GREMLIN Database
DUF3482 - Domain of unknown function (DUF3482)
PFAM: PF11981 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 293 (263)
Sequences: 1672 (1296)
Seq/√Len: 79.9
META: 0.818

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_D102_R4.5151.00
64_L106_A4.1761.00
72_A99_L4.1411.00
168_T172_T3.9221.00
72_A217_L3.8191.00
75_Y98_R2.8931.00
258_L262_H2.5401.00
68_L106_A2.4961.00
103_E220_R2.4401.00
64_L113_L2.3171.00
93_E97_E2.3031.00
163_G167_A2.2961.00
111_L224_L2.2801.00
253_W258_L2.2511.00
195_G198_L2.2371.00
139_S142_T2.1911.00
194_G197_L2.1911.00
255_R259_K2.1481.00
186_L190_G2.0801.00
144_K147_G2.0421.00
77_E98_R2.0181.00
195_G199_A1.9561.00
21_C24_Q1.9511.00
182_L186_L1.9151.00
196_R199_A1.9081.00
77_E94_R1.8581.00
64_L109_A1.8351.00
138_F147_G1.7941.00
106_A221_A1.7721.00
96_Q100_R1.7561.00
262_H265_A1.7481.00
171_L175_A1.7321.00
54_R57_R1.7171.00
194_G198_L1.7041.00
258_L265_A1.6821.00
142_T146_L1.6441.00
68_L72_A1.6341.00
92_E96_Q1.6231.00
135_E141_E1.6161.00
39_W42_A1.6161.00
162_A166_L1.5881.00
67_E109_A1.5781.00
254_L258_L1.5631.00
103_E107_V1.5581.00
168_T171_L1.5560.99
145_L148_L1.5460.99
171_L174_G1.5420.99
58_F114_Y1.5270.99
135_E142_T1.5150.99
153_G184_G1.5100.99
61_A110_L1.5080.99
65_I221_A1.5040.99
138_F148_L1.4930.99
100_R136_D1.4840.99
124_P127_P1.4560.99
254_L257_A1.4550.99
171_L177_A1.4440.99
26_I47_I1.4380.99
73_A214_L1.4340.99
142_T147_G1.4220.99
61_A225_Y1.3910.99
61_A114_Y1.3880.99
155_A159_A1.3870.99
138_F145_L1.3770.99
89_E93_E1.3760.99
68_L221_A1.3550.99
26_I51_E1.3470.99
166_L169_G1.3440.99
143_W147_G1.3310.98
161_G171_L1.3220.98
137_L146_L1.3170.98
143_W148_L1.3140.98
27_R40_R1.3110.98
27_R30_E1.3040.98
107_V221_A1.3000.98
40_R44_E1.2970.98
258_L264_K1.2960.98
144_K148_L1.2960.98
253_W261_L1.2930.98
75_Y95_L1.2910.98
196_R200_K1.2660.98
88_K92_E1.2650.98
145_L149_S1.2650.98
44_E48_A1.2610.98
65_I225_Y1.2590.98
162_A177_A1.2550.98
68_L102_R1.2530.98
110_L224_L1.2510.98
156_A159_A1.2470.98
107_V111_L1.2460.98
91_L95_L1.2420.97
30_E47_I1.2380.97
85_E88_K1.2380.97
97_E101_Q1.2330.97
256_E263_K1.2330.97
169_G189_A1.2300.97
58_F62_A1.2140.97
198_L202_R1.2120.97
155_A158_A1.2110.97
256_E259_K1.2080.97
258_L268_H1.1790.97
262_H266_R1.1740.96
138_F146_L1.1710.96
84_E87_A1.1620.96
92_E98_R1.1620.96
43_L167_A1.1560.96
194_G199_A1.1560.96
160_A163_G1.1520.96
265_A268_H1.1520.96
53_D115_G1.1490.96
165_D173_L1.1440.96
90_A94_R1.1420.96
138_F141_E1.1390.96
16_D19_A1.1370.96
96_Q99_L1.1340.96
256_E262_H1.1310.96
52_A183_L1.1060.95
224_L228_V1.1050.95
261_L265_A1.1050.95
146_L149_S1.1040.95
199_A202_R1.1030.95
30_E51_E1.0970.95
84_E88_K1.0940.95
29_L181_A1.0900.95
86_A90_A1.0880.95
142_T145_L1.0870.95
143_W146_L1.0820.94
254_L262_H1.0790.94
114_Y225_Y1.0760.94
182_L185_A1.0680.94
234_A238_W1.0680.94
179_I183_L1.0670.94
100_R104_Q1.0660.94
258_L266_R1.0590.94
46_L50_L1.0510.94
25_E232_G1.0500.94
137_L144_K1.0440.93
203_G209_V1.0290.93
213_F224_L1.0280.93
22_F54_R1.0180.92
216_V220_R1.0030.92
52_A56_Q1.0000.92
114_Y229_A0.9980.92
116_H232_G0.9970.92
91_L104_Q0.9960.92
220_R224_L0.9950.92
139_S147_G0.9930.91
137_L142_T0.9900.91
9_F13_R0.9830.91
107_V110_L0.9800.91
45_R52_A0.9800.91
178_L181_A0.9780.91
185_A189_A0.9730.91
78_S206_E0.9660.90
137_L143_W0.9650.90
164_I176_G0.9590.90
165_D172_T0.9570.90
69_L218_L0.9560.90
68_L217_L0.9560.90
139_S148_L0.9470.89
26_I54_R0.9440.89
134_G137_L0.9390.89
259_K266_R0.9380.89
110_L225_Y0.9370.89
20_A25_E0.9360.89
68_L71_D0.9330.89
100_R103_E0.9280.88
25_E57_R0.9280.88
153_G196_R0.9240.88
203_G210_N0.9180.88
138_F220_R0.9180.88
142_T148_L0.9050.87
111_L121_A0.9040.87
89_E92_E0.9010.87
26_I35_L0.9000.87
58_F225_Y0.9000.87
268_H271_W0.8980.87
76_R208_T0.8950.87
176_G179_I0.8930.86
8_Y32_L0.8900.86
60_A109_A0.8900.86
165_D174_G0.8880.86
225_Y228_V0.8780.86
92_E100_R0.8750.85
253_W262_H0.8740.85
260_K264_K0.8700.85
25_E53_D0.8630.85
137_L220_R0.8630.85
23_V27_R0.8580.84
253_W256_E0.8570.84
141_E146_L0.8560.84
233_H236_R0.8520.84
31_A39_W0.8440.83
262_H268_H0.8430.83
80_D85_E0.8420.83
17_A20_A0.8400.83
203_G207_L0.8310.82
95_L210_N0.8280.82
33_A44_E0.8180.81
244_P249_W0.8170.81
49_A53_D0.8170.81
97_E100_R0.8150.81
150_A158_A0.8120.81
122_E240_E0.8060.80
8_Y11_A0.8050.80
21_C230_H0.7910.79
137_L147_G0.7910.79
18_V232_G0.7890.79
68_L224_L0.7840.78
255_R262_H0.7830.78
253_W264_K0.7790.78
256_E266_R0.7730.77
88_K99_L0.7720.77
193_Y197_L0.7710.77
16_D66_A0.7710.77
138_F143_W0.7660.77
6_R10_H0.7650.77
8_Y34_Q0.7600.76
242_E246_H0.7560.76
137_L148_L0.7540.76
87_A92_E0.7530.76
104_Q108_D0.7520.75
17_A107_V0.7500.75
51_E57_R0.7470.75
89_E94_R0.7470.75
141_E145_L0.7460.75
105_R112_A0.7460.75
259_K262_H0.7410.74
175_A178_L0.7410.74
177_A189_A0.7400.74
111_L116_H0.7370.74
159_A163_G0.7360.74
264_K268_H0.7340.74
140_P149_S0.7310.73
127_P140_P0.7280.73
109_A112_A0.7280.73
231_R234_A0.7260.73
140_P181_A0.7250.73
26_I30_E0.7220.72
263_K266_R0.7210.72
266_R271_W0.7210.72
163_G205_R0.7210.72
193_Y196_R0.7190.72
253_W257_A0.7170.72
143_W189_A0.7170.72
189_A193_Y0.7150.72
99_L217_L0.7120.71
4_L12_V0.7120.71
51_E55_E0.7110.71
119_L123_E0.7080.71
6_R174_G0.7050.71
226_L230_H0.7000.70
140_P146_L0.6980.70
166_L170_G0.6930.69
53_D57_R0.6910.69
169_G187_G0.6900.69
94_R247_E0.6900.69
168_T173_L0.6880.69
147_G233_H0.6880.69
15_F54_R0.6840.68
135_E138_F0.6810.68
116_H119_L0.6810.68
18_V183_L0.6810.68
196_R209_V0.6790.68
94_R98_R0.6780.68
257_A264_K0.6770.68
265_A271_W0.6730.67
29_L47_I0.6730.67
33_A47_I0.6720.67
159_A162_A0.6690.67
140_P147_G0.6690.67
60_A122_E0.6680.67
72_A209_V0.6670.66
4_L9_F0.6660.66
108_D222_L0.6660.66
141_E149_S0.6650.66
16_D61_A0.6620.66
137_L140_P0.6520.65
136_D143_W0.6510.65
67_E158_A0.6470.64
87_A90_A0.6390.63
225_Y229_A0.6370.63
54_R229_A0.6370.63
135_E139_S0.6350.63
125_E129_L0.6350.63
18_V234_A0.6330.62
47_I112_A0.6280.62
254_L266_R0.6280.62
68_L220_R0.6270.62
65_I106_A0.6260.62
191_G194_G0.6260.62
265_A269_P0.6240.61
34_Q40_R0.6220.61
231_R235_R0.6210.61
16_D24_Q0.6200.61
48_A51_E0.6200.61
111_L119_L0.6200.61
20_A24_Q0.6190.61
172_T250_R0.6190.61
71_D105_R0.6180.61
87_A94_R0.6180.61
30_E33_A0.6160.60
263_K270_E0.6130.60
22_F50_L0.6120.60
254_L259_K0.6090.59
52_A101_Q0.6080.59
230_H236_R0.6080.59
255_R261_L0.6080.59
31_A37_E0.6070.59
138_F142_T0.6070.59
159_A166_L0.6020.59
67_E84_E0.6020.59
21_C25_E0.6010.58
94_R241_L0.5990.58
5_A10_H0.5970.58
10_H36_L0.5970.58
62_A65_I0.5940.58
22_F26_I0.5910.57
28_L153_G0.5890.57
137_L141_E0.5880.57
267_A271_W0.5840.56
24_Q173_L0.5840.56
139_S144_K0.5830.56
162_A171_L0.5810.56
20_A233_H0.5810.56
175_A179_I0.5810.56
43_L68_L0.5800.56
254_L261_L0.5790.56
141_E144_K0.5790.56
54_R68_L0.5760.55
252_E259_K0.5760.55
177_A181_A0.5740.55
20_A23_V0.5730.55
45_R48_A0.5690.54
57_R139_S0.5690.54
262_H267_A0.5650.54
255_R258_L0.5640.54
98_R101_Q0.5640.54
194_G200_K0.5630.54
266_R269_P0.5630.54
191_G196_R0.5610.53
57_R194_G0.5590.53
231_R241_L0.5560.53
188_A215_Y0.5540.52
26_I29_L0.5530.52
81_E94_R0.5530.52
166_L171_L0.5530.52
80_D205_R0.5510.52
47_I86_A0.5490.52
200_K203_G0.5490.52
216_V219_D0.5480.52
91_L102_R0.5480.52
125_E134_G0.5480.52
164_I172_T0.5470.51
93_E96_Q0.5440.51
110_L172_T0.5430.51
11_A267_A0.5410.51
117_R237_D0.5410.51
55_E244_P0.5380.50
9_F19_A0.5370.50
148_L212_N0.5360.50
99_L103_E0.5350.50
181_A210_N0.5340.50
169_G175_A0.5340.50
174_G212_N0.5310.49
225_Y234_A0.5300.49
10_H174_G0.5300.49
173_L213_F0.5300.49
100_R164_I0.5250.49
87_A91_L0.5250.49
25_E225_Y0.5220.48
33_A219_D0.5220.48
18_V174_G0.5200.48
42_A45_R0.5190.48
46_L232_G0.5160.47
252_E255_R0.5150.47
153_G188_A0.5140.47
116_H233_H0.5140.47
65_I179_I0.5130.47
204_G207_L0.5120.47
146_L209_V0.5110.47
201_V207_L0.5110.47
161_G176_G0.5090.47
195_G201_V0.5080.46
25_E214_L0.5070.46
91_L98_R0.5070.46
6_R12_V0.5060.46
30_E44_E0.5040.46
153_G156_A0.5040.46
9_F26_I0.5040.46
155_A209_V0.5030.46
14_V204_G0.5010.46
27_R44_E0.5000.45
148_L215_Y0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2j69A 1 0.8191 89.5 0.928 Contact Map
1rh1A 1 0.6485 58 0.946 Contact Map
4kblA 2 0.4096 53.9 0.947 Contact Map
1colA 1 0.5119 45.8 0.949 Contact Map
3fewX 1 0.6587 40.6 0.951 Contact Map
1ciiA 1 0.6587 20 0.958 Contact Map
4aurA 1 0.8976 18.7 0.958 Contact Map
4hlsA 2 0.2799 18.7 0.958 Contact Map
2lbgA 1 0.0922 15.9 0.96 Contact Map
1a87A 1 0.6826 15 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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