GREMLIN Database
DUF3572 - Protein of unknown function (DUF3572)
PFAM: PF12096 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 83 (82)
Sequences: 5521 (3719)
Seq/√Len: 410.7
META: 0.913

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_Q67_A2.2251.00
39_A42_D2.1151.00
23_G27_A2.1011.00
51_D78_R2.0521.00
16_A22_L1.9841.00
18_D21_R1.9781.00
63_F67_A1.9431.00
54_L75_A1.9371.00
78_R82_P1.9111.00
32_G35_D1.7691.00
57_E60_L1.7271.00
12_L40_A1.6951.00
39_A45_F1.6591.00
24_R28_L1.6461.00
7_L69_L1.6341.00
65_E71_P1.5761.00
6_T10_Q1.5691.00
14_F63_F1.5091.00
56_D59_L1.4411.00
73_A76_A1.4351.00
10_Q69_L1.4041.00
54_L78_R1.3981.00
17_G66_A1.3771.00
51_D82_P1.3771.00
53_L63_F1.3671.00
35_D39_A1.3511.00
11_A53_L1.3351.00
18_D62_A1.3341.00
70_D73_A1.2841.00
21_R52_F1.2571.00
6_T9_L1.2271.00
21_R59_L1.2061.00
22_L36_L1.1971.00
51_D54_L1.1771.00
50_L77_A1.1681.00
19_P23_G1.1511.00
62_A66_A1.1311.00
63_F74_V1.1291.00
39_A44_A1.0971.00
64_A71_P1.0911.00
47_A82_P1.0781.00
55_A59_L1.0711.00
60_L74_V1.0401.00
62_A65_E1.0361.00
72_E76_A1.0311.00
76_A80_A1.0221.00
36_L45_F1.0091.00
75_A79_A1.0041.00
25_F48_A1.0001.00
3_D73_A0.9981.00
42_D46_L0.9661.00
26_L36_L0.9481.00
53_L59_L0.9461.00
14_F62_A0.9331.00
69_L73_A0.9301.00
54_L82_P0.9281.00
64_A74_V0.9241.00
24_R52_F0.9091.00
31_L45_F0.9001.00
58_P61_L0.8931.00
11_A50_L0.8891.00
6_T13_A0.8821.00
3_D6_T0.8731.00
61_L71_P0.8681.00
20_E23_G0.8431.00
14_F21_R0.8411.00
15_L49_V0.8401.00
10_Q13_A0.8391.00
13_A16_A0.8291.00
24_R59_L0.8231.00
23_G33_P0.8191.00
9_L16_A0.8191.00
4_A80_A0.8181.00
9_L13_A0.8171.00
57_E61_L0.8151.00
7_L77_A0.8081.00
45_F49_V0.7931.00
58_P62_A0.7911.00
2_E6_T0.7811.00
5_E43_P0.7611.00
26_L31_L0.7521.00
38_A41_G0.7511.00
76_A79_A0.7471.00
21_R24_R0.7401.00
11_A63_F0.7311.00
3_D7_L0.7041.00
25_F49_V0.7041.00
10_Q63_F0.6891.00
35_D38_A0.6851.00
21_R62_A0.6720.99
40_A49_V0.6690.99
5_E46_L0.6650.99
44_A47_A0.6490.99
79_A82_P0.6390.99
53_L60_L0.6340.99
23_G32_G0.6330.99
33_P36_L0.6290.99
43_P46_L0.6250.99
27_A32_G0.6060.99
3_D10_Q0.6030.99
24_R27_A0.5990.99
72_E75_A0.5940.99
55_A60_L0.5910.99
31_L35_D0.5820.99
28_L55_A0.5660.98
33_P37_R0.5640.98
22_L33_P0.5610.98
15_L53_L0.5600.98
12_L36_L0.5490.98
73_A80_A0.5340.97
15_L21_R0.5310.97
2_E5_E0.5270.97
45_F48_A0.5260.97
18_D23_G0.5230.97
75_A78_R0.5220.97
8_A46_L0.5200.97
20_E62_A0.5120.97
50_L78_R0.5110.97
25_F63_F0.5090.97
5_E9_L0.5080.97
37_R45_F0.5060.96
41_G46_L0.5030.96
47_A50_L0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ugmA 1 0.8795 26.9 0.877 Contact Map
1ywfA 1 0.988 21.2 0.883 Contact Map
3bq3A 2 0.8193 20.5 0.884 Contact Map
3cuqA 1 0.9398 15 0.891 Contact Map
2xvcA 1 0.5542 13.4 0.893 Contact Map
3kp1E 1 0.9036 13.3 0.894 Contact Map
4fp9B 2 0.8072 13.2 0.894 Contact Map
3mvaO 1 0.9518 12.3 0.895 Contact Map
1u5tA 1 0.9639 11.7 0.896 Contact Map
2qdjA 1 0.3494 11.3 0.897 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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