DUF3444 - PFAM28P - GREMLIN Contacts

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DUF3444 - Domain of unknown function (DUF3444)

PFAM:	PF11926	Sequences: PESIEVPDPDFHDFDKDRSEESFAVGQIWALYDDDDGMPRYYARIRKVISSPPFKLRITWLEPKPDEEGEINWVDEGLPVSCGKFRVGKSETTDDLNMFSHLVSWEKGGRRSYRIYPRKGEVWALYKNWSPDWSSDPDEHRKYEYDIVEVLSDYSEEAGVSVAPLVKVKGFKSVFKRHEDEGSKAIFTIPKEELLRFSHQVPSFRLTGEE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	210 (206)
Sequences:	793 (486)
Seq/√Len:	33.8
META:	0.064

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
174_V	206_L	7.052	1.00
137_P	140_H	4.400	1.00
13_D	16_K	3.912	1.00
147_I	201_V	3.469	1.00
129_W	133_W	3.264	1.00
127_K	146_D	3.084	1.00
137_P	141_R	2.701	1.00
170_G	173_S	2.519	1.00
136_D	140_H	2.517	1.00
149_E	177_R	2.502	1.00
10_D	80_V	2.468	1.00
64_K	201_V	2.434	1.00
108_G	111_R	2.335	0.99
6_V	97_N	2.294	0.99
30_A	101_H	2.291	0.99
23_F	99_F	2.287	0.99
128_N	144_E	2.284	0.99
138_D	141_R	2.207	0.99
73_W	195_L	2.138	0.99
118_R	153_D	2.129	0.99
193_E	196_R	2.003	0.98
152_S	161_S	1.988	0.98
26_G	58_I	1.896	0.97
14_F	18_R	1.892	0.97
156_E	160_V	1.859	0.97
129_W	195_L	1.850	0.97
60_W	122_V	1.811	0.96
33_D	40_R	1.798	0.96
62_E	99_F	1.793	0.96
149_E	205_R	1.784	0.96
55_K	192_E	1.748	0.95
180_D	184_K	1.728	0.95
77_G	167_K	1.718	0.95
118_R	205_R	1.704	0.95
167_K	170_G	1.673	0.94
190_P	196_R	1.605	0.93
46_R	90_S	1.598	0.93
12_H	163_A	1.596	0.93
8_D	11_F	1.581	0.92
130_S	134_S	1.553	0.92
115_I	192_E	1.541	0.91
36_D	113_Y	1.470	0.89
33_D	38_M	1.461	0.89
88_G	119_K	1.442	0.88
93_T	96_L	1.430	0.88
68_E	89_K	1.401	0.87
73_W	129_W	1.377	0.86
130_S	193_E	1.362	0.85
5_E	47_K	1.343	0.84
65_P	131_P	1.319	0.83
25_V	31_L	1.316	0.83
168_V	175_F	1.306	0.83
61_L	85_F	1.303	0.82
28_I	112_S	1.299	0.82
159_G	164_P	1.263	0.80
135_S	140_H	1.253	0.80
55_K	196_R	1.252	0.80
106_E	114_R	1.231	0.79
67_E	70_E	1.218	0.78
36_D	146_D	1.217	0.78
25_V	56_L	1.210	0.77
167_K	175_F	1.198	0.77
31_L	56_L	1.197	0.77
164_P	205_R	1.186	0.76
48_V	167_K	1.186	0.76
122_V	137_P	1.171	0.75
58_I	209_E	1.169	0.75
43_A	60_W	1.146	0.73
103_V	200_Q	1.140	0.73
23_F	54_F	1.127	0.72
113_Y	119_K	1.123	0.72
119_K	125_L	1.122	0.72
122_V	203_S	1.121	0.72
38_M	54_F	1.116	0.71
154_Y	159_G	1.114	0.71
19_S	127_K	1.111	0.71
54_F	196_R	1.104	0.71
56_L	155_S	1.104	0.71
71_I	207_T	1.100	0.70
16_K	22_S	1.098	0.70
21_E	26_G	1.075	0.69
73_W	133_W	1.071	0.68
12_H	20_E	1.070	0.68
166_V	178_H	1.057	0.67
20_E	54_F	1.053	0.67
155_S	158_A	1.047	0.66
81_S	154_Y	1.039	0.66
8_D	41_Y	1.038	0.66
102_L	122_V	1.031	0.65
150_V	163_A	1.029	0.65
104_S	122_V	1.024	0.65
41_Y	63_P	1.011	0.64
56_L	207_T	1.009	0.64
135_S	139_E	1.005	0.63
163_A	196_R	1.000	0.63
9_P	15_D	0.998	0.63
35_D	103_V	0.987	0.62
44_R	58_I	0.983	0.61
29_W	83_G	0.982	0.61
161_S	188_T	0.981	0.61
162_V	197_F	0.981	0.61
43_A	57_R	0.978	0.61
6_V	15_D	0.976	0.61
20_E	97_N	0.974	0.61
26_G	92_T	0.965	0.60
54_F	99_F	0.958	0.59
24_A	121_E	0.957	0.59
12_H	22_S	0.938	0.58
30_A	58_I	0.935	0.58
74_V	128_N	0.923	0.57
3_S	6_V	0.920	0.56
34_D	41_Y	0.919	0.56
43_A	190_P	0.918	0.56
40_R	99_F	0.916	0.56
178_H	203_S	0.916	0.56
26_G	143_Y	0.914	0.56
121_E	200_Q	0.914	0.56
150_V	164_P	0.914	0.56
102_L	206_L	0.910	0.56
48_V	156_E	0.896	0.54
15_D	71_I	0.893	0.54
15_D	145_Y	0.884	0.53
171_F	174_V	0.884	0.53
25_V	121_E	0.877	0.53
125_L	146_D	0.875	0.53
125_L	171_F	0.874	0.52
134_S	160_V	0.871	0.52
11_F	60_W	0.866	0.52
170_G	175_F	0.866	0.52
117_P	123_W	0.865	0.52
72_N	75_D	0.861	0.51
34_D	37_G	0.858	0.51
11_F	171_F	0.858	0.51
31_L	99_F	0.855	0.51
31_L	102_L	0.853	0.51
170_G	174_V	0.851	0.51
44_R	111_R	0.845	0.50
146_D	160_V	0.837	0.49
150_V	162_V	0.827	0.49
188_T	207_T	0.825	0.48
87_V	115_I	0.824	0.48
163_A	166_V	0.824	0.48
12_H	17_D	0.822	0.48
63_P	77_G	0.822	0.48
147_I	157_E	0.817	0.48
178_H	187_F	0.812	0.47
65_P	79_P	0.810	0.47
46_R	59_T	0.808	0.47
89_K	95_D	0.807	0.47
45_I	179_E	0.805	0.47
25_V	59_T	0.805	0.47
28_I	87_V	0.805	0.47
79_P	84_K	0.804	0.47
105_W	108_G	0.799	0.46
18_R	165_L	0.797	0.46
64_K	109_G	0.795	0.46
168_V	176_K	0.792	0.46
84_K	87_V	0.787	0.45
41_Y	60_W	0.784	0.45
52_P	201_V	0.777	0.44
4_I	55_K	0.775	0.44
23_F	56_L	0.775	0.44
24_A	81_S	0.774	0.44
28_I	113_Y	0.769	0.44
27_Q	149_E	0.767	0.44
47_K	207_T	0.765	0.43
139_E	179_E	0.760	0.43
3_S	158_A	0.758	0.43
121_E	150_V	0.757	0.43
12_H	206_L	0.756	0.43
157_E	201_V	0.748	0.42
45_I	96_L	0.743	0.42
95_D	169_K	0.741	0.41
146_D	150_V	0.737	0.41
127_K	189_I	0.736	0.41
57_R	102_L	0.735	0.41
136_D	195_L	0.732	0.41
81_S	192_E	0.731	0.41
132_D	136_D	0.729	0.40
19_S	200_Q	0.728	0.40
181_E	185_A	0.728	0.40
10_D	97_N	0.726	0.40
63_P	113_Y	0.722	0.40
52_P	72_N	0.720	0.40
23_F	39_P	0.715	0.39
118_R	152_S	0.712	0.39
21_E	113_Y	0.710	0.39
125_L	206_L	0.709	0.39
48_V	57_R	0.707	0.39
56_L	114_R	0.706	0.39
42_Y	162_V	0.706	0.39
119_K	153_D	0.699	0.38
53_P	184_K	0.699	0.38
57_R	150_V	0.697	0.38
45_I	151_L	0.696	0.38
13_D	191_K	0.691	0.37
9_P	45_I	0.691	0.37
118_R	176_K	0.691	0.37
160_V	163_A	0.691	0.37
18_R	172_K	0.686	0.37
106_E	110_R	0.686	0.37
110_R	145_Y	0.684	0.37
11_F	15_D	0.681	0.37
55_K	94_D	0.678	0.36
122_V	143_Y	0.678	0.36
146_D	196_R	0.676	0.36
74_V	195_L	0.674	0.36
125_L	162_V	0.674	0.36
158_A	201_V	0.670	0.36
63_P	145_Y	0.670	0.36
128_N	190_P	0.669	0.36
136_D	141_R	0.668	0.36
168_V	194_L	0.667	0.35
61_L	145_Y	0.666	0.35
22_S	118_R	0.662	0.35
168_V	172_K	0.661	0.35
97_N	173_S	0.655	0.35
73_W	131_P	0.652	0.34
54_F	58_I	0.649	0.34
41_Y	93_T	0.649	0.34
16_K	175_F	0.643	0.34
71_I	111_R	0.641	0.33
94_D	104_S	0.640	0.33
82_C	85_F	0.639	0.33
4_I	109_G	0.638	0.33
72_N	113_Y	0.636	0.33
43_A	88_G	0.635	0.33
19_S	22_S	0.632	0.33
73_W	147_I	0.630	0.33
38_M	172_K	0.629	0.33
74_V	111_R	0.629	0.33
189_I	197_F	0.629	0.33
70_E	78_L	0.629	0.33
133_W	167_K	0.627	0.32
113_Y	181_E	0.625	0.32
118_R	179_E	0.624	0.32
82_C	115_I	0.620	0.32
102_L	139_E	0.619	0.32
10_D	23_F	0.614	0.31
10_D	204_F	0.614	0.31
15_D	20_E	0.614	0.31
99_F	128_N	0.609	0.31
93_T	155_S	0.607	0.31
180_D	186_I	0.607	0.31
26_G	177_R	0.603	0.31
135_S	138_D	0.602	0.31
41_Y	62_E	0.602	0.31
149_E	162_V	0.601	0.31
132_D	186_I	0.601	0.31
159_G	168_V	0.600	0.30
15_D	34_D	0.598	0.30
71_I	103_V	0.597	0.30
64_K	105_W	0.597	0.30
191_K	200_Q	0.597	0.30
41_Y	98_M	0.596	0.30
48_V	69_G	0.592	0.30
90_S	140_H	0.589	0.30
21_E	112_S	0.589	0.30
52_P	125_L	0.589	0.30
11_F	14_F	0.588	0.30
4_I	8_D	0.585	0.29
109_G	189_I	0.584	0.29
49_I	57_R	0.580	0.29
59_T	149_E	0.578	0.29
34_D	147_I	0.576	0.29
86_R	155_S	0.574	0.29
21_E	96_L	0.574	0.29
148_V	162_V	0.573	0.29
33_D	37_G	0.572	0.29
8_D	202_P	0.572	0.29
22_S	74_V	0.569	0.28
81_S	197_F	0.566	0.28
159_G	167_K	0.566	0.28
135_S	141_R	0.565	0.28
70_E	133_W	0.551	0.27
4_I	7_P	0.545	0.27
3_S	7_P	0.545	0.27
47_K	79_P	0.541	0.26
30_A	199_H	0.541	0.26
43_A	130_S	0.539	0.26
180_D	189_I	0.538	0.26
27_Q	83_G	0.536	0.26
32_Y	101_H	0.534	0.26
41_Y	146_D	0.531	0.26
37_G	201_V	0.530	0.26
6_V	16_K	0.528	0.26
4_I	185_A	0.527	0.26
54_F	146_D	0.524	0.25
51_S	94_D	0.522	0.25
31_L	34_D	0.521	0.25
12_H	19_S	0.520	0.25
7_P	109_G	0.520	0.25
111_R	172_K	0.519	0.25
113_Y	137_P	0.518	0.25
62_E	169_K	0.518	0.25
100_S	165_L	0.517	0.25
74_V	133_W	0.516	0.25
105_W	115_I	0.515	0.25
66_D	69_G	0.510	0.24
31_L	60_W	0.510	0.24
82_C	90_S	0.510	0.24
3_S	26_G	0.509	0.24
136_D	139_E	0.507	0.24
45_I	125_L	0.505	0.24
7_P	129_W	0.505	0.24
155_S	159_G	0.504	0.24
75_D	112_S	0.501	0.24
48_V	114_R	0.501	0.24
91_E	188_T	0.500	0.24

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1s4cA	2	0.2714	7.8	0.97	Contact Map
2mh8A	1	0.2667	5.8	0.972	Contact Map
3h8zA	1	0.3238	5.3	0.972	Contact Map
2mk5A	1	0.2857	4.6	0.973	Contact Map
2ia1A	2	0.3095	3.8	0.974	Contact Map
1xc0A	1	0.1571	3.3	0.975	Contact Map
1t62A	2	0.4619	2.9	0.975	Contact Map
1r77A	1	0.2762	2.8	0.976	Contact Map
2y4xA	1	0.3524	2.5	0.976	Contact Map
3gk5A	1	0.3238	2.3	0.977	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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