DUF3549 - PFAM28P - GREMLIN Contacts

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DUF3549 - Protein of unknown function (DUF3549)

PFAM:	PF12069	Sequences: QTIHTLSEFLTQSGAQYRVFDLGRRVQKISKEQFAAIENGQQPYPYPLQQHAWLAILFWQPKQSQQPYIWFLKLPLDEQGLLKQAARDHFLKRLLEALGTNLTAELSEEQQELLKDNPYAFKPSQDKMAAFHALARAQLGQPASQYYEHAQAYLSGQLGWDQWQFLGLQGIADVAARLDEDNNEALLAKALPHLPAEPLYALCGCLEHVELPEALAQALLERLAADEPDLELLAALLRALSGSPAQELVQQLLDALLASPALSHPEVLAAIAGRCWEALEDEELLELFLERLAQTEQALFNQLFADLVAIPGLRPPVLQLLRSPERSEALAQAIGQLF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	338 (337)
Sequences:	533 (392)
Seq/√Len:	21.3
META:	0.508

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
254_D	284_L	4.543	1.00
156_G	159_G	3.769	1.00
69_I	131_F	3.608	1.00
51_H	73_K	3.468	1.00
326_R	335_G	3.346	1.00
322_R	326_R	3.346	1.00
199_L	236_L	3.291	1.00
322_R	335_G	3.038	0.99
159_G	190_A	2.971	0.99
20_F	138_Q	2.961	0.99
304_F	308_V	2.958	0.99
290_E	327_S	2.901	0.99
172_A	205_C	2.873	0.99
57_L	135_A	2.808	0.99
93_R	117_N	2.707	0.99
326_R	334_I	2.584	0.98
198_P	201_A	2.577	0.98
132_H	136_R	2.548	0.98
143_A	177_R	2.543	0.98
191_L	222_R	2.541	0.98
133_A	172_A	2.536	0.98
314_R	318_L	2.422	0.97
326_R	331_A	2.401	0.97
249_V	278_A	2.397	0.97
253_L	278_A	2.393	0.97
130_A	205_C	2.383	0.97
149_H	166_L	2.371	0.97
154_L	171_I	2.357	0.97
223_L	252_L	2.308	0.96
5_T	43_P	2.280	0.96
134_L	209_V	2.269	0.96
149_H	159_G	2.206	0.95
89_H	119_Y	2.191	0.95
216_A	243_S	2.165	0.95
18_R	28_K	2.130	0.94
273_G	276_W	2.106	0.94
131_F	147_Y	2.085	0.94
211_L	216_A	2.078	0.94
51_H	75_P	2.018	0.93
335_G	338_F	1.977	0.92
162_Q	165_F	1.976	0.92
18_R	30_S	1.939	0.91
171_I	201_A	1.935	0.91
147_Y	183_N	1.918	0.90
217_Q	248_L	1.889	0.90
97_A	308_V	1.857	0.89
6_L	321_L	1.848	0.89
291_R	294_Q	1.839	0.88
75_P	86_A	1.827	0.88
48_L	53_W	1.822	0.88
327_S	330_L	1.819	0.88
56_I	166_L	1.803	0.87
72_L	94_L	1.752	0.86
150_A	166_L	1.747	0.86
306_D	310_I	1.741	0.85
10_L	58_F	1.705	0.84
175_A	202_L	1.700	0.84
96_E	99_G	1.682	0.83
154_L	165_F	1.673	0.83
89_H	93_R	1.659	0.83
283_E	287_L	1.644	0.82
273_G	323_S	1.632	0.81
40_G	84_Q	1.597	0.80
272_A	313_L	1.592	0.80
151_Q	174_V	1.583	0.79
215_L	223_L	1.582	0.79
36_A	208_H	1.573	0.79
178_L	183_N	1.572	0.79
49_Q	273_G	1.563	0.79
143_A	148_E	1.553	0.78
144_S	170_G	1.543	0.78
18_R	138_Q	1.533	0.77
218_A	222_R	1.528	0.77
331_A	335_G	1.521	0.77
17_Y	59_W	1.513	0.76
272_A	288_F	1.512	0.76
93_R	116_D	1.497	0.75
24_R	306_D	1.489	0.75
58_F	99_G	1.481	0.75
156_G	276_W	1.469	0.74
142_P	251_Q	1.444	0.73
223_L	236_L	1.439	0.72
266_E	297_Q	1.437	0.72
167_G	198_P	1.412	0.71
136_R	141_Q	1.408	0.71
326_R	338_F	1.405	0.71
167_G	170_G	1.395	0.70
258_A	287_L	1.380	0.69
195_P	288_F	1.369	0.69
254_D	287_L	1.369	0.69
327_S	335_G	1.358	0.68
148_E	151_Q	1.358	0.68
26_V	157_Q	1.342	0.67
55_A	131_F	1.327	0.66
96_E	132_H	1.310	0.65
9_F	15_A	1.299	0.64
160_W	190_A	1.295	0.64
304_F	337_L	1.292	0.64
303_L	314_R	1.285	0.63
142_P	281_D	1.276	0.63
19_V	34_F	1.268	0.62
97_A	304_F	1.267	0.62
29_I	44_Y	1.264	0.62
38_E	87_R	1.262	0.62
45_P	49_Q	1.257	0.62
202_L	219_L	1.246	0.61
188_A	218_A	1.244	0.61
146_Y	167_G	1.239	0.61
89_H	94_L	1.238	0.61
44_Y	59_W	1.229	0.60
33_Q	42_Q	1.217	0.59
36_A	41_Q	1.216	0.59
141_Q	332_Q	1.215	0.59
11_T	35_A	1.206	0.58
44_Y	127_K	1.200	0.58
97_A	119_Y	1.186	0.57
68_Y	132_H	1.184	0.57
54_L	181_D	1.166	0.56
299_L	308_V	1.158	0.55
179_D	267_V	1.145	0.54
174_V	187_L	1.133	0.54
301_N	337_L	1.133	0.54
6_L	313_L	1.132	0.54
9_F	67_P	1.131	0.54
56_I	132_H	1.128	0.53
25_R	268_L	1.124	0.53
80_G	86_A	1.123	0.53
112_E	116_D	1.115	0.52
147_Y	174_V	1.113	0.52
297_Q	301_N	1.102	0.52
152_A	157_Q	1.100	0.51
26_V	133_A	1.099	0.51
74_L	171_I	1.096	0.51
213_E	217_Q	1.092	0.51
21_D	44_Y	1.090	0.51
149_H	165_F	1.090	0.51
184_E	212_P	1.086	0.50
114_L	119_Y	1.070	0.49
207_E	238_R	1.067	0.49
166_L	180_E	1.064	0.49
290_E	326_R	1.062	0.49
86_A	89_H	1.061	0.49
60_Q	67_P	1.058	0.49
98_L	266_E	1.058	0.49
25_R	242_G	1.056	0.48
90_F	99_G	1.054	0.48
28_K	271_I	1.053	0.48
99_G	102_L	1.047	0.48
92_K	96_E	1.047	0.48
28_K	219_L	1.039	0.47
155_S	190_A	1.036	0.47
149_H	162_Q	1.032	0.47
148_E	157_Q	1.031	0.47
128_M	279_L	1.030	0.47
237_L	261_A	1.030	0.47
22_L	135_A	1.028	0.47
276_W	306_D	1.028	0.47
146_Y	170_G	1.028	0.47
306_D	314_R	1.022	0.46
168_L	229_D	1.019	0.46
43_P	161_D	1.015	0.46
290_E	334_I	1.012	0.46
73_K	127_K	1.010	0.45
147_Y	170_G	1.008	0.45
274_R	306_D	1.006	0.45
104_A	108_E	1.001	0.45
217_Q	247_E	0.997	0.45
107_S	179_D	0.997	0.45
299_L	303_L	0.984	0.44
201_A	208_H	0.983	0.44
55_A	67_P	0.982	0.44
179_D	212_P	0.976	0.43
14_G	195_P	0.966	0.43
68_Y	93_R	0.965	0.42
328_E	331_A	0.960	0.42
40_G	86_A	0.955	0.42
241_S	267_V	0.947	0.41
251_Q	281_D	0.942	0.41
55_A	103_T	0.939	0.41
79_Q	192_P	0.932	0.40
187_L	194_L	0.930	0.40
48_L	304_F	0.929	0.40
150_A	174_V	0.928	0.40
137_A	191_L	0.928	0.40
250_Q	271_I	0.927	0.40
6_L	25_R	0.926	0.40
34_F	38_E	0.926	0.40
69_I	130_A	0.922	0.40
279_L	292_L	0.922	0.40
68_Y	94_L	0.919	0.39
10_L	80_G	0.918	0.39
273_G	288_F	0.917	0.39
200_Y	235_A	0.912	0.39
58_F	68_Y	0.912	0.39
256_L	259_S	0.911	0.39
50_Q	270_A	0.911	0.39
66_Q	269_A	0.909	0.39
154_L	167_G	0.908	0.39
156_G	198_P	0.907	0.39
74_L	154_L	0.907	0.39
75_P	87_R	0.905	0.39
89_H	304_F	0.905	0.39
101_N	167_G	0.892	0.38
23_G	55_A	0.889	0.38
22_L	208_H	0.889	0.38
53_W	73_K	0.887	0.37
290_E	294_Q	0.885	0.37
322_R	338_F	0.884	0.37
143_A	157_Q	0.883	0.37
299_L	304_F	0.882	0.37
74_L	214_A	0.878	0.37
144_S	173_D	0.877	0.37
331_A	334_I	0.874	0.37
55_A	139_L	0.862	0.36
206_L	219_L	0.859	0.36
166_L	174_V	0.859	0.36
26_V	138_Q	0.859	0.36
307_L	310_I	0.857	0.36
69_I	113_L	0.855	0.35
84_Q	111_Q	0.854	0.35
120_A	303_L	0.853	0.35
49_Q	54_L	0.847	0.35
272_A	318_L	0.846	0.35
84_Q	88_D	0.846	0.35
290_E	338_F	0.843	0.35
154_L	175_A	0.842	0.35
58_F	90_F	0.841	0.35
128_M	132_H	0.840	0.35
193_H	281_D	0.839	0.34
93_R	132_H	0.834	0.34
41_Q	55_A	0.834	0.34
242_G	307_L	0.833	0.34
37_I	134_L	0.830	0.34
68_Y	89_H	0.828	0.34
146_Y	149_H	0.826	0.34
285_L	317_V	0.818	0.33
327_S	334_I	0.815	0.33
150_A	198_P	0.814	0.33
54_L	132_H	0.812	0.33
233_L	267_V	0.808	0.33
255_A	282_E	0.807	0.33
151_Q	183_N	0.805	0.32
137_A	179_D	0.800	0.32
294_Q	329_A	0.799	0.32
132_H	154_L	0.792	0.32
252_L	255_A	0.791	0.32
35_A	209_V	0.786	0.31
326_R	330_L	0.785	0.31
17_Y	34_F	0.781	0.31
187_L	288_F	0.779	0.31
92_K	119_Y	0.777	0.31
76_L	229_D	0.776	0.31
146_Y	189_K	0.776	0.31
188_A	211_L	0.776	0.31
188_A	214_A	0.773	0.31
322_R	334_I	0.771	0.30
91_L	208_H	0.769	0.30
226_D	239_A	0.767	0.30
304_F	313_L	0.766	0.30
102_L	269_A	0.764	0.30
133_A	162_Q	0.761	0.30
265_P	299_L	0.759	0.30
5_T	96_E	0.758	0.30
324_P	331_A	0.758	0.30
21_D	29_I	0.758	0.30
256_L	267_V	0.754	0.30
309_A	334_I	0.750	0.29
4_H	8_E	0.749	0.29
141_Q	273_G	0.747	0.29
263_S	291_R	0.744	0.29
9_F	58_F	0.744	0.29
131_F	146_Y	0.742	0.29
74_L	117_N	0.742	0.29
19_V	59_W	0.740	0.29
30_S	33_Q	0.737	0.29
94_L	114_L	0.736	0.29
193_H	212_P	0.735	0.28
5_T	132_H	0.733	0.28
117_N	160_W	0.732	0.28
304_F	309_A	0.730	0.28
164_Q	197_E	0.729	0.28
285_L	320_L	0.722	0.28
46_Y	191_L	0.721	0.28
25_R	76_L	0.720	0.28
334_I	338_F	0.719	0.28
17_Y	99_G	0.719	0.28
50_Q	66_Q	0.717	0.28
239_A	327_S	0.716	0.27
116_D	172_A	0.715	0.27
136_R	167_G	0.715	0.27
16_Q	28_K	0.714	0.27
74_L	125_Q	0.713	0.27
87_R	94_L	0.707	0.27
308_V	337_L	0.705	0.27
26_V	276_W	0.705	0.27
223_L	240_L	0.704	0.27
328_E	333_A	0.702	0.27
101_N	128_M	0.701	0.27
208_H	305_A	0.701	0.27
201_A	302_Q	0.699	0.27
187_L	222_R	0.699	0.27
68_Y	136_R	0.696	0.26
91_L	241_S	0.695	0.26
68_Y	308_V	0.691	0.26
260_P	273_G	0.691	0.26
220_L	252_L	0.690	0.26
154_L	198_P	0.690	0.26
9_F	135_A	0.689	0.26
113_L	305_A	0.686	0.26
88_D	94_L	0.685	0.26
76_L	202_L	0.684	0.26
43_P	165_F	0.683	0.26
135_A	212_P	0.683	0.26
54_L	57_L	0.682	0.26
21_D	127_K	0.677	0.25
124_S	332_Q	0.677	0.25
281_D	284_L	0.676	0.25
90_F	276_W	0.674	0.25
52_A	144_S	0.674	0.25
44_Y	52_A	0.672	0.25
58_F	273_G	0.672	0.25
66_Q	76_L	0.671	0.25
147_Y	151_Q	0.670	0.25
219_L	323_S	0.668	0.25
96_E	276_W	0.668	0.25
6_L	72_L	0.666	0.25
78_E	114_L	0.666	0.25
80_G	173_D	0.666	0.25
268_L	288_F	0.666	0.25
29_I	65_Q	0.665	0.25
176_A	208_H	0.665	0.25
23_G	26_V	0.664	0.25
148_E	284_L	0.664	0.25
187_L	212_P	0.663	0.25
274_R	310_I	0.661	0.25
150_A	156_G	0.661	0.25
167_G	177_R	0.658	0.24
222_R	269_A	0.656	0.24
37_I	40_G	0.652	0.24
16_Q	177_R	0.651	0.24
25_R	134_L	0.651	0.24
191_L	248_L	0.650	0.24
5_T	37_I	0.649	0.24
122_K	204_G	0.648	0.24
10_L	34_F	0.647	0.24
56_I	216_A	0.647	0.24
81_L	86_A	0.646	0.24
196_A	210_E	0.646	0.24
178_L	209_V	0.642	0.24
90_F	273_G	0.642	0.24
66_Q	73_K	0.641	0.24
189_K	196_A	0.637	0.23
85_A	302_Q	0.636	0.23
171_I	222_R	0.636	0.23
122_K	198_P	0.635	0.23
149_H	156_G	0.634	0.23
244_P	325_E	0.631	0.23
166_L	201_A	0.630	0.23
217_Q	226_D	0.629	0.23
191_L	199_L	0.629	0.23
115_K	122_K	0.623	0.23
183_N	206_L	0.620	0.23
69_I	253_L	0.620	0.23
174_V	328_E	0.619	0.23
327_S	331_A	0.618	0.23
280_E	312_G	0.618	0.23
324_P	335_G	0.615	0.22
271_I	298_A	0.615	0.22
32_E	36_A	0.615	0.22
276_W	310_I	0.614	0.22
8_E	22_L	0.614	0.22
111_Q	303_L	0.613	0.22
46_Y	241_S	0.613	0.22
78_E	314_R	0.613	0.22
266_E	301_N	0.612	0.22
87_R	322_R	0.611	0.22
79_Q	83_K	0.610	0.22
21_D	53_W	0.609	0.22
20_F	55_A	0.608	0.22
65_Q	141_Q	0.606	0.22
49_Q	276_W	0.605	0.22
191_L	225_A	0.605	0.22
53_W	57_L	0.605	0.22
102_L	106_L	0.603	0.22
150_A	171_I	0.603	0.22
141_Q	221_E	0.602	0.22
20_F	57_L	0.600	0.22
194_L	313_L	0.599	0.22
171_I	320_L	0.599	0.22
10_L	49_Q	0.598	0.22
192_P	218_A	0.598	0.22
237_L	270_A	0.597	0.22
81_L	120_A	0.597	0.22
250_Q	281_D	0.595	0.21
156_G	160_W	0.593	0.21
58_F	75_P	0.593	0.21
98_L	274_R	0.592	0.21
214_A	220_L	0.588	0.21
10_L	69_I	0.587	0.21
149_H	160_W	0.586	0.21
127_K	208_H	0.586	0.21
16_Q	334_I	0.585	0.21
153_Y	198_P	0.584	0.21
290_E	320_L	0.582	0.21
117_N	308_V	0.577	0.21
249_V	275_C	0.577	0.21
15_A	83_K	0.575	0.21
220_L	258_A	0.575	0.21
83_K	303_L	0.575	0.21
73_K	204_G	0.575	0.21
48_L	54_L	0.573	0.21
214_A	258_A	0.572	0.20
187_L	306_D	0.571	0.20
164_Q	318_L	0.570	0.20
208_H	277_E	0.569	0.20
13_S	289_L	0.569	0.20
176_A	209_V	0.567	0.20
280_E	296_E	0.567	0.20
286_E	320_L	0.566	0.20
48_L	119_Y	0.566	0.20
137_A	194_L	0.564	0.20
315_P	319_Q	0.562	0.20
236_L	259_S	0.562	0.20
34_F	288_F	0.561	0.20
119_Y	122_K	0.560	0.20
321_L	334_I	0.558	0.20
58_F	86_A	0.558	0.20
50_Q	288_F	0.557	0.20
36_A	62_K	0.557	0.20
74_L	273_G	0.556	0.20
48_L	269_A	0.555	0.20
137_A	210_E	0.554	0.20
299_L	302_Q	0.553	0.20
272_A	314_R	0.551	0.20
24_R	38_E	0.551	0.20
97_A	313_L	0.551	0.20
54_L	174_V	0.550	0.20
175_A	317_V	0.549	0.19
97_A	337_L	0.548	0.19
73_K	102_L	0.548	0.19
209_V	262_L	0.545	0.19
97_A	309_A	0.545	0.19
191_L	218_A	0.540	0.19
3_I	99_G	0.540	0.19
257_L	268_L	0.540	0.19
38_E	288_F	0.540	0.19
6_L	20_F	0.540	0.19
29_I	223_L	0.540	0.19
20_F	226_D	0.539	0.19
211_L	220_L	0.539	0.19
63_Q	189_K	0.537	0.19
10_L	285_L	0.536	0.19
305_A	318_L	0.535	0.19
37_I	138_Q	0.535	0.19
161_D	165_F	0.535	0.19
26_V	205_C	0.532	0.19
140_G	176_A	0.532	0.19
3_I	27_Q	0.531	0.19
88_D	269_A	0.531	0.19
149_H	158_L	0.531	0.19
40_G	74_L	0.530	0.19
317_V	321_L	0.530	0.19
68_Y	97_A	0.530	0.19
265_P	296_E	0.529	0.19
20_F	223_L	0.529	0.19
20_F	60_Q	0.528	0.19
54_L	161_D	0.528	0.19
205_C	222_R	0.526	0.19
88_D	309_A	0.526	0.19
157_Q	190_A	0.526	0.19
42_Q	50_Q	0.525	0.18
254_D	258_A	0.525	0.18
68_Y	87_R	0.524	0.18
25_R	289_L	0.521	0.18
14_G	117_N	0.521	0.18
27_Q	106_L	0.520	0.18
112_E	273_G	0.519	0.18
79_Q	272_A	0.519	0.18
113_L	116_D	0.518	0.18
10_L	35_A	0.517	0.18
143_A	332_Q	0.516	0.18
199_L	222_R	0.516	0.18
175_A	182_N	0.516	0.18
69_I	293_A	0.514	0.18
221_E	225_A	0.514	0.18
116_D	133_A	0.511	0.18
177_R	206_L	0.511	0.18
59_W	330_L	0.510	0.18
113_L	302_Q	0.510	0.18
219_L	224_A	0.509	0.18
241_S	253_L	0.508	0.18
289_L	320_L	0.508	0.18
23_G	48_L	0.507	0.18
37_I	240_L	0.504	0.18
203_C	216_A	0.504	0.18
94_L	240_L	0.503	0.18
148_E	214_A	0.503	0.18
28_K	140_G	0.503	0.18
131_F	216_A	0.503	0.18
171_I	306_D	0.503	0.18
30_S	224_A	0.502	0.18
178_L	185_A	0.502	0.18
189_K	220_L	0.502	0.18
91_L	132_H	0.500	0.18
8_E	35_A	0.500	0.18
22_L	175_A	0.500	0.18

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ksaA	3	0.4379	45.9	0.972	Contact Map
4ksfA	3	0.3462	38.4	0.973	Contact Map
3ltjA	2	0.5533	31.9	0.974	Contact Map
1oyzA	1	0.6746	25	0.976	Contact Map
4d4zA	1	0.5828	21.9	0.976	Contact Map
4o8wA	3	0.2692	17.9	0.977	Contact Map
2bptA	1	0.429	16.8	0.977	Contact Map
2yd0A	1	0.9083	15.1	0.978	Contact Map
4ks9A	2	0.3107	14.3	0.978	Contact Map
3ltmA	1	0.5355	14.3	0.978	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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