GREMLIN Database
DUF3567 - Protein of unknown function (DUF3567)
PFAM: PF12091 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 88 (88)
Sequences: 1303 (630)
Seq/√Len: 67.1
META: 0.928

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_V74_L2.9861.00
58_E62_E2.9851.00
29_R46_D2.9651.00
51_E55_Q2.6491.00
20_A24_A2.2931.00
75_E78_A2.0391.00
74_L82_Q1.9381.00
18_P23_A1.8511.00
11_A35_V1.8501.00
51_E54_Q1.8091.00
83_Q86_V1.7691.00
51_E58_E1.6690.99
20_A23_A1.5700.99
59_A62_E1.5540.99
22_A25_A1.5110.99
23_A27_P1.5050.99
3_M6_N1.4600.98
38_F41_K1.4020.98
61_I74_L1.3960.98
72_D75_E1.3930.98
28_A79_G1.3910.98
21_A25_A1.3870.98
67_E72_D1.3310.97
21_A24_A1.3140.97
85_V88_H1.2840.96
20_A26_A1.2800.96
65_P69_E1.2730.96
22_A27_P1.2690.96
18_P24_A1.2650.96
8_D11_A1.2630.96
61_I65_P1.2580.96
23_A26_A1.2340.96
4_L14_E1.2140.95
15_F42_E1.1960.95
19_A25_A1.1930.95
32_F54_Q1.1820.94
29_R35_V1.1640.94
61_I81_A1.1570.94
24_A27_P1.1500.94
32_F42_E1.1470.93
32_F61_I1.1380.93
11_A15_F1.1360.93
52_S55_Q1.1230.93
75_E81_A1.1220.93
57_V60_L1.1010.92
10_F55_Q1.0980.92
14_E54_Q1.0880.92
20_A27_P1.0740.91
62_E69_E1.0730.91
2_Q35_V1.0490.90
15_F60_L0.9950.87
20_A25_A0.9870.87
6_N68_E0.9870.87
22_A26_A0.9800.87
12_V49_L0.9730.86
10_F78_A0.9440.84
73_F76_G0.9310.84
19_A26_A0.9130.82
45_L53_F0.9110.82
16_D44_F0.9100.82
3_M56_G0.8920.81
40_R57_V0.8700.79
66_S69_E0.8640.79
19_A28_A0.8600.79
19_A24_A0.8460.77
17_A20_A0.8380.77
60_L69_E0.8330.76
31_G42_E0.8280.76
30_G60_L0.8090.74
49_L61_I0.7970.73
56_G74_L0.7960.73
35_V85_V0.7860.72
8_D35_V0.7820.72
40_R52_S0.7820.72
39_A68_E0.7740.71
21_A27_P0.7740.71
44_F51_E0.7730.71
73_F77_Y0.7660.70
63_N69_E0.7640.70
2_Q27_P0.7450.68
14_E70_V0.7430.68
1_M7_S0.7410.67
22_A45_L0.7320.67
64_E67_E0.7290.66
49_L79_G0.7250.66
49_L52_S0.7210.65
27_P62_E0.7180.65
40_R43_I0.6990.63
61_I70_V0.6960.63
56_G73_F0.6860.62
70_V79_G0.6790.61
13_V17_A0.6690.60
69_E72_D0.6640.59
13_V76_G0.6610.59
64_E70_V0.6560.58
2_Q11_A0.6550.58
50_A57_V0.6490.57
12_V54_Q0.6460.57
1_M4_L0.6370.56
44_F71_D0.6340.56
4_L29_R0.6320.55
20_A76_G0.6270.55
8_D38_F0.6230.54
56_G59_A0.6220.54
52_S77_Y0.6150.53
41_K62_E0.6130.53
72_D77_Y0.5940.51
61_I64_E0.5930.51
34_I69_E0.5880.50
52_S58_E0.5800.49
9_S77_Y0.5790.49
12_V53_F0.5720.48
18_P28_A0.5700.48
43_I66_S0.5690.48
35_V46_D0.5690.48
61_I71_D0.5640.47
10_F87_L0.5610.47
45_L81_A0.5600.47
16_D28_A0.5590.47
67_E71_D0.5580.47
3_M13_V0.5570.46
48_A52_S0.5430.45
84_P88_H0.5380.44
68_E73_F0.5340.44
1_M5_Y0.5340.44
14_E28_A0.5260.43
46_D54_Q0.5100.41
9_S85_V0.5050.40
14_E78_A0.5040.40
39_A49_L0.5020.40
14_E81_A0.5020.40
16_D68_E0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wyuA 2 0.8068 24.8 0.917 Contact Map
1kijA 2 0.625 13.8 0.926 Contact Map
3ly1A 2 0.7614 12.2 0.928 Contact Map
1u8vA 3 0.7045 9.7 0.931 Contact Map
2xvlA 1 0.9205 9 0.932 Contact Map
3getA 2 0.7273 8.6 0.933 Contact Map
4lnjA 4 0.7386 7.2 0.935 Contact Map
3n0aA 1 0.8182 6.8 0.935 Contact Map
3v0dA 1 0.9545 6.8 0.936 Contact Map
3b5iA 2 0.9773 6.7 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0053 seconds.