GREMLIN Database
DUF3566 - Transmembrane domain of unknown function (DUF3566)
PFAM: PF12089 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 118 (117)
Sequences: 3018 (1715)
Seq/√Len: 158.5
META: 0.831

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_G84_G4.7641.00
24_S95_A4.1381.00
36_A77_L3.0761.00
16_V99_A2.7891.00
53_S57_D2.7821.00
35_V80_A2.7771.00
20_S95_A2.6741.00
11_I16_V2.6081.00
106_A109_V2.3801.00
49_D53_S2.0971.00
50_S53_S2.0671.00
30_V34_A1.9801.00
19_V105_I1.9531.00
19_V112_I1.9221.00
52_N66_D1.8951.00
36_A73_G1.8561.00
13_P100_F1.8461.00
32_V81_A1.7771.00
8_L116_L1.7021.00
66_D69_D1.6661.00
77_L80_A1.6361.00
32_V77_L1.5781.00
31_L84_G1.5091.00
91_L95_A1.4911.00
67_L71_F1.4561.00
42_L47_V1.4351.00
85_L89_V1.4031.00
31_L35_V1.4001.00
21_F92_T1.3991.00
46_G49_D1.3981.00
75_R79_F1.3891.00
65_F69_D1.3761.00
39_W43_D1.3131.00
28_G88_V1.2871.00
87_N91_L1.2831.00
16_V20_S1.2811.00
93_A96_T1.2451.00
24_S92_T1.2391.00
71_F76_V1.2341.00
28_G32_V1.2171.00
2_R6_L1.2001.00
10_R13_P1.1981.00
4_A7_V1.1931.00
88_V92_T1.1901.00
20_S24_S1.1781.00
104_L109_V1.1681.00
65_F68_A1.1671.00
102_Y106_A1.1421.00
25_L29_I1.1011.00
17_L21_F1.0910.99
20_S96_T1.0860.99
73_G77_L1.0810.99
16_V95_A1.0740.99
83_I87_N1.0630.99
73_G81_A1.0550.99
52_N56_G1.0510.99
14_W18_K1.0480.99
56_G61_S1.0380.99
5_R113_E1.0000.99
21_F24_S1.0000.99
40_L118_E0.9980.99
9_R117_A0.9930.99
8_L114_V0.9900.99
86_V90_L0.9630.99
49_D52_N0.9620.99
21_F88_V0.9550.99
39_W101_L0.9060.98
47_V50_S0.8980.98
81_A85_L0.8960.98
54_F58_L0.8900.98
59_G64_G0.8810.98
57_D60_G0.8780.98
3_R8_L0.8720.97
58_L61_S0.8600.97
51_I55_V0.8480.97
6_L116_L0.8390.97
49_D62_G0.8320.97
12_D18_K0.8310.97
2_R13_P0.8190.96
17_L96_T0.8060.96
40_L43_D0.8030.96
17_L20_S0.7740.95
39_W75_R0.7700.95
93_A108_L0.7690.95
40_L44_A0.7640.95
18_K108_L0.7580.94
8_L11_I0.7560.94
24_S91_L0.7560.94
64_G68_A0.7560.94
72_S75_R0.7480.94
48_F71_F0.7450.94
16_V112_I0.7430.94
2_R7_V0.7420.94
22_L109_V0.7380.94
7_V14_W0.7340.93
101_L107_D0.7230.93
68_A71_F0.7230.93
30_V50_S0.7180.93
21_F25_L0.7170.93
18_K22_L0.7170.93
41_V96_T0.7160.92
32_V38_L0.7150.92
2_R118_E0.7130.92
53_S58_L0.7130.92
28_G31_L0.6970.91
60_G63_S0.6940.91
76_V79_F0.6920.91
43_D48_F0.6900.91
48_F52_N0.6690.90
40_L56_G0.6690.90
57_D65_F0.6650.89
13_P17_L0.6640.89
22_L26_A0.6600.89
55_V59_G0.6590.89
53_S102_Y0.6530.89
10_R90_L0.6490.88
102_Y113_E0.6480.88
95_A99_A0.6370.87
25_L85_L0.6350.87
25_L88_V0.6340.87
39_W45_T0.6300.87
95_A98_G0.6270.87
54_F57_D0.6260.86
17_L26_A0.6260.86
11_I99_A0.6220.86
68_A97_L0.6130.85
19_V39_W0.6130.85
59_G63_S0.6110.85
58_L62_G0.6040.84
49_D68_A0.6040.84
50_S82_L0.6010.84
4_A116_L0.5970.84
89_V93_A0.5960.84
26_A101_L0.5950.84
52_N68_A0.5920.83
52_N69_D0.5890.83
24_S76_V0.5830.82
23_L26_A0.5760.82
104_L107_D0.5740.81
86_V101_L0.5720.81
19_V109_V0.5700.81
9_R17_L0.5700.81
33_V37_V0.5640.80
90_L98_G0.5630.80
40_L74_G0.5620.80
25_L45_T0.5600.80
59_G71_F0.5570.79
97_L100_F0.5510.79
24_S88_V0.5500.79
4_A16_V0.5470.78
37_V41_V0.5450.78
19_V91_L0.5440.78
23_L101_L0.5430.78
4_A114_V0.5410.77
113_E117_A0.5410.77
29_I80_A0.5360.77
97_L107_D0.5360.77
28_G109_V0.5350.77
47_V113_E0.5340.76
17_L100_F0.5310.76
56_G64_G0.5290.76
98_G108_L0.5210.75
37_V40_L0.5190.74
71_F75_R0.5190.74
38_L42_L0.5180.74
2_R5_R0.5160.74
30_V94_L0.5150.74
23_L98_G0.5130.74
93_A100_F0.5100.73
27_L31_L0.5070.73
43_D77_L0.5050.72
33_V87_N0.5040.72
28_G81_A0.5030.72
79_F83_I0.5020.72
29_I33_V0.5010.72
10_R55_V0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2onkC 2 0.7712 6.8 0.924 Contact Map
3d31C 2 0.7627 5.2 0.928 Contact Map
4f35D 2 0.339 3.8 0.933 Contact Map
4tquN 1 0.9322 2.9 0.936 Contact Map
2kogA 1 0.339 2.6 0.938 Contact Map
1vx77 1 0.2712 2.4 0.939 Contact Map
4v3iA 2 0 2.1 0.941 Contact Map
3zf7h 1 0.339 2.1 0.941 Contact Map
4j7cI 2 0.7881 2 0.942 Contact Map
3pjsK 4 0.8475 1.9 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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