GREMLIN Database
DUF3429 - Protein of unknown function (DUF3429)
PFAM: PF11911 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 137 (134)
Sequences: 4678 (3552)
Seq/√Len: 306.9
META: 0.802

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_G125_L4.1081.00
10_Y124_R3.7921.00
39_L136_A3.6371.00
47_L97_G3.4061.00
102_L123_L3.3841.00
39_L133_L2.5941.00
45_V76_A2.3441.00
99_L130_V2.3261.00
13_L128_V2.2861.00
19_L39_L2.2691.00
95_A130_V2.2601.00
98_F129_V2.2501.00
53_V118_Y2.1871.00
78_L97_G2.0241.00
20_A132_S1.9981.00
43_G133_L1.9471.00
17_V132_S1.9381.00
17_V128_V1.7991.00
101_L105_D1.7791.00
6_L10_Y1.7311.00
51_G75_P1.6791.00
40_L90_A1.6601.00
82_A93_L1.6551.00
43_G94_L1.6251.00
41_A83_L1.5781.00
126_T130_V1.5221.00
16_F129_V1.4021.00
82_A94_L1.3651.00
127_A131_L1.3621.00
6_L124_R1.3511.00
19_L35_A1.3471.00
13_L17_V1.3381.00
120_R124_R1.3301.00
45_V80_W1.3151.00
47_L98_F1.2831.00
50_L101_L1.2811.00
129_V132_S1.2631.00
49_F55_W1.2571.00
92_L137_L1.2441.00
39_L43_G1.2441.00
10_Y13_L1.2381.00
44_A48_S1.2281.00
14_I18_A1.2201.00
73_V76_A1.1871.00
44_A83_L1.1831.00
71_L101_L1.1761.00
46_I50_L1.1671.00
48_S80_W1.1661.00
12_G46_I1.1241.00
95_A137_L1.1051.00
5_A117_W1.0971.00
28_P31_L1.0971.00
3_R7_L1.0661.00
70_L73_V1.0581.00
16_F46_I1.0571.00
104_V108_L1.0561.00
34_L37_Y1.0451.00
9_G13_L1.0351.00
47_L79_A1.0341.00
107_R111_R1.0291.00
48_S76_A1.0281.00
109_A119_L1.0271.00
130_V134_L1.0211.00
82_A90_A1.0181.00
9_G121_L1.0161.00
71_L104_V1.0001.00
102_L106_R0.9981.00
37_Y41_A0.9911.00
78_L93_L0.9671.00
57_L114_L0.9641.00
13_L125_L0.9641.00
59_L118_Y0.9631.00
53_V56_G0.9621.00
41_A80_W0.9601.00
107_R110_R0.9471.00
133_L136_A0.9451.00
54_H68_R0.9211.00
102_L105_D0.9121.00
90_A94_L0.9081.00
128_V132_S0.9051.00
20_A136_A0.9021.00
123_L127_A0.8971.00
51_G79_A0.8951.00
8_L73_V0.8891.00
89_A92_L0.8831.00
54_H101_L0.8821.00
58_A69_L0.8761.00
95_A134_L0.8751.00
54_H105_D0.8681.00
101_L104_V0.8681.00
33_A37_Y0.8591.00
93_L96_A0.8571.00
3_R6_L0.8521.00
46_I73_V0.8401.00
4_L70_L0.8381.00
44_A79_A0.8331.00
46_I76_A0.8301.00
38_A84_L0.8171.00
10_Y128_V0.8031.00
25_W28_P0.8011.00
50_L72_S0.8001.00
32_R36_L0.7991.00
38_A80_W0.7971.00
40_L91_L0.7891.00
103_L106_R0.7841.00
103_L107_R0.7810.99
124_R127_A0.7810.99
109_A114_L0.7690.99
36_L87_P0.7620.99
57_L60_R0.7600.99
22_L35_A0.7580.99
42_Y77_L0.7580.99
54_H118_Y0.7550.99
8_L70_L0.7540.99
106_R110_R0.7440.99
46_I129_V0.7350.99
15_P42_Y0.7330.99
7_L10_Y0.7330.99
121_L125_L0.7300.99
53_V72_S0.7230.99
51_G73_V0.7230.99
130_V133_L0.7210.99
91_L136_A0.7160.99
101_L118_Y0.7130.99
30_G34_L0.7120.99
61_A64_P0.7070.99
125_L129_V0.7030.99
102_L126_T0.7020.99
54_H102_L0.7010.99
89_A93_L0.7000.99
42_Y46_I0.6980.99
12_G129_V0.6930.99
54_H104_V0.6890.99
131_L135_L0.6790.99
41_A84_L0.6750.99
6_L9_G0.6750.99
5_A69_L0.6510.98
63_G66_A0.6440.98
47_L101_L0.6430.98
19_L38_A0.6410.98
18_A22_L0.6360.98
24_L27_L0.6360.98
20_A135_L0.6360.98
63_G67_A0.6350.98
31_L34_L0.6320.98
24_L28_P0.6260.98
40_L87_P0.6250.98
70_L74_V0.6240.98
77_L81_L0.6120.97
120_R123_L0.6120.97
50_L76_A0.6100.97
109_A112_G0.6090.97
22_L34_L0.6080.97
40_L94_L0.6040.97
16_F43_G0.5980.97
74_V93_L0.5980.97
42_Y55_W0.5980.97
75_P100_A0.5970.97
11_A46_I0.5960.97
71_L105_D0.5960.97
29_P32_R0.5940.97
50_L129_V0.5930.97
56_G60_R0.5870.96
95_A133_L0.5830.96
14_I17_V0.5810.96
69_L72_S0.5800.96
39_L129_V0.5780.96
85_L90_A0.5760.96
27_L31_L0.5750.96
57_L115_P0.5750.96
18_A21_L0.5730.96
16_F39_L0.5690.96
61_A66_A0.5680.96
46_I55_W0.5660.96
53_V57_L0.5640.96
27_L30_G0.5640.96
106_R123_L0.5630.95
5_A121_L0.5630.95
98_F126_T0.5610.95
106_R119_L0.5580.95
7_L11_A0.5500.95
58_A72_S0.5490.95
44_A76_A0.5470.95
41_A45_V0.5460.95
22_L30_G0.5440.95
11_A14_I0.5430.95
98_F101_L0.5390.94
60_R64_P0.5370.94
8_L77_L0.5370.94
124_R128_V0.5350.94
44_A53_V0.5310.94
46_I49_F0.5290.94
91_L137_L0.5290.94
22_L27_L0.5270.94
26_L32_R0.5250.94
85_L93_L0.5180.93
52_G71_L0.5100.93
81_L85_L0.5070.92
48_S51_G0.5030.92
54_H108_L0.5000.92
109_A115_P0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q2eA 2 0.4745 2.5 0.932 Contact Map
3lbwA 3 0.1606 1.3 0.942 Contact Map
4tphA 2 0.9416 1.2 0.943 Contact Map
2mmuA 1 0.3431 1.1 0.944 Contact Map
2mwrA 1 0.2628 0.9 0.948 Contact Map
2mgyA 1 0.3796 0.9 0.948 Contact Map
3ne5A 3 0.8467 0.9 0.948 Contact Map
3bkdA 4 0.1825 0.7 0.951 Contact Map
4wzgA 1 0.2774 0.7 0.951 Contact Map
2jp3A 1 0.2409 0.7 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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