GREMLIN Database
DUF3465 - Protein of unknown function (DUF3465)
PFAM: PF11948 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 125 (112)
Sequences: 2727 (1931)
Seq/√Len: 182.4
META: 0.914

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
118_K123_T4.6811.00
35_G88_F3.5811.00
32_Q89_Y3.1461.00
34_E89_Y2.4831.00
84_D119_H2.4821.00
40_T58_R2.4701.00
87_E118_K2.3711.00
68_A100_V2.3001.00
23_A31_V2.2021.00
34_E87_E2.1741.00
32_Q112_H2.1131.00
45_D76_R2.0931.00
95_N100_V2.0601.00
47_N51_R2.0541.00
93_E100_V2.0311.00
21_A25_A1.9441.00
67_V101_I1.8511.00
21_A63_Q1.8421.00
57_L117_L1.7821.00
36_E87_E1.7061.00
88_F117_L1.6391.00
32_Q91_E1.6361.00
24_F63_Q1.6301.00
73_L108_P1.6251.00
77_I119_H1.6201.00
30_D91_E1.6041.00
110_G114_G1.6011.00
36_E85_T1.5981.00
89_Y113_E1.5761.00
59_L62_G1.5131.00
32_Q113_E1.4281.00
38_T58_R1.4241.00
42_L82_V1.4221.00
22_R26_N1.4081.00
55_F86_V1.3571.00
55_F80_L1.3491.00
51_R71_I1.3401.00
52_H102_H1.3321.00
44_P54_R1.3291.00
51_R72_D1.3241.00
20_L33_V1.2611.00
65_L101_I1.2111.00
79_G119_H1.2111.00
57_L88_F1.2091.00
33_V101_I1.1991.00
77_I80_L1.1481.00
69_H104_T1.1271.00
22_R28_R1.1071.00
30_D93_E1.1061.00
69_H74_A1.0831.00
41_R82_V1.0761.00
35_G101_I1.0751.00
20_L63_Q1.0221.00
92_Y99_G1.0010.99
27_R94_W0.9890.99
32_Q114_G0.9620.99
79_G124_Y0.9290.99
35_G57_L0.9190.99
42_L78_P0.9170.99
24_F92_Y0.9120.99
35_G117_L0.9080.99
28_R31_V0.9070.99
55_F67_V0.9020.99
91_E112_H0.8820.99
54_R66_L0.8660.98
56_I97_K0.8580.98
39_V80_L0.8430.98
38_T85_T0.8420.98
22_R25_A0.8360.98
114_G125_Q0.8330.98
102_H105_H0.8310.98
20_L24_F0.8310.98
59_L63_Q0.8140.98
39_V84_D0.8120.97
57_L86_V0.8060.97
14_D17_A0.7960.97
72_D103_W0.7930.97
67_V88_F0.7920.97
57_L67_V0.7890.97
14_D19_A0.7520.96
119_H124_Y0.7510.96
47_N50_S0.7500.96
50_S97_K0.7440.96
106_H114_G0.7390.96
70_N102_H0.7040.94
41_R56_I0.7040.94
52_H103_W0.7020.94
60_A63_Q0.6970.94
15_D19_A0.6900.94
19_A31_V0.6890.94
46_D49_G0.6870.94
29_S93_E0.6870.94
85_T120_N0.6850.93
75_P122_R0.6840.93
103_W108_P0.6790.93
43_L46_D0.6780.93
52_H70_N0.6730.93
46_D53_Q0.6680.93
116_W119_H0.6670.93
89_Y114_G0.6490.91
46_D54_R0.6480.91
94_W99_G0.6470.91
42_L54_R0.6460.91
49_G103_W0.6460.91
56_I64_T0.6440.91
34_E38_T0.6430.91
20_L31_V0.6430.91
15_D60_A0.6400.91
40_T82_V0.6330.90
50_S73_L0.6310.90
109_Q113_E0.6260.90
21_A61_S0.6230.90
106_H125_Q0.6230.90
46_D51_R0.6220.90
88_F101_I0.6150.89
13_A17_A0.6140.89
77_I117_L0.6130.89
34_E113_E0.6130.89
46_D66_L0.6110.89
52_H105_H0.6080.89
51_R68_A0.6070.89
56_I95_N0.6060.88
20_L88_F0.6000.88
78_P124_Y0.5990.88
87_E123_T0.5970.88
31_V94_W0.5930.87
107_D111_R0.5900.87
78_P122_R0.5900.87
60_A78_P0.5850.87
19_A23_A0.5840.87
19_A22_R0.5770.86
67_V94_W0.5760.86
54_R95_N0.5740.86
69_H77_I0.5730.86
60_A85_T0.5720.85
16_A82_V0.5700.85
118_K121_G0.5680.85
73_L97_K0.5670.85
67_V104_T0.5640.85
67_V70_N0.5600.84
120_N124_Y0.5550.84
94_W98_G0.5470.83
36_E40_T0.5400.82
84_D120_N0.5390.82
49_G54_R0.5330.81
106_H111_R0.5320.81
21_A58_R0.5290.81
24_F27_R0.5280.81
68_A93_E0.5270.81
95_N99_G0.5230.80
58_R61_S0.5220.80
96_E120_N0.5210.80
46_D103_W0.5210.80
13_A16_A0.5200.80
70_N73_L0.5190.80
19_A38_T0.5190.80
52_H64_T0.5180.79
43_L53_Q0.5150.79
41_R97_K0.5150.79
26_N111_R0.5120.79
35_G61_S0.5090.78
23_A27_R0.5090.78
21_A24_F0.5050.78
35_G65_L0.5030.77
19_A28_R0.5010.77
54_R68_A0.5010.77
23_A94_W0.5000.77
86_V119_H0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nnxA 1 0.68 79.5 0.901 Contact Map
2dgyA 1 0.784 69.9 0.908 Contact Map
4mnoA 1 0.68 62.6 0.912 Contact Map
1ah9A 1 0.56 59.5 0.914 Contact Map
3wbkC 1 0.008 57.5 0.915 Contact Map
1jt8A 1 0.784 56.1 0.916 Contact Map
4ql5A 4 0.536 55.3 0.916 Contact Map
1hr0W 1 0.56 49.5 0.919 Contact Map
3i4oA 1 0.536 34.2 0.926 Contact Map
3j80i 1 0.672 30.2 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0059 seconds.