GREMLIN Database
GldM_N - GldM N-terminal domain
PFAM: PF12081 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 194 (193)
Sequences: 6450 (5030)
Seq/√Len: 362.1
META: 0.924

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
105_K108_E3.8831.00
46_Y50_Q3.5821.00
115_E119_K3.3791.00
55_L119_K3.2101.00
57_D61_N2.7261.00
69_E105_K2.6631.00
43_K47_E2.6181.00
111_K115_E2.5591.00
175_K179_D2.5471.00
62_Y112_K2.4771.00
107_K111_K2.3661.00
110_K114_N2.3531.00
54_K58_E2.2791.00
158_E162_E2.1831.00
55_L58_E2.1671.00
58_E112_K2.1631.00
10_N14_E2.0921.00
108_E112_K2.0571.00
64_E68_D2.0531.00
118_E122_A2.0041.00
65_D69_E1.9341.00
51_E54_K1.9171.00
110_K157_E1.8921.00
112_K115_E1.8811.00
63_I173_L1.8611.00
56_S116_Y1.8121.00
107_K157_E1.8011.00
61_N65_D1.7971.00
25_E29_A1.7901.00
86_K89_N1.7541.00
32_E50_Q1.7281.00
119_K122_A1.7081.00
67_K177_Q1.7031.00
68_D72_K1.6741.00
29_A32_E1.6211.00
60_Y177_Q1.6111.00
52_V123_L1.6051.00
52_V120_L1.6021.00
32_E36_K1.5501.00
32_E46_Y1.5471.00
73_E95_R1.5381.00
28_Y53_K1.5371.00
127_I130_D1.5151.00
51_E55_L1.5121.00
53_K184_E1.4821.00
53_K57_D1.4691.00
89_N92_A1.4431.00
114_N118_E1.4351.00
106_G157_E1.4141.00
47_E51_E1.4071.00
96_L105_K1.3961.00
174_S177_Q1.3881.00
21_D25_E1.3571.00
56_S180_V1.3511.00
29_A33_A1.3401.00
155_D158_E1.3301.00
111_K114_N1.3111.00
62_Y66_L1.3071.00
64_E177_Q1.2991.00
35_A43_K1.2541.00
91_D95_R1.2541.00
117_R121_L1.2531.00
44_P48_K1.2481.00
69_E72_K1.2421.00
69_E73_E1.2391.00
51_E119_K1.2291.00
93_P169_A1.2281.00
128_P131_R1.2101.00
59_L180_V1.2011.00
136_K139_S1.1981.00
116_Y120_L1.1931.00
33_A36_K1.1871.00
50_Q53_K1.1851.00
57_D181_K1.1841.00
59_L113_I1.1661.00
74_A166_L1.1541.00
108_E111_K1.1521.00
35_A42_V1.1271.00
21_D181_K1.1261.00
90_L163_G1.1171.00
121_L135_E1.1131.00
22_E25_E1.0811.00
67_K174_S1.0611.00
52_V187_V1.0581.00
128_P132_K1.0541.00
18_E22_E1.0491.00
99_G103_K1.0481.00
66_L109_L1.0471.00
70_L166_L1.0471.00
47_E50_Q1.0421.00
16_S20_V1.0361.00
120_L183_A1.0341.00
48_K51_E1.0231.00
28_Y49_A1.0211.00
69_E96_L1.0201.00
50_Q54_K1.0191.00
40_E44_P1.0151.00
35_A46_Y1.0121.00
39_P43_K1.0051.00
60_Y64_E0.9731.00
9_V171_T0.9711.00
34_K37_E0.9661.00
63_I180_V0.9611.00
24_N188_L0.9571.00
62_Y65_D0.9541.00
65_D68_D0.9531.00
1_E4_N0.9501.00
107_K110_K0.9411.00
148_D154_K0.9331.00
71_I76_G0.9271.00
114_N140_T0.9241.00
33_A37_E0.9211.00
12_S175_K0.9201.00
133_S137_N0.9171.00
129_K132_K0.9171.00
115_E118_E0.9151.00
35_A39_P0.9121.00
99_G104_G0.9061.00
58_E62_Y0.9061.00
186_E189_N0.9051.00
119_K123_L0.9031.00
104_G107_K0.9011.00
73_E96_L0.8881.00
59_L112_K0.8771.00
44_P47_E0.8631.00
45_W48_K0.8581.00
7_K87_K0.8561.00
135_E139_S0.8561.00
70_L96_L0.8531.00
59_L63_I0.8491.00
139_S143_P0.8431.00
81_L84_I0.8421.00
17_N178_N0.8361.00
63_I109_L0.8341.00
139_S142_D0.8311.00
10_N174_S0.8281.00
38_N41_K0.8191.00
90_L93_P0.8161.00
62_Y105_K0.8131.00
60_Y181_K0.8121.00
31_F49_A0.8091.00
84_I166_L0.7991.00
66_L97_M0.7991.00
94_T162_E0.7891.00
172_I175_K0.7831.00
20_V23_K0.7801.00
26_A29_A0.7741.00
10_N67_K0.7731.00
55_L115_E0.7701.00
73_E92_A0.7641.00
74_A86_K0.7621.00
185_S189_N0.7601.00
92_A95_R0.7551.00
164_M169_A0.7531.00
132_K135_E0.7531.00
140_T143_P0.7521.00
90_L94_T0.7521.00
126_D131_R0.7461.00
13_L174_S0.7431.00
84_I87_K0.7421.00
66_L96_L0.7401.00
14_E18_E0.7401.00
31_F45_W0.7331.00
127_I131_R0.7321.00
121_L131_R0.7311.00
55_L116_Y0.7311.00
34_K192_L0.7291.00
28_Y188_L0.7221.00
107_K155_D0.7211.00
136_K142_D0.7200.99
23_K27_I0.7150.99
147_K153_K0.7130.99
182_N185_S0.7120.99
137_N140_T0.7110.99
72_K77_K0.7100.99
132_K136_K0.7090.99
80_D83_D0.7090.99
154_K158_E0.7060.99
52_V188_L0.7050.99
32_E35_A0.7030.99
164_M172_I0.7000.99
12_S179_D0.7000.99
51_E123_L0.6990.99
151_G154_K0.6970.99
52_V55_L0.6960.99
181_K184_E0.6960.99
71_I170_L0.6950.99
30_S33_A0.6900.99
9_V13_L0.6880.99
4_N7_K0.6850.99
187_V191_L0.6820.99
165_P168_A0.6820.99
135_E140_T0.6780.99
66_L105_K0.6770.99
138_L141_D0.6760.99
22_E26_A0.6750.99
61_N64_E0.6750.99
138_L142_D0.6740.99
90_L162_E0.6730.99
118_E121_L0.6700.99
55_L59_L0.6670.99
149_K152_K0.6660.99
172_I176_L0.6650.99
12_S20_V0.6630.99
71_I74_A0.6620.99
136_K141_D0.6620.99
125_D128_P0.6620.99
58_E61_N0.6580.99
70_L93_P0.6540.99
15_K18_E0.6490.99
42_V45_W0.6460.99
148_D152_K0.6420.99
144_K147_K0.6420.99
94_T98_I0.6400.99
167_V171_T0.6400.99
160_N172_I0.6380.99
142_D153_K0.6380.99
7_K167_V0.6350.99
131_R135_E0.6350.99
63_I176_L0.6280.99
4_N87_K0.6270.99
137_N142_D0.6200.99
60_Y180_V0.6160.98
59_L62_Y0.6140.98
137_N141_D0.6100.98
14_E67_K0.6070.98
135_E141_D0.6050.98
190_Y193_S0.6040.98
68_D71_I0.6010.98
28_Y184_E0.5990.98
28_Y31_F0.5950.98
27_I30_S0.5950.98
48_K125_D0.5940.98
114_N117_R0.5940.98
58_E119_K0.5920.98
36_K39_P0.5890.98
77_K84_I0.5870.98
101_G104_G0.5820.98
178_N182_N0.5810.98
70_L169_A0.5800.98
116_Y119_K0.5770.98
30_S34_K0.5750.98
113_I180_V0.5730.98
39_P42_V0.5670.97
7_K11_E0.5670.97
147_K150_D0.5670.97
92_A96_L0.5660.97
65_D105_K0.5660.97
143_P146_V0.5650.97
31_F188_L0.5640.97
95_R100_E0.5620.97
12_S16_S0.5620.97
55_L123_L0.5610.97
34_K42_V0.5610.97
52_V119_K0.5590.97
24_N185_S0.5560.97
41_K44_P0.5550.97
59_L116_Y0.5490.97
9_V172_I0.5470.97
64_E67_K0.5460.97
62_Y108_E0.5440.97
89_N93_P0.5430.97
94_T163_G0.5420.97
74_A92_A0.5390.96
189_N193_S0.5390.96
98_I162_E0.5370.96
134_I137_N0.5370.96
187_V190_Y0.5370.96
23_K189_N0.5350.96
48_K123_L0.5350.96
2_V7_K0.5330.96
124_L131_R0.5290.96
165_P174_S0.5290.96
26_A30_S0.5280.96
56_S60_Y0.5280.96
23_K185_S0.5280.96
24_N27_I0.5270.96
27_I189_N0.5260.96
113_I176_L0.5260.96
137_N143_P0.5240.96
116_Y180_V0.5230.96
138_L143_P0.5210.96
28_Y46_Y0.5180.96
32_E53_K0.5140.95
55_L122_A0.5130.95
11_E14_E0.5130.95
38_N43_K0.5110.95
118_E135_E0.5090.95
112_K116_Y0.5040.95
9_V12_S0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1t3jA 2 0.3196 9.1 0.925 Contact Map
2ieqA 3 0.3557 7.2 0.928 Contact Map
1i4dA 2 0.5052 6.4 0.93 Contact Map
4k1pA 1 0.3196 4.9 0.934 Contact Map
2marA 1 0.3763 3 0.94 Contact Map
4gipD 3 0.1546 2.8 0.941 Contact Map
2ch7A 2 0.3454 2.7 0.942 Contact Map
1k04A 2 0.3505 2.5 0.943 Contact Map
1pehA 1 0.1701 2.1 0.945 Contact Map
4e9mA 2 0.2732 2 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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