GREMLIN Database
DUF3565 - Protein of unknown function (DUF3565)
PFAM: PF12088 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 57 (57)
Sequences: 3690 (1999)
Seq/√Len: 264.7
META: 0.942

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_H14_E3.9161.00
14_E20_T2.9941.00
50_D55_D2.6961.00
37_T40_G2.6861.00
38_E42_A2.6251.00
44_R47_T2.5061.00
4_H20_T2.4951.00
4_H12_V2.3601.00
26_D30_Q2.3431.00
20_T53_K2.0181.00
52_K56_E1.9871.00
5_Q9_G1.8281.00
23_V49_L1.7891.00
10_D26_D1.7061.00
40_G43_S1.5551.00
5_Q11_W1.4491.00
53_K57_G1.3031.00
25_H36_L1.2831.00
2_G14_E1.2431.00
3_F23_V1.1391.00
39_E42_A1.1191.00
26_D29_W0.9821.00
53_K56_E0.9731.00
29_W36_L0.9711.00
18_G31_N0.9431.00
12_V20_T0.9121.00
29_W32_R0.8981.00
52_K55_D0.8921.00
16_E31_N0.8821.00
39_E43_S0.8731.00
24_R28_P0.8711.00
21_Q52_K0.8661.00
33_P36_L0.8210.99
22_H25_H0.8210.99
12_V29_W0.8160.99
51_C54_C0.7860.99
21_Q30_Q0.7440.99
21_Q32_R0.7400.99
18_G29_W0.7300.99
28_P35_V0.7280.99
22_H27_P0.7090.98
42_A45_L0.7000.98
49_L52_K0.6940.98
23_V32_R0.6900.98
21_Q25_H0.6860.98
41_R46_G0.6850.98
16_E53_K0.6780.98
2_G15_L0.6500.97
20_T57_G0.6480.97
10_D32_R0.6470.97
13_A49_L0.6390.97
28_P34_W0.6140.96
25_H28_P0.6090.96
24_R27_P0.6020.95
43_S48_E0.5880.95
50_D56_E0.5880.95
8_E47_T0.5800.94
2_G45_L0.5780.94
35_V43_S0.5760.94
22_H28_P0.5720.94
7_E55_D0.5710.94
30_Q44_R0.5660.93
21_Q24_R0.5650.93
14_E53_K0.5620.93
15_L23_V0.5590.93
18_G57_G0.5590.93
33_P37_T0.5560.93
43_S56_E0.5560.93
6_D13_A0.5550.93
18_G36_L0.5540.93
23_V35_V0.5530.93
40_G44_R0.5460.92
16_E56_E0.5380.92
15_L28_P0.5360.92
3_F47_T0.5330.91
30_Q57_G0.5320.91
45_L55_D0.5310.91
32_R36_L0.5270.91
40_G45_L0.5220.90
5_Q16_E0.5220.90
17_C46_G0.5120.90
6_D11_W0.5110.90
16_E55_D0.5070.89
47_T53_K0.5040.89
32_R55_D0.5030.89
20_T56_E0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z84A 2 0.5614 15.2 0.896 Contact Map
1gupA 2 0.7544 14.6 0.897 Contact Map
4r2yA 4 0.7895 7.1 0.91 Contact Map
2l0bA 1 0.7368 6.6 0.912 Contact Map
2y1nA 1 0.7018 6.5 0.912 Contact Map
4a0kB 1 0 6 0.913 Contact Map
1hxrA 1 0.3684 5.6 0.915 Contact Map
4ui9B 1 0.7895 5.2 0.916 Contact Map
2kizA 1 0.7368 5.1 0.916 Contact Map
3dplR 1 0.6842 4.8 0.917 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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