GREMLIN Database
DUF3487 - Protein of unknown function (DUF3487)
PFAM: PF11990 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 114 (112)
Sequences: 692 (493)
Seq/√Len: 46.6
META: 0.655

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_R70_G4.4101.00
13_E23_S3.6121.00
36_G64_T3.4681.00
93_A104_T3.0571.00
94_R104_T2.8211.00
15_V21_T2.7171.00
91_W95_L2.7161.00
82_G86_R2.5791.00
20_L28_I2.3671.00
92_L97_L2.3591.00
87_R91_W2.2431.00
79_R110_S2.1721.00
16_V28_I2.0631.00
76_K80_P2.0300.99
20_L69_G1.9110.99
12_R81_D1.8850.99
51_A60_G1.7850.99
17_F20_L1.7450.98
30_G34_A1.6430.98
11_N16_V1.5920.97
18_R79_R1.5830.97
50_W53_G1.4940.96
50_W73_R1.4710.95
29_A54_P1.4620.95
76_K109_W1.3870.94
19_G24_E1.3780.93
13_E22_A1.3640.93
25_L65_V1.3380.92
105_R109_W1.3350.92
53_G56_L1.3100.91
47_F56_L1.2380.89
85_Y102_L1.2220.88
34_A38_P1.2210.88
54_P68_G1.1840.87
26_W30_G1.1770.86
27_L87_R1.1760.86
30_G56_L1.1600.85
25_L76_K1.1510.85
35_V39_L1.1450.85
68_G77_R1.1070.83
3_I8_D1.0970.82
19_G28_I1.0970.82
32_S68_G1.0880.82
71_L75_L1.0500.79
28_I49_S1.0320.78
11_N78_G1.0220.77
16_V21_T1.0060.76
16_V64_T1.0060.76
17_F25_L1.0050.76
45_L52_M1.0000.76
76_K81_D0.9950.75
17_F22_A0.9900.75
56_L67_V0.9870.75
10_L15_V0.9810.74
72_L76_K0.9770.74
40_G83_Y0.9540.72
41_L100_S0.9500.72
23_S26_W0.9450.72
22_A25_L0.9370.71
30_G54_P0.9300.70
31_L35_V0.9270.70
100_S114_S0.9190.69
68_G78_G0.9030.68
58_L72_L0.8890.67
41_L95_L0.8770.66
10_L51_A0.8770.66
18_R69_G0.8740.65
34_A48_G0.8690.65
54_P98_G0.8650.65
6_L9_R0.8590.64
17_F76_K0.8580.64
69_G72_L0.8430.63
8_D14_P0.8430.63
28_I31_L0.8380.62
89_Q102_L0.8360.62
65_V75_L0.8300.61
35_V55_T0.8260.61
10_L69_G0.8180.60
7_P20_L0.8180.60
30_G37_L0.8160.60
38_P72_L0.8160.60
55_T98_G0.8120.60
55_T61_V0.8100.60
95_L99_G0.8050.59
82_G102_L0.7920.58
103_I109_W0.7870.57
8_D16_V0.7870.57
20_L65_V0.7820.57
40_G109_W0.7780.56
19_G80_P0.7760.56
16_V88_L0.7750.56
14_P20_L0.7680.55
83_Y86_R0.7670.55
37_L90_L0.7660.55
23_S29_A0.7470.53
98_G102_L0.7440.53
7_P10_L0.7420.53
7_P16_V0.7340.52
57_A70_G0.7330.52
50_W71_L0.7170.50
79_R108_A0.7100.50
4_D39_L0.7080.50
61_V111_I0.7010.49
95_L102_L0.7000.49
46_L110_S0.6980.49
10_L46_L0.6950.48
33_A87_R0.6880.48
68_G102_L0.6840.47
69_G77_R0.6830.47
3_I7_P0.6790.47
72_L89_Q0.6760.46
16_V76_K0.6740.46
6_L10_L0.6690.46
13_E75_L0.6690.46
57_A108_A0.6670.45
86_R89_Q0.6650.45
38_P48_G0.6580.45
45_L51_A0.6550.44
54_P95_L0.6520.44
6_L40_G0.6500.44
21_T69_G0.6470.44
71_L93_A0.6310.42
47_F54_P0.6260.42
9_R76_K0.6210.41
71_L74_R0.6210.41
29_A82_G0.6170.41
26_W65_V0.6140.40
39_L53_G0.6120.40
13_E84_L0.6100.40
45_L53_G0.6080.40
18_R25_L0.6080.40
10_L19_G0.5920.38
5_F20_L0.5880.38
44_A49_S0.5770.37
34_A53_G0.5690.36
28_I35_V0.5660.36
67_V71_L0.5650.36
38_P44_A0.5640.36
11_N77_R0.5610.35
54_P88_L0.5570.35
39_L114_S0.5550.35
11_N14_P0.5500.34
40_G107_G0.5500.34
34_A47_F0.5490.34
58_L62_A0.5470.34
13_E17_F0.5430.34
56_L60_G0.5410.34
32_S107_G0.5380.33
36_G83_Y0.5380.33
8_D13_E0.5360.33
9_R69_G0.5310.33
50_W61_V0.5280.32
19_G69_G0.5250.32
3_I20_L0.5250.32
103_I114_S0.5240.32
25_L74_R0.5220.32
32_S101_P0.5180.32
48_G78_G0.5170.32
38_P101_P0.5170.32
97_L100_S0.5140.31
20_L83_Y0.5100.31
47_F59_L0.5090.31
71_L88_L0.5080.31
17_F53_G0.5080.31
36_G40_G0.5070.31
70_G99_G0.5020.30
60_G64_T0.5020.30
48_G75_L0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xq2A 2 0.614 21.1 0.908 Contact Map
2zxeA 1 0.7807 17.9 0.91 Contact Map
3ixzA 1 0.7807 11.8 0.918 Contact Map
1q90G 1 0.2632 9.5 0.921 Contact Map
2wswA 3 0.6404 8.7 0.922 Contact Map
2l9uA 2 0.3509 7.2 0.925 Contact Map
3aqpA 1 0.6579 6.9 0.926 Contact Map
1cf2P 4 0.3246 5.7 0.928 Contact Map
2ks1B 1 0.386 4.8 0.931 Contact Map
2cobA 1 0.3947 4.8 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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