GREMLIN Database
DUF3438 - Protein of unknown function (DUF3438)
PFAM: PF11920 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 284 (267)
Sequences: 580 (414)
Seq/√Len: 25.3
META: 0.516

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
178_V181_I5.6671.00
246_Q263_Y5.3761.00
45_R81_Q4.9561.00
19_L26_L4.5041.00
161_T244_T4.0701.00
203_A221_L3.9341.00
254_G258_D3.5471.00
203_A219_V3.3321.00
165_A263_Y2.9341.00
44_V65_V2.9291.00
58_V67_L2.7100.99
251_G257_E2.5980.99
73_F93_I2.5610.99
60_S63_G2.4940.99
55_K71_E2.4760.99
219_V262_V2.1820.97
42_R82_D2.0350.96
46_V65_V2.0100.95
165_A246_Q1.9740.95
233_P245_F1.9740.95
223_N227_R1.9370.94
7_L11_A1.9110.94
247_H263_Y1.8760.93
216_V265_V1.8730.93
202_E222_T1.7790.91
56_L67_L1.7630.91
215_Y269_R1.7580.91
121_Y153_E1.7470.90
89_I237_Q1.7170.89
6_L11_A1.6610.88
201_V250_L1.6330.87
82_D89_I1.6240.87
186_L263_Y1.6230.87
47_G245_F1.6150.86
210_R215_Y1.6140.86
31_P105_L1.6080.86
184_V224_T1.6000.86
23_R64_A1.5950.86
210_R213_D1.5690.85
254_G259_T1.5500.84
32_V95_A1.5470.84
269_R274_A1.5460.84
236_L243_A1.5250.83
47_G57_R1.5180.83
35_E77_R1.5120.82
73_F270_P1.5020.82
21_W26_L1.5010.82
183_R207_A1.4850.81
91_L236_L1.4770.81
77_R92_D1.4750.81
31_P34_Q1.4720.81
66_Y170_A1.4650.80
78_L93_I1.4420.79
40_F89_I1.4400.79
190_L205_P1.4070.77
94_A270_P1.4010.77
65_V114_G1.3970.77
57_R92_D1.3970.77
269_R273_E1.3960.77
231_L245_F1.3860.76
204_T220_K1.3840.76
59_Q231_L1.3810.76
17_E36_R1.3590.75
234_R245_F1.3320.73
257_E262_V1.3300.73
5_L12_A1.3250.73
157_P241_L1.3170.72
34_Q105_L1.3080.72
193_T278_E1.2990.71
186_L246_Q1.2900.71
273_E279_P1.2900.71
214_L241_L1.2770.70
40_F80_L1.2770.70
42_R85_S1.2750.70
24_L37_I1.2650.69
271_L275_L1.2640.69
217_T275_L1.2580.69
249_R278_E1.2550.69
25_P30_L1.2550.69
56_L90_L1.2500.68
35_E92_D1.2460.68
32_V72_P1.2440.68
215_Y270_P1.2410.68
3_L6_L1.2350.67
196_L203_A1.2340.67
8_L13_A1.2240.67
10_S13_A1.2120.66
4_L7_L1.2100.66
231_L234_R1.2050.66
47_G81_Q1.2040.65
88_I91_L1.2010.65
72_P104_P1.1930.65
268_G272_A1.1880.64
44_V208_A1.1870.64
49_P209_W1.1830.64
38_V44_V1.1790.64
163_Y271_L1.1790.64
193_T219_V1.1730.63
271_L274_A1.1660.63
62_G216_V1.1550.62
38_V235_A1.1460.62
170_A195_L1.1360.61
230_T248_P1.1300.60
197_P237_Q1.1250.60
209_W238_G1.1220.60
92_D247_H1.1170.60
114_G221_L1.1160.59
30_L57_R1.1120.59
168_L261_V1.0990.58
232_D245_F1.0890.58
167_S175_V1.0800.57
170_A174_T1.0750.57
6_L13_A1.0700.56
170_A210_R1.0690.56
56_L59_Q1.0630.56
21_W233_P1.0610.56
170_A221_L1.0530.55
67_L89_I1.0500.55
92_D231_L1.0390.54
10_S16_V1.0380.54
165_A259_T1.0350.54
201_V221_L1.0350.54
78_L176_E1.0350.54
28_V108_V1.0320.53
170_A246_Q1.0310.53
59_Q68_R1.0280.53
207_A218_A1.0270.53
45_R60_S1.0240.53
61_A90_L1.0210.53
43_N62_G1.0140.52
150_P214_L1.0090.52
225_S263_Y1.0080.52
161_T263_Y1.0070.52
3_L7_L1.0070.52
200_P229_V1.0040.51
26_L89_I1.0020.51
188_R221_L0.9990.51
66_Y195_L0.9890.50
48_V53_G0.9840.50
92_D209_W0.9780.49
6_L9_L0.9770.49
48_V189_P0.9730.49
23_R259_T0.9690.49
4_L72_P0.9670.49
8_L12_A0.9660.49
237_Q240_F0.9640.48
40_F44_V0.9620.48
258_D264_L0.9560.48
47_G86_G0.9540.48
59_Q208_A0.9530.48
39_F64_A0.9480.47
267_R270_P0.9440.47
221_L262_V0.9420.47
3_L8_L0.9420.47
162_R166_Q0.9380.47
42_R61_A0.9380.47
6_L10_S0.9370.46
84_D208_A0.9300.46
13_A184_V0.9240.46
25_P247_H0.9130.45
82_D85_S0.9130.45
84_D214_L0.9130.45
248_P255_T0.9100.45
167_S237_Q0.9090.44
75_P105_L0.9060.44
168_L218_A0.9050.44
73_F95_A0.9020.44
29_P108_V0.8980.44
38_V220_K0.8980.44
26_L62_G0.8920.43
167_S183_R0.8880.43
175_V210_R0.8860.43
145_A279_P0.8850.43
110_I113_G0.8850.43
23_R41_D0.8840.43
84_D279_P0.8840.43
17_E158_V0.8680.42
143_D146_A0.8670.41
246_Q264_L0.8650.41
109_R252_P0.8620.41
32_V57_R0.8580.41
272_A275_L0.8520.40
46_V245_F0.8490.40
88_I222_T0.8460.40
122_G262_V0.8450.40
90_L165_A0.8320.39
233_P238_G0.8320.39
258_D263_Y0.8300.39
256_P274_A0.8300.39
145_A148_P0.8260.39
7_L12_A0.8230.38
207_A233_P0.8210.38
47_G166_Q0.8200.38
257_E273_E0.8190.38
90_L245_F0.8190.38
82_D109_R0.8140.38
209_W218_A0.8120.38
31_P99_K0.8120.38
75_P94_A0.8090.37
95_A209_W0.8090.37
28_V62_G0.8060.37
164_A216_V0.8020.37
160_L164_A0.8000.37
66_Y209_W0.7980.37
70_S233_P0.7980.37
41_D241_L0.7950.36
96_T186_L0.7940.36
41_D64_A0.7890.36
178_V244_T0.7890.36
60_S243_A0.7860.36
38_V150_P0.7850.36
105_L267_R0.7850.36
170_A247_H0.7850.36
170_A242_A0.7800.35
32_V49_P0.7780.35
240_F266_T0.7780.35
120_R153_E0.7780.35
40_F174_T0.7770.35
59_Q166_Q0.7690.35
49_P95_A0.7660.35
165_A247_H0.7650.34
69_A105_L0.7640.34
63_G234_R0.7610.34
89_I157_P0.7600.34
231_L236_L0.7590.34
85_S112_E0.7570.34
33_G96_T0.7570.34
110_I201_V0.7570.34
120_R274_A0.7520.34
251_G255_T0.7510.34
224_T253_A0.7510.34
89_I112_E0.7500.33
63_G236_L0.7490.33
26_L172_L0.7470.33
163_Y251_G0.7430.33
45_R166_Q0.7420.33
26_L56_L0.7370.33
38_V193_T0.7330.32
57_R68_R0.7270.32
114_G122_G0.7240.32
107_P110_I0.7230.32
169_Y231_L0.7230.32
21_W221_L0.7220.32
88_I261_V0.7210.32
271_L277_P0.7170.31
33_G74_E0.7120.31
46_V162_R0.7110.31
179_P228_P0.7110.31
246_Q260_T0.7110.31
67_L78_L0.7100.31
5_L14_Q0.7090.31
72_P97_P0.7080.31
119_A146_A0.7030.31
7_L273_E0.7020.30
29_P75_P0.7000.30
59_Q246_Q0.6990.30
220_K259_T0.6990.30
154_T215_Y0.6960.30
37_I45_R0.6950.30
266_T271_L0.6910.30
221_L250_L0.6900.30
57_R162_R0.6900.30
55_K222_T0.6890.30
158_V162_R0.6860.29
43_N83_V0.6860.29
98_A229_V0.6850.29
6_L12_A0.6830.29
47_G233_P0.6800.29
55_K78_L0.6780.29
30_L69_A0.6760.29
135_A150_P0.6760.29
85_S185_P0.6750.29
48_V91_L0.6740.29
188_R205_P0.6700.29
58_V91_L0.6680.28
157_P197_P0.6660.28
5_L131_D0.6650.28
139_P150_P0.6640.28
40_F266_T0.6610.28
196_L206_L0.6600.28
93_I121_Y0.6570.28
3_L11_A0.6550.28
25_P243_A0.6540.28
257_E278_E0.6520.27
58_V178_V0.6510.27
57_R168_L0.6490.27
47_G64_A0.6460.27
190_L272_A0.6460.27
19_L28_V0.6450.27
181_I244_T0.6430.27
21_W66_Y0.6420.27
47_G60_S0.6420.27
79_Q184_V0.6400.27
83_V206_L0.6370.27
274_A278_E0.6360.27
21_W234_R0.6310.26
19_L210_R0.6310.26
86_G195_L0.6280.26
47_G68_R0.6260.26
189_P252_P0.6250.26
23_R44_V0.6250.26
244_T264_L0.6190.26
72_P122_G0.6180.26
91_L109_R0.6170.25
205_P279_P0.6170.25
52_L157_P0.6170.25
38_V108_V0.6140.25
6_L14_Q0.6130.25
3_L146_A0.6110.25
60_S247_H0.6100.25
157_P234_R0.6060.25
23_R66_Y0.6050.25
18_I271_L0.6050.25
117_S143_D0.6030.25
12_A262_V0.6030.25
48_V275_L0.6030.25
68_R276_L0.6000.25
219_V264_L0.5990.24
170_A261_V0.5960.24
59_Q165_A0.5950.24
69_A90_L0.5950.24
45_R63_G0.5930.24
183_R186_L0.5930.24
46_V60_S0.5910.24
151_R222_T0.5880.24
147_A150_P0.5880.24
204_T239_D0.5880.24
82_D237_Q0.5870.24
168_L246_Q0.5860.24
53_G84_D0.5800.23
57_R86_G0.5770.23
206_L210_R0.5750.23
23_R36_R0.5750.23
243_A262_V0.5740.23
172_L211_L0.5720.23
7_L132_S0.5690.23
5_L205_P0.5680.23
96_T260_T0.5670.23
64_A109_R0.5660.23
21_W90_L0.5660.23
47_G90_L0.5660.23
134_A147_A0.5620.23
115_E250_L0.5580.22
96_T185_P0.5570.22
63_G260_T0.5570.22
67_L76_T0.5560.22
62_G265_V0.5540.22
169_Y218_A0.5530.22
50_A214_L0.5510.22
246_Q258_D0.5500.22
59_Q262_V0.5490.22
54_G214_L0.5490.22
37_I64_A0.5490.22
174_T266_T0.5480.22
104_P109_R0.5460.22
245_F263_Y0.5460.22
74_E83_V0.5440.22
47_G76_T0.5430.22
275_L279_P0.5430.22
39_F43_N0.5400.21
12_A273_E0.5400.21
270_P275_L0.5360.21
58_V65_V0.5360.21
154_T211_L0.5360.21
77_R173_R0.5350.21
157_P242_A0.5340.21
36_R59_Q0.5330.21
174_T250_L0.5320.21
130_S143_D0.5310.21
47_G165_A0.5310.21
139_P146_A0.5300.21
218_A238_G0.5300.21
22_E206_L0.5300.21
65_V181_I0.5300.21
91_L110_I0.5270.21
54_G68_R0.5270.21
182_R210_R0.5250.21
52_L221_L0.5250.21
85_S184_V0.5240.21
65_V242_A0.5240.21
205_P240_F0.5240.21
243_A264_L0.5240.21
179_P252_P0.5220.21
175_V232_D0.5210.21
155_P197_P0.5200.20
133_S147_A0.5200.20
204_T208_A0.5170.20
3_L34_Q0.5150.20
167_S186_L0.5130.20
249_R269_R0.5130.20
166_Q176_E0.5130.20
37_I104_P0.5110.20
41_D157_P0.5100.20
59_Q218_A0.5080.20
33_G250_L0.5080.20
95_A184_V0.5070.20
47_G59_Q0.5060.20
113_G214_L0.5050.20
262_V268_G0.5030.20
82_D231_L0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zbjA 3 0.3873 20.8 0.965 Contact Map
4x23V 1 0.0775 4.2 0.974 Contact Map
2l66A 2 0.1796 2.8 0.977 Contact Map
3cjsB 1 0.1514 2.5 0.977 Contact Map
4jutA 4 0.2218 2.2 0.978 Contact Map
2lifA 1 0.0669 2.1 0.978 Contact Map
4hn1A 3 0.4789 2.1 0.978 Contact Map
4nyqA 1 0.2007 2 0.978 Contact Map
1wxmA 1 0.1549 2 0.978 Contact Map
3aabA 2 0.25 2 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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