GREMLIN Database
DUF3577 - Protein of unknown function (DUF3577)
PFAM: PF12101 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 132 (128)
Sequences: 675 (426)
Seq/√Len: 37.6
META: 0.673

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_Y104_G3.2851.00
84_L109_G3.2661.00
41_R50_T2.8821.00
68_L117_I2.5141.00
36_T51_Y2.4571.00
72_V78_V2.4561.00
64_L117_I2.4001.00
87_L109_G2.1950.99
81_G116_W2.1820.99
21_I72_V2.1590.99
92_F104_G2.0610.99
14_G82_F1.9720.98
60_E63_E1.9630.98
69_Q73_E1.9520.98
76_K120_D1.9270.98
80_I114_I1.8990.98
13_T83_R1.8590.98
93_T103_T1.8300.98
16_G37_I1.8000.97
23_E66_R1.7620.97
39_A82_F1.7500.97
68_L71_A1.7180.96
89_A105_V1.7010.96
33_L56_V1.6720.96
91_T103_T1.6570.95
91_T105_V1.5230.93
87_L107_L1.5230.93
99_K102_E1.5100.93
50_T54_C1.5000.92
123_V126_K1.4630.91
85_G112_L1.4540.91
9_D112_L1.4380.91
8_F17_Y1.4300.90
15_I79_L1.4220.90
62_Q66_R1.4070.90
97_G102_E1.4020.90
6_K9_D1.3740.89
33_L62_Q1.3670.88
52_F84_L1.3660.88
38_A51_Y1.3570.88
12_T84_L1.3480.88
40_L47_V1.3260.87
33_L66_R1.3130.86
35_C72_V1.3040.86
40_L79_L1.2980.86
17_Y49_Y1.2870.85
9_D13_T1.2530.83
26_P29_G1.2330.82
39_A52_F1.2240.82
8_F118_K1.2130.81
90_D106_S1.2060.81
20_R36_T1.1690.79
56_V61_A1.1640.79
38_A49_Y1.1600.78
58_G110_R1.1170.76
101_G104_G1.1160.76
70_P74_A1.1160.76
113_R127_A1.1000.75
9_D20_R1.0810.73
97_G100_A1.0550.71
34_A53_D1.0510.71
64_L68_L1.0410.70
92_F97_G1.0380.70
78_V119_V1.0340.70
58_G112_L1.0290.69
97_G101_G1.0150.68
105_V109_G1.0050.68
92_F101_G0.9770.65
18_L72_V0.9760.65
10_L14_G0.9760.65
18_L65_V0.9690.65
41_R88_Y0.9640.64
58_G85_G0.9610.64
12_T87_L0.9590.64
16_G52_F0.9580.64
16_G39_A0.9480.63
21_I69_Q0.9460.63
28_K48_E0.9440.63
50_T87_L0.9430.63
103_T107_L0.9230.61
10_L16_G0.9010.59
54_C109_G0.8880.58
79_L116_W0.8720.56
67_R119_V0.8700.56
10_L39_A0.8680.56
59_K63_E0.8650.56
61_A112_L0.8650.56
23_E31_P0.8630.56
65_V123_V0.8570.55
33_L65_V0.8550.55
36_T54_C0.8540.55
76_K119_V0.8540.55
24_V34_A0.8510.55
12_T52_F0.8400.54
37_I82_F0.8250.52
56_V62_Q0.8220.52
126_K129_P0.8180.52
67_R125_Y0.8020.50
63_E67_R0.8010.50
89_A119_V0.7870.49
37_I80_I0.7820.49
27_K88_Y0.7770.48
96_K114_I0.7570.46
93_T110_R0.7520.46
44_A65_V0.7420.45
68_L119_V0.7410.45
94_Y102_E0.7400.45
28_K85_G0.7360.44
26_P30_D0.7350.44
71_A76_K0.7190.43
6_K15_I0.7150.43
59_K114_I0.7130.42
21_I78_V0.7080.42
17_Y40_L0.7060.42
52_F87_L0.7060.42
49_Y79_L0.7050.42
24_V110_R0.7010.41
29_G40_L0.6980.41
89_A130_K0.6950.41
90_D108_K0.6940.41
9_D110_R0.6920.41
23_E33_L0.6880.40
43_P50_T0.6830.40
127_A130_K0.6800.40
35_C80_I0.6780.39
61_A85_G0.6730.39
86_D108_K0.6720.39
16_G84_L0.6640.38
116_W123_V0.6600.38
66_R69_Q0.6580.38
18_L78_V0.6530.37
95_K129_P0.6360.36
6_K44_A0.6320.36
35_C86_D0.6310.36
22_R108_K0.6280.35
15_I81_G0.6270.35
125_Y130_K0.6220.35
53_D108_K0.6180.34
88_Y102_E0.6180.34
25_T75_E0.6170.34
99_K104_G0.6150.34
67_R76_K0.6140.34
82_F117_I0.6140.34
6_K126_K0.6050.33
59_K98_E0.6020.33
11_H32_F0.5990.33
6_K35_C0.5990.33
27_K55_R0.5960.33
12_T51_Y0.5940.33
14_G37_I0.5930.32
37_I54_C0.5900.32
15_I116_W0.5880.32
30_D69_Q0.5780.31
24_V61_A0.5770.31
97_G104_G0.5750.31
81_G118_K0.5750.31
58_G61_A0.5740.31
50_T88_Y0.5660.30
9_D85_G0.5660.30
113_R130_K0.5630.30
22_R53_D0.5600.30
21_I35_C0.5590.30
60_E64_L0.5550.30
53_D83_R0.5540.30
24_V32_F0.5530.29
17_Y79_L0.5530.29
50_T89_A0.5510.29
41_R90_D0.5490.29
8_F11_H0.5490.29
126_K130_K0.5470.29
47_V79_L0.5470.29
30_D75_E0.5450.29
80_I112_L0.5410.29
9_D101_G0.5400.29
67_R73_E0.5400.29
79_L97_G0.5390.28
95_K109_G0.5370.28
79_L87_L0.5370.28
50_T102_E0.5360.28
98_E102_E0.5350.28
19_N38_A0.5290.28
75_E130_K0.5270.28
50_T91_T0.5270.28
55_R81_G0.5190.27
32_F89_A0.5180.27
41_R47_V0.5170.27
20_R86_D0.5170.27
65_V81_G0.5160.27
13_T115_K0.5120.27
53_D112_L0.5010.26
78_V118_K0.5010.26
15_I47_V0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lgjA 2 0.6591 21.7 0.934 Contact Map
3vdyA 3 0.7424 12.5 0.94 Contact Map
2mjgA 2 0.3333 12.4 0.94 Contact Map
3eivA 3 0.8182 11.8 0.941 Contact Map
4qqbX 1 0.447 11.2 0.942 Contact Map
3pgzA 2 0.7727 8.5 0.945 Contact Map
3afpA 3 0.7879 8.2 0.945 Contact Map
1z9fA 4 0.6061 7.8 0.946 Contact Map
4dniA 1 0.8333 7.5 0.946 Contact Map
2fxqA 2 0.7197 7.3 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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