GREMLIN Database
DUF3467 - Protein of unknown function (DUF3467)
PFAM: PF11950 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 91 (81)
Sequences: 14767 (7423)
Seq/√Len: 824.8
META: 0.971

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
72_L76_Q3.4591.00
80_K84_A2.6731.00
76_Q80_K2.5341.00
77_D81_K2.2431.00
69_K83_E2.1341.00
68_A75_L2.0941.00
72_L79_I1.9941.00
73_R76_Q1.9331.00
30_N40_E1.8531.00
81_K84_A1.8371.00
63_L71_L1.7501.00
39_E70_R1.7071.00
32_A71_L1.6451.00
44_D60_R1.6431.00
20_D23_V1.5921.00
19_L57_V1.5861.00
18_E54_K1.5771.00
28_Y40_E1.5601.00
77_D80_K1.5521.00
39_E66_Q1.5071.00
38_P66_Q1.4741.00
34_I74_A1.4391.00
45_F61_I1.4141.00
28_Y64_S1.3991.00
29_A61_I1.3991.00
63_L68_A1.3901.00
25_E58_K1.3861.00
20_D56_K1.3391.00
73_R77_D1.3201.00
29_A45_F1.3161.00
36_H78_N1.2881.00
81_K85_R1.2611.00
41_F65_P1.2201.00
27_V59_S1.1911.00
18_E21_E1.1851.00
68_A79_I1.1781.00
41_F78_N1.1621.00
36_H41_F1.0761.00
27_V58_K1.0751.00
23_V56_K1.0441.00
47_R58_K0.9901.00
46_A49_M0.9881.00
68_A72_L0.9871.00
57_V60_R0.9661.00
38_P90_K0.9471.00
32_A43_L0.9371.00
42_V62_I0.9321.00
25_E56_K0.9271.00
79_I89_I0.9091.00
64_S67_H0.8981.00
41_F68_A0.8811.00
79_I83_E0.8771.00
48_V53_P0.8751.00
51_G54_K0.8711.00
69_K79_I0.8641.00
43_L63_L0.8561.00
23_V26_G0.8461.00
31_L46_A0.8401.00
21_E24_A0.8361.00
32_A63_L0.8281.00
36_H74_A0.8221.00
25_E47_R0.8141.00
78_N81_K0.7991.00
46_A57_V0.7841.00
74_A78_N0.7741.00
26_G44_D0.7631.00
42_V60_R0.7631.00
34_I78_N0.7621.00
66_Q90_K0.7381.00
66_Q70_R0.7291.00
66_Q89_I0.7271.00
50_P53_P0.7241.00
82_Y86_F0.7191.00
40_E62_I0.7081.00
25_E59_S0.7051.00
73_R80_K0.7031.00
39_E64_S0.7031.00
26_G62_I0.7021.00
18_E56_K0.7011.00
48_V55_A0.7011.00
43_L68_A0.6981.00
52_V55_A0.6901.00
47_R51_G0.6851.00
36_H65_P0.6851.00
27_V61_I0.6731.00
43_L71_L0.6721.00
64_S69_K0.6661.00
33_I46_A0.6621.00
26_G60_R0.6571.00
16_N54_K0.6521.00
39_E67_H0.6261.00
63_L67_H0.6171.00
35_T42_V0.6151.00
29_A63_L0.6141.00
49_M53_P0.6081.00
71_L75_L0.6031.00
33_I44_D0.6031.00
34_I43_L0.6001.00
67_H70_R0.5961.00
69_K73_R0.5821.00
10_Q13_Q0.5771.00
42_V47_R0.5761.00
74_A81_K0.5751.00
35_T78_N0.5731.00
41_F79_I0.5701.00
27_V45_F0.5591.00
58_K70_R0.5521.00
23_V58_K0.5521.00
19_L44_D0.5441.00
36_H82_Y0.5421.00
69_K88_E0.5391.00
70_R73_R0.5381.00
32_A74_A0.5341.00
62_I65_P0.5301.00
65_P69_K0.5271.00
28_Y70_R0.5221.00
19_L23_V0.5201.00
36_H77_D0.5181.00
28_Y39_E0.5101.00
32_A67_H0.5091.00
51_G55_A0.5021.00
32_A37_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hslX 2 0.7912 12.3 0.883 Contact Map
3fx7A 2 0.3297 11.9 0.883 Contact Map
2mjgA 2 0.5055 7.8 0.893 Contact Map
2q83A 1 0.3187 6.9 0.895 Contact Map
2z0lA 3 0.8132 6.7 0.896 Contact Map
4jo7E 2 0.3297 6.3 0.897 Contact Map
4rxlA 1 0.3187 5.2 0.901 Contact Map
4aq4A 1 0.3956 5.2 0.901 Contact Map
2mn6B 2 0.5165 4.5 0.904 Contact Map
3whpA 1 0 4.4 0.904 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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