GREMLIN Database
DUF3485 - Protein of unknown function (DUF3485)
PFAM: PF11984 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 204 (199)
Sequences: 12809 (11097)
Seq/√Len: 786.6
META: 0.947

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_T74_N3.3681.00
49_P53_D3.3321.00
48_D51_V2.8721.00
160_R164_R2.8611.00
175_V194_A2.7901.00
58_D81_A2.6671.00
142_Q147_V2.6031.00
67_N71_R2.5981.00
125_R187_E2.5841.00
111_T122_P2.4211.00
105_V129_Q2.3841.00
35_Q40_R2.3841.00
192_A196_A2.3661.00
177_T190_L2.3461.00
156_L160_R2.1881.00
177_T189_R2.1541.00
177_T186_A2.0511.00
191_Q195_R2.0421.00
111_T120_P2.0211.00
129_Q134_R2.0121.00
91_H96_C1.9751.00
146_R157_Y1.9461.00
136_L179_V1.9401.00
142_Q145_G1.9371.00
150_S153_W1.9181.00
138_L187_E1.7681.00
157_Y160_R1.7601.00
188_A192_A1.6831.00
185_A188_A1.6471.00
27_A31_S1.6211.00
108_G125_R1.6121.00
71_R189_R1.6011.00
116_L119_G1.5941.00
38_G68_P1.5911.00
50_W53_D1.5881.00
135_Q176_S1.5881.00
187_E191_Q1.5871.00
155_K158_L1.5851.00
153_W157_Y1.5841.00
74_N176_S1.5711.00
138_L190_L1.5561.00
73_V193_F1.5561.00
192_A195_R1.5521.00
38_G67_N1.5261.00
175_V190_L1.5051.00
52_P57_A1.5041.00
34_L41_G1.4801.00
162_A168_T1.4421.00
85_Q88_S1.4351.00
93_P96_C1.4291.00
84_R87_A1.3991.00
37_G196_A1.3871.00
49_P52_P1.3791.00
110_V191_Q1.3701.00
65_Y193_F1.3691.00
12_A15_A1.3691.00
148_V157_Y1.3231.00
188_A191_Q1.3221.00
7_L10_A1.2981.00
144_G161_D1.2981.00
109_R122_P1.2981.00
146_R160_R1.2941.00
14_A17_L1.2911.00
94_E107_S1.2701.00
10_A14_A1.2681.00
128_I137_V1.2661.00
44_D47_L1.2621.00
113_P120_P1.2581.00
67_N70_G1.2471.00
136_L187_E1.2461.00
35_Q38_G1.2451.00
8_L12_A1.2321.00
11_A14_A1.2221.00
127_V134_R1.2181.00
41_G47_L1.2121.00
73_V177_T1.2121.00
42_G47_L1.2051.00
10_A13_A1.1981.00
22_P25_L1.1881.00
5_L9_A1.1871.00
66_R72_P1.1801.00
123_V140_W1.1711.00
34_L63_R1.1611.00
146_R161_D1.1601.00
78_A172_L1.1461.00
42_G45_A1.1441.00
9_A13_A1.1431.00
94_E151_E1.1421.00
194_A197_L1.1371.00
180_G183_E1.1271.00
14_A18_A1.1091.00
28_P59_D1.1031.00
41_G44_D1.0981.00
62_S76_Y1.0771.00
129_Q132_G1.0751.00
153_W156_L1.0711.00
9_A12_A1.0641.00
130_K133_R1.0541.00
10_A15_A1.0471.00
123_V138_L1.0411.00
60_Y76_Y1.0361.00
41_G46_P1.0351.00
107_S124_N1.0331.00
40_R66_R1.0281.00
6_L9_A1.0211.00
194_A198_L0.9951.00
90_I141_Y0.9881.00
96_C101_G0.9771.00
62_S74_N0.9751.00
109_R124_N0.9641.00
179_V186_A0.9561.00
15_A18_A0.9561.00
110_V123_V0.9551.00
113_P195_R0.9531.00
43_D46_P0.9521.00
133_R178_P0.9451.00
175_V193_F0.9451.00
79_Y169_D0.9411.00
156_L159_V0.9381.00
13_A17_L0.9381.00
128_I135_Q0.9361.00
32_F61_L0.9281.00
19_R22_P0.9261.00
67_N192_A0.9231.00
51_V54_V0.9131.00
199_P202_P0.9111.00
67_N72_P0.9041.00
109_R149_A0.9001.00
39_W73_V0.8961.00
110_V125_R0.8931.00
58_D87_A0.8931.00
12_A16_A0.8861.00
54_V57_A0.8811.00
90_I95_N0.8741.00
74_N135_Q0.8691.00
50_W54_V0.8671.00
104_I126_Y0.8631.00
57_A76_Y0.8611.00
53_D56_G0.8561.00
64_T72_P0.8551.00
185_A189_R0.8541.00
6_L10_A0.8541.00
183_E189_R0.8481.00
103_E129_Q0.8461.00
77_V171_A0.8441.00
42_G46_P0.8361.00
155_K159_V0.8331.00
11_A15_A0.8301.00
121_I147_V0.8291.00
51_V57_A0.8221.00
189_R192_A0.8091.00
36_I196_A0.8071.00
88_S155_K0.8061.00
138_L191_Q0.8021.00
9_A14_A0.7941.00
83_Q170_G0.7911.00
125_R138_L0.7821.00
179_V183_E0.7761.00
8_L11_A0.7751.00
20_T23_V0.7701.00
186_A189_R0.7681.00
154_A158_L0.7681.00
4_A8_L0.7601.00
53_D57_A0.7591.00
94_E126_Y0.7581.00
39_W67_N0.7501.00
136_L177_T0.7471.00
157_Y161_D0.7451.00
79_Y171_A0.7441.00
112_L123_V0.7411.00
16_A19_R0.7401.00
190_L194_A0.7381.00
4_A7_L0.7381.00
196_A200_A0.7381.00
13_A16_A0.7361.00
43_D64_T0.7331.00
197_L200_A0.7321.00
52_P55_L0.7281.00
148_V154_A0.7251.00
57_A78_A0.7221.00
143_V154_A0.7211.00
110_V187_E0.7191.00
91_H101_G0.7161.00
126_Y139_Y0.7091.00
137_V176_S0.7051.00
41_G45_A0.7001.00
47_L51_V0.6991.00
181_D184_E0.6851.00
141_Y151_E0.6841.00
198_L202_P0.6841.00
36_I197_L0.6831.00
96_C99_G0.6821.00
138_L194_A0.6771.00
114_V118_G0.6761.00
75_L197_L0.6701.00
175_V197_L0.6701.00
40_R68_P0.6701.00
46_P52_P0.6671.00
107_S126_Y0.6641.00
18_A21_E0.6601.00
82_S85_Q0.6581.00
144_G165_G0.6571.00
90_I170_G0.6571.00
66_R70_G0.6561.00
110_V113_P0.6541.00
169_D172_L0.6521.00
162_A166_R0.6511.00
139_Y172_L0.6511.00
125_R136_L0.6471.00
38_G196_A0.6461.00
187_E190_L0.6401.00
83_Q90_I0.6371.00
21_E24_P0.6361.00
83_Q88_S0.6341.00
17_L20_T0.6301.00
14_A20_T0.6271.00
3_L7_L0.6271.00
51_V56_G0.6261.00
75_L193_F0.6261.00
96_C139_Y0.6251.00
17_L21_E0.6241.00
15_A20_T0.6231.00
32_F197_L0.6221.00
90_I154_A0.6201.00
38_G192_A0.6201.00
22_P26_R0.6121.00
58_D61_L0.6111.00
151_E154_A0.6091.00
57_A60_Y0.6081.00
181_D185_A0.6071.00
154_A157_Y0.6041.00
189_R196_A0.6041.00
20_T25_L0.6021.00
32_F63_R0.6021.00
127_V136_L0.6011.00
105_V134_R0.6001.00
121_I198_L0.5961.00
143_V170_G0.5931.00
12_A17_L0.5911.00
190_L193_F0.5901.00
52_P60_Y0.5871.00
186_A190_L0.5821.00
87_A90_I0.5781.00
195_R199_P0.5731.00
14_A19_R0.5711.00
158_L168_T0.5691.00
71_R180_G0.5671.00
135_Q178_P0.5671.00
3_L6_L0.5641.00
148_V151_E0.5611.00
92_S95_N0.5601.00
80_Y90_I0.5591.00
146_R153_W0.5581.00
74_N97_L0.5531.00
139_Y174_R0.5521.00
161_D166_R0.5491.00
47_L60_Y0.5491.00
5_L8_L0.5461.00
71_R185_A0.5451.00
7_L11_A0.5441.00
51_V55_L0.5431.00
110_V138_L0.5421.00
42_G66_R0.5421.00
34_L42_G0.5411.00
62_S66_R0.5411.00
6_L11_A0.5351.00
195_R198_L0.5331.00
73_V189_R0.5331.00
104_I107_S0.5311.00
88_S154_A0.5291.00
29_L59_D0.5291.00
14_A21_E0.5291.00
33_P65_Y0.5251.00
137_V174_R0.5231.00
123_V128_I0.5231.00
143_V158_L0.5221.00
61_L65_Y0.5211.00
73_V175_V0.5201.00
179_V185_A0.5191.00
124_N149_A0.5191.00
179_V182_G0.5181.00
52_P56_G0.5181.00
41_G63_R0.5171.00
122_P147_V0.5171.00
8_L13_A0.5171.00
85_Q158_L0.5171.00
15_A21_E0.5131.00
80_Y83_Q0.5121.00
77_V173_V0.5121.00
104_I128_I0.5111.00
54_V172_L0.5091.00
115_P119_G0.5081.00
152_Y156_L0.5071.00
20_T26_R0.5061.00
83_Q169_D0.5051.00
29_L32_F0.5041.00
48_D53_D0.5041.00
45_A64_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z21A 1 0.3382 13.6 0.925 Contact Map
5a1uH 1 0.3775 5.6 0.937 Contact Map
1kdlA 1 0.0686 5.5 0.938 Contact Map
4p6zM 1 0.3873 4.3 0.941 Contact Map
4hmyS 1 0.3873 4.3 0.941 Contact Map
2vglS 1 0.3873 3.7 0.943 Contact Map
2ggtA 1 0.4461 3.6 0.943 Contact Map
1jrmA 1 0.3235 3.4 0.944 Contact Map
3j7yb 1 0.2696 3.3 0.944 Contact Map
2vglM 1 0.3873 3.1 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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