GREMLIN Database
CAF1A - Chromatin assembly factor 1 subunit A
PFAM: PF12253 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 74 (71)
Sequences: 736 (547)
Seq/√Len: 64.9
META: 0.402

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_D44_E3.9681.00
41_Y46_E3.7521.00
21_S33_D2.6961.00
13_Y16_T2.5881.00
4_Q12_P2.4631.00
17_W37_L2.4431.00
2_L14_Y2.1871.00
58_D61_D2.0921.00
9_V44_E2.0761.00
21_S24_V2.0181.00
3_L6_H1.8251.00
55_D58_D1.7651.00
24_V33_D1.7311.00
10_R47_W1.6640.99
16_T42_D1.3600.97
41_Y44_E1.3150.97
2_L12_P1.2300.95
30_F33_D1.2120.95
11_P47_W1.2020.94
13_Y18_T1.1360.93
16_T41_Y1.1260.92
1_K16_T1.1130.92
9_V45_A1.1110.92
59_D62_E1.1090.92
20_K67_D1.0720.90
8_D42_D1.0590.90
29_P33_D1.0490.89
22_S65_E1.0450.89
39_Y42_D1.0340.88
52_E56_L0.9990.87
11_P43_S0.9940.86
17_W24_V0.9930.86
8_D45_A0.9900.86
68_E71_D0.9790.86
39_Y43_S0.9790.86
22_S25_G0.9620.85
18_T41_Y0.9460.84
10_R49_E0.9280.82
21_S30_F0.9280.82
17_W36_D0.9240.82
17_W48_E0.9230.82
64_E67_D0.8880.80
32_K35_P0.8680.78
28_N60_D0.8670.78
34_L37_L0.8550.77
40_D54_E0.8370.75
16_T51_E0.8350.75
65_E68_E0.8340.75
28_N31_A0.8310.75
21_S26_P0.8260.74
25_G28_N0.8150.73
60_D63_E0.8100.73
45_A55_D0.8020.72
64_E69_D0.7890.71
13_Y17_W0.7830.70
18_T59_D0.7720.69
65_E70_D0.7620.68
8_D32_K0.7560.68
10_R48_E0.7560.68
26_P30_F0.7440.66
45_A57_D0.7420.66
42_D47_W0.7410.66
17_W50_E0.7370.66
41_Y69_D0.7270.65
10_R43_S0.7260.65
1_K18_T0.7230.64
40_D50_E0.7200.64
40_D44_E0.7040.62
49_E52_E0.7030.62
43_S46_E0.7020.62
31_A55_D0.6880.60
41_Y52_E0.6830.60
23_V31_A0.6600.57
39_Y47_W0.6590.57
18_T55_D0.6430.55
22_S67_D0.6400.55
59_D66_E0.6390.55
23_V66_E0.6340.54
37_L53_G0.6330.54
38_D52_E0.6330.54
18_T25_G0.6320.54
21_S27_R0.6290.54
30_F38_D0.6190.52
24_V31_A0.6170.52
23_V63_E0.6110.52
34_L40_D0.6050.51
5_F8_D0.6020.50
3_L12_P0.5980.50
4_Q9_V0.5970.50
33_D36_D0.5930.49
41_Y48_E0.5920.49
21_S25_G0.5920.49
43_S47_W0.5900.49
37_L50_E0.5900.49
36_D50_E0.5800.48
20_K68_E0.5580.45
11_P41_Y0.5540.45
51_E56_L0.5440.44
4_Q54_E0.5310.42
19_K46_E0.5300.42
27_R38_D0.5270.42
60_D64_E0.5210.41
6_H22_S0.5200.41
10_R19_K0.5130.40
23_V67_D0.5060.39
12_P56_L0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kblA 2 0 54 0.85 Contact Map
4u7aA 1 0 41.7 0.86 Contact Map
2ca6A 1 0.6486 28.7 0.872 Contact Map
4fp9B 2 0.5541 25.5 0.875 Contact Map
4gyiA 1 0.5946 18.7 0.883 Contact Map
2ayuA 2 0.5405 16.8 0.885 Contact Map
4ui9I 1 0.6351 6.5 0.904 Contact Map
2a1xA 1 0.2703 3.8 0.914 Contact Map
1tljA 2 0.1351 3.8 0.915 Contact Map
1vluA 2 0.1757 3.6 0.915 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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