GREMLIN Database
DUF3593 - Protein of unknown function (DUF3593)
PFAM: PF12159 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 87 (85)
Sequences: 635 (262)
Seq/√Len: 28.4
META: 0.775

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_K59_N4.2361.00
34_L37_L2.8961.00
19_T33_Y2.6681.00
8_L12_L2.1340.98
48_Y52_V1.8490.95
74_S83_R1.8210.94
14_F32_F1.7460.93
78_I82_F1.7370.92
41_V70_F1.7120.92
34_L77_L1.6990.92
35_T74_S1.6710.91
18_L24_T1.6390.90
29_L33_Y1.5500.87
66_G69_S1.5470.87
7_S10_P1.5180.86
34_L73_L1.4560.84
65_G68_E1.4410.83
4_F7_S1.4380.83
28_A82_F1.4380.83
30_I34_L1.4160.82
79_V82_F1.3860.81
76_L83_R1.3850.80
4_F10_P1.3670.80
42_T72_T1.3550.79
44_P48_Y1.3470.79
49_A63_L1.3290.78
27_L80_L1.3020.76
47_I50_K1.3000.76
45_A75_N1.2720.74
68_E71_L1.2630.74
7_S67_A1.2560.73
7_S14_F1.2450.73
3_L9_F1.2170.71
80_L83_R1.1920.69
34_L70_F1.1830.69
20_R45_A1.1710.68
55_K60_V1.1260.65
11_Y14_F1.0980.63
20_R23_S1.0940.63
30_I33_Y1.0870.62
1_E6_L1.0750.61
5_A9_F1.0710.61
31_G68_E1.0570.60
42_T58_A1.0270.58
32_F78_I1.0220.57
31_G71_L1.0200.57
2_P46_G0.9980.55
8_L25_P0.9720.53
25_P36_L0.9700.53
61_D64_H0.9680.53
7_S32_F0.9640.53
37_L49_A0.9620.53
31_G65_G0.9470.52
28_A74_S0.9340.51
22_K69_S0.9080.49
82_F85_A0.9020.48
4_F8_L0.8970.48
37_L73_L0.8860.47
13_G17_F0.8800.46
18_L30_I0.8800.46
62_W79_V0.8750.46
51_V66_G0.8750.46
44_P50_K0.8660.45
19_T30_I0.8430.44
28_A59_N0.8430.44
2_P6_L0.8410.43
45_A63_L0.8390.43
50_K59_N0.8350.43
20_R49_A0.8340.43
19_T29_L0.8320.43
54_G80_L0.8150.41
2_P5_A0.7930.40
67_A71_L0.7920.40
65_G71_L0.7890.40
42_T67_A0.7870.39
42_T81_G0.7690.38
41_V74_S0.7660.38
40_A73_L0.7510.37
24_T35_T0.7440.36
24_T85_A0.7400.36
28_A58_A0.7380.36
10_P39_V0.7370.36
74_S78_I0.7350.36
1_E9_F0.7310.35
14_F79_V0.7300.35
47_I53_Y0.7240.35
76_L79_V0.7230.35
19_T79_V0.7160.34
33_Y40_A0.7150.34
64_H68_E0.7120.34
39_V43_I0.7020.33
1_E23_S0.6920.33
18_L35_T0.6810.32
16_W23_S0.6770.32
5_A58_A0.6690.31
26_K48_Y0.6610.31
14_F67_A0.6590.30
21_S29_L0.6530.30
46_G65_G0.6470.30
56_S59_N0.6370.29
56_S70_F0.6340.29
25_P85_A0.6310.29
2_P37_L0.6270.28
17_F30_I0.6260.28
45_A49_A0.6250.28
5_A66_G0.6180.28
34_L74_S0.6160.28
31_G67_A0.6150.28
15_L57_L0.5980.27
50_K54_G0.5870.26
8_L17_F0.5840.26
43_I47_I0.5770.25
14_F78_I0.5760.25
2_P13_G0.5710.25
56_S79_V0.5690.25
3_L8_L0.5480.24
36_L69_S0.5430.23
52_V66_G0.5380.23
30_I40_A0.5380.23
9_F44_P0.5370.23
18_L29_L0.5340.23
39_V57_L0.5280.23
60_V70_F0.5270.23
71_L81_G0.5260.22
6_L22_K0.5210.22
46_G76_L0.5100.22
24_T28_A0.5040.21
45_A48_Y0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3m73A 3 0.8621 6.2 0.932 Contact Map
3ayfA 2 0.9885 6.2 0.932 Contact Map
4ryoA 1 0.3333 3.1 0.941 Contact Map
1milA 1 0.3793 3 0.942 Contact Map
3wfdB 1 0.9655 2.1 0.946 Contact Map
1bnxA 1 0.2414 1.3 0.952 Contact Map
4cbcA 3 0.6322 1.2 0.954 Contact Map
4fc5A 5 0.5172 1.1 0.955 Contact Map
3mk7A 1 1 1.1 0.955 Contact Map
1bzkA 1 0.2414 1 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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