GREMLIN Database
DUF3413 - Domain of unknown function (DUF3413)
PFAM: PF11893 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 247 (239)
Sequences: 1479 (1175)
Seq/√Len: 76.0
META: 0.734

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_N144_E4.2961.00
183_A208_A4.2001.00
186_D209_K4.1551.00
211_F215_L3.9861.00
187_A212_L3.7231.00
126_I129_S3.4301.00
125_E129_S3.3761.00
115_L119_T3.1351.00
124_G127_F3.1221.00
148_A152_W2.9001.00
66_L70_P2.6651.00
31_R100_T2.5981.00
186_D207_T2.5691.00
99_D109_H2.5681.00
103_F199_Y2.5651.00
14_G64_F2.5571.00
239_N242_L2.5101.00
110_L115_L2.4411.00
187_A208_A2.3701.00
123_G127_F2.3121.00
28_I100_T2.2821.00
125_E128_G2.2451.00
208_A212_L2.1941.00
183_A206_L2.1921.00
175_F179_H2.1811.00
124_G129_S2.1521.00
124_G128_G2.1141.00
50_L174_C2.1041.00
164_G168_A1.8431.00
62_L67_L1.8391.00
116_N120_T1.7911.00
59_L63_P1.7821.00
21_N24_L1.7731.00
60_A63_P1.7681.00
59_L62_L1.7641.00
130_W134_A1.7611.00
54_G174_C1.7361.00
175_F178_S1.7051.00
55_H59_L1.6771.00
120_T127_F1.6261.00
55_H179_H1.6091.00
184_W188_N1.5930.99
179_H206_L1.5890.99
123_G126_I1.5730.99
209_K212_L1.5600.99
114_V118_L1.5520.99
123_G128_G1.5310.99
183_A212_L1.5120.99
20_F147_L1.4930.99
16_W164_G1.4900.99
204_Y208_A1.4880.99
179_H182_H1.4460.99
99_D202_L1.4380.99
89_A93_L1.4320.99
133_L144_E1.4200.99
47_Y51_A1.4160.99
52_W200_L1.4140.99
121_P125_E1.4140.99
25_A93_L1.3900.99
17_F144_E1.3760.98
149_R153_R1.3700.98
95_L176_L1.3610.98
17_F21_N1.3540.98
47_Y197_T1.3460.98
32_Y99_D1.3340.98
208_A211_F1.3340.98
150_W154_R1.3340.98
177_A180_L1.3270.98
207_T210_R1.2860.98
112_G122_G1.2710.97
243_A246_Q1.2700.97
47_Y189_Y1.2630.97
39_P44_G1.2600.97
193_I205_P1.2520.97
178_S203_Y1.2500.97
178_S182_H1.2480.97
182_H205_P1.2270.97
113_F128_G1.2250.97
142_A146_L1.2140.97
51_A55_H1.1980.96
123_G129_S1.1960.96
165_R169_L1.1640.96
131_L144_E1.1580.96
108_F199_Y1.1550.96
187_A209_K1.1500.95
179_H203_Y1.1480.95
183_A211_F1.1460.95
139_V144_E1.1380.95
94_T98_L1.1310.95
102_V117_L1.1240.95
235_A239_N1.1230.95
18_A63_P1.1220.95
70_P73_L1.1160.95
13_W148_A1.1140.95
185_A192_P1.1120.94
11_L14_G1.0870.94
131_L134_A1.0830.94
197_T203_Y1.0810.94
171_L175_F1.0670.93
238_L244_P1.0650.93
19_L23_L1.0650.93
67_L70_P1.0600.93
18_A22_I1.0590.93
107_R128_G1.0390.92
90_T141_L1.0280.92
25_A96_L1.0240.92
103_F202_L1.0160.91
131_L135_L1.0080.91
144_E148_A1.0070.91
59_L92_G1.0020.91
96_L202_L1.0020.91
212_L216_G0.9990.91
22_I26_L0.9970.91
26_L52_W0.9950.90
25_A28_I0.9930.90
188_N217_L0.9900.90
63_P66_L0.9890.90
95_L110_L0.9880.90
168_A172_L0.9860.90
185_A194_T0.9780.90
182_H197_T0.9730.89
118_L123_G0.9700.89
164_G167_L0.9680.89
182_H208_A0.9640.89
132_F135_L0.9230.87
67_L85_A0.9220.87
120_T126_I0.9220.87
82_R85_A0.9170.86
18_A54_G0.9120.86
8_S11_L0.9120.86
108_F118_L0.9080.86
187_A219_D0.9060.86
162_R165_R0.9010.85
91_L151_L0.9000.85
102_V126_I0.8970.85
146_L150_W0.8950.85
146_L149_R0.8910.85
109_H201_P0.8900.85
145_L149_R0.8880.85
63_P67_L0.8870.85
102_V105_L0.8860.85
36_S39_P0.8850.84
83_G87_L0.8840.84
206_L210_R0.8810.84
222_E226_R0.8780.84
100_T107_R0.8750.84
114_V117_L0.8650.83
107_R199_Y0.8630.83
147_L151_L0.8620.83
112_G115_L0.8560.82
102_V205_P0.8540.82
57_A62_L0.8500.82
122_G129_S0.8500.82
184_W217_L0.8490.82
144_E147_L0.8420.81
185_A193_I0.8410.81
19_L157_R0.8360.81
195_S199_Y0.8260.80
172_L183_A0.8220.80
38_W45_W0.8150.79
214_K233_P0.8140.79
51_A113_F0.8130.79
189_Y195_S0.8090.79
119_T123_G0.8090.79
47_Y194_T0.8060.78
177_A181_I0.7980.78
29_G56_F0.7970.78
207_T212_L0.7960.78
52_W191_R0.7940.77
46_L173_L0.7930.77
184_W187_A0.7890.77
131_L142_A0.7870.77
121_P126_I0.7860.77
16_W19_L0.7850.77
174_C212_L0.7810.76
176_L180_L0.7720.75
12_R15_H0.7720.75
120_T129_S0.7680.75
108_F111_N0.7670.75
57_A60_A0.7660.75
120_T128_G0.7610.74
122_G126_I0.7610.74
27_L30_L0.7550.74
95_L117_L0.7550.74
138_L142_A0.7500.73
55_H60_A0.7480.73
31_R37_P0.7430.73
10_L81_L0.7410.72
10_L76_P0.7390.72
113_F123_G0.7390.72
65_L166_P0.7390.72
107_R198_R0.7380.72
102_V182_H0.7380.72
62_L70_P0.7370.72
27_L244_P0.7360.72
11_L176_L0.7350.72
32_Y45_W0.7350.72
102_V127_F0.7340.72
101_L104_A0.7330.72
183_A194_T0.7300.71
122_G125_E0.7300.71
51_A200_L0.7280.71
66_L74_L0.7260.71
99_D200_L0.7220.70
189_Y224_R0.7180.70
77_S174_C0.7060.69
51_A54_G0.7050.69
90_T196_Q0.7010.68
8_S12_R0.6990.68
162_R169_L0.6980.68
173_L246_Q0.6960.68
47_Y208_A0.6950.68
62_L87_L0.6940.67
106_Y182_H0.6930.67
79_R88_L0.6880.67
54_G175_F0.6860.67
137_F153_R0.6850.66
136_I139_V0.6830.66
51_A202_L0.6820.66
48_L202_L0.6810.66
184_W208_A0.6700.65
103_F132_F0.6660.64
27_L31_R0.6620.64
10_L13_W0.6620.64
223_Y227_L0.6590.63
47_Y202_L0.6580.63
80_L143_L0.6580.63
133_L139_V0.6570.63
76_P83_G0.6570.63
95_L181_I0.6550.63
111_N114_V0.6540.63
187_A217_L0.6530.63
203_Y206_L0.6510.62
114_V121_P0.6510.62
55_H58_F0.6510.62
242_L245_L0.6500.62
18_A127_F0.6490.62
102_V124_G0.6480.62
179_H207_T0.6480.62
45_W49_L0.6470.62
13_W17_F0.6470.62
77_S167_L0.6450.62
51_A203_Y0.6450.62
144_E151_L0.6440.62
181_I245_L0.6410.61
59_L137_F0.6400.61
135_L144_E0.6400.61
13_W186_D0.6360.61
89_A92_G0.6330.60
11_L15_H0.6310.60
51_A178_S0.6310.60
185_A190_Y0.6220.59
146_L153_R0.6220.59
86_V148_A0.6220.59
55_H189_Y0.6210.59
84_L134_A0.6200.59
231_G242_L0.6190.59
63_P104_A0.6170.58
182_H185_A0.6170.58
55_H120_T0.6120.58
48_L52_W0.6100.58
114_V119_T0.6090.57
32_Y109_H0.6060.57
111_N208_A0.6040.57
23_L177_A0.6030.57
181_I193_I0.6030.57
144_E153_R0.6010.56
108_F120_T0.6000.56
68_L141_L0.6000.56
132_F136_I0.5990.56
180_L184_W0.5990.56
173_L177_A0.5980.56
111_N122_G0.5940.56
113_F204_Y0.5930.55
84_L87_L0.5910.55
113_F197_T0.5900.55
148_A151_L0.5860.55
45_W195_S0.5850.54
73_L103_F0.5840.54
181_I192_P0.5810.54
182_H204_Y0.5800.54
137_F145_L0.5790.54
55_H178_S0.5790.54
21_N28_I0.5770.53
19_L44_G0.5760.53
138_L159_P0.5740.53
149_R154_R0.5710.53
113_F126_I0.5700.53
222_E225_E0.5690.52
28_I93_L0.5680.52
150_W153_R0.5680.52
147_L153_R0.5660.52
195_S204_Y0.5660.52
56_F59_L0.5640.52
113_F186_D0.5640.52
182_H186_D0.5640.52
113_F179_H0.5630.52
112_G200_L0.5630.52
241_P244_P0.5630.52
161_R166_P0.5630.52
136_I147_L0.5590.51
156_R169_L0.5560.51
140_I150_W0.5550.51
94_T122_G0.5540.50
163_L166_P0.5520.50
115_L197_T0.5520.50
195_S198_R0.5520.50
72_T140_I0.5510.50
179_H204_Y0.5500.50
118_L122_G0.5500.50
187_A206_L0.5480.50
104_A191_R0.5470.50
233_P239_N0.5470.50
47_Y113_F0.5440.49
37_P42_L0.5440.49
53_L64_F0.5430.49
117_L127_F0.5420.49
13_W152_W0.5420.49
101_L109_H0.5390.49
31_R99_D0.5390.49
16_W22_I0.5390.49
87_L169_L0.5380.48
103_F233_P0.5370.48
65_L153_R0.5360.48
51_A171_L0.5350.48
130_W144_E0.5340.48
216_G219_D0.5330.48
204_Y207_T0.5330.48
57_A66_L0.5320.48
108_F114_V0.5320.48
157_R161_R0.5260.47
87_L141_L0.5220.46
97_L131_L0.5220.46
159_P172_L0.5220.46
43_L177_A0.5200.46
186_D204_Y0.5190.46
32_Y41_T0.5180.46
55_H208_A0.5170.46
141_L155_L0.5170.46
173_L180_L0.5160.46
79_R157_R0.5160.46
48_L65_L0.5140.45
102_V121_P0.5140.45
121_P128_G0.5130.45
217_L220_P0.5130.45
113_F118_L0.5110.45
222_E233_P0.5100.45
55_H127_F0.5100.45
22_I25_A0.5090.45
111_N209_K0.5090.45
206_L211_F0.5090.45
105_L111_N0.5080.45
144_E152_W0.5050.44
23_L172_L0.5050.44
56_F209_K0.5040.44
60_A64_F0.5020.44
80_L84_L0.5000.44
113_F116_N0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i0uA 4 0.2753 8.7 0.954 Contact Map
2l2tA 2 0.1781 8.5 0.955 Contact Map
4ev6A 3 0.2834 8.2 0.955 Contact Map
2m8rA 1 0.1498 3.4 0.963 Contact Map
1pi7A 1 0.0769 2.6 0.964 Contact Map
5bq9A 1 0.2794 2.6 0.965 Contact Map
2jwaA 2 0.1781 2.4 0.965 Contact Map
2cqyA 1 0.2065 2.2 0.966 Contact Map
2k1aA 1 0.17 1.8 0.968 Contact Map
2micA 2 0.1619 1.6 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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