GREMLIN Database
DUF3556 - Transmembrane protein of unknown function (DUF3556)
PFAM: PF12077 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 573 (570)
Sequences: 684 (410)
Seq/√Len: 17.2
META: 0.692

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
276_D279_D6.8571.00
141_D510_E6.5271.00
121_L152_A5.1751.00
516_P542_A5.1541.00
97_L117_I4.9981.00
502_E537_R4.6651.00
508_V519_L4.4331.00
235_L307_L4.2921.00
309_S315_T4.1961.00
559_R565_D3.9691.00
545_V548_R3.8931.00
138_T198_R3.8771.00
115_G119_Y3.7481.00
439_G442_T3.6881.00
489_V508_V3.3360.99
319_A354_G3.3140.99
473_D476_D3.2130.99
535_H548_R3.1830.99
539_V545_V3.1600.99
26_R30_R3.0620.99
201_T499_L3.0220.99
528_P531_R3.0120.99
54_Y91_T2.9840.99
248_H557_V2.8690.98
259_S274_Y2.8130.98
135_V138_T2.6980.97
418_K518_E2.6680.97
242_A300_F2.6560.97
96_V202_I2.6040.97
462_A551_V2.5990.97
60_L64_L2.5680.96
57_G61_F2.5440.96
416_E480_R2.5320.96
234_I348_G2.4600.95
96_V154_L2.4530.95
157_S191_L2.4420.95
516_P543_T2.3350.94
315_T319_A2.3160.93
536_Y547_E2.2730.93
302_V321_V2.2360.92
258_M332_T2.2270.92
15_E18_K2.2110.92
323_V346_I2.1970.91
315_T357_P2.1930.91
527_Q532_Q2.1810.91
127_R198_R2.1540.91
129_P134_R2.1150.90
524_L551_V2.1060.90
119_Y426_S2.1000.89
33_A281_L2.1000.89
186_V190_V2.1000.89
243_T300_F2.0850.89
130_P197_L2.0650.89
192_L206_A2.0550.88
158_L188_I2.0530.88
387_R390_K2.0370.88
383_L387_R2.0320.88
103_S114_I2.0230.88
486_A490_L1.9860.87
185_L215_L1.9840.87
82_I166_G1.9480.85
124_G137_L1.9410.85
92_M158_L1.9400.85
189_L212_G1.9370.85
243_T529_I1.9310.85
552_R555_D1.9300.85
89_L158_L1.9280.85
96_V206_A1.9180.85
160_V187_P1.9050.84
15_E19_K1.8780.83
242_A325_F1.8580.83
154_L188_I1.8520.82
214_A233_V1.8450.82
201_T490_L1.8170.81
514_F518_E1.8130.81
505_L523_W1.8030.81
268_W272_R1.7940.80
239_W300_F1.7810.80
19_K27_P1.7650.79
406_T524_L1.7600.79
345_M348_G1.7470.78
462_A466_L1.7340.78
234_I345_M1.7320.78
57_G60_L1.7300.78
89_L161_A1.7260.78
382_V391_V1.7130.77
160_V164_S1.7120.77
323_V350_F1.6880.76
31_H35_Q1.6760.75
420_D425_K1.6690.75
51_I339_L1.6640.75
311_G357_P1.6520.74
214_A234_I1.6270.73
380_L391_V1.6210.73
534_Q556_M1.6160.73
91_T270_K1.6110.72
130_P198_R1.6000.72
94_F101_C1.5970.72
56_L71_F1.5920.71
527_Q530_H1.5800.71
469_R547_E1.5750.71
127_R138_T1.5670.70
168_G173_P1.5600.70
89_L180_L1.5400.69
317_I320_V1.5340.69
328_F524_L1.5240.68
73_D76_S1.5120.67
225_D231_K1.5060.67
113_P118_L1.4840.66
82_I85_Q1.4820.66
94_F100_G1.4670.65
247_N251_P1.4580.64
309_S427_A1.4580.64
124_G148_V1.4540.64
146_L347_F1.4530.64
84_F230_A1.4420.64
89_L142_R1.4390.63
131_W138_T1.4390.63
313_W317_I1.4380.63
556_M568_I1.4320.63
195_L202_I1.4290.63
58_G62_A1.4270.63
142_R424_V1.4260.63
321_V325_F1.4250.63
145_P149_A1.4220.62
538_I546_I1.4220.62
328_F332_T1.4140.62
131_W395_P1.4090.62
51_I343_V1.3980.61
25_I39_T1.3960.61
4_L8_L1.3940.61
59_W71_F1.3940.61
111_K437_F1.3870.60
457_H487_G1.3850.60
240_G382_V1.3840.60
311_G481_E1.3810.60
56_L59_W1.3810.60
193_A212_G1.3790.60
289_L515_E1.3770.60
466_L469_R1.3750.60
485_V519_L1.3720.60
204_L394_L1.3680.59
168_G172_L1.3630.59
191_L215_L1.3580.59
305_V309_S1.3510.58
135_V198_R1.3430.58
496_D516_P1.3430.58
528_P535_H1.3380.58
304_L308_F1.3340.57
407_S519_L1.3330.57
214_A230_A1.3290.57
52_L55_V1.2980.55
124_G424_V1.2960.55
129_P139_G1.2930.55
312_G481_E1.2910.55
51_I56_L1.2870.55
124_G142_R1.2860.55
102_G107_T1.2810.54
45_L48_V1.2730.54
200_K351_F1.2680.53
446_L449_K1.2620.53
528_P533_T1.2570.53
5_K272_R1.2540.53
470_A522_V1.2510.52
85_Q218_F1.2510.52
423_L489_V1.2400.52
65_T82_I1.2390.52
237_I302_V1.2340.51
258_M273_L1.2320.51
129_P503_Q1.2300.51
305_V452_A1.2290.51
55_V343_V1.2260.51
11_V29_A1.2140.50
533_T550_Y1.2130.50
34_E271_R1.2080.50
84_F87_A1.2070.50
126_I511_R1.2060.50
326_H397_M1.1970.49
503_Q506_A1.1900.49
24_R357_P1.1890.49
129_P132_P1.1850.48
423_L508_V1.1850.48
537_R545_V1.1810.48
287_A290_M1.1790.48
417_E421_R1.1780.48
540_D544_G1.1750.48
470_A538_I1.1730.48
149_A276_D1.1700.48
156_A160_V1.1700.48
171_P174_G1.1700.48
168_G177_V1.1660.47
379_G383_L1.1660.47
523_W537_R1.1650.47
450_G481_E1.1590.47
254_V295_G1.1560.47
37_F91_T1.1540.47
495_G498_H1.1520.47
43_V46_F1.1510.46
411_F485_V1.1490.46
67_G82_I1.1480.46
61_F162_L1.1460.46
313_W383_L1.1430.46
383_L390_K1.1370.46
157_S187_P1.1360.46
115_G118_L1.1330.45
311_G315_T1.1310.45
298_V325_F1.1300.45
472_D476_D1.1280.45
235_L239_W1.1200.45
213_P377_L1.1190.45
58_G61_F1.1180.44
463_L524_L1.1160.44
407_S523_W1.1130.44
316_T354_G1.1120.44
259_S438_Y1.1090.44
19_K23_E1.1050.44
118_L466_L1.1020.44
140_G198_R1.1000.43
68_L106_L1.1000.43
54_Y344_F1.0950.43
225_D358_G1.0920.43
54_Y337_V1.0910.43
297_A321_V1.0820.42
502_E506_A1.0790.42
107_T407_S1.0770.42
101_C213_P1.0750.42
34_E277_F1.0750.42
308_F363_D1.0750.42
535_H550_Y1.0730.42
228_V366_S1.0720.42
295_G328_F1.0690.42
30_R281_L1.0670.41
134_R423_L1.0660.41
522_V538_I1.0650.41
140_G144_T1.0600.41
467_L479_V1.0550.41
551_V556_M1.0550.41
544_G549_G1.0540.41
524_L534_Q1.0530.41
119_Y425_K1.0460.40
129_P477_Y1.0460.40
370_L417_E1.0450.40
69_G74_V1.0390.40
487_G493_N1.0380.40
412_R472_D1.0380.40
8_L14_A1.0370.40
89_L215_L1.0360.40
138_T197_L1.0330.40
210_H345_M1.0300.39
531_R535_H1.0290.39
209_E403_N1.0280.39
456_M472_D1.0270.39
206_A291_A1.0240.39
254_V261_S1.0210.39
111_K436_R1.0190.39
21_R25_I1.0170.39
519_L538_I1.0160.39
6_P438_Y1.0150.38
66_P69_G1.0150.38
56_L60_L1.0120.38
431_V444_E1.0090.38
187_P190_V1.0060.38
515_E518_E1.0050.38
339_L372_L1.0030.38
273_L451_L1.0010.38
407_S486_A1.0010.38
354_G357_P1.0000.38
145_P190_V0.9980.38
296_T325_F0.9950.37
87_A110_F0.9940.37
411_F546_I0.9940.37
69_G78_W0.9890.37
469_R570_V0.9890.37
173_P176_T0.9880.37
172_L175_T0.9880.37
51_I65_T0.9870.37
170_A173_P0.9820.37
289_L546_I0.9820.37
466_L470_A0.9810.37
336_G487_G0.9810.37
319_A349_A0.9760.36
157_S194_L0.9730.36
386_L529_I0.9730.36
419_L566_G0.9710.36
224_V229_A0.9690.36
81_P227_I0.9640.36
455_S479_V0.9620.36
306_L318_A0.9620.36
482_G491_G0.9610.35
47_Y50_K0.9490.35
127_R139_G0.9490.35
198_R479_V0.9490.35
457_H461_R0.9480.35
159_V163_V0.9470.35
190_V193_A0.9470.35
88_V233_V0.9430.34
397_M401_A0.9430.34
118_L122_R0.9430.34
457_H493_N0.9420.34
74_V78_W0.9390.34
110_F434_L0.9380.34
14_A26_R0.9370.34
249_H253_V0.9370.34
373_L377_L0.9350.34
387_R391_V0.9320.34
92_M192_L0.9320.34
371_A513_G0.9320.34
449_K456_M0.9310.34
37_F54_Y0.9290.34
148_V152_A0.9270.34
173_P177_V0.9250.34
101_C336_G0.9230.33
111_K227_I0.9210.33
43_V48_V0.9190.33
456_M467_L0.9170.33
306_L315_T0.9160.33
170_A175_T0.9100.33
204_L392_S0.9090.33
257_M295_G0.9060.32
489_V519_L0.9030.32
323_V327_L0.9020.32
454_R460_G0.9020.32
59_W72_G0.9010.32
9_P149_A0.9010.32
189_L216_V0.8990.32
119_Y344_F0.8990.32
209_E244_S0.8970.32
202_I208_G0.8970.32
89_L135_V0.8970.32
523_W539_V0.8950.32
63_S69_G0.8940.32
92_M379_G0.8940.32
183_W187_P0.8940.32
350_F382_V0.8940.32
59_W62_A0.8920.32
257_M260_N0.8920.32
210_H380_L0.8910.32
168_G175_T0.8890.32
293_V297_A0.8890.32
118_L123_P0.8890.32
107_T116_G0.8850.31
438_Y536_Y0.8830.31
377_L381_P0.8820.31
121_L246_L0.8790.31
467_L481_E0.8790.31
420_D432_D0.8750.31
110_F370_L0.8740.31
405_A501_N0.8720.31
540_D549_G0.8680.31
482_G492_W0.8610.30
85_Q226_M0.8600.30
202_I490_L0.8570.30
305_V314_L0.8570.30
518_E524_L0.8570.30
32_W259_S0.8500.30
192_L208_G0.8500.30
300_F420_D0.8490.30
94_F102_G0.8490.30
227_I361_L0.8440.29
124_G490_L0.8420.29
231_K261_S0.8410.29
202_I499_L0.8410.29
414_G417_E0.8400.29
74_V80_E0.8390.29
286_L290_M0.8390.29
305_V467_L0.8380.29
96_V155_L0.8360.29
182_P187_P0.8360.29
154_L202_I0.8350.29
63_S71_F0.8340.29
496_D503_Q0.8330.29
410_L471_V0.8330.29
261_S335_M0.8320.29
109_R121_L0.8320.29
103_S381_P0.8310.29
381_P410_L0.8310.29
220_F369_L0.8280.29
165_P339_L0.8240.28
6_P449_K0.8230.28
396_S526_S0.8220.28
405_A525_E0.8200.28
15_E27_P0.8190.28
118_L209_E0.8160.28
169_P175_T0.8140.28
311_G314_L0.8130.28
492_W499_L0.8130.28
319_A357_P0.8130.28
89_L188_I0.8100.28
179_L293_V0.8090.28
93_L159_V0.8090.28
186_V224_V0.8090.28
455_S464_F0.8080.28
542_A548_R0.8070.28
227_I427_A0.8060.27
55_V73_D0.8040.27
429_N432_D0.8040.27
413_P476_D0.8020.27
129_P425_K0.8000.27
501_N535_H0.7990.27
249_H338_P0.7980.27
216_V255_S0.7980.27
29_A33_A0.7980.27
505_L541_A0.7970.27
53_L90_W0.7960.27
150_L373_L0.7950.27
168_G176_T0.7950.27
201_T206_A0.7930.27
418_K515_E0.7920.27
387_R516_P0.7920.27
8_L449_K0.7910.27
348_G366_S0.7890.27
38_G55_V0.7890.27
482_G519_L0.7880.27
453_F459_H0.7870.27
95_E100_G0.7860.27
282_R369_L0.7840.26
137_L317_I0.7810.26
55_V62_A0.7800.26
7_D31_H0.7780.26
146_L159_V0.7770.26
509_Q514_F0.7760.26
419_L508_V0.7760.26
214_A237_I0.7750.26
130_P138_T0.7750.26
243_T527_Q0.7730.26
310_T316_T0.7710.26
302_V322_M0.7710.26
144_T287_A0.7710.26
249_H322_M0.7710.26
90_W278_P0.7670.26
217_V277_F0.7650.26
508_V545_V0.7640.25
330_L346_I0.7640.25
257_M329_I0.7630.25
36_G54_Y0.7610.25
211_Y338_P0.7610.25
273_L346_I0.7610.25
407_S482_G0.7610.25
259_S337_V0.7580.25
466_L530_H0.7570.25
154_L205_A0.7560.25
89_L96_V0.7560.25
101_C499_L0.7550.25
25_I455_S0.7540.25
38_G54_Y0.7540.25
22_A26_R0.7520.25
168_G171_P0.7510.25
310_T357_P0.7500.25
126_I489_V0.7490.25
351_F356_H0.7460.25
553_V557_V0.7440.25
26_R161_A0.7440.25
317_I321_V0.7430.25
153_A191_L0.7430.25
141_D511_R0.7430.25
333_F396_S0.7420.25
169_P172_L0.7420.25
61_F139_G0.7400.24
54_Y343_V0.7390.24
163_V216_V0.7390.24
102_G336_G0.7380.24
466_L536_Y0.7360.24
505_L548_R0.7360.24
123_P504_L0.7350.24
11_V28_L0.7350.24
64_L163_V0.7340.24
139_G423_L0.7340.24
129_P145_P0.7340.24
440_P445_I0.7330.24
531_R550_Y0.7330.24
159_V378_V0.7320.24
181_P184_L0.7320.24
166_G193_A0.7310.24
548_R560_Q0.7310.24
128_L507_A0.7280.24
100_G524_L0.7280.24
4_L68_L0.7280.24
508_V512_C0.7280.24
114_I119_Y0.7260.24
243_T437_F0.7250.24
4_L18_K0.7250.24
139_G159_V0.7200.24
152_A183_W0.7200.24
261_S332_T0.7190.23
48_V55_V0.7180.23
387_R435_E0.7170.23
442_T446_L0.7170.23
74_V79_T0.7170.23
457_H525_E0.7150.23
467_L489_V0.7140.23
165_P514_F0.7140.23
45_L71_F0.7130.23
486_A523_W0.7120.23
61_F64_L0.7090.23
180_L379_G0.7090.23
51_I57_G0.7070.23
549_G561_P0.7060.23
6_P54_Y0.7060.23
565_D568_I0.7040.23
144_T148_V0.7030.23
175_T223_F0.7030.23
127_R479_V0.7030.23
114_I426_S0.7030.23
337_V438_Y0.7020.23
186_V289_L0.7020.23
109_R119_Y0.7010.23
438_Y446_L0.6990.23
4_L159_V0.6990.23
49_V155_L0.6990.23
108_G450_G0.6980.23
415_A418_K0.6980.23
505_L539_V0.6970.23
7_D146_L0.6970.23
546_I558_A0.6960.23
228_V348_G0.6960.23
286_L289_L0.6950.22
167_V290_M0.6950.22
320_V522_V0.6950.22
423_L511_R0.6940.22
316_T361_L0.6930.22
154_L195_L0.6900.22
193_A243_T0.6900.22
221_P373_L0.6900.22
102_G211_Y0.6880.22
493_N498_H0.6880.22
320_V324_L0.6870.22
261_S311_G0.6860.22
1_M9_P0.6860.22
216_V220_F0.6840.22
150_L195_L0.6830.22
90_W381_P0.6820.22
1_M5_K0.6820.22
232_L377_L0.6810.22
306_L311_G0.6810.22
56_L80_E0.6800.22
102_G251_P0.6800.22
29_A281_L0.6790.22
239_W327_L0.6790.22
256_V487_G0.6790.22
416_E431_V0.6770.22
237_I345_M0.6730.22
322_M337_V0.6720.22
247_N364_L0.6720.22
386_L397_M0.6710.21
531_R536_Y0.6680.21
51_I61_F0.6670.21
259_S277_F0.6660.21
127_R130_P0.6640.21
110_F449_K0.6600.21
407_S505_L0.6600.21
309_S312_G0.6590.21
434_L442_T0.6590.21
343_V439_G0.6590.21
307_L526_S0.6580.21
456_M471_V0.6580.21
460_G483_E0.6550.21
551_V559_R0.6550.21
295_G457_H0.6540.21
230_A348_G0.6540.21
109_R251_P0.6510.21
372_L376_A0.6510.21
368_L427_A0.6510.21
423_L513_G0.6480.21
16_W36_G0.6480.21
108_G300_F0.6470.21
43_V437_F0.6470.21
114_I149_A0.6470.21
48_V106_L0.6470.21
186_V243_T0.6460.20
491_G495_G0.6460.20
44_Y107_T0.6460.20
382_V529_I0.6450.20
335_M459_H0.6440.20
161_A188_I0.6440.20
44_Y74_V0.6430.20
62_A83_V0.6430.20
28_L258_M0.6420.20
258_M290_M0.6390.20
32_W47_Y0.6390.20
358_G365_S0.6390.20
319_A505_L0.6380.20
274_Y519_L0.6360.20
290_M362_S0.6360.20
91_T337_V0.6350.20
14_A25_I0.6350.20
285_R293_V0.6340.20
305_V318_A0.6340.20
274_Y407_S0.6330.20
396_S525_E0.6310.20
127_R197_L0.6300.20
69_G103_S0.6300.20
337_V500_H0.6270.20
140_G197_L0.6270.20
206_A336_G0.6270.20
74_V382_V0.6250.20
84_F345_M0.6250.20
373_L378_V0.6240.20
470_A570_V0.6240.20
309_S318_A0.6240.20
275_R530_H0.6240.20
21_R464_F0.6230.20
138_T240_G0.6220.20
57_G263_L0.6220.20
523_W526_S0.6220.20
219_L370_L0.6210.20
158_L305_V0.6210.20
208_G212_G0.6200.19
325_F397_M0.6190.19
257_M393_F0.6190.19
492_W503_Q0.6180.19
466_L482_G0.6170.19
492_W495_G0.6170.19
121_L156_A0.6160.19
325_F385_N0.6160.19
285_R386_L0.6160.19
55_V452_A0.6160.19
301_L417_E0.6160.19
10_P13_P0.6160.19
25_I45_L0.6150.19
446_L450_G0.6140.19
211_Y249_H0.6130.19
259_S386_L0.6120.19
472_D477_Y0.6110.19
307_L361_L0.6110.19
269_L273_L0.6110.19
249_H500_H0.6100.19
131_W198_R0.6100.19
534_Q553_V0.6100.19
169_P173_P0.6080.19
32_W39_T0.6080.19
395_P414_G0.6080.19
165_P187_P0.6070.19
298_V537_R0.6070.19
316_T319_A0.6060.19
159_V513_G0.6050.19
532_Q552_R0.6050.19
396_S405_A0.6050.19
263_L268_W0.6040.19
471_V475_D0.6040.19
134_R276_D0.6040.19
556_M559_R0.6040.19
243_T246_L0.6030.19
178_G218_F0.6030.19
11_V31_H0.6030.19
408_V479_V0.6020.19
492_W498_H0.6020.19
242_A254_V0.6020.19
153_A420_D0.6010.19
132_P477_Y0.6010.19
418_K477_Y0.6010.19
328_F459_H0.6000.19
43_V188_I0.6000.19
289_L313_W0.5990.19
162_L403_N0.5970.19
142_R311_G0.5970.19
46_F111_K0.5950.19
6_P15_E0.5950.19
194_L291_A0.5940.19
298_V302_V0.5940.19
532_Q547_E0.5930.18
269_L272_R0.5920.18
190_V463_L0.5920.18
102_G109_R0.5900.18
466_L570_V0.5890.18
210_H228_V0.5890.18
149_A554_A0.5890.18
54_Y259_S0.5880.18
88_V218_F0.5880.18
57_G423_L0.5870.18
74_V314_L0.5860.18
13_P17_L0.5850.18
11_V16_W0.5850.18
290_M511_R0.5850.18
58_G66_P0.5840.18
347_F351_F0.5840.18
412_R515_E0.5840.18
65_T85_Q0.5830.18
309_S358_G0.5820.18
127_R137_L0.5820.18
425_K439_G0.5820.18
172_L177_V0.5820.18
23_E538_I0.5820.18
41_V263_L0.5810.18
161_A264_L0.5810.18
101_C379_G0.5800.18
255_S282_R0.5780.18
224_V366_S0.5780.18
144_T529_I0.5780.18
282_R374_A0.5780.18
535_H545_V0.5770.18
484_F508_V0.5770.18
538_I566_G0.5770.18
78_W81_P0.5770.18
370_L513_G0.5760.18
440_P455_S0.5740.18
90_W411_F0.5730.18
3_F345_M0.5720.18
306_L319_A0.5720.18
55_V572_V0.5710.18
29_A453_F0.5710.18
157_S188_I0.5710.18
7_D35_Q0.5690.18
53_L501_N0.5690.18
67_G85_Q0.5690.18
516_P548_R0.5690.18
355_G391_V0.5690.18
440_P443_A0.5680.18
317_I357_P0.5680.18
126_I377_L0.5670.18
24_R391_V0.5660.18
85_Q166_G0.5650.18
80_E216_V0.5650.18
92_M215_L0.5630.17
249_H403_N0.5610.17
207_R404_W0.5610.17
452_A469_R0.5590.17
248_H251_P0.5580.17
267_K479_V0.5570.17
516_P536_Y0.5570.17
229_A355_G0.5570.17
431_V440_P0.5570.17
367_P371_A0.5560.17
87_A163_V0.5560.17
489_V510_E0.5550.17
62_A347_F0.5550.17
156_A285_R0.5550.17
1_M224_V0.5540.17
49_V358_G0.5540.17
189_L370_L0.5540.17
93_L155_L0.5540.17
536_Y546_I0.5540.17
159_V227_I0.5540.17
152_A286_L0.5530.17
454_R483_E0.5530.17
210_H237_I0.5530.17
554_A557_V0.5510.17
75_G141_D0.5510.17
387_R501_N0.5510.17
149_A367_P0.5510.17
524_L556_M0.5510.17
33_A190_V0.5500.17
94_F213_P0.5500.17
263_L332_T0.5490.17
325_F434_L0.5490.17
15_E56_L0.5490.17
555_D558_A0.5490.17
481_E490_L0.5480.17
232_L378_V0.5470.17
115_G339_L0.5470.17
501_N506_A0.5470.17
227_I308_F0.5470.17
243_T452_A0.5440.17
129_P220_F0.5430.17
120_W123_P0.5420.17
122_R460_G0.5420.17
228_V364_L0.5410.17
23_E79_T0.5410.17
522_V565_D0.5400.17
7_D308_F0.5400.17
265_R453_F0.5400.17
174_G193_A0.5400.17
192_L212_G0.5400.17
507_A534_Q0.5380.17
318_A321_V0.5380.17
522_V539_V0.5380.17
201_T210_H0.5380.17
153_A161_A0.5370.17
36_G106_L0.5370.17
248_H361_L0.5360.17
456_M461_R0.5360.17
189_L301_L0.5360.17
110_F450_G0.5360.17
417_E432_D0.5350.16
430_Q451_L0.5350.16
240_G327_L0.5340.16
239_W242_A0.5330.16
512_C528_P0.5330.16
221_P226_M0.5320.16
2_G9_P0.5310.16
559_R564_P0.5310.16
200_K503_Q0.5310.16
486_A500_H0.5300.16
462_A536_Y0.5300.16
201_T376_A0.5300.16
298_V315_T0.5300.16
160_V184_L0.5290.16
201_T496_D0.5280.16
32_W116_G0.5280.16
13_P446_L0.5270.16
43_V439_G0.5250.16
27_P64_L0.5250.16
339_L383_L0.5250.16
315_T391_V0.5250.16
56_L69_G0.5230.16
301_L347_F0.5230.16
293_V323_V0.5220.16
277_F408_V0.5220.16
59_W74_V0.5220.16
10_P440_P0.5220.16
490_L499_L0.5210.16
128_L205_A0.5200.16
97_L155_L0.5200.16
305_V519_L0.5200.16
273_L371_A0.5200.16
351_F357_P0.5190.16
14_A146_L0.5190.16
126_I141_D0.5180.16
435_E440_P0.5180.16
343_V437_F0.5180.16
185_L412_R0.5170.16
255_S287_A0.5170.16
80_E374_A0.5160.16
189_L314_L0.5160.16
476_D502_E0.5160.16
382_V506_A0.5150.16
335_M453_F0.5150.16
494_F499_L0.5150.16
221_P432_D0.5130.16
214_A345_M0.5120.16
212_G332_T0.5120.16
208_G389_D0.5110.16
361_L413_P0.5110.16
415_A518_E0.5110.16
64_L70_G0.5110.16
53_L56_L0.5110.16
425_K488_T0.5100.16
97_L301_L0.5100.16
34_E501_N0.5100.16
6_P18_K0.5100.16
228_V417_E0.5100.16
157_S160_V0.5090.16
379_G424_V0.5090.16
28_L452_A0.5090.16
56_L254_V0.5080.16
259_S331_S0.5080.16
14_A18_K0.5080.16
13_P242_A0.5080.16
108_G487_G0.5080.16
6_P106_L0.5070.16
254_V324_L0.5060.16
381_P458_S0.5060.16
549_G562_W0.5060.16
431_V443_A0.5060.16
261_S309_S0.5060.16
468_P487_G0.5060.16
189_L395_P0.5050.16
381_P414_G0.5050.16
100_G399_Y0.5050.16
533_T553_V0.5030.15
225_D363_D0.5020.15
298_V321_V0.5020.15
3_F63_S0.5020.15
335_M500_H0.5010.15
92_M267_K0.5000.15
107_T487_G0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2igtA 4 0.1169 51.3 0.985 Contact Map
4kgbA 2 0.1745 31.7 0.987 Contact Map
3h7lA 2 0.1117 29.3 0.987 Contact Map
3cdkA 2 0.1763 24.3 0.988 Contact Map
1gvhA 3 0.2775 21.3 0.988 Contact Map
3gzkA 1 0.103 19.1 0.988 Contact Map
3x17B 1 0.1169 18 0.988 Contact Map
3rrlA 2 0.1728 13.7 0.989 Contact Map
4i66A 2 0.2548 10 0.99 Contact Map
2pfzA 1 0.1449 8.4 0.99 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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