DUF3418 - PFAM28P - GREMLIN Contacts

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DUF3418 - Domain of unknown function (DUF3418)

PFAM:	PF11898	Sequences: KRGQVVAYERVTLYGLPIVARRRVNYGRIDPAEAREIFIRHALVEGEWDTRHPFLAHNRKLLEEVEELEHKARRRDILVDDEALFAFYDARIPADVVSGRHFERWWKKAEREDPDLLFLTREDLLRHEAAGVTEADFPDTLRLGGLRLPLSYRFEPGAPDDGVTVTVPLALLNQVDPERFEWLVPGLLEEKVTALIKSLPKALRRNLVPAPDFARAFLARLAAEPPGDGPLLDALARELRRLTGVRVPADDWDLDALPPHLRMNFRVVDEDGRVLAEGRDLAALRARLGGQARAAFAAAAADAERTGLTDWDFGDLPETVEIRRGGQTVTGYPALVDEGDSVALRLFDTPAEAAAAHRAGVRRLLLLALPSPLKYLEKNLPNLQKLALAYAPLGSVEALRDDLLAAALDRLFLGPLPRDEAAFEALLEAVRARLVDTAQEVARLVAAILAAYHEVRKRLKGLKSLAALADIRAQLARLVPPGFVAATPWERLAHLPRYLKAIELRLEKLPADPARDRQRMAEVAPLEQRYQRLLAALPAGRADDPALEEFRWMLEELRVSLFAQELGTAYPVSEKRLEKAWAQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	583 (579)
Sequences:	5814 (4164)
Seq/√Len:	173.0
META:	0.72

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
3_G	99_G	4.225	1.00
248_P	251_D	4.149	1.00
501_A	559_V	3.912	1.00
420_E	424_E	3.829	1.00
30_D	33_E	3.810	1.00
419_D	422_A	3.683	1.00
189_E	215_R	3.609	1.00
338_E	343_A	3.331	1.00
8_Y	21_R	3.321	1.00
180_F	265_F	3.079	1.00
494_H	497_R	3.041	1.00
553_M	570_Y	3.025	1.00
106_W	110_E	2.859	1.00
41_H	45_E	2.818	1.00
362_R	409_D	2.795	1.00
196_I	210_A	2.759	1.00
315_D	419_D	2.724	1.00
522_E	574_E	2.711	1.00
314_G	420_E	2.666	1.00
305_R	312_D	2.635	1.00
264_N	279_R	2.620	1.00
64_E	121_R	2.602	1.00
166_T	268_V	2.549	1.00
454_E	503_E	2.542	1.00
155_E	158_A	2.526	1.00
331_G	346_L	2.526	1.00
471_I	502_I	2.512	1.00
115_D	118_F	2.503	1.00
166_T	266_R	2.482	1.00
337_D	363_R	2.464	1.00
494_H	569_A	2.358	1.00
217_F	221_L	2.347	1.00
40_R	82_E	2.340	1.00
98_S	101_H	2.260	1.00
308_L	312_D	2.243	1.00
307_G	341_S	2.213	1.00
57_H	118_F	2.198	1.00
350_P	354_A	2.166	1.00
236_A	252_W	2.139	1.00
151_S	166_T	2.130	1.00
37_I	41_H	2.120	1.00
142_R	147_R	2.113	1.00
316_L	344_L	2.096	1.00
550_F	581_W	2.092	1.00
82_E	86_A	2.083	1.00
347_F	356_A	2.082	1.00
334_A	347_F	2.079	1.00
140_T	147_R	2.008	1.00
526_L	578_E	2.007	1.00
216_A	242_L	1.952	1.00
11_V	19_V	1.933	1.00
120_T	123_D	1.931	1.00
109_A	113_D	1.925	1.00
451_A	503_E	1.915	1.00
240_R	246_R	1.907	1.00
27_G	97_V	1.901	1.00
559_V	566_L	1.897	1.00
97_V	101_H	1.896	1.00
557_L	574_E	1.875	1.00
551_R	555_E	1.861	1.00
5_V	26_Y	1.858	1.00
363_R	367_L	1.857	1.00
480_P	486_A	1.852	1.00
458_R	507_E	1.838	1.00
229_G	237_R	1.828	1.00
366_L	408_L	1.819	1.00
550_F	577_L	1.816	1.00
305_R	308_L	1.812	1.00
217_F	238_E	1.809	1.00
35_R	89_D	1.807	1.00
310_D	368_A	1.803	1.00
266_R	277_E	1.803	1.00
264_N	277_E	1.788	1.00
25_N	28_R	1.783	1.00
4_Q	25_N	1.783	1.00
148_L	165_V	1.772	1.00
150_L	163_V	1.771	1.00
104_R	108_K	1.745	1.00
167_V	175_V	1.734	1.00
336_V	347_F	1.732	1.00
208_V	211_P	1.731	1.00
52_H	103_E	1.714	1.00
529_R	578_E	1.708	1.00
33_E	36_E	1.708	1.00
36_E	40_R	1.706	1.00
50_T	55_L	1.693	1.00
321_E	328_T	1.690	1.00
26_Y	33_E	1.675	1.00
236_A	249_A	1.669	1.00
165_V	180_F	1.659	1.00
109_A	116_L	1.656	1.00
80_D	83_A	1.648	1.00
276_A	287_R	1.644	1.00
86_A	90_A	1.638	1.00
39_I	92_I	1.636	1.00
10_R	17_P	1.634	1.00
276_A	288_L	1.618	1.00
269_D	273_R	1.617	1.00
318_E	418_R	1.616	1.00
455_V	502_I	1.616	1.00
283_A	287_R	1.607	1.00
504_L	565_E	1.594	1.00
233_D	249_A	1.583	1.00
207_L	239_L	1.583	1.00
253_D	256_A	1.574	1.00
113_D	116_L	1.574	1.00
220_R	238_E	1.569	1.00
487_T	495_L	1.556	1.00
38_F	42_A	1.552	1.00
85_F	89_D	1.547	1.00
62_L	78_L	1.539	1.00
210_A	214_A	1.536	1.00
337_D	341_S	1.527	1.00
477_R	527_E	1.519	1.00
267_V	288_L	1.515	1.00
214_A	218_L	1.504	1.00
338_E	345_R	1.499	1.00
192_V	217_F	1.499	1.00
153_R	160_D	1.496	1.00
424_E	428_E	1.495	1.00
192_V	218_L	1.493	1.00
318_E	350_P	1.491	1.00
109_A	112_E	1.489	1.00
133_T	136_D	1.488	1.00
451_A	454_E	1.481	1.00
458_R	503_E	1.473	1.00
87_F	119_L	1.471	1.00
267_V	278_G	1.465	1.00
274_V	277_E	1.465	1.00
142_R	145_G	1.464	1.00
553_M	580_A	1.459	1.00
491_R	494_H	1.453	1.00
189_E	193_T	1.451	1.00
212_D	215_R	1.445	1.00
17_P	20_A	1.442	1.00
48_W	99_G	1.441	1.00
280_D	283_A	1.435	1.00
195_L	232_L	1.434	1.00
119_L	123_D	1.434	1.00
77_I	125_L	1.426	1.00
357_H	361_V	1.425	1.00
445_V	484_V	1.423	1.00
164_T	266_R	1.419	1.00
365_L	427_L	1.415	1.00
304_E	345_R	1.408	1.00
217_F	235_L	1.407	1.00
84_L	119_L	1.405	1.00
65_V	78_L	1.402	1.00
452_Y	456_R	1.400	1.00
259_P	262_R	1.399	1.00
8_Y	23_R	1.395	1.00
366_L	405_A	1.395	1.00
334_A	353_A	1.391	1.00
313_F	344_L	1.388	1.00
319_T	330_T	1.385	1.00
92_I	102_F	1.375	1.00
412_F	430_V	1.373	1.00
203_L	251_D	1.356	1.00
337_D	367_L	1.355	1.00
451_A	500_K	1.348	1.00
467_A	509_L	1.342	1.00
160_D	277_E	1.339	1.00
526_L	574_E	1.337	1.00
55_L	88_Y	1.332	1.00
41_H	47_E	1.327	1.00
519_R	522_E	1.321	1.00
311_W	314_G	1.319	1.00
278_G	283_A	1.313	1.00
67_E	71_K	1.313	1.00
402_D	482_G	1.311	1.00
306_T	343_A	1.308	1.00
437_T	440_E	1.305	1.00
230_P	233_D	1.295	1.00
493_A	496_P	1.295	1.00
352_E	356_A	1.293	1.00
266_R	274_V	1.289	1.00
198_S	252_W	1.288	1.00
512_D	518_Q	1.284	1.00
265_F	281_L	1.282	1.00
549_E	570_Y	1.279	1.00
368_A	427_L	1.278	1.00
46_G	59_R	1.276	1.00
527_E	531_Q	1.274	1.00
192_V	235_L	1.270	1.00
71_K	139_D	1.269	1.00
375_Y	379_N	1.265	1.00
578_E	582_A	1.261	1.00
28_R	97_V	1.258	1.00
411_L	430_V	1.257	1.00
471_I	506_L	1.254	1.00
137_F	186_G	1.254	1.00
146_L	171_L	1.250	1.00
102_F	106_W	1.244	1.00
571_P	576_R	1.243	1.00
334_A	357_H	1.240	1.00
153_R	158_A	1.236	1.00
7_A	26_Y	1.235	1.00
524_A	528_Q	1.233	1.00
470_D	474_Q	1.231	1.00
520_M	524_A	1.230	1.00
192_V	231_L	1.223	1.00
455_V	503_E	1.220	1.00
307_G	343_A	1.212	1.00
549_E	580_A	1.209	1.00
546_A	549_E	1.206	1.00
518_Q	522_E	1.206	1.00
308_L	313_F	1.206	1.00
198_S	255_D	1.205	1.00
5_V	37_I	1.202	1.00
45_E	81_D	1.201	1.00
96_V	101_H	1.199	1.00
568_T	571_P	1.198	1.00
238_E	242_L	1.195	1.00
207_L	243_T	1.195	1.00
69_E	75_R	1.189	1.00
221_L	238_E	1.189	1.00
193_T	210_A	1.182	1.00
353_A	418_R	1.182	1.00
19_V	22_R	1.180	1.00
468_L	472_R	1.179	1.00
526_L	550_F	1.179	1.00
11_V	22_R	1.176	1.00
106_W	114_P	1.173	1.00
523_V	554_L	1.172	1.00
177_P	282_A	1.169	1.00
150_L	263_M	1.167	1.00
365_L	426_L	1.165	1.00
529_R	581_W	1.164	1.00
482_G	486_A	1.163	1.00
308_L	341_S	1.157	1.00
390_Y	394_G	1.156	1.00
557_L	577_L	1.153	1.00
533_L	547_L	1.152	1.00
52_H	102_F	1.152	1.00
574_E	578_E	1.149	1.00
282_A	285_R	1.149	1.00
448_I	495_L	1.144	1.00
110_E	114_P	1.141	1.00
526_L	554_L	1.137	1.00
196_I	217_F	1.137	1.00
183_L	263_M	1.136	1.00
323_R	328_T	1.133	1.00
181_E	230_P	1.130	1.00
387_A	396_V	1.127	1.00
66_E	70_H	1.123	1.00
238_E	241_R	1.120	1.00
347_F	357_H	1.118	1.00
308_L	343_A	1.118	1.00
163_V	263_M	1.113	1.00
575_K	579_K	1.112	1.00
336_V	356_A	1.111	1.00
56_A	60_K	1.111	1.00
470_D	520_M	1.111	1.00
192_V	214_A	1.110	1.00
474_Q	502_I	1.110	1.00
310_D	420_E	1.110	1.00
517_R	521_A	1.105	1.00
220_R	241_R	1.104	1.00
193_T	197_K	1.097	1.00
63_E	66_E	1.091	1.00
26_Y	34_A	1.090	1.00
29_I	34_A	1.087	1.00
425_A	429_A	1.084	1.00
106_W	118_F	1.076	1.00
10_R	20_A	1.071	1.00
428_E	431_R	1.071	1.00
52_H	106_W	1.069	1.00
220_R	242_L	1.060	1.00
475_L	502_I	1.058	1.00
6_V	23_R	1.057	1.00
48_W	102_F	1.056	1.00
306_T	338_E	1.056	1.00
207_L	213_F	1.055	1.00
410_R	489_W	1.053	1.00
528_Q	532_R	1.053	1.00
306_T	345_R	1.052	1.00
401_D	405_A	1.049	0.99
398_A	481_P	1.046	0.99
82_E	85_F	1.041	0.99
500_K	504_L	1.039	0.99
358_R	409_D	1.039	0.99
203_L	248_P	1.034	0.99
198_S	254_L	1.031	0.99
342_V	363_R	1.030	0.99
183_L	187_L	1.028	0.99
177_P	285_R	1.025	0.99
143_L	179_R	1.023	0.99
342_V	367_L	1.022	0.99
479_V	495_L	1.019	0.99
361_V	365_L	1.017	0.99
36_E	85_F	1.012	0.99
67_E	70_H	1.011	0.99
402_D	485_A	1.010	0.99
83_A	86_A	1.007	0.99
229_G	234_A	1.006	0.99
26_Y	29_I	1.006	0.99
62_L	66_E	1.004	0.99
12_T	17_P	1.003	0.99
176_D	179_R	0.999	0.99
530_Y	554_L	0.998	0.99
356_A	359_A	0.997	0.99
491_R	549_E	0.994	0.99
349_T	352_E	0.992	0.99
217_F	239_L	0.991	0.99
72_A	132_V	0.989	0.99
341_S	363_R	0.988	0.99
341_S	367_L	0.987	0.99
57_H	60_K	0.986	0.99
247_V	252_W	0.985	0.99
6_V	25_N	0.985	0.99
194_A	197_K	0.977	0.99
395_S	398_A	0.975	0.99
338_E	341_S	0.973	0.99
226_P	229_G	0.972	0.99
258_P	261_L	0.972	0.99
456_R	472_R	0.971	0.99
527_E	530_Y	0.971	0.99
375_Y	435_V	0.968	0.99
444_L	448_I	0.968	0.99
477_R	555_E	0.968	0.99
403_L	484_V	0.967	0.99
533_L	550_F	0.964	0.99
321_E	330_T	0.963	0.99
35_R	39_I	0.962	0.99
577_L	581_W	0.961	0.99
525_P	529_R	0.960	0.99
65_V	121_R	0.959	0.99
390_Y	449_L	0.958	0.99
232_L	254_L	0.955	0.99
494_H	559_V	0.954	0.99
163_V	187_L	0.954	0.99
39_I	89_D	0.954	0.99
11_V	18_I	0.952	0.99
195_L	231_L	0.952	0.99
472_R	476_A	0.952	0.99
425_A	428_E	0.951	0.99
323_R	326_G	0.950	0.99
530_Y	534_L	0.949	0.99
248_P	252_W	0.948	0.99
515_R	519_R	0.947	0.99
549_E	553_M	0.947	0.99
526_L	557_L	0.945	0.99
410_R	437_T	0.943	0.99
196_I	207_L	0.943	0.99
88_Y	119_L	0.943	0.99
188_L	191_K	0.942	0.99
25_N	98_S	0.940	0.99
194_A	258_P	0.937	0.99
427_L	431_R	0.935	0.99
336_V	345_R	0.931	0.99
336_V	343_A	0.931	0.99
61_L	121_R	0.930	0.99
151_S	266_R	0.930	0.99
42_A	47_E	0.927	0.99
278_G	287_R	0.921	0.99
164_T	264_N	0.920	0.99
305_R	343_A	0.919	0.99
567_G	571_P	0.918	0.99
382_N	385_K	0.918	0.99
3_G	48_W	0.917	0.99
27_G	34_A	0.917	0.99
480_P	487_T	0.916	0.99
368_A	423_F	0.915	0.99
9_E	22_R	0.914	0.99
435_V	439_Q	0.913	0.99
546_A	580_A	0.911	0.99
50_T	103_E	0.911	0.99
183_L	257_L	0.909	0.99
189_E	214_A	0.901	0.98
474_Q	558_R	0.897	0.98
86_A	89_D	0.897	0.98
193_T	218_L	0.896	0.98
497_R	559_V	0.895	0.98
467_A	520_M	0.889	0.98
206_N	213_F	0.888	0.98
79_V	83_A	0.886	0.98
2_R	6_V	0.883	0.98
514_A	518_Q	0.882	0.98
307_G	367_L	0.882	0.98
60_K	64_E	0.880	0.98
50_T	56_A	0.880	0.98
357_H	418_R	0.876	0.98
38_F	102_F	0.875	0.98
522_E	557_L	0.875	0.98
450_A	454_E	0.874	0.98
365_L	412_F	0.874	0.98
5_V	38_F	0.873	0.98
168_P	171_L	0.871	0.98
109_A	114_P	0.871	0.98
93_P	96_V	0.871	0.98
7_A	29_I	0.870	0.98
114_P	118_F	0.867	0.98
533_L	581_W	0.865	0.98
275_L	288_L	0.864	0.98
2_R	23_R	0.863	0.98
491_R	569_A	0.862	0.98
522_E	561_L	0.861	0.98
183_L	191_K	0.861	0.98
69_E	76_D	0.857	0.98
447_A	500_K	0.856	0.98
474_Q	477_R	0.856	0.98
525_P	574_E	0.855	0.98
309_T	340_D	0.850	0.98
537_L	542_A	0.849	0.98
165_V	263_M	0.848	0.98
196_I	214_A	0.847	0.98
26_Y	30_D	0.846	0.98
527_E	554_L	0.844	0.98
32_A	94_A	0.843	0.98
537_L	544_D	0.842	0.98
488_P	491_R	0.841	0.98
309_T	367_L	0.841	0.98
169_L	275_L	0.840	0.98
237_R	241_R	0.840	0.98
127_H	133_T	0.839	0.98
40_R	45_E	0.839	0.98
30_D	36_E	0.839	0.98
33_E	37_I	0.833	0.97
550_F	580_A	0.833	0.97
240_R	243_T	0.833	0.97
202_A	205_R	0.833	0.97
498_Y	569_A	0.832	0.97
361_V	416_L	0.831	0.97
102_F	110_E	0.831	0.97
216_A	220_R	0.828	0.97
411_L	437_T	0.828	0.97
529_R	532_R	0.825	0.97
232_L	236_A	0.821	0.97
30_D	34_A	0.821	0.97
145_G	174_Q	0.821	0.97
213_F	243_T	0.819	0.97
48_W	55_L	0.817	0.97
167_V	267_V	0.816	0.97
508_K	565_E	0.814	0.97
90_A	123_D	0.814	0.97
52_H	110_E	0.813	0.97
53_P	57_H	0.810	0.97
106_W	109_A	0.809	0.97
440_E	443_R	0.809	0.97
320_V	331_G	0.808	0.97
315_D	421_A	0.806	0.97
337_D	342_V	0.806	0.97
129_A	132_V	0.804	0.97
444_L	447_A	0.803	0.97
376_L	438_A	0.802	0.97
198_S	256_A	0.797	0.97
526_L	529_R	0.796	0.97
429_A	433_R	0.794	0.97
121_R	125_L	0.789	0.96
65_V	124_L	0.789	0.96
292_A	296_F	0.787	0.96
225_P	228_D	0.786	0.96
518_Q	521_A	0.782	0.96
359_A	362_R	0.782	0.96
148_L	167_V	0.782	0.96
501_A	563_A	0.781	0.96
213_F	217_F	0.780	0.96
100_R	104_R	0.779	0.96
148_L	175_V	0.777	0.96
405_A	485_A	0.777	0.96
215_R	219_A	0.776	0.96
426_L	429_A	0.775	0.96
24_V	29_I	0.775	0.96
456_R	476_A	0.770	0.96
491_R	496_P	0.768	0.96
421_A	425_A	0.768	0.96
403_L	407_A	0.766	0.96
308_L	344_L	0.765	0.96
56_A	59_R	0.765	0.96
57_H	61_L	0.765	0.96
5_V	27_G	0.764	0.96
134_E	139_D	0.764	0.96
42_A	48_W	0.763	0.96
53_P	56_A	0.763	0.96
70_H	75_R	0.763	0.96
421_A	424_E	0.763	0.96
530_Y	547_L	0.763	0.96
189_E	218_L	0.763	0.96
471_I	474_Q	0.761	0.96
540_G	544_D	0.760	0.96
311_W	315_D	0.759	0.96
141_L	165_V	0.757	0.96
567_G	570_Y	0.755	0.95
61_L	119_L	0.754	0.95
111_R	114_P	0.754	0.95
545_P	549_E	0.753	0.95
221_L	234_A	0.752	0.95
213_F	242_L	0.751	0.95
61_L	64_E	0.751	0.95
504_L	507_E	0.751	0.95
165_V	265_F	0.751	0.95
444_L	493_A	0.750	0.95
427_L	430_V	0.749	0.95
307_G	340_D	0.747	0.95
254_L	262_R	0.747	0.95
7_A	34_A	0.746	0.95
424_E	427_L	0.745	0.95
149_P	166_T	0.744	0.95
553_M	572_V	0.743	0.95
519_R	564_Q	0.743	0.95
101_H	104_R	0.743	0.95
48_W	52_H	0.740	0.95
110_E	113_D	0.738	0.95
541_R	544_D	0.738	0.95
422_A	425_A	0.738	0.95
412_F	426_L	0.737	0.95
296_F	331_G	0.737	0.95
568_T	576_R	0.737	0.95
507_E	511_A	0.736	0.95
537_L	540_G	0.735	0.95
210_A	213_F	0.734	0.95
216_A	243_T	0.734	0.95
110_E	116_L	0.734	0.95
51_R	56_A	0.733	0.95
459_L	471_I	0.733	0.95
55_L	59_R	0.732	0.95
359_A	405_A	0.732	0.95
34_A	37_I	0.731	0.95
491_R	552_W	0.731	0.95
467_A	471_I	0.730	0.95
317_P	333_P	0.729	0.95
406_A	441_V	0.729	0.95
512_D	519_R	0.728	0.94
564_Q	568_T	0.726	0.94
477_R	531_Q	0.726	0.94
403_L	441_V	0.725	0.94
229_G	233_D	0.724	0.94
52_H	55_L	0.724	0.94
514_A	517_R	0.724	0.94
479_V	483_F	0.723	0.94
447_A	451_A	0.723	0.94
304_E	343_A	0.722	0.94
389_A	450_A	0.721	0.94
195_L	254_L	0.721	0.94
10_R	21_R	0.721	0.94
451_A	455_V	0.720	0.94
448_I	496_P	0.719	0.94
188_L	231_L	0.719	0.94
173_N	296_F	0.718	0.94
448_I	479_V	0.718	0.94
487_T	491_R	0.717	0.94
35_R	93_P	0.716	0.94
360_G	363_R	0.710	0.94
172_L	281_L	0.710	0.94
49_D	99_G	0.709	0.94
193_T	215_R	0.709	0.94
334_A	356_A	0.708	0.94
311_W	367_L	0.708	0.94
178_E	230_P	0.707	0.94
36_E	89_D	0.706	0.94
371_S	375_Y	0.704	0.93
5_V	25_N	0.704	0.93
473_A	531_Q	0.703	0.93
351_A	354_A	0.701	0.93
54_F	58_N	0.701	0.93
281_L	285_R	0.700	0.93
507_E	510_P	0.700	0.93
491_R	570_Y	0.699	0.93
315_D	420_E	0.698	0.93
254_L	257_L	0.697	0.93
379_N	439_Q	0.694	0.93
342_V	360_G	0.694	0.93
503_E	507_E	0.694	0.93
440_E	493_A	0.693	0.93
172_L	284_L	0.692	0.93
375_Y	439_Q	0.691	0.93
463_K	472_R	0.688	0.93
394_G	449_L	0.688	0.93
13_L	18_I	0.687	0.93
169_L	288_L	0.685	0.93
366_L	373_L	0.685	0.93
59_R	63_E	0.684	0.92
369_L	427_L	0.684	0.92
7_A	24_V	0.684	0.92
108_K	112_E	0.683	0.92
573_S	576_R	0.682	0.92
526_L	581_W	0.681	0.92
523_V	527_E	0.679	0.92
169_L	292_A	0.679	0.92
5_V	34_A	0.678	0.92
236_A	240_R	0.678	0.92
181_E	232_L	0.677	0.92
125_L	129_A	0.677	0.92
417_P	426_L	0.676	0.92
456_R	475_L	0.674	0.92
520_M	523_V	0.672	0.92
365_L	413_L	0.671	0.92
526_L	577_L	0.671	0.92
473_A	476_A	0.671	0.92
451_A	499_L	0.670	0.92
106_W	116_L	0.669	0.92
115_D	120_T	0.669	0.92
159_P	264_N	0.668	0.92
198_S	257_L	0.668	0.92
150_L	165_V	0.667	0.91
232_L	249_A	0.666	0.91
436_D	440_E	0.666	0.91
473_A	527_E	0.666	0.91
110_E	118_F	0.666	0.91
62_L	84_L	0.665	0.91
190_E	260_H	0.664	0.91
310_D	424_E	0.663	0.91
184_V	187_L	0.661	0.91
552_W	555_E	0.660	0.91
208_V	212_D	0.659	0.91
455_V	499_L	0.658	0.91
433_R	437_T	0.656	0.91
406_A	410_R	0.655	0.91
465_L	469_A	0.655	0.91
508_K	519_R	0.654	0.91
360_G	367_L	0.654	0.91
362_R	366_L	0.654	0.91
64_E	67_E	0.653	0.91
337_D	360_G	0.653	0.91
196_I	213_F	0.652	0.91
348_D	352_E	0.650	0.90
84_L	124_L	0.650	0.90
127_H	131_G	0.650	0.90
8_Y	20_A	0.650	0.90
560_S	568_T	0.649	0.90
69_E	74_R	0.648	0.90
443_R	447_A	0.647	0.90
218_L	221_L	0.647	0.90
29_I	33_E	0.647	0.90
439_Q	443_R	0.645	0.90
337_D	340_D	0.644	0.90
309_T	341_S	0.644	0.90
103_E	106_W	0.643	0.90
87_F	91_R	0.643	0.90
198_S	253_D	0.643	0.90
550_F	553_M	0.640	0.90
91_R	123_D	0.639	0.90
373_L	404_L	0.639	0.90
282_A	286_A	0.639	0.90
237_R	240_R	0.638	0.90
40_R	85_F	0.637	0.90
512_D	515_R	0.636	0.89
62_L	119_L	0.636	0.89
522_E	525_P	0.635	0.89
92_I	96_V	0.635	0.89
405_A	408_L	0.635	0.89
163_V	183_L	0.634	0.89
368_A	424_E	0.633	0.89
357_H	360_G	0.633	0.89
391_A	394_G	0.633	0.89
102_F	114_P	0.632	0.89
528_Q	531_Q	0.631	0.89
193_T	214_A	0.631	0.89
215_R	218_L	0.629	0.89
519_R	561_L	0.629	0.89
50_T	99_G	0.629	0.89
76_D	79_V	0.629	0.89
191_K	263_M	0.625	0.89
352_E	355_A	0.622	0.88
320_V	346_L	0.621	0.88
213_F	216_A	0.621	0.88
300_A	303_A	0.621	0.88
37_I	47_E	0.621	0.88
402_D	406_A	0.620	0.88
28_R	34_A	0.619	0.88
560_S	564_Q	0.619	0.88
458_R	461_G	0.615	0.88
206_N	245_V	0.614	0.88
440_E	489_W	0.614	0.88
388_L	391_A	0.614	0.88
524_A	527_E	0.613	0.88
68_L	72_A	0.613	0.88
470_D	558_R	0.612	0.88
533_L	537_L	0.612	0.88
167_V	265_F	0.612	0.88
102_F	116_L	0.611	0.88
159_P	259_P	0.611	0.88
557_L	561_L	0.610	0.87
428_E	432_A	0.609	0.87
319_T	350_P	0.609	0.87
157_G	259_P	0.607	0.87
176_D	181_E	0.605	0.87
167_V	180_F	0.605	0.87
249_A	252_W	0.604	0.87
143_L	176_D	0.604	0.87
362_R	405_A	0.604	0.87
173_N	348_D	0.603	0.87
447_A	450_A	0.602	0.87
141_L	150_L	0.602	0.87
153_R	159_P	0.602	0.87
410_R	441_V	0.602	0.87
141_L	191_K	0.599	0.86
259_P	279_R	0.599	0.86
408_L	430_V	0.597	0.86
40_R	81_D	0.597	0.86
516_D	520_M	0.596	0.86
322_I	331_G	0.596	0.86
500_K	503_E	0.595	0.86
153_R	157_G	0.595	0.86
496_P	500_K	0.595	0.86
243_T	252_W	0.595	0.86
373_L	408_L	0.595	0.86
577_L	580_A	0.594	0.86
538_P	541_R	0.593	0.86
276_A	284_L	0.593	0.86
100_R	103_E	0.591	0.86
95_D	101_H	0.591	0.86
456_R	460_K	0.590	0.86
32_A	36_E	0.590	0.86
519_R	525_P	0.590	0.86
178_E	229_G	0.589	0.86
532_R	536_A	0.588	0.85
284_L	288_L	0.587	0.85
58_N	88_Y	0.586	0.85
313_F	316_L	0.586	0.85
406_A	484_V	0.585	0.85
407_A	441_V	0.584	0.85
411_L	433_R	0.584	0.85
494_H	566_L	0.582	0.85
216_A	219_A	0.582	0.85
213_F	238_E	0.581	0.85
579_K	582_A	0.579	0.85
167_V	263_M	0.579	0.85
68_L	76_D	0.579	0.85
455_V	506_L	0.576	0.84
455_V	458_R	0.576	0.84
208_V	213_F	0.575	0.84
347_F	353_A	0.574	0.84
564_Q	567_G	0.573	0.84
305_R	346_L	0.573	0.84
173_N	289_G	0.571	0.84
307_G	337_D	0.571	0.84
268_V	272_G	0.571	0.84
473_A	524_A	0.570	0.84
482_G	485_A	0.569	0.84
441_V	489_W	0.569	0.84
406_A	489_W	0.569	0.84
484_V	492_L	0.567	0.83
344_L	361_V	0.566	0.83
141_L	263_M	0.565	0.83
407_A	438_A	0.563	0.83
491_R	548_E	0.562	0.83
121_R	124_L	0.562	0.83
151_S	160_D	0.562	0.83
212_D	216_A	0.562	0.83
383_L	387_A	0.561	0.83
171_L	174_Q	0.561	0.83
7_A	27_G	0.561	0.83
106_W	113_D	0.560	0.83
239_L	243_T	0.560	0.83
556_E	568_T	0.560	0.83
444_L	496_P	0.560	0.83
547_L	581_W	0.559	0.83
457_K	461_G	0.558	0.82
297_A	300_A	0.558	0.82
418_R	422_A	0.557	0.82
166_T	274_V	0.557	0.82
190_E	193_T	0.557	0.82
305_R	344_L	0.557	0.82
385_K	389_A	0.557	0.82
452_Y	502_I	0.556	0.82
108_K	111_R	0.556	0.82
129_A	133_T	0.556	0.82
563_A	566_L	0.556	0.82
318_E	353_A	0.555	0.82
560_S	572_V	0.555	0.82
175_V	179_R	0.554	0.82
69_E	77_I	0.553	0.82
511_A	515_R	0.552	0.82
354_A	418_R	0.552	0.82
344_L	347_F	0.552	0.82
236_A	248_P	0.550	0.82
525_P	578_E	0.549	0.81
59_R	62_L	0.549	0.81
559_V	569_A	0.549	0.81
299_A	303_A	0.549	0.81
76_D	126_R	0.549	0.81
506_L	510_P	0.547	0.81
234_A	237_R	0.546	0.81
70_H	77_I	0.546	0.81
62_L	65_V	0.546	0.81
455_V	459_L	0.544	0.81
452_Y	475_L	0.544	0.81
340_D	363_R	0.543	0.81
394_G	398_A	0.543	0.81
292_A	295_A	0.543	0.81
531_Q	534_L	0.542	0.81
322_I	329_V	0.542	0.81
367_L	423_F	0.540	0.80
369_L	408_L	0.540	0.80
62_L	124_L	0.540	0.80
537_L	541_R	0.539	0.80
437_T	489_W	0.539	0.80
568_T	572_V	0.538	0.80
83_A	126_R	0.538	0.80
576_R	579_K	0.537	0.80
48_W	103_E	0.537	0.80
382_N	386_L	0.537	0.80
68_L	77_I	0.537	0.80
315_D	422_A	0.536	0.80
305_R	314_G	0.536	0.80
4_Q	27_G	0.536	0.80
530_Y	533_L	0.536	0.80
195_L	252_W	0.535	0.80
313_F	335_L	0.534	0.80
159_P	277_E	0.533	0.79
403_L	445_V	0.533	0.79
397_E	400_R	0.532	0.79
354_A	416_L	0.532	0.79
35_R	94_A	0.531	0.79
523_V	561_L	0.531	0.79
191_K	257_L	0.531	0.79
453_H	457_K	0.531	0.79
217_F	242_L	0.531	0.79
206_N	239_L	0.530	0.79
372_P	408_L	0.530	0.79
389_A	446_A	0.529	0.79
154_F	208_V	0.529	0.79
60_K	63_E	0.529	0.79
184_V	263_M	0.529	0.79
433_R	440_E	0.525	0.78
396_V	400_R	0.525	0.78
165_V	179_R	0.525	0.78
55_L	92_I	0.525	0.78
7_A	69_E	0.524	0.78
477_R	480_P	0.524	0.78
306_T	341_S	0.523	0.78
390_Y	393_L	0.523	0.78
103_E	110_E	0.522	0.78
489_W	493_A	0.522	0.78
125_L	132_V	0.522	0.78
361_V	417_P	0.522	0.78
578_E	581_W	0.520	0.78
107_K	111_R	0.520	0.78
195_L	198_S	0.520	0.78
111_R	116_L	0.519	0.78
70_H	153_R	0.518	0.78
39_I	44_V	0.516	0.77
296_F	348_D	0.516	0.77
467_A	517_R	0.515	0.77
192_V	221_L	0.514	0.77
79_V	119_L	0.514	0.77
408_L	412_F	0.514	0.77
105_W	116_L	0.513	0.77
160_D	279_R	0.513	0.77
311_W	316_L	0.513	0.77
521_A	524_A	0.513	0.77
240_R	252_W	0.512	0.77
7_A	25_N	0.511	0.77
381_P	400_R	0.511	0.77
95_D	108_K	0.510	0.76
365_L	369_L	0.510	0.76
182_W	226_P	0.510	0.76
175_V	180_F	0.510	0.76
523_V	557_L	0.509	0.76
228_D	234_A	0.509	0.76
3_G	98_S	0.508	0.76
332_Y	350_P	0.508	0.76
61_L	65_V	0.508	0.76
143_L	175_V	0.505	0.76
194_A	257_L	0.504	0.76
203_L	206_N	0.503	0.75
42_A	55_L	0.503	0.75
51_R	107_K	0.503	0.75
92_I	116_L	0.502	0.75
187_L	261_L	0.502	0.75
446_A	450_A	0.502	0.75
311_W	423_F	0.502	0.75
172_L	267_V	0.501	0.75
182_W	234_A	0.501	0.75
173_N	331_G	0.501	0.75
177_P	181_E	0.500	0.75
362_R	408_L	0.500	0.75

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1pd3A	2	0.0738	11.8	0.984	Contact Map
2a3dA	1	0.1235	11.2	0.984	Contact Map
3vfzA	2	0.1029	9.7	0.984	Contact Map
1wpbA	6	0.2693	8.8	0.984	Contact Map
2fkiA	1	0.1509	8.4	0.985	Contact Map
4ykcA	1	0.1063	8.1	0.985	Contact Map
4g6dA	1	0.0943	7.9	0.985	Contact Map
2ebmA	1	0.2127	7.3	0.985	Contact Map
1lbqA	2	0.3293	6.8	0.985	Contact Map
3whrA	1	0.3705	6.4	0.985	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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