GREMLIN Database
DUF3596 - Domain of unknown function (DUF3596)
PFAM: PF12167 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 65 (63)
Sequences: 4680 (3347)
Seq/√Len: 421.7
META: 0.856

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_L47_E2.8131.00
56_D59_K2.7251.00
5_R13_R2.4191.00
15_D22_R2.3861.00
49_E60_Y2.3631.00
31_D36_R2.2531.00
48_A52_L2.0351.00
15_D24_R1.8731.00
42_L60_Y1.7651.00
49_E59_K1.7141.00
40_E44_A1.6661.00
45_R49_E1.5991.00
27_T39_A1.5661.00
25_E64_S1.5461.00
25_E57_Y1.5061.00
38_R42_L1.3601.00
2_G43_L1.3501.00
50_I55_F1.2831.00
29_L35_N1.2761.00
12_L36_R1.2711.00
45_R48_A1.2381.00
16_F23_C1.2371.00
11_K30_P1.2351.00
23_C57_Y1.2341.00
41_R44_A1.1951.00
14_I43_L1.1831.00
45_R60_Y1.1681.00
7_R26_T1.1611.00
48_A51_A1.1401.00
14_I42_L1.1351.00
14_I39_A1.1271.00
49_E54_T1.0511.00
12_L31_D1.0441.00
5_R15_D1.0391.00
13_R26_T1.0101.00
32_T35_N0.9841.00
47_E51_A0.9591.00
38_R41_R0.9591.00
29_L38_R0.8841.00
42_L45_R0.8811.00
7_R13_R0.8661.00
33_P37_K0.8421.00
46_I50_I0.8161.00
13_R17_R0.8111.00
6_V36_R0.7991.00
18_Y50_I0.7911.00
37_K40_E0.7891.00
44_A48_A0.7851.00
18_Y23_C0.7841.00
12_L39_A0.7801.00
46_I60_Y0.7791.00
41_R45_R0.7701.00
17_R22_R0.7691.00
34_A38_R0.7671.00
6_V31_D0.7621.00
57_Y64_S0.7231.00
19_R23_C0.7211.00
6_V10_G0.7071.00
11_K28_G0.6901.00
57_Y61_F0.6811.00
41_R51_A0.6681.00
11_K26_T0.6650.99
10_G30_P0.6640.99
45_R54_T0.6620.99
8_S26_T0.6570.99
12_L35_N0.6570.99
45_R52_L0.6450.99
6_V12_L0.6450.99
9_G26_T0.6390.99
2_G40_E0.6390.99
38_R52_L0.6300.99
8_S13_R0.6210.99
37_K41_R0.6200.99
8_S11_K0.6180.99
58_A64_S0.6060.99
3_G8_S0.6020.99
34_A41_R0.5890.99
19_R56_D0.5880.99
14_I46_I0.5790.99
3_G17_R0.5650.98
34_A37_K0.5530.98
35_N39_A0.5500.98
10_G31_D0.5490.98
5_R17_R0.5440.98
3_G13_R0.5360.98
36_R40_E0.5290.97
13_R24_R0.5250.97
3_G47_E0.5220.97
42_L46_I0.5200.97
35_N38_R0.5190.97
16_F22_R0.5180.97
25_E46_I0.5050.97
11_K31_D0.5030.97
29_L32_T0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3jtzA 2 0.8 50.9 0.814 Contact Map
1z1bA 3 0.9538 45.8 0.82 Contact Map
3ju0A 1 0.9692 44.3 0.821 Contact Map
1b69A 1 0.7692 34.8 0.832 Contact Map
5bxgA 1 0.4154 16.7 0.855 Contact Map
3a54A 1 0.9231 13 0.862 Contact Map
3bwgA 2 0.4615 6.6 0.879 Contact Map
3tqnA 2 0.5692 6 0.881 Contact Map
4q8wA 2 0.9846 6 0.881 Contact Map
4y21A 1 0.4769 6 0.881 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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