GREMLIN Database
DUF3611 - Protein of unknown function (DUF3611)
PFAM: PF12263 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 177 (174)
Sequences: 791 (574)
Seq/√Len: 43.5
META: 0.671

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_W75_T4.7731.00
153_Q157_N3.6001.00
74_Y102_G3.3521.00
66_F105_A3.3201.00
139_Q142_S3.3171.00
70_W102_G3.0791.00
75_T78_A3.0541.00
60_G113_S2.9231.00
171_W175_R2.5711.00
129_L133_Q2.3871.00
85_D88_L2.3071.00
14_L168_F2.2541.00
66_F70_W2.2321.00
77_L95_V2.1361.00
99_L169_S2.0220.99
133_Q137_V2.0180.99
140_P143_W2.0020.99
106_S122_G1.9700.99
47_N53_G1.9540.99
125_L149_I1.9160.99
72_F75_T1.8730.99
65_L68_I1.8290.98
35_F126_A1.8010.98
102_G172_L1.6920.97
57_A151_V1.6410.97
26_G64_L1.6120.97
133_Q138_I1.6060.96
50_L53_G1.6040.96
73_R90_P1.5790.96
116_G162_H1.5350.95
132_P136_P1.5300.95
132_P135_V1.5130.95
47_N50_L1.5120.95
53_G101_I1.5060.95
169_S172_L1.5010.95
59_A63_V1.4780.94
162_H165_G1.4700.94
119_A122_G1.4380.94
67_S162_H1.4200.93
114_L165_G1.4000.93
114_L163_F1.3520.91
137_V144_V1.3360.91
125_L133_Q1.3280.90
122_G153_Q1.3240.90
125_L150_F1.3040.90
8_A78_A1.2990.89
55_F59_A1.2980.89
129_L148_D1.2880.89
8_A152_V1.2860.89
64_L144_V1.2630.88
126_A159_L1.2590.88
62_L66_F1.2590.88
92_K95_V1.2520.88
14_L21_L1.2500.88
134_G137_V1.2470.87
81_L154_A1.2470.87
32_L56_L1.2410.87
12_R78_A1.2280.87
124_L152_V1.2200.86
142_S146_A1.2200.86
67_S106_S1.2070.86
36_A149_I1.1950.85
18_G71_S1.1610.83
154_A157_N1.1520.83
15_G74_Y1.1500.83
118_Q157_N1.1430.82
15_G18_G1.1380.82
39_F129_L1.1280.82
56_L145_S1.1220.81
70_W101_I1.1200.81
41_R78_A1.1170.81
3_A8_A1.1130.81
132_P137_V1.1100.80
16_W76_R1.1010.80
136_P140_P1.0920.79
91_S176_V1.0910.79
25_L69_Y1.0900.79
123_S127_K1.0860.79
121_V153_Q1.0740.78
7_L11_F1.0590.77
4_L89_R1.0570.77
34_L43_A1.0540.77
159_L165_G1.0390.76
23_L85_D1.0340.76
109_G162_H1.0210.75
118_Q156_T1.0200.75
16_W22_Q1.0170.74
112_L151_V0.9970.73
25_L119_A0.9900.72
157_N168_F0.9850.72
118_Q160_F0.9800.72
114_L160_F0.9570.70
12_R16_W0.9540.69
47_N54_L0.9520.69
29_S125_L0.9490.69
130_S136_P0.9420.68
31_L96_I0.9380.68
136_P143_W0.9360.68
122_G154_A0.9360.68
20_W75_T0.9340.68
156_T166_L0.9310.68
123_S149_I0.9200.67
86_P121_V0.9200.67
8_A124_L0.9180.66
7_L17_I0.9180.66
90_P105_A0.9170.66
57_A155_N0.9110.66
16_W124_L0.9090.66
70_W74_Y0.8950.64
135_V150_F0.8910.64
5_Q9_R0.8810.63
14_L18_G0.8770.63
124_L149_I0.8760.63
145_S149_I0.8670.62
20_W24_V0.8670.62
30_A89_R0.8670.62
151_V155_N0.8660.62
50_L54_L0.8660.62
33_L37_L0.8480.60
120_E148_D0.8470.60
108_L112_L0.8440.60
64_L106_S0.8430.60
32_L152_V0.8410.60
63_V105_A0.8400.60
89_R95_V0.8390.59
36_A123_S0.8390.59
131_Q143_W0.8370.59
36_A40_R0.8270.58
25_L28_V0.8260.58
85_D144_V0.8040.56
11_F99_L0.8010.56
64_L153_Q0.7990.56
101_I125_L0.7980.56
76_R93_A0.7940.55
130_S147_L0.7940.55
27_V95_V0.7870.55
11_F38_V0.7870.55
34_L62_L0.7870.55
34_L159_L0.7840.54
5_Q8_A0.7750.53
116_G127_K0.7730.53
39_F42_S0.7680.53
26_G145_S0.7670.53
131_Q138_I0.7630.52
30_A174_F0.7580.52
13_R78_A0.7570.52
15_G165_G0.7520.51
120_E145_S0.7500.51
144_V175_R0.7440.50
145_S151_V0.7350.50
82_R86_P0.7310.49
61_L65_L0.7270.49
31_L150_F0.7250.49
7_L10_A0.7180.48
125_L129_L0.7170.48
23_L96_I0.7160.48
52_F93_A0.7110.47
135_V138_I0.7100.47
120_E152_V0.7100.47
28_V53_G0.7080.47
114_L122_G0.7070.47
96_I161_A0.7060.47
90_P94_E0.7050.47
143_W149_I0.7040.47
71_S97_R0.7000.46
107_L165_G0.6920.45
3_A38_V0.6910.45
3_A6_R0.6900.45
72_F92_K0.6870.45
17_I26_G0.6850.45
113_S134_G0.6800.44
88_L166_L0.6770.44
161_A164_V0.6720.44
11_F70_W0.6720.44
17_I27_V0.6720.44
113_S176_V0.6650.43
70_W176_V0.6650.43
10_A13_R0.6640.43
64_L173_L0.6630.43
120_E143_W0.6620.43
86_P158_T0.6620.43
6_R110_M0.6590.42
20_W35_F0.6550.42
24_V111_L0.6480.41
107_L122_G0.6460.41
7_L15_G0.6460.41
91_S96_I0.6450.41
110_M160_F0.6430.41
31_L114_L0.6380.40
39_F145_S0.6360.40
60_G161_A0.6320.40
72_F80_R0.6310.40
7_L92_K0.6260.39
155_N162_H0.6260.39
85_D91_S0.6250.39
63_V135_V0.6220.39
98_L156_T0.6210.39
84_A95_V0.6170.39
39_F134_G0.6170.39
28_V61_L0.6140.38
121_V142_S0.6130.38
10_A86_P0.6100.38
7_L30_A0.6090.38
116_G128_A0.6090.38
58_I107_L0.6080.38
78_A82_R0.6080.38
115_L119_A0.6050.37
137_V140_P0.5980.37
51_G54_L0.5960.37
23_L68_I0.5920.36
62_L153_Q0.5910.36
58_I161_A0.5850.36
64_L166_L0.5790.35
131_Q144_V0.5740.35
60_G150_F0.5710.34
141_T166_L0.5690.34
35_F147_L0.5680.34
10_A32_L0.5680.34
116_G139_Q0.5630.34
34_L130_S0.5620.34
92_K99_L0.5610.34
14_L66_F0.5600.33
96_I176_V0.5590.33
28_V31_L0.5590.33
64_L143_W0.5580.33
110_M115_L0.5580.33
40_R111_L0.5580.33
61_L89_R0.5550.33
38_V124_L0.5530.33
21_L164_V0.5520.33
159_L163_F0.5410.32
113_S128_A0.5410.32
26_G62_L0.5380.32
99_L114_L0.5370.32
57_A158_T0.5320.31
24_V68_I0.5320.31
124_L137_V0.5320.31
149_I160_F0.5310.31
47_N51_G0.5290.31
56_L129_L0.5290.31
161_A165_G0.5280.31
154_A167_V0.5280.31
18_G165_G0.5240.30
133_Q143_W0.5230.30
119_A123_S0.5230.30
128_A162_H0.5190.30
101_I107_L0.5180.30
122_G157_N0.5160.30
144_V150_F0.5160.30
109_G116_G0.5160.30
12_R34_L0.5160.30
10_A141_T0.5150.30
144_V148_D0.5120.30
81_L117_A0.5120.30
4_L92_K0.5090.29
7_L168_F0.5080.29
26_G126_A0.5080.29
87_A147_L0.5070.29
9_R111_L0.5020.29
94_E115_L0.5000.29
70_W75_T0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ayfA 2 0.887 34.1 0.939 Contact Map
3o7qA 1 0.8983 13.6 0.949 Contact Map
2m20A 2 0.2938 7.8 0.955 Contact Map
4ev6A 3 0.3785 7.8 0.955 Contact Map
2ljbA 3 0.1412 7.6 0.955 Contact Map
2l2tA 2 0.2486 6.7 0.956 Contact Map
3s8fA 1 0.774 6.4 0.956 Contact Map
4i0uA 4 0.3672 6 0.957 Contact Map
1ytrA 1 0.0904 5.3 0.958 Contact Map
3bkdA 4 0.1412 4.8 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0063 seconds.