GREMLIN Database
DUF3592 - Protein of unknown function (DUF3592)
PFAM: PF12158 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 148 (131)
Sequences: 17236 (15473)
Seq/√Len: 1351.8
META: 0.892

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_G100_V4.5071.00
38_T99_T3.5311.00
32_A36_W3.4891.00
40_E97_T3.1751.00
93_P96_D3.0741.00
103_D109_E3.0411.00
40_E99_T3.0161.00
38_T101_Y3.0121.00
69_Y75_Y2.3581.00
17_A21_L2.3191.00
42_T97_T2.2921.00
39_T102_Y2.1961.00
20_V24_R2.1791.00
69_Y102_Y1.9761.00
23_L27_L1.9601.00
44_V68_T1.9571.00
85_V89_P1.9091.00
41_G98_V1.8381.00
45_S64_V1.5601.00
36_W103_D1.5551.00
44_V66_R1.5401.00
68_T74_R1.4691.00
123_W128_L1.4151.00
86_G89_P1.4001.00
66_R76_T1.3951.00
101_Y113_E1.3791.00
24_R28_R1.3671.00
127_L131_G1.3581.00
100_V110_A1.3551.00
21_L25_L1.3141.00
36_W101_Y1.3051.00
31_R35_S1.2961.00
13_L17_A1.2321.00
42_T68_T1.2241.00
69_Y110_A1.2171.00
46_S93_P1.2031.00
101_Y111_V1.2001.00
46_S94_V1.1931.00
47_E64_V1.1871.00
126_P129_L1.1761.00
62_R86_G1.1641.00
86_G90_P1.1461.00
65_V69_Y1.1301.00
85_V88_S1.1211.00
123_W126_P1.1191.00
45_S94_V1.1171.00
122_L126_P1.1031.00
106_N109_E1.0851.00
123_W127_L1.0731.00
37_P101_Y1.0711.00
66_R74_R1.0561.00
100_V112_L1.0281.00
31_R34_R1.0251.00
69_Y72_G1.0241.00
30_A34_R1.0231.00
9_L13_L1.0191.00
12_L16_L1.0181.00
37_P104_P1.0111.00
125_L129_L1.0001.00
22_G26_L0.9991.00
45_S66_R0.9951.00
46_S96_D0.9901.00
38_T113_E0.9821.00
124_L128_L0.9781.00
23_L26_L0.9721.00
22_G25_L0.9721.00
16_L20_V0.9691.00
33_S111_V0.9691.00
43_V92_Y0.9521.00
33_S37_P0.9501.00
88_S91_R0.9471.00
15_G19_L0.9451.00
29_R33_S0.9421.00
122_L125_L0.9411.00
65_V110_A0.9331.00
35_S103_D0.9321.00
8_G12_L0.9321.00
32_A111_V0.9281.00
99_T113_E0.9131.00
37_P102_Y0.9071.00
92_Y95_G0.9051.00
128_L131_G0.9011.00
26_L30_A0.9011.00
123_W130_A0.8921.00
78_F82_S0.8921.00
36_W111_V0.8801.00
7_F11_F0.8771.00
52_R55_G0.8741.00
79_T82_S0.8701.00
39_T100_V0.8611.00
69_Y73_R0.8561.00
137_V141_I0.8521.00
15_G22_G0.8461.00
25_L29_R0.8381.00
78_F110_A0.8371.00
33_S36_W0.8361.00
103_D106_N0.8291.00
46_S90_P0.8271.00
30_A33_S0.8251.00
10_I14_V0.8141.00
92_Y96_D0.8061.00
127_L130_A0.7841.00
11_F15_G0.7801.00
121_G124_L0.7781.00
126_P130_A0.7761.00
51_R56_G0.7751.00
75_Y108_S0.7721.00
28_R32_A0.7701.00
92_Y98_V0.7681.00
73_R76_T0.7651.00
87_S91_R0.7641.00
50_S55_G0.7621.00
41_G102_Y0.7561.00
29_R111_V0.7551.00
53_S57_G0.7521.00
44_V76_T0.7481.00
67_Y110_A0.7441.00
51_R54_D0.7341.00
98_V112_L0.7341.00
21_L24_R0.7291.00
14_V18_L0.7261.00
53_S56_G0.7241.00
54_D57_G0.7231.00
43_V65_V0.7211.00
81_G84_N0.7201.00
80_S83_D0.7171.00
9_L12_L0.7071.00
42_T95_G0.6951.00
136_L140_L0.6941.00
49_E57_G0.6931.00
12_L15_G0.6901.00
18_L21_L0.6841.00
19_L22_G0.6801.00
20_V23_L0.6781.00
135_G139_L0.6781.00
121_G125_L0.6761.00
17_A20_V0.6731.00
85_V91_R0.6731.00
37_P70_E0.6681.00
19_L23_L0.6641.00
110_A113_E0.6541.00
50_S53_S0.6541.00
36_W109_E0.6481.00
46_S92_Y0.6471.00
78_F81_G0.6421.00
124_L127_L0.6421.00
60_T63_P0.6351.00
25_L28_R0.6261.00
52_R56_G0.6251.00
52_R57_G0.6221.00
15_G18_L0.6191.00
36_W104_P0.6101.00
14_V17_A0.5971.00
125_L130_A0.5971.00
24_R27_L0.5971.00
27_L31_R0.5961.00
137_V140_L0.5951.00
6_L10_I0.5921.00
107_P110_A0.5901.00
43_V46_S0.5891.00
62_R79_T0.5881.00
52_R58_G0.5881.00
123_W129_L0.5881.00
28_R109_E0.5841.00
18_L22_G0.5831.00
121_G126_P0.5831.00
52_R59_T0.5801.00
49_E52_R0.5741.00
78_F83_D0.5731.00
139_L143_L0.5691.00
44_V94_V0.5681.00
43_V98_V0.5671.00
38_T100_V0.5631.00
41_G67_Y0.5611.00
50_S56_G0.5611.00
46_S63_P0.5611.00
59_T63_P0.5481.00
50_S57_G0.5461.00
50_S59_T0.5401.00
87_S90_P0.5391.00
46_S89_P0.5381.00
122_L130_A0.5341.00
55_G58_G0.5341.00
120_G123_W0.5331.00
92_Y112_L0.5311.00
32_A35_S0.5281.00
125_L128_L0.5281.00
8_G11_F0.5251.00
92_Y113_E0.5241.00
50_S54_D0.5201.00
121_G127_L0.5171.00
131_G134_L0.5161.00
13_L16_L0.5131.00
12_L19_L0.5131.00
40_E100_V0.5071.00
75_Y78_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1v54D 1 0.6757 37.3 0.868 Contact Map
3h90A 3 0.7027 33.4 0.872 Contact Map
2y69D 1 0.6757 21.4 0.883 Contact Map
3j1zP 8 0.7297 9.5 0.901 Contact Map
3wguB 1 0.3851 7.9 0.904 Contact Map
3ixzB 1 0.2027 7.6 0.905 Contact Map
2zxeB 1 0.2095 7.4 0.906 Contact Map
5a2fA 1 0 5.5 0.911 Contact Map
4um9B 2 0 5.5 0.911 Contact Map
1ah9A 1 0.4797 4.9 0.913 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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