GREMLIN Database
PCIF1_WW - Phosphorylated CTD interacting factor 1 WW domain
PFAM: PF12237 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 172 (157)
Sequences: 524 (474)
Seq/√Len: 37.8
META: 0.752

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_F23_V4.7641.00
103_N106_F4.7281.00
102_A114_M3.7461.00
99_S133_S3.6111.00
29_R79_D3.5131.00
65_P81_D3.0661.00
67_N103_N2.8501.00
111_M138_V2.5021.00
163_P166_E2.4311.00
111_M146_A2.2991.00
48_F101_E2.2660.99
114_M118_I2.1600.99
64_S67_N2.0720.99
117_H121_L2.0480.99
97_S130_E2.0450.99
114_M136_V2.0290.99
102_A118_I1.9920.99
111_M115_V1.9910.99
79_D86_S1.9910.99
26_L66_L1.9840.99
111_M141_W1.9440.98
74_C93_F1.9400.98
48_F134_F1.8740.98
75_S86_S1.8060.97
38_G103_N1.7010.96
41_A107_V1.6870.96
78_P82_K1.6630.96
57_V99_S1.6600.96
27_L66_L1.6600.96
22_R83_Y1.6560.96
101_E137_I1.6340.95
62_F91_F1.6260.95
51_L135_V1.5330.93
67_N106_F1.5230.93
61_C90_F1.5140.93
33_L42_A1.4860.92
59_F72_R1.4690.92
59_F87_L1.4670.92
22_R80_T1.4660.92
49_D69_Y1.4400.91
90_F118_I1.4270.90
40_Q64_S1.4130.90
90_F134_F1.4100.90
88_G105_P1.4020.90
59_F74_C1.2950.86
115_V146_A1.2790.85
67_N141_W1.2700.84
20_L23_V1.2690.84
74_C87_L1.2660.84
79_D88_G1.2490.83
90_F105_P1.2390.83
72_R87_L1.2240.82
43_L48_F1.1990.81
103_N141_W1.1950.81
38_G106_F1.1940.81
49_D53_K1.1660.79
122_L134_F1.1560.78
57_V133_S1.1490.78
95_P117_H1.0910.74
95_P121_L1.0810.73
66_L158_K1.0610.72
100_F134_F1.0540.72
161_V166_E1.0490.71
61_C100_F1.0370.70
98_G134_F1.0200.69
40_Q67_N1.0110.68
119_E122_L1.0070.68
101_E106_F1.0070.68
86_S89_S1.0000.67
137_I169_Y0.9970.67
119_E123_E0.9860.66
67_N104_P0.9860.66
156_L170_R0.9810.66
164_A168_G0.9730.65
136_V146_A0.9710.65
80_T131_P0.9600.64
98_G132_L0.9500.63
60_E103_N0.9470.63
63_A75_S0.9350.62
60_E67_N0.9310.62
19_F27_L0.9290.62
39_Q107_V0.9240.61
99_S135_V0.9200.61
151_E154_P0.9180.61
108_E141_W0.9110.60
33_L106_F0.9100.60
156_L163_P0.9080.60
101_E108_E0.9020.59
148_K152_K0.9010.59
48_F76_A0.8910.58
146_A150_L0.8680.56
106_F141_W0.8680.56
119_E149_R0.8660.56
105_P110_L0.8610.56
18_A22_R0.8580.56
19_F68_C0.8560.55
26_L80_T0.8440.54
43_L70_L0.8340.53
152_K166_E0.8320.53
94_K117_H0.8300.53
154_P163_P0.8250.53
152_K161_V0.8240.53
34_G137_I0.8080.51
106_F114_M0.8050.51
80_T86_S0.7990.50
84_F98_G0.7990.50
160_L167_H0.7980.50
151_E155_F0.7980.50
98_G122_L0.7960.50
100_F133_S0.7940.50
67_N105_P0.7920.50
99_S131_P0.7780.48
121_L132_L0.7680.48
166_E170_R0.7680.48
65_P73_Y0.7630.47
23_V77_F0.7620.47
39_Q76_A0.7610.47
53_K155_F0.7540.46
48_F68_C0.7530.46
40_Q106_F0.7500.46
42_A149_R0.7430.45
61_C102_A0.7420.45
152_K156_L0.7400.45
62_F67_N0.7390.45
36_G76_A0.7350.45
53_K142_R0.7340.45
23_V133_S0.7330.44
13_D16_E0.7250.44
24_F134_F0.7240.44
49_D154_P0.7220.43
112_E145_E0.7220.43
107_V138_V0.7180.43
25_C80_T0.7170.43
162_L167_H0.7120.43
86_S105_P0.7040.42
118_I134_F0.7030.42
52_R68_C0.6980.41
120_E124_A0.6940.41
118_I136_V0.6930.41
64_S103_N0.6920.41
63_A68_C0.6690.39
116_D148_K0.6690.39
160_L169_Y0.6680.39
49_D123_E0.6660.39
42_A60_E0.6640.38
34_G39_Q0.6640.38
158_K163_P0.6630.38
111_M136_V0.6630.38
46_S73_Y0.6630.38
89_S92_D0.6610.38
102_A136_V0.6580.38
165_G170_R0.6580.38
44_P168_G0.6540.38
24_F28_L0.6520.37
164_A170_R0.6490.37
58_T131_P0.6440.37
108_E146_A0.6400.36
26_L34_G0.6380.36
143_D164_A0.6380.36
137_I142_R0.6370.36
154_P159_H0.6370.36
153_S156_L0.6370.36
66_L75_S0.6360.36
91_F113_A0.6360.36
43_L103_N0.6320.36
154_P165_G0.6280.35
40_Q103_N0.6270.35
40_Q105_P0.6260.35
36_G41_A0.6250.35
37_G114_M0.6250.35
15_K129_N0.6240.35
100_F132_L0.6230.35
37_G140_A0.6220.35
98_G101_E0.6220.35
55_F135_V0.6200.35
12_D16_E0.6190.35
35_G47_V0.6190.35
35_G101_E0.6180.35
123_E129_N0.6170.35
151_E164_A0.6160.34
162_L169_Y0.6090.34
65_P137_I0.6040.34
58_T100_F0.6040.34
48_F60_E0.6030.33
28_L32_T0.6030.33
75_S104_P0.6030.33
115_V136_V0.5970.33
42_A64_S0.5920.33
100_F121_L0.5920.33
70_L106_F0.5880.32
68_C135_V0.5870.32
122_L132_L0.5820.32
101_E134_F0.5810.32
59_F98_G0.5800.32
70_L97_S0.5800.32
52_R58_T0.5780.31
37_G44_P0.5780.31
33_L89_S0.5760.31
31_Q55_F0.5740.31
53_K82_K0.5740.31
14_P17_E0.5740.31
73_Y169_Y0.5730.31
146_A164_A0.5720.31
60_E64_S0.5720.31
44_P65_P0.5680.31
155_F159_H0.5650.30
159_H163_P0.5590.30
165_G168_G0.5570.30
43_L66_L0.5570.30
24_F101_E0.5530.30
51_L65_P0.5530.30
159_H164_A0.5500.29
39_Q143_D0.5450.29
81_D167_H0.5390.29
33_L90_F0.5370.28
79_D90_F0.5340.28
44_P81_D0.5330.28
93_F117_H0.5320.28
38_G137_I0.5300.28
123_E155_F0.5280.28
156_L165_G0.5240.27
50_V55_F0.5200.27
116_D149_R0.5200.27
162_L166_E0.5180.27
159_H168_G0.5160.27
118_I164_A0.5130.27
46_S96_T0.5130.27
111_M114_M0.5120.27
41_A101_E0.5080.26
13_D18_A0.5060.26
93_F100_F0.5040.26
24_F149_R0.5030.26
44_P47_V0.5030.26
122_L155_F0.5030.26
152_K163_P0.5010.26
58_T99_S0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2uz1A 4 0.3372 4.7 0.955 Contact Map
3qocA 1 0.3488 4.5 0.955 Contact Map
4w8jA 2 0.7965 4.2 0.956 Contact Map
4cidA 2 0.3198 4.2 0.956 Contact Map
2ce7A 3 0.2733 3.3 0.958 Contact Map
3eyaA 5 0.3314 3.3 0.958 Contact Map
3ufbA 1 0.9942 3.3 0.958 Contact Map
1ovmA 4 0.3372 3.2 0.958 Contact Map
2pgnA 4 0.3372 3.2 0.959 Contact Map
2c31A 4 0.343 3.2 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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