G0.5451.00
92_V101_W0.5431.00
75_P81_A0.5421.00
10_L16_A0.5401.00
97_N121_T0.5381.00
34_T61_Q0.5371.00
34_T147_I0.5371.00
134_G138_G0.5361.00
12_L20_A0.5341.00
13_A18_A0.5311.00
12_L17_A0.5301.00
113_T131_T0.5271.00
14_A21_A0.5271.00
8_A17_A0.5251.00
120_F123_D0.5241.00
124_S150_K0.5221.00
37_E42_P0.5210.99
126_Y129_T0.5180.99
6_L12_L0.5130.99
8_A15_A0.5100.99
103_M132_M0.5100.99
98_T115_E0.5090.99
13_A16_A0.5090.99
25_I30_W0.5090.99
44_M56_M0.5070.99
113_T133_T0.5030.99
93_K102_D0.5010.99
109_G112_G0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zbiC 1 0.1783 65.5 0.86 Contact Map
4jrbA 1 0.3503 4.2 0.924 Contact Map
3gb3A 2 0.3376 3.9 0.925 Contact Map
1y0gA 2 0.7643 3.7 0.926 Contact Map
4pj0O 1 0.7452 3.6 0.927 Contact Map
2qzuA 2 0.6497 2.9 0.93 Contact Map
4rh7A 1 0 2.7 0.931 Contact Map
3ai5A 1 0.3376 2.4 0.933 Contact Map
3ai4A 1 0.3439 2.4 0.933 Contact Map
1tzsX 1 0.0318 2.4 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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