GREMLIN Database
DUF3433 - Protein of unknown function (DUF3433)
PFAM: PF11915 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 88 (87)
Sequences: 2053 (1693)
Seq/√Len: 181.5
META: 0.478

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_Q33_Q3.7851.00
22_D26_R3.6901.00
25_V72_S2.7601.00
22_D72_S2.6691.00
33_Q66_H2.5701.00
39_A44_S2.5481.00
24_A27_R2.4291.00
61_A70_A2.3751.00
62_L70_A2.1041.00
49_Y66_H1.9031.00
43_R64_N1.7451.00
67_W70_A1.5831.00
11_A86_A1.5291.00
3_W11_A1.5031.00
41_A46_L1.5001.00
52_L60_K1.4901.00
41_A44_S1.4431.00
79_A82_L1.4331.00
49_Y69_V1.3861.00
34_L45_L1.3691.00
80_S84_I1.3691.00
41_A45_L1.3141.00
80_S86_A1.3141.00
22_D73_S1.2951.00
40_P43_R1.2891.00
29_Q66_H1.2861.00
33_Q43_R1.2821.00
61_A69_V1.2631.00
2_L6_L1.2271.00
29_Q32_A1.1821.00
83_T87_S1.1351.00
67_W71_L1.1341.00
16_L19_Q1.1301.00
58_L73_S1.1291.00
39_A43_R1.1231.00
53_L56_L1.1231.00
79_A84_I1.1131.00
17_L20_S1.0911.00
47_L66_H1.0671.00
31_F79_A1.0451.00
18_W72_S1.0431.00
3_W7_P1.0421.00
80_S83_T1.0341.00
81_L84_I1.0291.00
23_F50_L1.0190.99
49_Y64_N0.9880.99
59_F63_R0.9710.99
13_L17_L0.9700.99
15_A83_T0.9340.99
8_T20_S0.9320.99
25_V68_L0.9170.99
33_Q44_S0.9130.99
58_L61_A0.8900.99
15_A19_Q0.8890.99
56_L60_K0.8830.99
2_L7_P0.8780.98
20_S31_F0.8770.98
52_L56_L0.8750.98
5_Y12_V0.8590.98
23_F69_V0.8550.98
8_T11_A0.8530.98
37_G43_R0.8460.98
29_Q68_L0.8430.98
18_W75_A0.8410.98
13_L18_W0.8410.98
28_L82_L0.8270.98
1_F6_L0.8220.98
77_L80_S0.8210.98
72_S76_S0.8120.97
55_L58_L0.8080.97
26_R69_V0.7970.97
22_D69_V0.7960.97
35_S53_L0.7930.97
20_S24_A0.7860.97
14_L33_Q0.7820.97
9_L35_S0.7650.96
44_S47_L0.7590.96
55_L59_F0.7460.96
19_Q23_F0.7450.96
11_A83_T0.7420.96
28_L32_A0.7380.96
78_L85_L0.7250.95
17_L78_L0.7190.95
76_S80_S0.7170.95
23_F31_F0.6940.94
19_Q72_S0.6880.93
78_L82_L0.6800.93
64_N67_W0.6730.93
29_Q49_Y0.6650.92
76_S83_T0.6580.92
23_F27_R0.6390.91
10_L63_R0.6340.90
20_S83_T0.6320.90
32_A35_S0.6300.90
25_V69_V0.6180.89
19_Q57_V0.6130.89
57_V65_R0.6060.88
34_L75_A0.5970.88
2_L82_L0.5970.88
34_L77_L0.5950.87
67_W78_L0.5940.87
37_G41_A0.5920.87
29_Q73_S0.5920.87
69_V78_L0.5860.87
60_K63_R0.5700.85
16_L70_A0.5690.85
59_F62_L0.5630.84
16_L26_R0.5610.84
33_Q58_L0.5570.84
54_P58_L0.5550.84
8_T12_V0.5530.83
34_L38_G0.5520.83
26_R57_V0.5510.83
1_F4_T0.5450.82
6_L13_L0.5420.82
7_P69_V0.5400.82
68_L72_S0.5370.82
24_A31_F0.5360.81
36_R39_A0.5350.81
25_V28_L0.5320.81
64_N70_A0.5320.81
52_L71_L0.5260.80
40_P45_L0.5250.80
6_L11_A0.5230.80
1_F85_L0.5200.79
81_L86_A0.5120.78
75_A78_L0.5110.78
12_V17_L0.5100.78
48_D69_V0.5090.78
10_L34_L0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wl1A 3 0 5.6 0.877 Contact Map
3w9iA 3 0.8523 3.9 0.886 Contact Map
4dx5A 3 0.8523 3.4 0.89 Contact Map
4mt1A 3 0.8523 3.3 0.89 Contact Map
4k0jA 3 0.8295 2.9 0.893 Contact Map
2dw3A 1 0.5455 2.4 0.898 Contact Map
3aqpA 1 0.8523 2.1 0.901 Contact Map
3mqzA 1 0.3409 1.9 0.903 Contact Map
3ne5A 3 0.9659 1.7 0.906 Contact Map
3b5xA 2 0.4205 1.6 0.907 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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