GREMLIN Database
DUF3440 - Domain of unknown function (DUF3440)
PFAM: PF11922 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 182 (181)
Sequences: 676 (368)
Seq/√Len: 27.4
META: 0.885

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_H69_S5.2351.00
2_V6_Q4.4971.00
83_R87_L4.2031.00
28_D31_T3.8191.00
3_P6_Q3.2311.00
61_L64_G3.2291.00
61_L65_H3.1621.00
106_E132_R3.0681.00
61_L69_S3.0651.00
95_K99_E3.0261.00
18_K45_G2.8161.00
28_D35_L2.7441.00
178_E181_E2.6500.99
177_K181_E2.5120.99
110_Q114_E2.2790.98
140_P153_S2.2580.98
68_K72_K2.2480.98
64_G69_S2.1760.98
72_K76_D2.1120.97
80_E84_E1.9800.96
68_K154_W1.9650.96
17_A20_S1.9100.95
139_Y152_P1.8790.94
42_A46_A1.8470.94
14_N17_A1.8170.93
22_N50_G1.7840.93
52_K162_L1.7400.92
28_D167_T1.7270.91
71_T154_W1.6810.90
2_V23_L1.6590.90
56_Y163_K1.6110.88
111_E147_S1.6100.88
84_E88_K1.5480.86
98_R138_E1.5280.85
85_N166_H1.5250.85
147_S150_D1.5050.85
71_T90_F1.4900.84
109_I134_V1.4670.83
113_E119_I1.4480.82
121_V132_R1.4310.81
71_T158_C1.4300.81
105_S130_D1.3990.80
72_K154_W1.3750.79
26_V46_A1.3640.78
110_Q113_E1.3310.76
10_A17_A1.3160.75
76_D113_E1.3150.75
31_T35_L1.3150.75
103_G133_P1.3040.75
68_K91_N1.2970.74
55_G70_Y1.2780.73
128_K131_K1.2710.73
148_F171_M1.2700.73
25_R47_I1.2490.72
157_M160_C1.2430.71
115_A143_L1.2410.71
92_T103_G1.2220.70
104_L109_I1.2160.69
93_S102_G1.2160.69
133_P136_M1.1950.68
70_Y178_E1.1830.67
121_V134_V1.1760.67
46_A52_K1.1750.67
61_L66_T1.1670.66
7_M14_N1.1430.65
51_T55_G1.1310.64
111_E146_K1.1220.63
154_W157_M1.1210.63
111_E145_I1.1110.62
111_E150_D1.1010.62
103_G109_I1.0860.61
112_L117_I1.0850.60
56_Y162_L1.0720.59
174_S180_Q1.0490.58
54_M162_L1.0450.58
14_N18_K1.0440.57
11_S14_N1.0430.57
99_E138_E1.0420.57
63_E69_S1.0350.57
156_R168_C1.0100.55
40_N82_T1.0070.55
14_N20_S1.0010.54
154_W179_Q0.9920.54
142_D148_F0.9870.53
122_N135_R0.9850.53
149_K160_C0.9740.52
11_S17_A0.9720.52
90_F140_P0.9650.51
102_G173_F0.9630.51
30_E138_E0.9620.51
50_G56_Y0.9530.51
42_A45_G0.9510.50
34_K40_N0.9440.50
124_K132_R0.9410.50
2_V7_M0.9120.47
10_A13_F0.9120.47
160_C171_M0.9060.47
104_L112_L0.8980.46
52_K60_K0.8910.46
36_V47_I0.8880.46
27_I134_V0.8860.46
108_T151_I0.8830.45
22_N30_E0.8820.45
160_C167_T0.8700.44
96_F104_L0.8670.44
176_T179_Q0.8600.44
38_R41_G0.8530.43
126_N129_T0.8530.43
70_Y163_K0.8480.43
51_T57_R0.8460.43
16_E70_Y0.8460.43
108_T111_E0.8440.42
143_L153_S0.8350.42
167_T175_L0.8300.41
27_I83_R0.8220.41
160_C166_H0.8210.41
90_F157_M0.8200.41
122_N133_P0.8190.41
113_E121_V0.8190.41
9_V24_Y0.8160.40
109_I115_A0.8060.40
125_T150_D0.8040.39
86_Y173_F0.8010.39
16_E45_G0.8000.39
58_S110_Q0.7990.39
160_C170_Y0.7940.39
11_S18_K0.7890.38
123_G132_R0.7870.38
94_I139_Y0.7830.38
126_N130_D0.7820.38
46_A54_M0.7760.37
30_E34_K0.7720.37
1_G8_R0.7710.37
121_V124_K0.7620.36
106_E110_Q0.7610.36
125_T160_C0.7600.36
7_M111_E0.7510.36
76_D80_E0.7510.36
86_Y156_R0.7500.36
120_E135_R0.7380.35
86_Y102_G0.7370.35
46_A162_L0.7370.35
111_E143_L0.7370.35
112_L129_T0.7340.35
111_E140_P0.7240.34
133_P158_C0.7230.34
75_L156_R0.7170.33
40_N159_I0.7160.33
144_D169_K0.7150.33
96_F126_N0.7150.33
22_N94_I0.7130.33
168_C171_M0.7130.33
169_K174_S0.7080.33
3_P87_L0.7060.33
26_V110_Q0.7060.33
102_G139_Y0.7050.33
78_L161_I0.7030.32
72_K99_E0.7010.32
93_S172_G0.6970.32
63_E95_K0.6970.32
113_E116_G0.6960.32
86_Y93_S0.6950.32
72_K87_L0.6920.32
119_I125_T0.6870.31
98_R137_K0.6850.31
148_F170_Y0.6830.31
105_S108_T0.6770.31
75_L86_Y0.6720.30
26_V33_G0.6720.30
13_F35_L0.6670.30
34_K118_K0.6640.30
80_E109_I0.6600.30
4_I120_E0.6580.29
159_I170_Y0.6570.29
103_G139_Y0.6550.29
114_E119_I0.6540.29
90_F136_M0.6530.29
85_N160_C0.6500.29
10_A14_N0.6480.29
33_G40_N0.6470.29
107_E110_Q0.6440.29
115_A119_I0.6410.28
122_N125_T0.6390.28
52_K153_S0.6390.28
111_E115_A0.6370.28
55_G139_Y0.6360.28
125_T174_S0.6360.28
24_Y170_Y0.6340.28
2_V20_S0.6340.28
157_M168_C0.6250.27
46_A56_Y0.6240.27
166_H169_K0.6220.27
28_D58_S0.6180.27
107_E124_K0.6150.27
12_P24_Y0.6100.27
15_D37_G0.6100.27
93_S156_R0.6090.26
95_K118_K0.6080.26
98_R136_M0.6060.26
2_V31_T0.6010.26
173_F177_K0.6010.26
52_K99_E0.6000.26
29_P63_E0.5990.26
31_T47_I0.5980.26
76_D104_L0.5930.26
13_F21_L0.5930.26
42_A90_F0.5910.25
16_E19_S0.5900.25
65_H167_T0.5860.25
114_E174_S0.5830.25
125_T167_T0.5810.25
9_V13_F0.5680.24
91_N99_E0.5630.24
8_R12_P0.5620.24
86_Y157_M0.5620.24
121_V125_T0.5600.24
129_T133_P0.5600.24
46_A58_S0.5600.24
32_W39_V0.5600.24
76_D118_K0.5580.24
156_R173_F0.5570.24
94_I119_I0.5550.23
35_L92_T0.5550.23
10_A49_G0.5550.23
10_A24_Y0.5540.23
109_I132_R0.5530.23
49_G73_F0.5530.23
107_E113_E0.5520.23
118_K123_G0.5510.23
11_S24_Y0.5500.23
40_N171_M0.5490.23
47_I52_K0.5480.23
52_K70_Y0.5480.23
124_K174_S0.5480.23
80_E169_K0.5460.23
76_D83_R0.5460.23
73_F77_T0.5450.23
87_L92_T0.5440.23
56_Y90_F0.5410.23
93_S155_K0.5410.23
78_L112_L0.5380.23
86_Y89_K0.5360.22
72_K91_N0.5320.22
36_V70_Y0.5310.22
103_G166_H0.5310.22
89_K169_K0.5310.22
37_G49_G0.5310.22
83_R145_I0.5300.22
139_Y154_W0.5270.22
95_K135_R0.5260.22
81_E85_N0.5250.22
53_A70_Y0.5200.22
88_K178_E0.5200.22
119_I126_N0.5190.22
5_D57_R0.5190.22
167_T179_Q0.5170.21
13_F17_A0.5160.21
88_K118_K0.5140.21
15_D20_S0.5120.21
50_G163_K0.5120.21
42_A52_K0.5110.21
34_K69_S0.5090.21
120_E145_I0.5080.21
92_T169_K0.5060.21
96_F125_T0.5050.21
11_S16_E0.5040.21
54_M179_Q0.5030.21
25_R58_S0.5020.21
24_Y93_S0.5020.21
1_G7_M0.5020.21
81_E114_E0.5010.21
69_S72_K0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xo0A 3 0.6593 21 0.964 Contact Map
4n4uA 1 0.8352 9.2 0.97 Contact Map
4nx1A 1 0.7637 9.1 0.97 Contact Map
4bolA 2 0.7967 8.4 0.97 Contact Map
4pf6A 1 0.8022 8.4 0.97 Contact Map
3iwfA 2 0.2582 7.9 0.97 Contact Map
2pfyA 1 0.7912 7.1 0.971 Contact Map
2pfzA 1 0.7967 6.6 0.972 Contact Map
1ujsA 1 0.3901 6.4 0.972 Contact Map
4bxjA 4 0.8187 6.4 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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