GREMLIN Database
DUF3493 - Protein of unknown function (DUF3493)
PFAM: PF11998 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 79 (71)
Sequences: 767 (397)
Seq/√Len: 47.1
META: 0.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_A68_V2.7061.00
26_F71_F2.6161.00
40_R57_A2.5551.00
37_M64_Q2.1151.00
58_L62_A2.0981.00
65_L69_A2.0811.00
36_I39_S1.9310.99
32_I59_P1.8690.99
38_L42_A1.8320.99
22_L26_F1.8310.99
74_L78_D1.7680.99
20_R78_D1.7640.99
18_L22_L1.7260.98
66_G70_L1.6920.98
33_G36_I1.6170.97
63_I67_A1.5510.97
32_I35_L1.4730.95
19_R78_D1.4560.95
33_G40_R1.4460.95
67_A71_F1.3730.93
21_F25_A1.3640.93
39_S42_A1.3260.92
41_L54_L1.3000.91
16_R78_D1.2840.91
4_K8_L1.2730.90
73_F77_L1.2550.90
65_L68_V1.2280.89
34_L67_A1.1550.86
60_N67_A1.1420.85
7_L11_A1.1390.85
10_E14_P1.1140.83
20_R24_I1.1040.83
7_L10_E1.1000.83
27_G75_L1.0950.82
31_F34_L1.0870.82
41_L57_A1.0790.81
29_S34_L1.0590.80
9_A13_A1.0560.80
29_S44_G1.0160.77
5_A8_L1.0090.77
22_L55_E0.9920.76
35_L39_S0.9740.74
31_F35_L0.9510.72
20_R79_R0.9470.72
40_R56_E0.9430.72
8_L36_I0.9220.70
28_A31_F0.9140.69
41_L58_L0.9120.69
13_A19_R0.8950.68
29_S64_Q0.8950.68
28_A68_V0.8700.66
23_Y74_L0.8440.63
54_L57_A0.8170.61
28_A32_I0.7870.58
31_F42_A0.7810.57
6_R63_I0.7670.56
39_S43_A0.7670.56
40_R54_L0.7590.55
34_L65_L0.7490.54
29_S37_M0.7420.53
60_N72_V0.7330.52
29_S33_G0.7260.52
53_D56_E0.7030.49
5_A9_A0.6990.49
76_R79_R0.6920.48
8_L11_A0.6910.48
8_L12_Q0.6830.47
15_F18_L0.6790.47
17_G37_M0.6760.47
44_G64_Q0.6750.47
15_F76_R0.6700.46
33_G61_L0.6630.45
32_I45_R0.6620.45
70_L74_L0.6590.45
25_A75_L0.6580.45
34_L68_V0.6450.44
2_E9_A0.6430.43
31_F63_I0.6390.43
41_L61_L0.6370.43
62_A66_G0.6290.42
35_L53_D0.6260.42
24_I31_F0.6230.42
3_L11_A0.6130.41
22_L39_S0.6070.40
34_L38_L0.6030.40
26_F67_A0.6020.40
13_A76_R0.5820.38
75_L78_D0.5780.37
6_R12_Q0.5690.36
27_G76_R0.5680.36
55_E59_P0.5650.36
12_Q75_L0.5640.36
28_A76_R0.5630.36
55_E68_V0.5600.36
17_G27_G0.5590.36
11_A56_E0.5560.35
53_D61_L0.5550.35
19_R23_Y0.5520.35
69_A73_F0.5480.35
6_R11_A0.5420.34
25_A28_A0.5380.34
3_L12_Q0.5190.32
39_S61_L0.5150.32
2_E8_L0.5140.32
28_A70_L0.5040.31
5_A77_L0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ki0A 1 0.2911 16.8 0.887 Contact Map
4efhB 1 0.2532 8.9 0.9 Contact Map
1m56C 2 0.7722 3.4 0.917 Contact Map
1sk7A 1 0.3418 3.2 0.919 Contact Map
3l1lA 2 0.9747 3.2 0.919 Contact Map
1mhsA 2 0.8861 3.2 0.919 Contact Map
3ar4A 1 0.9367 3 0.92 Contact Map
2oasA 3 0.2405 3 0.92 Contact Map
4k7cA 5 0.3418 3 0.92 Contact Map
1abzA 1 0.1646 2.8 0.921 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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