GREMLIN Database
DUF3551 - Protein of unknown function (DUF3551)
PFAM: PF12071 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 76 (67)
Sequences: 12224 (8438)
Seq/√Len: 1030.8
META: 0.97

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_L51_R3.5101.00
31_A54_A3.1781.00
27_Y45_T2.7321.00
45_T49_Q2.6571.00
21_P24_A2.3921.00
48_E52_A2.1591.00
48_E51_R2.1281.00
40_G62_V2.0271.00
32_Q62_V1.8241.00
29_W47_L1.7331.00
54_A57_R1.5461.00
54_A59_G1.4561.00
19_A24_A1.4531.00
52_A55_S1.4411.00
62_V65_P1.3951.00
51_R55_S1.3621.00
10_A13_A1.3481.00
3_R6_L1.3191.00
28_P63_P1.3181.00
29_W63_P1.3141.00
32_Q40_G1.2321.00
11_L14_L1.2091.00
9_L12_A1.1701.00
51_R54_A1.1541.00
20_A23_Q1.1521.00
53_T57_R1.1441.00
41_N44_F1.1001.00
32_Q36_G1.0671.00
28_P67_Y1.0591.00
28_P46_S1.0331.00
33_G36_G1.0061.00
36_G39_Y1.0041.00
26_D66_Y0.9831.00
11_L15_A0.9831.00
4_L8_A0.9821.00
31_A53_T0.9771.00
32_Q38_G0.9701.00
20_A24_A0.9661.00
32_Q37_G0.9351.00
12_A15_A0.9331.00
15_A18_A0.9301.00
13_A16_A0.9101.00
5_L9_L0.8871.00
19_A22_A0.8711.00
35_G38_G0.8571.00
25_P45_T0.8511.00
49_Q53_T0.8411.00
31_A59_G0.8331.00
34_G37_G0.8331.00
34_G39_Y0.8181.00
33_G37_G0.8121.00
28_P45_T0.8111.00
39_Y43_G0.8111.00
3_R7_A0.8001.00
9_L13_A0.7811.00
28_P64_N0.7781.00
12_A17_A0.7671.00
10_A14_L0.7591.00
7_A15_A0.7421.00
7_A10_A0.7421.00
49_Q52_A0.7371.00
19_A23_Q0.7351.00
33_G38_G0.7301.00
9_L15_A0.7291.00
8_A18_A0.7171.00
13_A18_A0.7061.00
26_D45_T0.6881.00
66_Y69_G0.6741.00
11_L16_A0.6641.00
27_Y43_G0.6611.00
5_L13_A0.6561.00
47_L60_F0.6471.00
11_L18_A0.6451.00
4_L7_A0.6391.00
8_A15_A0.6341.00
9_L18_A0.6281.00
14_L17_A0.6221.00
6_L14_L0.6201.00
65_P68_A0.6181.00
34_G38_G0.6141.00
44_F53_T0.6051.00
44_F49_Q0.5851.00
8_A12_A0.5821.00
26_D68_A0.5781.00
17_A21_P0.5651.00
36_G60_F0.5621.00
14_L18_A0.5591.00
9_L14_L0.5551.00
46_S49_Q0.5441.00
7_A11_L0.5381.00
3_R8_A0.5301.00
22_A26_D0.5291.00
53_T58_G0.5291.00
60_F63_P0.5251.00
61_C64_N0.5171.00
12_A18_A0.5151.00
33_G39_Y0.5131.00
9_L17_A0.5121.00
27_Y44_F0.5041.00
6_L10_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kt0F 1 0.3026 39 0.827 Contact Map
1jb0F 1 0.3026 34.9 0.831 Contact Map
3v83A 6 0.6711 7.7 0.875 Contact Map
3zbiC 1 0.3158 5.6 0.883 Contact Map
3m8tA 1 0.5395 5.1 0.885 Contact Map
4fp5D 3 0.4605 4.8 0.886 Contact Map
2vdaB 1 0.2763 4.2 0.89 Contact Map
3bx4B 1 0.5789 3 0.897 Contact Map
4coqA 3 0.6842 2.8 0.899 Contact Map
2zzsA 4 0.5263 2.4 0.903 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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