DUF3438 - PFAM28P - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

DUF3438 - Protein of unknown function (DUF3438)

PFAM:	PF11920	Sequences: WLLLLLLLLSAAAQAVEILRWERLPLAVPLPVGQERIVFFDRNVRVGVPASLGGKLRVQSAGGAVYLRASEPFEPTRLQLQDVDSGEIILLDIAATPAKAGQPPLEPVRIVEGGEVSPARYGDQAAVAGSDSSAASSTPAAEDAAAAPAPRRETPVPVVLTRYAAQSLYAPLRTVEPVPGIRRVPLRRPLPLTTLLPGLPVEATPLAAWRLGDLYVTAVKLTNTSARPVTLDPRALQGDFLAATFQHPRLGPAGTPEDTTVVYLVTRGRPLAEALLPEPSPIDA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	284 (267)
Sequences:	580 (414)
Seq/√Len:	25.3
META:	0.516

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
178_V	181_I	5.667	1.00
246_Q	263_Y	5.376	1.00
45_R	81_Q	4.956	1.00
19_L	26_L	4.504	1.00
161_T	244_T	4.070	1.00
203_A	221_L	3.934	1.00
254_G	258_D	3.547	1.00
203_A	219_V	3.332	1.00
165_A	263_Y	2.934	1.00
44_V	65_V	2.929	1.00
58_V	67_L	2.710	0.99
251_G	257_E	2.598	0.99
73_F	93_I	2.561	0.99
60_S	63_G	2.494	0.99
55_K	71_E	2.476	0.99
219_V	262_V	2.182	0.97
42_R	82_D	2.035	0.96
46_V	65_V	2.010	0.95
165_A	246_Q	1.974	0.95
233_P	245_F	1.974	0.95
223_N	227_R	1.937	0.94
7_L	11_A	1.911	0.94
247_H	263_Y	1.876	0.93
216_V	265_V	1.873	0.93
202_E	222_T	1.779	0.91
56_L	67_L	1.763	0.91
215_Y	269_R	1.758	0.91
121_Y	153_E	1.747	0.90
89_I	237_Q	1.717	0.89
6_L	11_A	1.661	0.88
201_V	250_L	1.633	0.87
82_D	89_I	1.624	0.87
186_L	263_Y	1.623	0.87
47_G	245_F	1.615	0.86
210_R	215_Y	1.614	0.86
31_P	105_L	1.608	0.86
184_V	224_T	1.600	0.86
23_R	64_A	1.595	0.86
210_R	213_D	1.569	0.85
254_G	259_T	1.550	0.84
32_V	95_A	1.547	0.84
269_R	274_A	1.546	0.84
236_L	243_A	1.525	0.83
47_G	57_R	1.518	0.83
35_E	77_R	1.512	0.82
73_F	270_P	1.502	0.82
21_W	26_L	1.501	0.82
183_R	207_A	1.485	0.81
91_L	236_L	1.477	0.81
77_R	92_D	1.475	0.81
31_P	34_Q	1.472	0.81
66_Y	170_A	1.465	0.80
78_L	93_I	1.442	0.79
40_F	89_I	1.440	0.79
190_L	205_P	1.407	0.77
94_A	270_P	1.401	0.77
65_V	114_G	1.397	0.77
57_R	92_D	1.397	0.77
269_R	273_E	1.396	0.77
231_L	245_F	1.386	0.76
204_T	220_K	1.384	0.76
59_Q	231_L	1.381	0.76
17_E	36_R	1.359	0.75
234_R	245_F	1.332	0.73
257_E	262_V	1.330	0.73
5_L	12_A	1.325	0.73
157_P	241_L	1.317	0.72
34_Q	105_L	1.308	0.72
193_T	278_E	1.299	0.71
186_L	246_Q	1.290	0.71
273_E	279_P	1.290	0.71
214_L	241_L	1.277	0.70
40_F	80_L	1.277	0.70
42_R	85_S	1.275	0.70
24_L	37_I	1.265	0.69
271_L	275_L	1.264	0.69
217_T	275_L	1.258	0.69
249_R	278_E	1.255	0.69
25_P	30_L	1.255	0.69
56_L	90_L	1.250	0.68
35_E	92_D	1.246	0.68
32_V	72_P	1.244	0.68
215_Y	270_P	1.241	0.68
3_L	6_L	1.235	0.67
196_L	203_A	1.234	0.67
8_L	13_A	1.224	0.67
10_S	13_A	1.212	0.66
4_L	7_L	1.210	0.66
231_L	234_R	1.205	0.66
47_G	81_Q	1.204	0.65
88_I	91_L	1.201	0.65
72_P	104_P	1.193	0.65
268_G	272_A	1.188	0.64
44_V	208_A	1.187	0.64
49_P	209_W	1.183	0.64
38_V	44_V	1.179	0.64
163_Y	271_L	1.179	0.64
193_T	219_V	1.173	0.63
271_L	274_A	1.166	0.63
62_G	216_V	1.155	0.62
38_V	235_A	1.146	0.62
170_A	195_L	1.136	0.61
230_T	248_P	1.130	0.60
197_P	237_Q	1.125	0.60
209_W	238_G	1.122	0.60
92_D	247_H	1.117	0.60
114_G	221_L	1.116	0.59
30_L	57_R	1.112	0.59
168_L	261_V	1.099	0.58
232_D	245_F	1.089	0.58
167_S	175_V	1.080	0.57
170_A	174_T	1.075	0.57
6_L	13_A	1.070	0.56
170_A	210_R	1.069	0.56
56_L	59_Q	1.063	0.56
21_W	233_P	1.061	0.56
170_A	221_L	1.053	0.55
67_L	89_I	1.050	0.55
92_D	231_L	1.039	0.54
10_S	16_V	1.038	0.54
165_A	259_T	1.035	0.54
201_V	221_L	1.035	0.54
78_L	176_E	1.035	0.54
28_V	108_V	1.032	0.53
170_A	246_Q	1.031	0.53
59_Q	68_R	1.028	0.53
207_A	218_A	1.027	0.53
45_R	60_S	1.024	0.53
61_A	90_L	1.021	0.53
43_N	62_G	1.014	0.52
150_P	214_L	1.009	0.52
225_S	263_Y	1.008	0.52
161_T	263_Y	1.007	0.52
3_L	7_L	1.007	0.52
200_P	229_V	1.004	0.51
26_L	89_I	1.002	0.51
188_R	221_L	0.999	0.51
66_Y	195_L	0.989	0.50
48_V	53_G	0.984	0.50
92_D	209_W	0.978	0.49
6_L	9_L	0.977	0.49
48_V	189_P	0.973	0.49
23_R	259_T	0.969	0.49
4_L	72_P	0.967	0.49
8_L	12_A	0.966	0.49
237_Q	240_F	0.964	0.48
40_F	44_V	0.962	0.48
258_D	264_L	0.956	0.48
47_G	86_G	0.954	0.48
59_Q	208_A	0.953	0.48
39_F	64_A	0.948	0.47
267_R	270_P	0.944	0.47
221_L	262_V	0.942	0.47
3_L	8_L	0.942	0.47
162_R	166_Q	0.938	0.47
42_R	61_A	0.938	0.47
6_L	10_S	0.937	0.46
84_D	208_A	0.930	0.46
13_A	184_V	0.924	0.46
25_P	247_H	0.913	0.45
82_D	85_S	0.913	0.45
84_D	214_L	0.913	0.45
248_P	255_T	0.910	0.45
167_S	237_Q	0.909	0.44
75_P	105_L	0.906	0.44
168_L	218_A	0.905	0.44
73_F	95_A	0.902	0.44
29_P	108_V	0.898	0.44
38_V	220_K	0.898	0.44
26_L	62_G	0.892	0.43
167_S	183_R	0.888	0.43
175_V	210_R	0.886	0.43
145_A	279_P	0.885	0.43
110_I	113_G	0.885	0.43
23_R	41_D	0.884	0.43
84_D	279_P	0.884	0.43
17_E	158_V	0.868	0.42
143_D	146_A	0.867	0.41
246_Q	264_L	0.865	0.41
109_R	252_P	0.862	0.41
32_V	57_R	0.858	0.41
272_A	275_L	0.852	0.40
46_V	245_F	0.849	0.40
88_I	222_T	0.846	0.40
122_G	262_V	0.845	0.40
90_L	165_A	0.832	0.39
233_P	238_G	0.832	0.39
258_D	263_Y	0.830	0.39
256_P	274_A	0.830	0.39
145_A	148_P	0.826	0.39
7_L	12_A	0.823	0.38
207_A	233_P	0.821	0.38
47_G	166_Q	0.820	0.38
257_E	273_E	0.819	0.38
90_L	245_F	0.819	0.38
82_D	109_R	0.814	0.38
209_W	218_A	0.812	0.38
31_P	99_K	0.812	0.38
75_P	94_A	0.809	0.37
95_A	209_W	0.809	0.37
28_V	62_G	0.806	0.37
164_A	216_V	0.802	0.37
160_L	164_A	0.800	0.37
66_Y	209_W	0.798	0.37
70_S	233_P	0.798	0.37
41_D	241_L	0.795	0.36
96_T	186_L	0.794	0.36
41_D	64_A	0.789	0.36
178_V	244_T	0.789	0.36
60_S	243_A	0.786	0.36
38_V	150_P	0.785	0.36
105_L	267_R	0.785	0.36
170_A	247_H	0.785	0.36
170_A	242_A	0.780	0.35
32_V	49_P	0.778	0.35
240_F	266_T	0.778	0.35
120_R	153_E	0.778	0.35
40_F	174_T	0.777	0.35
59_Q	166_Q	0.769	0.35
49_P	95_A	0.766	0.35
165_A	247_H	0.765	0.34
69_A	105_L	0.764	0.34
63_G	234_R	0.761	0.34
89_I	157_P	0.760	0.34
231_L	236_L	0.759	0.34
85_S	112_E	0.757	0.34
33_G	96_T	0.757	0.34
110_I	201_V	0.757	0.34
120_R	274_A	0.752	0.34
251_G	255_T	0.751	0.34
224_T	253_A	0.751	0.34
89_I	112_E	0.750	0.33
63_G	236_L	0.749	0.33
26_L	172_L	0.747	0.33
163_Y	251_G	0.743	0.33
45_R	166_Q	0.742	0.33
26_L	56_L	0.737	0.33
38_V	193_T	0.733	0.32
57_R	68_R	0.727	0.32
114_G	122_G	0.724	0.32
107_P	110_I	0.723	0.32
169_Y	231_L	0.723	0.32
21_W	221_L	0.722	0.32
88_I	261_V	0.721	0.32
271_L	277_P	0.717	0.31
33_G	74_E	0.712	0.31
46_V	162_R	0.711	0.31
179_P	228_P	0.711	0.31
246_Q	260_T	0.711	0.31
67_L	78_L	0.710	0.31
5_L	14_Q	0.709	0.31
72_P	97_P	0.708	0.31
119_A	146_A	0.703	0.31
7_L	273_E	0.702	0.30
29_P	75_P	0.700	0.30
59_Q	246_Q	0.699	0.30
220_K	259_T	0.699	0.30
154_T	215_Y	0.696	0.30
37_I	45_R	0.695	0.30
266_T	271_L	0.691	0.30
221_L	250_L	0.690	0.30
57_R	162_R	0.690	0.30
55_K	222_T	0.689	0.30
158_V	162_R	0.686	0.29
43_N	83_V	0.686	0.29
98_A	229_V	0.685	0.29
6_L	12_A	0.683	0.29
47_G	233_P	0.680	0.29
55_K	78_L	0.678	0.29
30_L	69_A	0.676	0.29
135_A	150_P	0.676	0.29
85_S	185_P	0.675	0.29
48_V	91_L	0.674	0.29
188_R	205_P	0.670	0.29
58_V	91_L	0.668	0.28
157_P	197_P	0.666	0.28
5_L	131_D	0.665	0.28
139_P	150_P	0.664	0.28
40_F	266_T	0.661	0.28
196_L	206_L	0.660	0.28
93_I	121_Y	0.657	0.28
3_L	11_A	0.655	0.28
25_P	243_A	0.654	0.28
257_E	278_E	0.652	0.27
58_V	178_V	0.651	0.27
57_R	168_L	0.649	0.27
47_G	64_A	0.646	0.27
190_L	272_A	0.646	0.27
19_L	28_V	0.645	0.27
181_I	244_T	0.643	0.27
21_W	66_Y	0.642	0.27
47_G	60_S	0.642	0.27
79_Q	184_V	0.640	0.27
83_V	206_L	0.637	0.27
274_A	278_E	0.636	0.27
21_W	234_R	0.631	0.26
19_L	210_R	0.631	0.26
86_G	195_L	0.628	0.26
47_G	68_R	0.626	0.26
189_P	252_P	0.625	0.26
23_R	44_V	0.625	0.26
244_T	264_L	0.619	0.26
72_P	122_G	0.618	0.26
91_L	109_R	0.617	0.25
205_P	279_P	0.617	0.25
52_L	157_P	0.617	0.25
38_V	108_V	0.614	0.25
6_L	14_Q	0.613	0.25
3_L	146_A	0.611	0.25
60_S	247_H	0.610	0.25
157_P	234_R	0.606	0.25
23_R	66_Y	0.605	0.25
18_I	271_L	0.605	0.25
117_S	143_D	0.603	0.25
12_A	262_V	0.603	0.25
48_V	275_L	0.603	0.25
68_R	276_L	0.600	0.25
219_V	264_L	0.599	0.24
170_A	261_V	0.596	0.24
59_Q	165_A	0.595	0.24
69_A	90_L	0.595	0.24
45_R	63_G	0.593	0.24
183_R	186_L	0.593	0.24
46_V	60_S	0.591	0.24
151_R	222_T	0.588	0.24
147_A	150_P	0.588	0.24
204_T	239_D	0.588	0.24
82_D	237_Q	0.587	0.24
168_L	246_Q	0.586	0.24
53_G	84_D	0.580	0.23
57_R	86_G	0.577	0.23
206_L	210_R	0.575	0.23
23_R	36_R	0.575	0.23
243_A	262_V	0.574	0.23
172_L	211_L	0.572	0.23
7_L	132_S	0.569	0.23
5_L	205_P	0.568	0.23
96_T	260_T	0.567	0.23
64_A	109_R	0.566	0.23
21_W	90_L	0.566	0.23
47_G	90_L	0.566	0.23
134_A	147_A	0.562	0.23
115_E	250_L	0.558	0.22
96_T	185_P	0.557	0.22
63_G	260_T	0.557	0.22
67_L	76_T	0.556	0.22
62_G	265_V	0.554	0.22
169_Y	218_A	0.553	0.22
50_A	214_L	0.551	0.22
246_Q	258_D	0.550	0.22
59_Q	262_V	0.549	0.22
54_G	214_L	0.549	0.22
37_I	64_A	0.549	0.22
174_T	266_T	0.548	0.22
104_P	109_R	0.546	0.22
245_F	263_Y	0.546	0.22
74_E	83_V	0.544	0.22
47_G	76_T	0.543	0.22
275_L	279_P	0.543	0.22
39_F	43_N	0.540	0.21
12_A	273_E	0.540	0.21
270_P	275_L	0.536	0.21
58_V	65_V	0.536	0.21
154_T	211_L	0.536	0.21
77_R	173_R	0.535	0.21
157_P	242_A	0.534	0.21
36_R	59_Q	0.533	0.21
174_T	250_L	0.532	0.21
130_S	143_D	0.531	0.21
47_G	165_A	0.531	0.21
139_P	146_A	0.530	0.21
218_A	238_G	0.530	0.21
22_E	206_L	0.530	0.21
65_V	181_I	0.530	0.21
91_L	110_I	0.527	0.21
54_G	68_R	0.527	0.21
182_R	210_R	0.525	0.21
52_L	221_L	0.525	0.21
85_S	184_V	0.524	0.21
65_V	242_A	0.524	0.21
205_P	240_F	0.524	0.21
243_A	264_L	0.524	0.21
179_P	252_P	0.522	0.21
175_V	232_D	0.521	0.21
155_P	197_P	0.520	0.20
133_S	147_A	0.520	0.20
204_T	208_A	0.517	0.20
3_L	34_Q	0.515	0.20
167_S	186_L	0.513	0.20
249_R	269_R	0.513	0.20
166_Q	176_E	0.513	0.20
37_I	104_P	0.511	0.20
41_D	157_P	0.510	0.20
59_Q	218_A	0.508	0.20
33_G	250_L	0.508	0.20
95_A	184_V	0.507	0.20
47_G	59_Q	0.506	0.20
113_G	214_L	0.505	0.20
262_V	268_G	0.503	0.20
82_D	231_L	0.500	0.20

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3zbjA	3	0.3873	20.8	0.965	Contact Map
4x23V	1	0.0775	4.2	0.974	Contact Map
2l66A	2	0.1796	2.8	0.977	Contact Map
3cjsB	1	0.1514	2.5	0.977	Contact Map
4jutA	4	0.2218	2.2	0.978	Contact Map
2lifA	1	0.0669	2.1	0.978	Contact Map
4hn1A	3	0.4789	2.1	0.978	Contact Map
4nyqA	1	0.2007	2	0.978	Contact Map
1wxmA	1	0.1549	2	0.978	Contact Map
3aabA	2	0.25	2	0.978	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0089 seconds.