GREMLIN Database
DUF3447 - Domain of unknown function (DUF3447)
PFAM: PF11929 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 76 (76)
Sequences: 1093 (729)
Seq/√Len: 83.6
META: 0.075

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_E35_C3.6331.00
11_E32_D3.0401.00
39_A48_V3.0221.00
24_E27_K2.6651.00
44_N47_F2.3131.00
49_T75_V2.0971.00
10_L35_C1.7401.00
36_M52_M1.7231.00
10_L31_P1.7021.00
19_P47_F1.6811.00
45_I75_V1.6511.00
36_M48_V1.6151.00
28_Y71_E1.5351.00
12_F38_Y1.5291.00
7_Q34_E1.5190.99
35_C38_Y1.4880.99
8_K11_E1.4340.99
56_N63_Y1.4140.99
11_E38_Y1.3840.99
16_G21_I1.3610.99
2_N7_Q1.3510.99
45_I67_Y1.3290.99
14_F17_G1.3120.99
19_P23_S1.2710.98
62_E66_K1.2700.98
1_F7_Q1.2660.98
10_L26_L1.2490.98
17_G44_N1.2240.98
37_E63_Y1.2070.97
20_E68_N1.1840.97
69_N72_A1.1620.97
7_Q33_E1.1520.97
2_N11_E1.1320.96
39_A51_L1.1190.96
70_L73_F1.0960.95
6_T9_C1.0800.95
47_F50_F1.0710.95
58_E61_L1.0680.95
14_F47_F1.0680.95
29_Q32_D1.0560.94
17_G47_F1.0520.94
15_L42_S1.0510.94
14_F40_I1.0230.93
16_G43_H1.0200.93
27_K47_F0.9990.93
48_V64_C0.9980.93
37_E60_D0.9870.92
40_I72_A0.9820.92
44_N70_L0.9170.89
14_F38_Y0.9150.89
39_A64_C0.8910.88
62_E65_G0.8780.87
10_L50_F0.8660.86
9_C50_F0.8630.86
2_N58_E0.8150.82
34_E67_Y0.8070.82
45_I48_V0.7910.81
15_L25_C0.7900.80
72_A76_Y0.7850.80
28_Y68_N0.7810.80
15_L41_I0.7680.79
49_T54_E0.7660.78
49_T71_E0.7580.78
2_N70_L0.7560.78
7_Q62_E0.7560.78
49_T53_N0.7510.77
14_F43_H0.7460.77
20_E71_E0.7430.76
3_S65_G0.7280.75
40_I43_H0.7220.74
1_F39_A0.7190.74
9_C25_C0.7070.73
58_E63_Y0.7070.73
4_E68_N0.6990.72
16_G23_S0.6880.71
63_Y67_Y0.6620.68
59_I64_C0.6550.67
15_L54_E0.6510.66
21_I43_H0.6490.66
13_S67_Y0.6430.65
64_C74_L0.6410.65
24_E43_H0.6370.65
36_M59_I0.6370.65
5_I25_C0.6250.63
25_C47_F0.6200.63
13_S24_E0.6140.62
18_N42_S0.6140.62
10_L48_V0.6100.61
50_F55_Y0.6090.61
2_N49_T0.6040.61
55_Y59_I0.5980.60
24_E53_N0.5960.60
30_K36_M0.5960.60
24_E44_N0.5810.58
9_C42_S0.5800.58
13_S41_I0.5780.57
9_C24_E0.5740.57
16_G71_E0.5730.57
38_Y42_S0.5630.55
21_I69_N0.5460.53
42_S51_L0.5460.53
37_E66_K0.5420.53
2_N62_E0.5390.52
21_I25_C0.5300.51
27_K42_S0.5250.50
14_F46_D0.5230.50
7_Q32_D0.5220.50
34_E66_K0.5190.49
71_E75_V0.5190.49
27_K54_E0.5180.49
19_P53_N0.5130.49
25_C42_S0.5040.48
2_N19_P0.5030.47
40_I59_I0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j9pD 4 0 95.5 0.702 Contact Map
1n11A 1 0.9868 95.1 0.71 Contact Map
4hbdA 1 0.7632 95 0.711 Contact Map
2dznA 1 0.9342 94.9 0.713 Contact Map
2ajaA 1 1 94.7 0.717 Contact Map
4rlvA 1 0.9868 94.4 0.72 Contact Map
3ljnA 1 1 94.2 0.723 Contact Map
4bszB 1 1 94.1 0.724 Contact Map
4oavB 2 1 93.7 0.729 Contact Map
3keaA 2 0.9868 93.6 0.729 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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