DUF3422 - PFAM28P - GREMLIN Contacts

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DUF3422 - Protein of unknown function (DUF3422)

PFAM:	PF11902	Sequences: QDHPLRYALANELHARPFPPLEAPARVSHLAFLADGRDREADRAHLAALCDRFGVPPPAPGATHFSADLGGFRLKWERHTEFSTYTFFRPGPAARPFDPPALDLVPADWLAALPGQLLVAVHLAVLPADDPAPDAEALARWFDGESLVGSRVADGAAVVATDFRIDADGFSRFLVFDRGLGPRRAGRLVQRLLEIETYRMMALLGLPVARELSPRLARIERELAELTARMASAAGLEDEEALLDELTALAAELERLAAATSFRFSATRAYYALVQQRIAELREERIEGLQTLGEFMERRLAPAMRTCEAVERRLEALSERVARASDLLRTRVDVELEAQNQALLASMNRRARLQLRLQQTVEGLSVAAISYYAVGLVGYLAKGLKAAGLPLSPELATALAVPVVVLLVWLGVRRIRRRH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	419 (416)
Sequences:	2569 (1800)
Seq/√Len:	88.3
META:	0.722

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
370_S	405_V	5.745	1.00
205_G	267_T	5.116	1.00
383_G	398_A	4.900	1.00
125_V	185_A	3.629	1.00
222_E	245_E	3.607	1.00
379_Y	382_K	3.387	1.00
278_I	296_M	3.224	1.00
152_V	188_L	3.028	1.00
377_V	400_A	2.936	1.00
28_S	122_H	2.891	1.00
378_G	397_T	2.884	1.00
382_K	394_E	2.881	1.00
271_Y	300_L	2.778	1.00
374_V	404_V	2.774	1.00
378_G	382_K	2.764	1.00
377_V	404_V	2.763	1.00
159_V	192_L	2.727	1.00
42_D	83_S	2.655	1.00
403_V	407_L	2.608	1.00
52_R	108_D	2.577	1.00
123_L	193_L	2.521	1.00
367_A	373_A	2.516	1.00
377_V	381_A	2.458	1.00
267_T	304_M	2.457	1.00
7_Y	11_N	2.403	1.00
159_V	292_L	2.395	1.00
32_F	113_L	2.357	1.00
229_R	245_E	2.318	1.00
120_A	170_F	2.303	1.00
43_R	47_A	2.229	1.00
87_F	105_V	2.225	1.00
282_R	285_R	2.223	1.00
69_L	72_F	2.220	1.00
315_E	319_E	2.219	1.00
342_A	345_A	2.179	1.00
156_A	179_G	2.144	1.00
385_K	394_E	2.139	1.00
55_V	65_F	2.118	1.00
222_E	252_E	2.114	1.00
406_L	410_L	2.109	1.00
382_K	385_K	2.108	1.00
161_T	173_F	2.104	1.00
412_V	415_I	2.098	1.00
381_A	396_A	2.066	1.00
121_V	173_F	2.063	1.00
29_H	86_T	2.059	1.00
40_E	44_A	2.053	1.00
218_R	252_E	1.999	1.00
151_R	155_G	1.961	1.00
26_R	91_G	1.959	1.00
2_D	117_L	1.956	1.00
5_L	8_A	1.946	1.00
240_E	338_A	1.924	1.00
215_R	252_E	1.910	1.00
21_L	25_A	1.902	1.00
329_R	333_D	1.893	1.00
68_D	73_R	1.881	1.00
212_L	260_T	1.872	1.00
384_L	389_L	1.847	1.00
271_Y	304_M	1.828	1.00
151_R	284_E	1.820	1.00
2_D	7_Y	1.810	1.00
126_L	176_F	1.786	1.00
215_R	218_R	1.785	1.00
149_G	289_L	1.767	1.00
395_L	399_L	1.764	1.00
106_P	109_W	1.763	1.00
410_L	413_R	1.761	1.00
23_A	185_A	1.752	1.00
157_A	180_L	1.735	1.00
254_E	323_R	1.730	1.00
360_T	364_L	1.714	1.00
271_Y	301_A	1.688	1.00
382_K	393_P	1.672	1.00
152_V	159_V	1.669	1.00
414_R	417_R	1.651	1.00
48_A	112_A	1.645	1.00
268_R	308_E	1.630	1.00
291_T	294_E	1.629	1.00
4_P	116_Q	1.623	1.00
253_L	314_L	1.583	1.00
148_V	163_F	1.582	1.00
82_F	201_M	1.579	1.00
180_L	188_L	1.573	1.00
343_L	346_S	1.564	1.00
202_A	300_L	1.560	1.00
68_D	72_F	1.558	1.00
123_L	189_V	1.553	1.00
353_L	356_R	1.552	1.00
51_D	57_P	1.535	1.00
35_D	116_Q	1.517	1.00
45_H	113_L	1.515	1.00
380_L	401_V	1.514	1.00
271_Y	275_Q	1.508	1.00
50_C	65_F	1.508	1.00
209_A	264_F	1.502	1.00
216_L	310_V	1.500	1.00
312_R	316_A	1.496	1.00
208_V	211_E	1.485	1.00
35_D	38_D	1.470	0.99
373_A	404_V	1.467	0.99
27_V	189_V	1.463	0.99
175_V	188_L	1.448	0.99
375_G	379_Y	1.443	0.99
153_A	188_L	1.424	0.99
105_V	108_D	1.410	0.99
386_A	394_E	1.406	0.99
392_S	395_L	1.398	0.99
400_A	404_V	1.398	0.99
69_L	87_F	1.396	0.99
348_N	352_R	1.378	0.99
142_F	162_D	1.365	0.99
212_L	314_L	1.356	0.99
253_L	321_V	1.350	0.99
25_A	88_F	1.349	0.99
375_G	382_K	1.344	0.99
336_L	340_N	1.330	0.99
48_A	52_R	1.323	0.99
42_D	85_Y	1.316	0.99
346_S	351_A	1.311	0.99
133_P	137_A	1.309	0.99
175_V	192_L	1.307	0.99
268_R	311_E	1.304	0.99
118_L	200_M	1.304	0.99
347_M	350_R	1.303	0.99
50_C	58_P	1.290	0.99
412_V	416_R	1.290	0.99
119_V	196_E	1.284	0.99
58_P	65_F	1.281	0.99
151_R	158_V	1.280	0.99
63_T	210_R	1.258	0.98
381_A	400_A	1.253	0.98
228_A	259_A	1.249	0.98
177_D	185_A	1.247	0.98
7_Y	165_I	1.231	0.98
29_H	197_T	1.225	0.98
29_H	84_T	1.220	0.98
273_L	300_L	1.219	0.98
163_F	333_D	1.219	0.98
220_E	313_R	1.218	0.98
122_H	168_D	1.216	0.98
411_G	415_I	1.199	0.98
108_D	111_A	1.196	0.98
19_P	66_S	1.193	0.98
375_G	378_G	1.184	0.98
345_A	348_N	1.176	0.97
166_D	171_S	1.171	0.97
265_S	309_A	1.155	0.97
211_E	259_A	1.153	0.97
227_T	324_A	1.152	0.97
28_S	101_A	1.151	0.97
395_L	398_A	1.143	0.97
13_L	18_F	1.142	0.97
19_P	73_R	1.138	0.97
408_V	412_V	1.122	0.97
28_S	87_F	1.118	0.97
100_P	122_H	1.107	0.96
126_L	137_A	1.106	0.96
381_A	393_P	1.102	0.96
149_G	160_A	1.099	0.96
391_L	396_A	1.096	0.96
177_D	180_L	1.093	0.96
34_A	38_D	1.089	0.96
276_Q	297_E	1.086	0.96
208_V	307_C	1.079	0.96
46_L	85_Y	1.074	0.96
276_Q	305_R	1.074	0.96
27_V	88_F	1.074	0.96
238_D	241_A	1.072	0.96
29_H	336_L	1.070	0.96
262_F	340_N	1.070	0.96
402_P	406_L	1.069	0.96
208_V	260_T	1.068	0.95
374_V	401_V	1.067	0.95
122_H	170_F	1.056	0.95
196_E	296_M	1.055	0.95
142_F	174_L	1.049	0.95
125_V	189_V	1.044	0.95
18_F	84_T	1.043	0.95
370_S	404_V	1.043	0.95
150_S	293_G	1.042	0.95
207_P	307_C	1.038	0.95
45_H	114_P	1.038	0.95
275_Q	301_A	1.030	0.94
409_W	413_R	1.028	0.94
121_V	193_L	1.026	0.94
48_A	51_D	1.020	0.94
231_A	251_A	1.018	0.94
369_I	375_G	1.017	0.94
157_A	188_L	1.012	0.94
222_E	248_A	1.009	0.94
360_T	363_G	1.004	0.94
385_K	388_G	1.002	0.94
144_G	147_L	1.001	0.94
262_F	265_S	0.999	0.94
121_V	171_S	0.996	0.93
29_H	329_R	0.995	0.93
384_L	387_A	0.991	0.93
184_R	294_E	0.982	0.93
117_L	120_A	0.975	0.93
239_E	331_R	0.972	0.93
282_R	294_E	0.972	0.93
74_L	87_F	0.968	0.92
213_S	310_V	0.963	0.92
333_D	337_E	0.961	0.92
370_S	374_V	0.958	0.92
134_D	138_L	0.957	0.92
22_E	182_P	0.956	0.92
150_S	291_T	0.953	0.92
254_E	320_R	0.951	0.92
28_S	102_L	0.949	0.92
219_I	256_L	0.948	0.92
311_E	314_L	0.947	0.92
85_Y	113_L	0.946	0.92
150_S	292_L	0.943	0.91
337_E	375_G	0.939	0.91
386_A	392_S	0.938	0.91
87_F	101_A	0.937	0.91
250_A	254_E	0.935	0.91
193_L	197_T	0.935	0.91
336_L	341_Q	0.934	0.91
158_V	178_R	0.933	0.91
393_P	397_T	0.931	0.91
240_E	244_D	0.931	0.91
93_A	124_A	0.930	0.91
32_F	117_L	0.929	0.91
278_I	293_G	0.927	0.91
150_S	283_E	0.927	0.91
100_P	103_D	0.926	0.91
380_L	384_L	0.926	0.91
195_I	278_I	0.924	0.91
271_Y	308_E	0.923	0.91
152_V	157_A	0.922	0.91
165_I	171_S	0.921	0.90
374_V	381_A	0.919	0.90
39_R	42_D	0.917	0.90
194_E	277_R	0.917	0.90
136_E	139_A	0.916	0.90
374_V	400_A	0.916	0.90
49_L	106_P	0.913	0.90
21_L	189_V	0.910	0.90
17_P	197_T	0.908	0.90
195_I	283_E	0.904	0.90
25_A	90_P	0.904	0.90
382_K	397_T	0.898	0.89
385_K	396_A	0.897	0.89
38_D	41_A	0.894	0.89
404_V	415_I	0.894	0.89
10_A	200_M	0.892	0.89
382_K	390_P	0.891	0.89
10_A	165_I	0.889	0.89
9_L	200_M	0.888	0.89
219_I	253_L	0.887	0.89
235_G	238_D	0.885	0.89
95_R	98_D	0.885	0.89
349_R	353_L	0.881	0.88
43_R	78_R	0.880	0.88
118_L	201_M	0.879	0.88
83_S	206_L	0.877	0.88
123_L	173_F	0.876	0.88
187_R	290_Q	0.868	0.88
189_V	193_L	0.864	0.87
142_F	147_L	0.863	0.87
225_E	229_R	0.860	0.87
36_G	39_R	0.860	0.87
44_A	47_A	0.859	0.87
26_R	122_H	0.858	0.87
46_L	74_L	0.858	0.87
145_E	166_D	0.856	0.87
350_R	353_L	0.855	0.87
374_V	397_T	0.855	0.87
254_E	258_A	0.852	0.87
34_A	42_D	0.851	0.87
101_A	122_H	0.851	0.87
187_R	320_R	0.850	0.87
212_L	261_S	0.844	0.86
414_R	418_R	0.844	0.86
44_A	51_D	0.842	0.86
149_G	286_I	0.839	0.86
248_A	252_E	0.837	0.86
12_E	15_A	0.836	0.86
66_S	73_R	0.834	0.86
17_P	283_E	0.833	0.85
224_A	318_S	0.832	0.85
356_R	359_Q	0.831	0.85
206_L	317_L	0.825	0.85
319_E	322_A	0.825	0.85
105_V	109_W	0.825	0.85
272_A	309_A	0.823	0.85
385_K	393_P	0.822	0.85
99_P	103_D	0.819	0.84
201_M	212_L	0.818	0.84
43_R	61_G	0.817	0.84
250_A	321_V	0.814	0.84
28_S	100_P	0.813	0.84
47_A	57_P	0.813	0.84
41_A	44_A	0.811	0.84
119_V	197_T	0.810	0.84
190_Q	298_R	0.808	0.84
72_F	105_V	0.805	0.83
264_F	310_V	0.803	0.83
382_K	395_L	0.798	0.83
390_P	396_A	0.797	0.83
171_S	196_E	0.797	0.83
188_L	281_L	0.796	0.83
392_S	396_A	0.796	0.83
212_L	256_L	0.795	0.83
363_G	366_V	0.791	0.82
79_H	82_F	0.791	0.82
32_F	85_Y	0.791	0.82
237_E	241_A	0.790	0.82
361_V	364_L	0.788	0.82
64_H	75_K	0.788	0.82
239_E	335_E	0.787	0.82
413_R	416_R	0.787	0.82
95_R	140_R	0.784	0.82
364_L	379_Y	0.784	0.82
269_A	302_P	0.780	0.81
366_V	409_W	0.780	0.81
154_D	284_E	0.779	0.81
397_T	401_V	0.779	0.81
134_D	137_A	0.777	0.81
29_H	119_V	0.777	0.81
161_T	283_E	0.777	0.81
154_D	287_E	0.771	0.81
279_A	293_G	0.770	0.81
173_F	192_L	0.769	0.81
45_H	246_L	0.765	0.80
131_P	134_D	0.764	0.80
325_S	334_V	0.760	0.80
131_P	175_V	0.754	0.79
286_I	289_L	0.752	0.79
126_L	133_P	0.752	0.79
202_A	307_C	0.746	0.79
42_D	78_R	0.745	0.78
154_D	285_R	0.743	0.78
64_H	409_W	0.741	0.78
385_K	392_S	0.741	0.78
14_H	17_P	0.740	0.78
256_L	314_L	0.739	0.78
291_T	301_A	0.736	0.78
205_G	208_V	0.735	0.77
326_D	329_R	0.734	0.77
23_A	177_D	0.734	0.77
102_L	170_F	0.733	0.77
255_R	259_A	0.731	0.77
6_R	12_E	0.728	0.77
345_A	349_R	0.727	0.77
184_R	300_L	0.726	0.77
27_V	193_L	0.726	0.77
34_A	39_R	0.725	0.77
78_R	83_S	0.724	0.76
18_F	31_A	0.724	0.76
405_V	415_I	0.722	0.76
218_R	222_E	0.721	0.76
160_A	176_F	0.721	0.76
19_P	75_K	0.720	0.76
130_D	133_P	0.715	0.76
11_N	84_T	0.713	0.75
89_R	104_L	0.712	0.75
22_E	90_P	0.711	0.75
394_E	397_T	0.711	0.75
56_P	65_F	0.710	0.75
122_H	166_D	0.710	0.75
390_P	399_L	0.710	0.75
202_A	262_F	0.709	0.75
264_F	283_E	0.704	0.74
163_F	292_L	0.704	0.74
17_P	75_K	0.704	0.74
380_L	383_G	0.704	0.74
50_C	55_V	0.703	0.74
49_L	109_W	0.698	0.74
32_F	45_H	0.696	0.74
155_G	284_E	0.693	0.73
220_E	326_D	0.692	0.73
360_T	369_I	0.691	0.73
381_A	385_K	0.691	0.73
407_L	411_G	0.690	0.73
76_W	83_S	0.689	0.73
196_E	283_E	0.688	0.73
267_T	271_Y	0.688	0.73
141_W	174_L	0.685	0.72
285_R	351_A	0.685	0.72
359_Q	411_G	0.682	0.72
331_R	335_E	0.680	0.72
112_A	381_A	0.679	0.72
250_A	332_V	0.679	0.72
45_H	48_A	0.678	0.72
151_R	178_R	0.678	0.72
240_E	341_Q	0.677	0.72
150_S	154_D	0.675	0.71
84_T	201_M	0.674	0.71
374_V	378_G	0.674	0.71
5_L	11_N	0.674	0.71
154_D	282_R	0.673	0.71
26_R	89_R	0.671	0.71
72_F	122_H	0.670	0.71
399_L	403_V	0.670	0.71
17_P	31_A	0.670	0.71
278_I	292_L	0.669	0.71
359_Q	416_R	0.669	0.71
215_R	256_L	0.669	0.71
125_V	175_V	0.667	0.70
387_A	399_L	0.666	0.70
28_S	89_R	0.665	0.70
184_R	290_Q	0.663	0.70
163_F	196_E	0.662	0.70
150_S	195_I	0.662	0.70
296_M	300_L	0.662	0.70
279_A	384_L	0.661	0.70
206_L	264_F	0.658	0.69
126_L	174_L	0.658	0.69
53_F	106_P	0.658	0.69
206_L	402_P	0.658	0.69
190_Q	245_E	0.658	0.69
116_Q	130_D	0.658	0.69
130_D	134_D	0.657	0.69
219_I	252_E	0.657	0.69
222_E	225_E	0.654	0.69
396_A	399_L	0.652	0.69
16_R	269_A	0.652	0.69
166_D	172_R	0.651	0.69
201_M	281_L	0.651	0.69
273_L	367_A	0.648	0.68
37_R	41_A	0.644	0.68
150_S	159_V	0.643	0.68
22_E	25_A	0.643	0.68
365_S	368_A	0.643	0.68
311_E	315_E	0.643	0.68
47_A	51_D	0.643	0.68
3_H	33_L	0.640	0.67
403_V	406_L	0.639	0.67
218_R	225_E	0.639	0.67
261_S	316_A	0.638	0.67
340_N	350_R	0.637	0.67
42_D	76_W	0.635	0.67
229_R	237_E	0.634	0.67
348_N	359_Q	0.634	0.67
175_V	189_V	0.634	0.67
308_E	312_R	0.633	0.66
163_F	205_G	0.633	0.66
45_H	109_W	0.632	0.66
338_A	341_Q	0.631	0.66
383_G	388_G	0.630	0.66
400_A	408_V	0.630	0.66
130_D	417_R	0.630	0.66
220_E	262_F	0.630	0.66
87_F	203_L	0.627	0.66
277_R	327_L	0.622	0.65
157_A	175_V	0.621	0.65
109_W	187_R	0.620	0.65
61_G	132_A	0.619	0.65
251_A	339_Q	0.618	0.65
153_A	220_E	0.618	0.65
87_F	104_L	0.615	0.64
29_H	75_K	0.614	0.64
11_N	45_H	0.614	0.64
64_H	162_D	0.611	0.64
362_E	365_S	0.610	0.64
67_A	71_G	0.609	0.63
260_T	314_L	0.608	0.63
230_M	315_E	0.608	0.63
363_G	370_S	0.605	0.63
41_A	45_H	0.605	0.63
163_F	340_N	0.604	0.63
45_H	112_A	0.604	0.63
39_R	262_F	0.602	0.63
171_S	200_M	0.601	0.62
148_V	311_E	0.599	0.62
406_L	409_W	0.597	0.62
385_K	398_A	0.596	0.62
40_E	43_R	0.596	0.62
209_A	310_V	0.596	0.62
251_A	314_L	0.596	0.62
142_F	145_E	0.595	0.62
217_A	260_T	0.593	0.61
152_V	285_R	0.593	0.61
180_L	185_A	0.592	0.61
34_A	83_S	0.592	0.61
148_V	296_M	0.592	0.61
53_F	108_D	0.592	0.61
254_E	350_R	0.591	0.61
223_L	374_V	0.590	0.61
148_V	171_S	0.590	0.61
157_A	181_G	0.590	0.61
11_N	52_R	0.590	0.61
234_A	316_A	0.589	0.61
64_H	67_A	0.588	0.61
99_P	400_A	0.586	0.60
219_I	222_E	0.586	0.60
66_S	86_T	0.585	0.60
365_S	372_Y	0.585	0.60
359_Q	418_R	0.583	0.60
184_R	197_T	0.583	0.60
12_E	16_R	0.583	0.60
288_G	294_E	0.582	0.60
114_P	333_D	0.582	0.60
209_A	307_C	0.581	0.60
175_V	406_L	0.579	0.60
389_L	396_A	0.578	0.59
187_R	282_R	0.577	0.59
394_E	398_A	0.577	0.59
212_L	267_T	0.577	0.59
216_L	260_T	0.575	0.59
276_Q	280_E	0.575	0.59
246_L	359_Q	0.574	0.59
161_T	271_Y	0.574	0.59
404_V	412_V	0.573	0.59
252_E	265_S	0.573	0.59
28_S	170_F	0.573	0.59
406_L	418_R	0.572	0.59
140_R	179_G	0.572	0.59
57_P	60_P	0.570	0.58
109_W	166_D	0.569	0.58
339_Q	351_A	0.569	0.58
407_L	410_L	0.566	0.58
268_R	312_R	0.566	0.58
127_P	177_D	0.565	0.58
261_S	320_R	0.564	0.58
25_A	125_V	0.564	0.58
203_L	306_T	0.561	0.57
227_T	255_R	0.560	0.57
387_A	395_L	0.559	0.57
17_P	196_E	0.559	0.57
218_R	245_E	0.558	0.57
285_R	294_E	0.558	0.57
358_Q	362_E	0.557	0.57
158_V	332_V	0.556	0.56
16_R	302_P	0.556	0.56
162_D	333_D	0.556	0.56
361_V	365_S	0.556	0.56
203_L	303_A	0.555	0.56
368_A	374_V	0.554	0.56
97_F	172_R	0.553	0.56
377_V	396_A	0.553	0.56
34_A	37_R	0.551	0.56
402_P	405_V	0.551	0.56
182_P	409_W	0.550	0.56
119_V	165_I	0.550	0.56
116_Q	175_V	0.549	0.56
265_S	311_E	0.549	0.56
402_P	407_L	0.548	0.55
50_C	337_E	0.547	0.55
18_F	75_K	0.546	0.55
82_F	194_E	0.546	0.55
243_L	330_T	0.545	0.55
153_A	280_E	0.545	0.55
374_V	405_V	0.545	0.55
70_G	97_F	0.545	0.55
359_Q	413_R	0.544	0.55
410_L	414_R	0.544	0.55
62_A	337_E	0.543	0.55
320_R	327_L	0.543	0.55
227_T	318_S	0.543	0.55
240_E	336_L	0.540	0.54
214_P	387_A	0.540	0.54
18_F	305_R	0.539	0.54
187_R	216_L	0.539	0.54
20_P	183_R	0.539	0.54
58_P	62_A	0.539	0.54
121_V	334_V	0.539	0.54
314_L	325_S	0.539	0.54
410_L	418_R	0.538	0.54
53_F	70_G	0.538	0.54
50_C	57_P	0.536	0.54
13_L	296_M	0.536	0.54
109_W	320_R	0.534	0.54
361_V	375_G	0.534	0.54
321_V	351_A	0.533	0.53
324_A	340_N	0.532	0.53
393_P	396_A	0.532	0.53
80_T	262_F	0.532	0.53
38_D	116_Q	0.530	0.53
381_A	397_T	0.528	0.53
216_L	256_L	0.525	0.52
395_L	414_R	0.525	0.52
109_W	113_L	0.524	0.52
32_F	292_L	0.522	0.52
84_T	212_L	0.522	0.52
295_F	350_R	0.522	0.52
75_K	274_V	0.520	0.52
95_R	100_P	0.520	0.52
44_A	48_A	0.518	0.51
29_H	188_L	0.518	0.51
380_L	403_V	0.517	0.51
133_P	138_L	0.517	0.51
250_A	329_R	0.517	0.51
376_L	401_V	0.516	0.51
83_S	124_A	0.516	0.51
39_R	268_R	0.516	0.51
195_I	322_A	0.516	0.51
102_L	122_H	0.515	0.51
43_R	84_T	0.515	0.51
222_E	229_R	0.514	0.51
55_V	69_L	0.513	0.51
82_F	299_R	0.513	0.51
177_D	184_R	0.513	0.51
94_A	130_D	0.512	0.51
82_F	302_P	0.511	0.50
283_E	341_Q	0.511	0.50
135_A	255_R	0.511	0.50
119_V	171_S	0.508	0.50
156_A	181_G	0.508	0.50
164_R	378_G	0.507	0.50
125_V	395_L	0.507	0.50
387_A	391_L	0.507	0.50
70_G	366_V	0.506	0.50
353_L	360_T	0.506	0.50
326_D	333_D	0.506	0.50
152_V	195_I	0.506	0.50
239_E	247_T	0.505	0.50
10_A	171_S	0.505	0.50
118_L	204_L	0.504	0.49
250_A	312_R	0.503	0.49
99_P	167_A	0.503	0.49
107_A	111_A	0.502	0.49
219_I	249_L	0.502	0.49
40_E	61_G	0.502	0.49
367_A	401_V	0.502	0.49
378_G	385_K	0.502	0.49
360_T	415_I	0.502	0.49
73_R	90_P	0.502	0.49
47_A	58_P	0.501	0.49
314_L	336_L	0.500	0.49

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ev6A	3	0.6993	22.7	0.978	Contact Map
2wpvA	1	0.2339	13.4	0.98	Contact Map
1rh5C	1	0.0764	7.7	0.982	Contact Map
4i0uA	4	0.7375	7.1	0.983	Contact Map
2l9uA	2	0.0859	7	0.983	Contact Map
2rmfA	1	0.0788	6.1	0.983	Contact Map
3htkB	1	0.1623	6	0.983	Contact Map
3p9yA	1	0.1933	5.6	0.984	Contact Map
2lzpA	1	0.0668	5.4	0.984	Contact Map
4p02A	1	0.1217	4.8	0.984	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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