GREMLIN Database
DUF3606 - Protein of unknown function (DUF3606)
PFAM: PF12244 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 54 (51)
Sequences: 13400 (8124)
Seq/√Len: 1137.6
META: 0.957

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_K52_Y2.5041.00
45_S48_A2.1381.00
32_E36_R1.9391.00
38_A52_Y1.9291.00
25_A32_E1.7811.00
31_S34_E1.7161.00
48_A51_K1.7101.00
27_K50_R1.6871.00
24_W28_L1.6701.00
7_P11_S1.6051.00
38_A42_V1.6021.00
30_V35_L1.5431.00
18_D22_R1.4341.00
12_R44_N1.3421.00
21_V32_E1.3181.00
28_L50_R1.3091.00
15_L36_R1.3091.00
33_E37_A1.2841.00
23_Y27_K1.2641.00
34_E37_A1.2561.00
39_V49_V1.1791.00
15_L39_V1.1441.00
36_R40_K1.1251.00
22_R32_E1.1061.00
46_A50_R1.0331.00
47_A51_K1.0001.00
24_W49_V0.9851.00
30_V34_E0.9811.00
21_V25_A0.9741.00
11_S45_S0.9641.00
30_V38_A0.9561.00
6_G10_R0.9511.00
14_N17_E0.9501.00
38_A49_V0.9491.00
22_R26_K0.9451.00
15_L21_V0.9411.00
49_V53_L0.9141.00
18_D32_E0.9041.00
24_W46_A0.8681.00
13_I24_W0.8331.00
4_K8_Q0.8321.00
12_R45_S0.8191.00
37_A40_K0.8131.00
14_N20_E0.8081.00
17_E20_E0.8021.00
42_V48_A0.7921.00
21_V36_R0.7891.00
24_W35_L0.7711.00
7_P10_R0.7671.00
15_L44_N0.7601.00
23_Y26_K0.7471.00
42_V52_Y0.7451.00
34_E38_A0.7401.00
20_E23_Y0.7351.00
37_A41_K0.7301.00
19_Y23_Y0.7181.00
35_L38_A0.6801.00
25_A35_L0.6761.00
14_N44_N0.6721.00
7_P23_Y0.6341.00
38_A53_L0.6171.00
8_Q11_S0.6141.00
35_L46_A0.6051.00
5_R10_R0.6021.00
28_L38_A0.6001.00
13_I49_V0.5831.00
42_V49_V0.5731.00
5_R8_Q0.5671.00
4_K7_P0.5581.00
28_L35_L0.5401.00
18_D26_K0.5221.00
3_T8_Q0.5151.00
9_D12_R0.5151.00
3_T6_G0.5131.00
33_E36_R0.5031.00
15_L40_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hu9A 1 0.963 27.8 0.79 Contact Map
4fe7A 2 1 16.7 0.81 Contact Map
3mklA 1 1 16.2 0.811 Contact Map
3gbgA 1 1 15.8 0.812 Contact Map
4e6kG 1 0.5926 14.9 0.815 Contact Map
3zf7w 1 1 13.9 0.817 Contact Map
3j61F 1 1 13.5 0.818 Contact Map
2k27A 1 0.9815 13.2 0.819 Contact Map
3oioA 1 1 12.9 0.82 Contact Map
3oouA 1 1 12.7 0.821 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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