GREMLIN Database
GldM_C - GldM C-terminal domain
PFAM: PF12080 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 175 (172)
Sequences: 6433 (4661)
Seq/√Len: 355.4
META: 0.934

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_D48_R3.7901.00
57_E75_E3.7131.00
5_D19_S3.5501.00
128_T169_D3.3651.00
59_T73_S2.8461.00
87_K112_K2.7371.00
141_E151_E2.6981.00
10_L47_V2.5451.00
59_T75_E2.5281.00
143_S152_A2.4761.00
15_D46_I2.3081.00
5_D44_K2.2711.00
122_F174_G2.1751.00
70_V73_S2.1561.00
126_S171_K2.1031.00
129_V152_A2.0531.00
123_K173_K2.0261.00
164_R168_E1.9501.00
160_K163_D1.9491.00
128_T140_T1.9391.00
99_S102_E1.9061.00
125_T173_K1.8881.00
128_T142_V1.8861.00
2_V74_K1.8341.00
86_A170_I1.7781.00
10_L18_V1.7661.00
133_G136_G1.7661.00
61_T70_V1.7261.00
6_K119_D1.6901.00
12_I80_R1.6831.00
38_K48_R1.6791.00
79_K117_D1.6721.00
143_S149_T1.6271.00
87_K114_E1.5891.00
149_T152_A1.5841.00
4_A76_F1.5551.00
40_S46_I1.5491.00
154_A157_R1.5181.00
63_S70_V1.5131.00
150_A154_A1.5061.00
100_K104_L1.4971.00
53_K75_E1.4931.00
61_T73_S1.4831.00
159_A165_V1.4311.00
141_E155_L1.3701.00
98_I103_L1.3611.00
20_I32_A1.3331.00
80_R83_D1.3281.00
109_V167_I1.3051.00
63_S68_G1.2901.00
151_E154_A1.2871.00
6_K17_P1.2661.00
156_I159_A1.2511.00
22_V71_M1.2491.00
19_S74_K1.2431.00
26_P29_K1.2281.00
37_I40_S1.2251.00
89_G106_Q1.2231.00
107_G147_R1.2011.00
141_E152_A1.1801.00
132_V135_R1.1781.00
129_V156_I1.1741.00
159_A163_D1.1691.00
153_K157_R1.1431.00
107_G153_K1.1351.00
104_L157_R1.1321.00
148_F156_I1.1291.00
127_F152_A1.1271.00
37_I47_V1.1231.00
39_K42_N1.1131.00
113_L122_F1.1131.00
18_V47_V1.1061.00
14_V118_F1.0971.00
19_S44_K1.0781.00
81_I116_F1.0781.00
127_F143_S1.0751.00
108_G148_F1.0631.00
102_E106_Q1.0581.00
145_G148_F1.0531.00
25_V29_K1.0311.00
100_K103_L1.0281.00
124_V172_A1.0151.00
53_K56_K1.0021.00
126_S142_V1.0011.00
154_A158_K1.0001.00
81_I122_F0.9961.00
92_K98_I0.9941.00
41_G44_K0.9901.00
14_V81_I0.9841.00
87_K110_G0.9821.00
93_K114_E0.9721.00
25_V64_A0.9671.00
103_L165_V0.9621.00
131_F134_K0.9621.00
150_A153_K0.9511.00
27_S43_G0.9501.00
128_T168_E0.9411.00
64_A71_M0.9381.00
103_L156_I0.9321.00
108_G147_R0.9321.00
152_A155_L0.9301.00
22_V64_A0.9281.00
129_V167_I0.9271.00
132_V136_G0.9121.00
39_K45_Y0.9111.00
40_S44_K0.9091.00
10_L49_P0.9061.00
111_A124_V0.9021.00
8_N77_R0.8871.00
145_G149_T0.8861.00
27_S39_K0.8741.00
116_F119_D0.8701.00
85_V114_E0.8671.00
14_V117_D0.8661.00
67_G71_M0.8601.00
91_K95_G0.8561.00
108_G146_N0.8541.00
88_I148_F0.8521.00
36_S48_R0.8491.00
86_A172_A0.8481.00
10_L76_F0.8411.00
125_T171_K0.8381.00
31_S68_G0.8381.00
31_S63_S0.8371.00
83_D93_K0.8371.00
101_A104_L0.8191.00
33_S63_S0.8171.00
130_T133_G0.8171.00
92_K102_E0.8171.00
22_V30_V0.8131.00
91_K94_G0.8051.00
9_V79_K0.8011.00
113_L116_F0.7971.00
134_K137_D0.7971.00
47_V60_I0.7741.00
6_K14_V0.7681.00
9_V77_R0.7671.00
5_D17_P0.7571.00
87_K93_K0.7531.00
20_I62_V0.7491.00
133_G163_D0.7381.00
148_F153_K0.7321.00
20_I60_I0.7291.00
131_F155_L0.7291.00
81_I120_L0.7271.00
83_D122_F0.7260.99
25_V65_L0.7200.99
148_F167_I0.7110.99
64_A69_K0.7020.99
38_K46_I0.7010.99
141_E149_T0.6990.99
101_A105_A0.6870.99
123_K146_N0.6860.99
3_S21_S0.6850.99
126_S144_N0.6850.99
86_A109_V0.6850.99
12_I51_P0.6830.99
14_V17_P0.6810.99
12_I49_P0.6810.99
90_G102_E0.6800.99
133_G160_K0.6790.99
130_T134_K0.6780.99
81_I174_G0.6770.99
131_F136_G0.6730.99
106_Q110_G0.6680.99
113_L120_L0.6660.99
109_V124_V0.6640.99
135_R139_V0.6630.99
89_G110_G0.6630.99
81_I113_L0.6590.99
34_G58_V0.6580.99
4_A7_M0.6580.99
88_I109_V0.6570.99
21_S24_G0.6570.99
116_F120_L0.6550.99
147_R153_K0.6530.99
20_I45_Y0.6520.99
129_V148_F0.6490.99
123_K174_G0.6490.99
92_K95_G0.6480.99
3_S19_S0.6470.99
33_S61_T0.6430.99
131_F135_R0.6410.99
7_M77_R0.6400.99
32_A37_I0.6370.99
130_T135_R0.6350.99
98_I102_E0.6330.99
107_G110_G0.6300.99
47_V58_V0.6270.99
138_A144_N0.6220.98
126_S169_D0.6190.98
52_G56_K0.6170.98
17_P118_F0.6150.98
89_G102_E0.6120.98
129_V141_E0.6100.98
7_M24_G0.6080.98
99_S103_L0.6050.98
51_P54_V0.6020.98
63_S71_M0.6000.98
148_F152_A0.5990.98
36_S49_P0.5960.98
4_A18_V0.5950.98
130_T138_A0.5920.98
49_P78_V0.5890.98
51_P80_R0.5830.98
22_V25_V0.5830.98
77_R117_D0.5820.98
134_K163_D0.5820.98
111_A167_I0.5760.97
110_G113_L0.5740.97
6_K118_F0.5720.97
50_T53_K0.5720.97
132_V166_Y0.5710.97
54_V58_V0.5690.97
143_S146_N0.5690.97
9_V117_D0.5670.97
60_I76_F0.5650.97
84_P122_F0.5640.97
34_G49_P0.5630.97
88_I103_L0.5590.97
139_V158_K0.5590.97
132_V137_D0.5560.97
77_R116_F0.5550.97
127_F146_N0.5550.97
34_G54_V0.5500.97
151_E155_L0.5480.97
55_G78_V0.5480.97
54_V78_V0.5460.96
39_K43_G0.5460.96
156_I165_V0.5450.96
85_V93_K0.5450.96
85_V112_K0.5420.96
69_K72_G0.5410.96
130_T168_E0.5400.96
94_G168_E0.5400.96
68_G71_M0.5390.96
79_K115_D0.5380.96
132_V138_A0.5370.96
130_T136_G0.5350.96
8_N74_K0.5340.96
97_A100_K0.5330.96
7_M117_D0.5320.96
110_G121_K0.5290.96
70_V74_K0.5280.96
4_A10_L0.5230.96
17_P119_D0.5210.95
140_T143_S0.5200.95
10_L60_I0.5190.95
3_S74_K0.5140.95
3_S6_K0.5130.95
125_T172_A0.5130.95
133_G137_D0.5110.95
131_F165_V0.5100.95
15_D38_K0.5100.95
29_K32_A0.5080.95
132_V140_T0.5070.95
4_A17_P0.5060.95
34_G50_T0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wvoA 1 0.1771 18.6 0.915 Contact Map
1ucsA 1 0.1543 13 0.921 Contact Map
2e9jA 1 0.48 11.1 0.923 Contact Map
3rghA 1 0.4057 10.4 0.924 Contact Map
1v05A 2 0.3943 9.3 0.926 Contact Map
2dj4A 1 0.4286 9.1 0.926 Contact Map
4ur6A 2 0.1486 9 0.926 Contact Map
3cnkA 2 0.3943 8.8 0.926 Contact Map
1msiA 1 0.16 8 0.928 Contact Map
2d7mA 1 0.4629 7.2 0.929 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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