GREMLIN Database
DUF3444 - Domain of unknown function (DUF3444)
PFAM: PF11926 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 210 (206)
Sequences: 793 (486)
Seq/√Len: 33.8
META: 0.064

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
174_V206_L7.0521.00
137_P140_H4.4001.00
13_D16_K3.9121.00
147_I201_V3.4691.00
129_W133_W3.2641.00
127_K146_D3.0841.00
137_P141_R2.7011.00
170_G173_S2.5191.00
136_D140_H2.5171.00
149_E177_R2.5021.00
10_D80_V2.4681.00
64_K201_V2.4341.00
108_G111_R2.3350.99
6_V97_N2.2940.99
30_A101_H2.2910.99
23_F99_F2.2870.99
128_N144_E2.2840.99
138_D141_R2.2070.99
73_W195_L2.1380.99
118_R153_D2.1290.99
193_E196_R2.0030.98
152_S161_S1.9880.98
26_G58_I1.8960.97
14_F18_R1.8920.97
156_E160_V1.8590.97
129_W195_L1.8500.97
60_W122_V1.8110.96
33_D40_R1.7980.96
62_E99_F1.7930.96
149_E205_R1.7840.96
55_K192_E1.7480.95
180_D184_K1.7280.95
77_G167_K1.7180.95
118_R205_R1.7040.95
167_K170_G1.6730.94
190_P196_R1.6050.93
46_R90_S1.5980.93
12_H163_A1.5960.93
8_D11_F1.5810.92
130_S134_S1.5530.92
115_I192_E1.5410.91
36_D113_Y1.4700.89
33_D38_M1.4610.89
88_G119_K1.4420.88
93_T96_L1.4300.88
68_E89_K1.4010.87
73_W129_W1.3770.86
130_S193_E1.3620.85
5_E47_K1.3430.84
65_P131_P1.3190.83
25_V31_L1.3160.83
168_V175_F1.3060.83
61_L85_F1.3030.82
28_I112_S1.2990.82
159_G164_P1.2630.80
135_S140_H1.2530.80
55_K196_R1.2520.80
106_E114_R1.2310.79
67_E70_E1.2180.78
36_D146_D1.2170.78
25_V56_L1.2100.77
167_K175_F1.1980.77
31_L56_L1.1970.77
164_P205_R1.1860.76
48_V167_K1.1860.76
122_V137_P1.1710.75
58_I209_E1.1690.75
43_A60_W1.1460.73
103_V200_Q1.1400.73
23_F54_F1.1270.72
113_Y119_K1.1230.72
119_K125_L1.1220.72
122_V203_S1.1210.72
38_M54_F1.1160.71
154_Y159_G1.1140.71
19_S127_K1.1110.71
54_F196_R1.1040.71
56_L155_S1.1040.71
71_I207_T1.1000.70
16_K22_S1.0980.70
21_E26_G1.0750.69
73_W133_W1.0710.68
12_H20_E1.0700.68
166_V178_H1.0570.67
20_E54_F1.0530.67
155_S158_A1.0470.66
81_S154_Y1.0390.66
8_D41_Y1.0380.66
102_L122_V1.0310.65
150_V163_A1.0290.65
104_S122_V1.0240.65
41_Y63_P1.0110.64
56_L207_T1.0090.64
135_S139_E1.0050.63
163_A196_R1.0000.63
9_P15_D0.9980.63
35_D103_V0.9870.62
44_R58_I0.9830.61
29_W83_G0.9820.61
161_S188_T0.9810.61
162_V197_F0.9810.61
43_A57_R0.9780.61
6_V15_D0.9760.61
20_E97_N0.9740.61
26_G92_T0.9650.60
54_F99_F0.9580.59
24_A121_E0.9570.59
12_H22_S0.9380.58
30_A58_I0.9350.58
74_V128_N0.9230.57
3_S6_V0.9200.56
34_D41_Y0.9190.56
43_A190_P0.9180.56
40_R99_F0.9160.56
178_H203_S0.9160.56
26_G143_Y0.9140.56
121_E200_Q0.9140.56
150_V164_P0.9140.56
102_L206_L0.9100.56
48_V156_E0.8960.54
15_D71_I0.8930.54
15_D145_Y0.8840.53
171_F174_V0.8840.53
25_V121_E0.8770.53
125_L146_D0.8750.53
125_L171_F0.8740.52
134_S160_V0.8710.52
11_F60_W0.8660.52
170_G175_F0.8660.52
117_P123_W0.8650.52
72_N75_D0.8610.51
34_D37_G0.8580.51
11_F171_F0.8580.51
31_L99_F0.8550.51
31_L102_L0.8530.51
170_G174_V0.8510.51
44_R111_R0.8450.50
146_D160_V0.8370.49
150_V162_V0.8270.49
188_T207_T0.8250.48
87_V115_I0.8240.48
163_A166_V0.8240.48
12_H17_D0.8220.48
63_P77_G0.8220.48
147_I157_E0.8170.48
178_H187_F0.8120.47
65_P79_P0.8100.47
46_R59_T0.8080.47
89_K95_D0.8070.47
45_I179_E0.8050.47
25_V59_T0.8050.47
28_I87_V0.8050.47
79_P84_K0.8040.47
105_W108_G0.7990.46
18_R165_L0.7970.46
64_K109_G0.7950.46
168_V176_K0.7920.46
84_K87_V0.7870.45
41_Y60_W0.7840.45
52_P201_V0.7770.44
4_I55_K0.7750.44
23_F56_L0.7750.44
24_A81_S0.7740.44
28_I113_Y0.7690.44
27_Q149_E0.7670.44
47_K207_T0.7650.43
139_E179_E0.7600.43
3_S158_A0.7580.43
121_E150_V0.7570.43
12_H206_L0.7560.43
157_E201_V0.7480.42
45_I96_L0.7430.42
95_D169_K0.7410.41
146_D150_V0.7370.41
127_K189_I0.7360.41
57_R102_L0.7350.41
136_D195_L0.7320.41
81_S192_E0.7310.41
132_D136_D0.7290.40
19_S200_Q0.7280.40
181_E185_A0.7280.40
10_D97_N0.7260.40
63_P113_Y0.7220.40
52_P72_N0.7200.40
23_F39_P0.7150.39
118_R152_S0.7120.39
21_E113_Y0.7100.39
125_L206_L0.7090.39
48_V57_R0.7070.39
56_L114_R0.7060.39
42_Y162_V0.7060.39
119_K153_D0.6990.38
53_P184_K0.6990.38
57_R150_V0.6970.38
45_I151_L0.6960.38
13_D191_K0.6910.37
9_P45_I0.6910.37
118_R176_K0.6910.37
160_V163_A0.6910.37
18_R172_K0.6860.37
106_E110_R0.6860.37
110_R145_Y0.6840.37
11_F15_D0.6810.37
55_K94_D0.6780.36
122_V143_Y0.6780.36
146_D196_R0.6760.36
74_V195_L0.6740.36
125_L162_V0.6740.36
158_A201_V0.6700.36
63_P145_Y0.6700.36
128_N190_P0.6690.36
136_D141_R0.6680.36
168_V194_L0.6670.35
61_L145_Y0.6660.35
22_S118_R0.6620.35
168_V172_K0.6610.35
97_N173_S0.6550.35
73_W131_P0.6520.34
54_F58_I0.6490.34
41_Y93_T0.6490.34
16_K175_F0.6430.34
71_I111_R0.6410.33
94_D104_S0.6400.33
82_C85_F0.6390.33
4_I109_G0.6380.33
72_N113_Y0.6360.33
43_A88_G0.6350.33
19_S22_S0.6320.33
73_W147_I0.6300.33
38_M172_K0.6290.33
74_V111_R0.6290.33
189_I197_F0.6290.33
70_E78_L0.6290.33
133_W167_K0.6270.32
113_Y181_E0.6250.32
118_R179_E0.6240.32
82_C115_I0.6200.32
102_L139_E0.6190.32
10_D23_F0.6140.31
10_D204_F0.6140.31
15_D20_E0.6140.31
99_F128_N0.6090.31
93_T155_S0.6070.31
180_D186_I0.6070.31
26_G177_R0.6030.31
135_S138_D0.6020.31
41_Y62_E0.6020.31
149_E162_V0.6010.31
132_D186_I0.6010.31
159_G168_V0.6000.30
15_D34_D0.5980.30
71_I103_V0.5970.30
64_K105_W0.5970.30
191_K200_Q0.5970.30
41_Y98_M0.5960.30
48_V69_G0.5920.30
90_S140_H0.5890.30
21_E112_S0.5890.30
52_P125_L0.5890.30
11_F14_F0.5880.30
4_I8_D0.5850.29
109_G189_I0.5840.29
49_I57_R0.5800.29
59_T149_E0.5780.29
34_D147_I0.5760.29
86_R155_S0.5740.29
21_E96_L0.5740.29
148_V162_V0.5730.29
33_D37_G0.5720.29
8_D202_P0.5720.29
22_S74_V0.5690.28
81_S197_F0.5660.28
159_G167_K0.5660.28
135_S141_R0.5650.28
70_E133_W0.5510.27
4_I7_P0.5450.27
3_S7_P0.5450.27
47_K79_P0.5410.26
30_A199_H0.5410.26
43_A130_S0.5390.26
180_D189_I0.5380.26
27_Q83_G0.5360.26
32_Y101_H0.5340.26
41_Y146_D0.5310.26
37_G201_V0.5300.26
6_V16_K0.5280.26
4_I185_A0.5270.26
54_F146_D0.5240.25
51_S94_D0.5220.25
31_L34_D0.5210.25
12_H19_S0.5200.25
7_P109_G0.5200.25
111_R172_K0.5190.25
113_Y137_P0.5180.25
62_E169_K0.5180.25
100_S165_L0.5170.25
74_V133_W0.5160.25
105_W115_I0.5150.25
66_D69_G0.5100.24
31_L60_W0.5100.24
82_C90_S0.5100.24
3_S26_G0.5090.24
136_D139_E0.5070.24
45_I125_L0.5050.24
7_P129_W0.5050.24
155_S159_G0.5040.24
75_D112_S0.5010.24
48_V114_R0.5010.24
91_E188_T0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1s4cA 2 0.2714 7.8 0.97 Contact Map
2mh8A 1 0.2667 5.8 0.972 Contact Map
3h8zA 1 0.3238 5.3 0.972 Contact Map
2mk5A 1 0.2857 4.6 0.973 Contact Map
2ia1A 2 0.3095 3.8 0.974 Contact Map
1xc0A 1 0.1571 3.3 0.975 Contact Map
1t62A 2 0.4619 2.9 0.975 Contact Map
1r77A 1 0.2762 2.8 0.976 Contact Map
2y4xA 1 0.3524 2.5 0.976 Contact Map
3gk5A 1 0.3238 2.3 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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