GREMLIN Database
DUF3613 - Protein of unknown function (DUF3613)
PFAM: PF12266 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 67 (59)
Sequences: 505 (341)
Seq/√Len: 44.4
META: 0.545

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_K56_K5.1431.00
25_L31_A2.5321.00
53_K58_P2.4771.00
46_L56_K2.1981.00
43_E47_A2.1731.00
24_A27_R1.9330.99
57_H61_E1.9070.99
46_L52_L1.8210.99
33_S37_Q1.7420.98
24_A28_S1.7040.98
8_A11_Q1.6620.97
23_L27_R1.6390.97
39_A47_A1.6330.97
29_G32_A1.5060.95
44_A48_Y1.4940.95
48_Y51_Y1.3980.93
41_G55_F1.3580.92
37_Q44_A1.3360.91
37_Q40_T1.3180.91
25_L28_S1.3000.90
41_G51_Y1.2600.89
43_E49_Q1.2210.87
39_A44_A1.2190.87
7_P11_Q1.2100.86
18_A22_W1.1980.86
22_W47_A1.1450.83
49_Q53_K1.1350.83
9_S12_Q1.0880.80
54_S57_H1.0440.77
41_G48_Y0.9640.71
14_E17_D0.9600.71
22_W25_L0.9490.70
21_A45_E0.8880.65
8_A12_Q0.8830.64
39_A55_F0.8730.63
7_P12_Q0.8650.63
7_P10_P0.8590.62
42_A46_L0.8380.60
15_V44_A0.8140.58
40_T59_I0.7890.56
29_G33_S0.7850.55
22_W31_A0.7730.54
16_G44_A0.7580.53
7_P34_P0.7480.52
33_S45_E0.7430.51
27_R30_R0.7430.51
35_T38_P0.7360.50
51_Y55_F0.7280.50
29_G47_A0.7100.48
29_G57_H0.7100.48
15_V38_P0.7090.48
9_S13_S0.7020.47
38_P51_Y0.6980.47
45_E64_D0.6830.45
20_R45_E0.6720.44
13_S17_D0.6550.43
57_H62_F0.6470.42
39_A42_A0.6420.41
37_Q43_E0.6420.41
15_V52_L0.6410.41
35_T47_A0.6230.40
23_L30_R0.6150.39
49_Q56_K0.6040.38
52_L56_K0.5970.37
10_P20_R0.5950.37
14_E25_L0.5800.36
39_A43_E0.5790.36
23_L60_P0.5750.35
28_S31_A0.5730.35
34_P59_I0.5560.34
28_S53_K0.5530.33
50_R60_P0.5530.33
20_R57_H0.5510.33
37_Q62_F0.5470.33
45_E63_F0.5440.33
38_P54_S0.5440.33
17_D58_P0.5390.32
17_D29_G0.5350.32
34_P42_A0.5310.32
17_D40_T0.5230.31
16_G19_T0.5220.31
14_E53_K0.5210.31
38_P42_A0.5170.30
16_G51_Y0.5100.30
31_A61_E0.5100.30
56_K61_E0.5020.29
12_Q17_D0.5020.29
54_S60_P0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ufiA 3 0.4925 5.6 0.902 Contact Map
3k0zA 2 0.6567 3.6 0.911 Contact Map
2lnjA 1 0.4627 3.2 0.913 Contact Map
1n4qB 2 0.403 2.9 0.915 Contact Map
2xb3A 1 0.3284 2.7 0.917 Contact Map
4ql6A 2 0.7761 2.5 0.918 Contact Map
2hsjA 3 0.4179 2.5 0.918 Contact Map
2ii3A 4 0.4776 2.4 0.918 Contact Map
2ec4A 1 0.4776 2.2 0.92 Contact Map
4pofA 3 0.4478 2.2 0.92 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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