GREMLIN Database
MTHFR_C - Methylene-tetrahydrofolate reductase C terminal
PFAM: PF12225 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 95 (93)
Sequences: 9030 (3695)
Seq/√Len: 383.1
META: 0.97

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
81_R84_K3.3611.00
58_K66_D3.2561.00
70_V74_E3.0751.00
9_L24_M3.0081.00
36_I68_A2.8841.00
54_S70_V2.5551.00
66_D71_L2.4701.00
34_G76_L2.3591.00
62_D65_R2.2721.00
2_P31_G2.0251.00
23_R40_T1.9351.00
53_G60_E1.9201.00
58_K64_D1.8011.00
32_E89_Q1.7791.00
43_P68_A1.7711.00
20_E30_L1.7081.00
13_R19_L1.6881.00
4_L12_E1.5441.00
13_R17_V1.4771.00
73_Y77_K1.4701.00
88_I91_P1.4471.00
41_R71_L1.4021.00
74_E78_A1.3641.00
77_K82_L1.3471.00
14_A17_V1.3241.00
39_M45_G1.2681.00
12_E18_W1.2161.00
39_M47_R1.2001.00
82_L85_L1.1921.00
4_L7_L1.1881.00
12_E15_V1.1661.00
15_V18_W1.1551.00
73_Y85_L1.1401.00
84_K87_E1.1291.00
30_L33_T1.1291.00
29_V92_K1.1011.00
5_N27_D1.0901.00
43_P61_V1.0821.00
21_R41_R1.0821.00
33_T72_I1.0651.00
10_G14_A1.0561.00
61_V65_R1.0161.00
11_V14_A1.0101.00
32_E87_E1.0051.00
73_Y82_L1.0041.00
74_E77_K0.9961.00
43_P65_R0.9761.00
11_V21_R0.9641.00
71_L74_E0.9611.00
14_A18_W0.9411.00
83_D86_E0.9401.00
12_E16_K0.9241.00
76_L81_R0.9121.00
29_V32_E0.8901.00
55_R63_P0.8881.00
55_R58_K0.8741.00
29_V47_R0.8731.00
86_E89_Q0.8721.00
52_G60_E0.8681.00
34_G79_L0.8661.00
36_I75_R0.8591.00
6_T9_L0.8521.00
82_L86_E0.8521.00
66_D74_E0.8511.00
44_K60_E0.8441.00
77_K80_G0.8361.00
68_A72_I0.8331.00
4_L8_F0.8261.00
58_K62_D0.8201.00
15_V19_L0.8181.00
29_V33_T0.8161.00
8_F11_V0.8121.00
44_K52_G0.7861.00
36_I41_R0.7841.00
76_L82_L0.7681.00
6_T10_G0.7671.00
8_F12_E0.7611.00
27_D92_K0.7601.00
36_I71_L0.7531.00
22_C29_V0.7471.00
38_P72_I0.7441.00
69_W72_I0.7401.00
7_L11_V0.7351.00
11_V19_L0.7351.00
76_L85_L0.7231.00
75_R79_L0.7181.00
36_I72_I0.7151.00
58_K63_P0.7121.00
41_R68_A0.7101.00
7_L12_E0.6940.99
4_L11_V0.6900.99
27_D93_D0.6890.99
76_L84_K0.6880.99
18_W21_R0.6870.99
57_G74_E0.6780.99
9_L12_E0.6770.99
13_R18_W0.6710.99
47_R92_K0.6700.99
75_R78_A0.6630.99
12_E21_R0.6600.99
29_V38_P0.6580.99
52_G57_G0.6560.99
76_L79_L0.6540.99
32_E84_K0.6530.99
55_R70_V0.6400.99
3_A12_E0.6360.99
41_R65_R0.6190.99
49_G60_E0.6180.99
81_R87_E0.6040.99
10_G13_R0.6010.98
13_R16_K0.6000.98
90_P94_W0.5950.98
40_T68_A0.5830.98
65_R68_A0.5830.98
6_T11_V0.5750.98
83_D87_E0.5710.98
4_L16_K0.5630.98
39_M92_K0.5590.98
11_V15_V0.5580.98
49_G53_G0.5570.98
12_E26_G0.5530.97
7_L18_W0.5420.97
54_S65_R0.5410.97
16_K21_R0.5400.97
4_L18_W0.5370.97
12_E17_V0.5350.97
26_G48_N0.5300.97
78_A83_D0.5300.97
23_R39_M0.5300.97
11_V31_G0.5220.96
80_G83_D0.5220.96
29_V39_M0.5200.96
35_G72_I0.5190.96
22_C31_G0.5190.96
46_L61_V0.5180.96
7_L24_M0.5140.96
88_I94_W0.5120.96
16_K19_L0.5030.96
43_P62_D0.5030.96
9_L13_R0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zbuA 1 0.6211 5.5 0.937 Contact Map
2c42A 2 0.8421 4.7 0.939 Contact Map
1kf6B 1 0.6421 4.1 0.94 Contact Map
4g2uA 2 0.4526 3.5 0.943 Contact Map
1h7bA 2 0.3895 3.4 0.943 Contact Map
2d10E 1 0.1158 3.1 0.944 Contact Map
2d11E 1 0.0947 3 0.944 Contact Map
1mhmA 1 0.8947 2.7 0.946 Contact Map
2md0A 1 0.4526 2.5 0.946 Contact Map
3swrA 1 0.8947 2.5 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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