GREMLIN Database
DUF3455 - Protein of unknown function (DUF3455)
PFAM: PF11937 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 180 (138)
Sequences: 3352 (2125)
Seq/√Len: 180.9
META: 0.854

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
149_N175_D3.1601.00
11_G81_I2.8201.00
21_C159_C2.6951.00
103_G128_L2.6291.00
148_V177_Y2.6061.00
7_L177_Y2.6021.00
106_V129_Q2.3711.00
111_A114_D2.0991.00
101_V145_I2.0221.00
160_D163_T1.9991.00
105_V108_S1.9951.00
130_A133_H1.9681.00
39_T50_Q1.9561.00
112_P115_A1.9341.00
151_V173_T1.9231.00
94_Q100_K1.9221.00
16_T169_R1.9191.00
84_H91_P1.9111.00
4_N144_F1.8941.00
104_K129_Q1.8931.00
10_V177_Y1.8711.00
8_F142_V1.8291.00
85_F94_Q1.8121.00
81_I84_H1.7971.00
121_G154_V1.7551.00
104_K131_V1.7411.00
111_A115_A1.7171.00
37_E169_R1.6731.00
25_A28_A1.6611.00
108_S124_P1.6381.00
20_V34_K1.6241.00
12_H175_D1.6211.00
163_T166_A1.5681.00
105_V126_L1.5571.00
106_V127_L1.5311.00
125_W148_V1.5301.00
129_Q144_F1.5211.00
172_Y176_Y1.4961.00
109_A114_D1.4681.00
95_S138_T1.4421.00
42_D49_K1.4331.00
4_N143_T1.3911.00
22_L32_T1.3551.00
7_L10_V1.3481.00
18_N35_A1.3411.00
110_D114_D1.3341.00
158_G163_T1.2991.00
41_F50_Q1.2941.00
109_A112_P1.2791.00
110_D113_S1.2761.00
125_W150_T1.2581.00
85_F100_K1.2391.00
100_K134_Q1.2351.00
109_A113_S1.2271.00
17_Q126_L1.2201.00
14_V41_F1.2011.00
139_L142_V1.1601.00
34_K167_E1.1461.00
110_D115_A1.1451.00
101_V130_A1.1401.00
109_A115_A1.1361.00
7_L179_Y1.1231.00
88_P91_P1.1221.00
20_V167_E1.1161.00
31_W161_A1.0951.00
11_G82_G1.0941.00
85_F91_P1.0941.00
7_L148_V1.0881.00
82_G88_P1.0871.00
83_T94_Q1.0791.00
81_I95_S1.0461.00
18_N169_R1.0311.00
9_L81_I1.0301.00
14_V171_P1.0090.99
102_W132_G0.9790.99
82_G85_F0.9720.99
17_Q84_H0.9710.99
92_T100_K0.9680.99
1_P4_N0.9590.99
84_H88_P0.9590.99
85_F88_P0.9540.99
94_Q98_G0.9500.99
82_G95_S0.9500.99
37_E83_T0.9470.99
17_Q128_L0.9290.99
133_H142_V0.9180.99
110_D124_P0.9030.99
16_T37_E0.8970.99
95_S139_L0.8790.98
13_A123_I0.8740.98
127_L144_F0.8720.98
98_G102_W0.8670.98
146_Q177_Y0.8650.98
10_V43_D0.8570.98
133_H140_S0.8430.98
122_A151_V0.8330.98
42_D47_A0.8250.98
99_S102_W0.8200.98
82_G91_P0.8100.97
3_G144_F0.8030.97
10_V175_D0.7820.97
154_V157_A0.7800.97
24_S27_G0.7710.96
9_L138_T0.7700.96
28_A164_V0.7630.96
85_F92_T0.7620.96
113_S121_G0.7450.96
108_S114_D0.7410.96
84_H126_L0.7320.95
25_A29_A0.7240.95
24_S28_A0.7180.95
31_W35_A0.7170.95
83_T91_P0.7140.95
18_N33_F0.7130.95
21_C160_D0.7110.94
11_G177_Y0.7110.94
84_H128_L0.7040.94
122_A125_W0.7030.94
83_T96_S0.7010.94
23_P27_G0.6990.94
108_S112_P0.6960.94
103_G130_A0.6950.94
107_A127_L0.6900.94
127_L146_Q0.6880.93
9_L178_F0.6860.93
156_P168_A0.6860.93
11_G178_F0.6860.93
108_S113_S0.6830.93
129_Q143_T0.6790.93
17_Q172_Y0.6740.93
123_I150_T0.6710.93
47_A50_Q0.6710.93
105_V131_V0.6700.93
158_G166_A0.6700.93
99_S103_G0.6690.92
153_G156_P0.6650.92
40_L82_G0.6650.92
161_A164_V0.6650.92
29_A32_T0.6640.92
124_P154_V0.6560.92
130_A142_V0.6490.91
42_D137_G0.6360.90
81_I88_P0.6340.90
10_V173_T0.6330.90
97_D103_G0.6280.90
35_A169_R0.6210.89
43_D47_A0.6170.89
123_I126_L0.6170.89
82_G90_G0.6150.89
148_V175_D0.6140.89
23_P26_A0.6100.89
47_A138_T0.6100.89
85_F89_A0.6060.88
49_K137_G0.6050.88
158_G168_A0.6020.88
6_K114_D0.5940.87
155_A158_G0.5910.87
82_G139_L0.5890.87
114_D122_A0.5880.87
138_T141_K0.5830.86
29_A164_V0.5830.86
17_Q36_P0.5830.86
23_P28_A0.5820.86
95_S99_S0.5810.86
121_G151_V0.5800.86
136_G140_S0.5790.86
162_A165_G0.5770.86
30_E33_F0.5760.86
34_K135_G0.5750.86
22_L34_K0.5720.85
82_G137_G0.5720.85
33_F36_P0.5710.85
98_G103_G0.5690.85
7_L11_G0.5690.85
137_G140_S0.5650.85
26_A151_V0.5590.84
156_P170_V0.5590.84
16_T39_T0.5550.83
29_A162_A0.5510.83
26_A29_A0.5500.83
101_V105_V0.5480.83
22_L121_G0.5450.82
126_L147_R0.5450.82
14_V173_T0.5450.82
42_D138_T0.5410.82
104_K107_A0.5390.82
106_V144_F0.5390.82
97_D139_L0.5380.82
123_I169_R0.5330.81
83_T89_A0.5320.81
146_Q179_Y0.5230.80
144_F179_Y0.5220.80
33_F152_G0.5220.80
22_L164_V0.5190.79
18_N37_E0.5190.79
133_H136_G0.5170.79
17_Q38_A0.5140.79
17_Q123_I0.5140.79
24_S29_A0.5130.78
88_P92_T0.5100.78
42_D48_G0.5090.78
26_A161_A0.5090.78
97_D102_W0.5080.78
128_L147_R0.5060.78
23_P143_T0.5050.77
93_W156_P0.5020.77
81_I91_P0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2y8tB 1 0.1944 6.9 0.95 Contact Map
4f2fA 1 0.1889 1.6 0.963 Contact Map
2y5pA 3 0.2056 1.6 0.963 Contact Map
2mryA 1 0.1833 1.6 0.963 Contact Map
1ibyA 3 0.2111 1.5 0.964 Contact Map
2ltlA 1 0.4833 1.4 0.965 Contact Map
1cjaA 1 0.5 1.2 0.966 Contact Map
4kunA 2 0.2278 1.2 0.966 Contact Map
2xfgB 1 0.4222 1.1 0.967 Contact Map
2l1tA 1 0.2833 0.9 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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