GREMLIN Database
DUF3612 - Protein of unknown function (DUF3612)
PFAM: PF12268 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 176 (174)
Sequences: 624 (304)
Seq/√Len: 23.0
META: 0.912

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
108_D111_E4.4431.00
96_I149_I3.9501.00
103_E109_A3.0971.00
99_N113_V3.0781.00
98_L149_I2.6920.99
74_L113_V2.5330.98
107_V136_A2.3050.97
134_K153_L2.2680.97
97_D100_P2.1540.96
47_A60_S2.1110.95
63_I129_I2.0930.95
21_R98_L2.0760.95
61_S78_H2.0670.95
164_S174_Y1.9930.93
40_S165_S1.9670.93
1_T4_S1.9660.93
21_R164_S1.9230.92
21_R90_H1.8110.90
90_H98_L1.7670.88
120_C125_G1.7600.88
116_I133_A1.6940.86
5_P98_L1.6900.86
53_N102_L1.6550.85
149_I168_P1.6440.84
147_A162_P1.6310.84
15_Y20_L1.6210.84
119_A127_A1.6170.83
2_A11_Y1.6100.83
9_W12_F1.5710.82
47_A77_C1.5690.82
51_M59_P1.5580.81
23_V41_D1.5360.80
134_K137_L1.4910.78
66_L81_R1.4830.78
150_E158_R1.4820.78
104_A126_S1.4710.77
35_N39_V1.4640.77
90_H145_N1.4590.76
52_L105_Q1.4550.76
76_C120_C1.4540.76
78_H94_V1.4530.76
141_A150_E1.4220.75
14_A18_G1.4130.74
74_L133_A1.3980.73
169_R173_C1.3910.73
50_R77_C1.3730.72
107_V139_S1.3670.72
36_M142_K1.3630.71
103_E140_V1.3620.71
18_G33_W1.3610.71
96_I146_I1.3550.71
161_C167_C1.3530.71
2_A7_P1.3490.71
159_I164_S1.3340.70
21_R85_M1.3260.69
52_L85_M1.3070.68
39_V79_S1.3010.68
6_Y9_W1.2880.67
115_E132_A1.2860.67
147_A158_R1.2530.65
44_P78_H1.2340.63
86_A127_A1.2310.63
68_D71_R1.2260.63
6_Y10_H1.2070.62
23_V28_G1.1970.61
143_I152_A1.1920.61
106_G112_I1.1830.60
34_G43_C1.1750.60
87_G140_V1.1600.59
87_G129_I1.1520.58
167_C173_C1.1350.57
128_P135_K1.1330.57
1_T6_Y1.1060.55
65_V122_R1.1030.55
142_K152_A1.0970.54
66_L73_R1.0960.54
78_H93_S1.0880.54
80_I149_I1.0830.53
31_L77_C1.0800.53
20_L35_N1.0620.52
37_R93_S1.0570.51
132_A135_K1.0420.50
70_D88_N1.0410.50
59_P124_G1.0400.50
10_H13_D1.0390.50
66_L88_N1.0340.50
162_P174_Y1.0280.49
105_Q142_K1.0250.49
149_I153_L1.0120.48
44_P93_S1.0010.48
45_H60_S0.9950.47
54_E116_I0.9910.47
6_Y12_F0.9910.47
61_S152_A0.9880.47
52_L90_H0.9860.47
1_T9_W0.9800.46
145_N148_W0.9750.46
38_Q141_A0.9750.46
9_W13_D0.9720.46
142_K156_P0.9570.45
80_I105_Q0.9540.44
112_I136_A0.9430.44
102_L107_V0.9430.44
98_L174_Y0.9430.44
44_P94_V0.9420.44
16_P21_R0.9410.43
50_R158_R0.9400.43
110_E114_A0.9380.43
103_E131_K0.9370.43
106_G117_K0.9350.43
44_P66_L0.9310.43
22_A36_M0.9290.43
67_R159_I0.9280.43
59_P105_Q0.9270.43
3_V6_Y0.9170.42
4_S9_W0.9120.41
65_V72_S0.9110.41
152_A156_P0.9010.41
33_W39_V0.8930.40
4_S10_H0.8890.40
21_R174_Y0.8720.39
124_G154_E0.8700.39
43_C62_Q0.8690.39
106_G111_E0.8680.39
38_Q164_S0.8630.38
5_P21_R0.8610.38
81_R96_I0.8600.38
113_V149_I0.8580.38
83_R110_E0.8550.38
19_Y152_A0.8400.37
91_V100_P0.8350.36
96_I127_A0.8350.36
111_E118_E0.8340.36
113_V117_K0.8320.36
142_K150_E0.8160.35
47_A102_L0.8120.35
107_V112_I0.8110.35
54_E122_R0.8080.35
166_A174_Y0.8070.35
80_I83_R0.8040.34
43_C161_C0.8020.34
104_A141_A0.7970.34
54_E135_K0.7920.34
135_K138_R0.7900.34
116_I129_I0.7900.34
36_M108_D0.7830.33
101_A140_V0.7810.33
166_A171_P0.7800.33
34_G62_Q0.7750.33
21_R162_P0.7740.33
114_A118_E0.7600.32
1_T12_F0.7560.31
54_E156_P0.7530.31
159_I165_S0.7460.31
123_N131_K0.7460.31
47_A50_R0.7450.31
40_S66_L0.7430.31
4_S12_F0.7350.30
33_W48_V0.7310.30
69_G72_S0.7290.30
61_S69_G0.7260.30
57_G132_A0.7230.30
159_I174_Y0.7200.29
141_A153_L0.7160.29
87_G116_I0.7160.29
131_K137_L0.7070.29
74_L85_M0.7060.29
30_P76_C0.7030.28
142_K145_N0.7000.28
91_V101_A0.6990.28
119_A130_P0.6950.28
129_I133_A0.6950.28
76_C80_I0.6940.28
37_R78_H0.6930.28
141_A158_R0.6900.28
138_R141_A0.6890.28
24_Y29_I0.6850.27
71_R102_L0.6740.27
108_D132_A0.6730.27
43_C75_Y0.6700.27
48_V51_M0.6680.26
111_E115_E0.6650.26
126_S156_P0.6650.26
52_L159_I0.6630.26
164_S172_H0.6620.26
68_D152_A0.6570.26
85_M126_S0.6510.26
166_A170_T0.6500.25
44_P68_D0.6490.25
112_I133_A0.6470.25
67_R70_D0.6450.25
2_A105_Q0.6440.25
71_R105_Q0.6430.25
35_N79_S0.6380.25
68_D93_S0.6350.25
137_L154_E0.6320.25
54_E147_A0.6310.24
22_A28_G0.6300.24
27_N106_G0.6240.24
131_K135_K0.6190.24
129_I134_K0.6100.23
85_M102_L0.6080.23
143_I153_L0.6080.23
55_P118_E0.6030.23
57_G137_L0.5990.23
74_L162_P0.5990.23
52_L82_T0.5970.23
68_D143_I0.5970.23
45_H152_A0.5960.23
83_R88_N0.5940.23
90_H126_S0.5940.23
105_Q108_D0.5900.22
93_S99_N0.5870.22
54_E57_G0.5850.22
137_L155_K0.5850.22
82_T117_K0.5850.22
73_R123_N0.5840.22
52_L99_N0.5840.22
112_I150_E0.5820.22
50_R141_A0.5810.22
81_R88_N0.5790.22
16_P162_P0.5780.22
159_I171_P0.5780.22
40_S74_L0.5770.22
117_K159_I0.5740.22
98_L164_S0.5710.22
131_K166_A0.5700.21
38_Q59_P0.5700.21
5_P149_I0.5680.21
76_C127_A0.5670.21
164_S169_R0.5660.21
45_H91_V0.5640.21
115_E154_E0.5630.21
31_L41_D0.5570.21
24_Y27_N0.5520.21
105_Q150_E0.5490.21
157_A160_I0.5460.20
18_G35_N0.5430.20
36_M117_K0.5430.20
21_R113_V0.5420.20
108_D131_K0.5420.20
59_P92_L0.5400.20
35_N52_L0.5400.20
23_V34_G0.5380.20
13_D91_V0.5330.20
53_N111_E0.5320.20
45_H126_S0.5280.20
89_P146_I0.5250.19
113_V116_I0.5240.19
141_A170_T0.5220.19
13_D90_H0.5220.19
78_H152_A0.5210.19
155_K166_A0.5210.19
138_R154_E0.5200.19
126_S153_L0.5160.19
70_D111_E0.5160.19
28_G41_D0.5150.19
80_I118_E0.5110.19
111_E139_S0.5090.19
63_I119_A0.5080.19
58_K111_E0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3n5nX 1 0.8636 8.8 0.974 Contact Map
4v0qA 2 0.5909 7.5 0.974 Contact Map
1r69A 1 0.3239 6.6 0.975 Contact Map
4k6mA 2 0.5909 5.2 0.976 Contact Map
2ckwA 1 0.8523 5.2 0.976 Contact Map
2k53A 1 0.3977 4.4 0.977 Contact Map
1oigA 1 0.108 4.2 0.977 Contact Map
3kz3A 2 0.4205 4.2 0.977 Contact Map
2nteA 1 0.5057 4.2 0.977 Contact Map
3vh7B 1 0.1193 4.1 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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