GREMLIN Database
ATPase-cat_bd - Putative metal-binding domain of cation transport ATPase
PFAM: PF12156 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 85 (81)
Sequences: 8975 (6351)
Seq/√Len: 705.7
META: 0.899

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_D48_R3.3411.00
3_F24_K2.9151.00
78_Q82_V2.6701.00
32_K36_E2.6581.00
16_T23_E2.5831.00
17_V26_F2.4041.00
29_A32_K2.3191.00
39_V44_D2.0621.00
67_D70_A1.9491.00
15_L29_A1.9311.00
18_E23_E1.8901.00
29_A33_A1.7991.00
45_D49_L1.6741.00
15_L32_K1.6721.00
74_D77_V1.6371.00
46_Y54_G1.6101.00
36_E40_E1.5671.00
33_A36_E1.5611.00
75_P79_A1.5411.00
21_G36_E1.4921.00
20_D25_P1.4781.00
35_Y39_V1.3981.00
26_F35_Y1.3491.00
9_C25_P1.3311.00
37_L41_N1.3181.00
76_E79_A1.3121.00
18_E25_P1.3071.00
19_I26_F1.2511.00
17_V32_K1.2341.00
75_P78_Q1.2021.00
7_L56_R1.2011.00
18_E21_G1.1921.00
44_D48_R1.1501.00
16_T25_P1.1431.00
1_A6_G1.1181.00
20_D48_R1.0971.00
9_C12_G1.0531.00
3_F35_Y1.0431.00
77_V81_F1.0361.00
34_V37_L1.0271.00
10_P17_V0.9981.00
21_G32_K0.9851.00
49_L53_P0.9821.00
12_G18_E0.9731.00
72_L81_F0.9371.00
33_A37_L0.9321.00
1_A8_P0.9211.00
74_D78_Q0.9191.00
10_P18_E0.9091.00
19_I35_Y0.9081.00
15_L26_F0.9081.00
67_D71_Y0.8791.00
37_L72_L0.8781.00
48_R51_T0.8761.00
35_Y38_I0.8531.00
26_F39_V0.8431.00
34_V38_I0.8401.00
6_G9_C0.8371.00
24_K35_Y0.8261.00
19_I39_V0.8171.00
26_F32_K0.8031.00
2_C5_C0.7901.00
60_A63_E0.7661.00
16_T26_F0.7541.00
70_A73_D0.7501.00
30_G33_A0.7341.00
42_G45_D0.7321.00
34_V74_D0.7271.00
21_G25_P0.7171.00
49_L69_F0.7131.00
63_E66_G0.7101.00
50_R53_P0.7101.00
3_F19_I0.7051.00
19_I24_K0.6891.00
52_A55_I0.6831.00
37_L69_F0.6781.00
11_A18_E0.6741.00
43_L77_V0.6731.00
34_V41_N0.6721.00
78_Q81_F0.6641.00
73_D78_Q0.6631.00
68_K71_Y0.6581.00
20_D39_V0.6551.00
17_V36_E0.6491.00
38_I46_Y0.6491.00
69_F73_D0.6421.00
30_G34_V0.6411.00
65_L69_F0.6391.00
77_V83_R0.6351.00
21_G24_K0.6221.00
51_T54_G0.6221.00
64_E67_D0.6151.00
39_V42_G0.6121.00
74_D82_V0.6101.00
20_D44_D0.5931.00
67_D83_R0.5881.00
46_Y53_P0.5791.00
59_E62_P0.5791.00
56_R59_E0.5751.00
54_G57_P0.5731.00
37_L49_L0.5731.00
61_P64_E0.5701.00
7_L37_L0.5621.00
61_P65_L0.5521.00
55_I58_E0.5491.00
80_K83_R0.5481.00
17_V39_V0.5471.00
69_F72_L0.5421.00
9_C15_L0.5401.00
3_F21_G0.5351.00
37_L57_P0.5351.00
42_G50_R0.5321.00
10_P25_P0.5261.00
43_L46_Y0.5251.00
44_D50_R0.5251.00
71_Y76_E0.5181.00
62_P65_L0.5171.00
65_L68_K0.5120.99
68_K72_L0.5090.99
57_P61_P0.5040.99
19_I22_E0.5010.99
38_I50_R0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fqhA 1 0.9059 82.7 0.802 Contact Map
3u52A 2 0.8353 78.1 0.811 Contact Map
1mtyD 2 0.9529 75.9 0.814 Contact Map
2incA 2 0.8588 74.1 0.817 Contact Map
3ge3A 2 0.8588 72.7 0.819 Contact Map
2dasA 1 0.4824 47 0.846 Contact Map
2kq9A 1 0.3529 42 0.851 Contact Map
4tmaI 1 0.5647 31.3 0.861 Contact Map
2hpuA 1 0.8471 31 0.861 Contact Map
2kgoA 1 0.6 28.6 0.864 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0048 seconds.