GREMLIN Database
DUF3574 - Protein of unknown function (DUF3574)
PFAM: PF12098 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 103 (101)
Sequences: 5035 (3423)
Seq/√Len: 340.6
META: 0.92

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_L63_I2.6981.00
42_D60_K2.6811.00
24_A28_E2.6551.00
8_R60_K2.6001.00
43_A59_S2.5121.00
33_R78_A2.4131.00
30_V62_L2.2291.00
30_V79_I2.1231.00
41_L61_V2.1011.00
39_T43_A2.0351.00
29_E82_A2.0341.00
31_T46_Q1.7971.00
74_A78_A1.7601.00
80_R94_R1.7121.00
2_T66_H1.6701.00
66_H72_A1.6381.00
3_E63_I1.6371.00
46_Q54_I1.6371.00
12_D15_G1.5511.00
28_E86_R1.5421.00
10_I88_R1.5321.00
77_E80_R1.5051.00
26_L30_V1.5041.00
81_A84_K1.4811.00
10_I15_G1.4791.00
10_I21_E1.4541.00
42_D58_R1.4261.00
18_S21_E1.4141.00
38_L46_Q1.3941.00
43_A61_V1.3561.00
2_T96_T1.3491.00
11_P14_G1.3471.00
26_L40_V1.3301.00
71_A75_K1.2581.00
16_G58_R1.2361.00
83_Y87_F1.2271.00
29_E33_R1.2161.00
46_Q56_R1.2001.00
69_T72_A1.1901.00
22_W40_V1.1861.00
49_G90_E1.1861.00
8_R19_E1.1831.00
49_G53_R1.1711.00
31_T38_L1.1621.00
25_F79_I1.1561.00
47_W91_S1.1511.00
82_A86_R1.1451.00
23_Q27_D1.1381.00
50_A90_E1.1371.00
6_F22_W1.1321.00
10_I17_V1.1281.00
77_E81_A1.1221.00
72_A75_K1.1131.00
57_E89_Q1.1101.00
68_D73_R1.0701.00
81_A85_R1.0541.00
29_E86_R1.0491.00
34_F64_I1.0321.00
68_D72_A1.0291.00
95_V99_V1.0241.00
11_P15_G1.0101.00
36_D48_R1.0041.00
75_K78_A0.9591.00
8_R17_V0.9571.00
82_A85_R0.9171.00
65_V95_V0.9131.00
48_R52_G0.9061.00
93_L101_V0.8861.00
48_R54_I0.8741.00
38_L64_I0.8731.00
8_R58_R0.8631.00
5_Y63_I0.8621.00
5_Y93_L0.8531.00
19_E23_Q0.8501.00
10_I16_G0.8461.00
29_E78_A0.8341.00
70_P74_A0.8281.00
5_Y95_V0.8281.00
11_P16_G0.8181.00
2_T76_I0.8111.00
35_P48_R0.8041.00
29_E79_I0.8001.00
66_H94_R0.7841.00
3_E95_V0.7350.99
73_R77_E0.7340.99
33_R82_A0.7330.99
79_I82_A0.7330.99
22_W47_W0.7320.99
73_R96_T0.7320.99
10_I14_G0.7230.99
78_A82_A0.7180.99
38_L54_I0.7150.99
31_T54_I0.7140.99
26_L38_L0.7120.99
47_W90_E0.7030.99
12_D88_R0.6970.99
19_E42_D0.6890.99
24_A86_R0.6880.99
65_V93_L0.6820.99
9_N16_G0.6770.99
93_L96_T0.6730.99
21_E24_A0.6720.99
7_G57_E0.6610.99
9_N55_V0.6560.99
83_Y89_Q0.6550.99
90_E93_L0.6460.99
6_F25_F0.6400.99
20_A24_A0.6330.98
93_L103_F0.6310.98
26_L32_P0.6260.98
26_L33_R0.6220.98
9_N12_D0.6200.98
5_Y59_S0.6190.98
2_T5_Y0.6130.98
60_K63_I0.6130.98
31_T35_P0.6010.98
36_D72_A0.5950.98
67_P72_A0.5900.97
44_Y58_R0.5860.97
19_E60_K0.5800.97
22_W26_L0.5790.97
73_R94_R0.5690.97
80_R84_K0.5590.97
66_H96_T0.5570.96
80_R96_T0.5550.96
9_N14_G0.5530.96
52_G64_I0.5510.96
22_W25_F0.5460.96
73_R80_R0.5430.96
65_V99_V0.5410.96
34_F38_L0.5380.96
34_F37_G0.5350.96
5_Y65_V0.5320.95
8_R16_G0.5310.95
39_T61_V0.5270.95
22_W60_K0.5230.95
68_D76_I0.5200.95
65_V101_V0.5180.95
24_A27_D0.5170.95
5_Y39_T0.5140.94
71_A74_A0.5130.94
25_F83_Y0.5110.94
97_R101_V0.5100.94
47_W89_Q0.5070.94
51_D55_V0.5060.94
49_G55_V0.5050.94
40_V62_L0.5030.94
27_D46_Q0.5020.94
3_E61_V0.5020.94
95_V101_V0.5010.94
10_I18_S0.5010.94
38_L45_G0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2dclA 5 0.8544 21.2 0.902 Contact Map
3hluA 2 0.7087 12.3 0.912 Contact Map
1o51A 3 0.8252 11.2 0.914 Contact Map
1pieA 1 0.2913 8.2 0.919 Contact Map
1dm5A 4 0.7184 7.3 0.921 Contact Map
1n00A 1 0.7087 7.2 0.921 Contact Map
3v2uC 2 0.4466 7.1 0.921 Contact Map
3lqvP 1 0.3204 5.7 0.925 Contact Map
4mduA 2 0.7961 5 0.927 Contact Map
2jh3A 2 0.4369 5 0.927 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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