GREMLIN Database
DUF3397 - Protein of unknown function (DUF3397)
PFAM: PF11877 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 112 (111)
Sequences: 713 (573)
Seq/√Len: 54.4
META: 0.332

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_D93_W3.5331.00
37_T41_L3.1111.00
38_T93_W2.9561.00
12_F41_L2.8061.00
2_A5_I2.3361.00
2_A6_T2.3151.00
16_Y30_F2.2981.00
15_V19_V2.1471.00
65_L92_F2.1331.00
88_F92_F2.0971.00
11_P40_F2.0901.00
16_Y26_K2.0891.00
72_L91_G1.9271.00
77_W83_I1.9211.00
106_L110_I1.8830.99
65_L68_L1.8570.99
33_A37_T1.8510.99
5_I12_F1.8260.99
48_L107_L1.8040.99
43_L74_L1.7670.99
96_S100_F1.7320.99
69_A88_F1.7270.99
73_G88_F1.7190.99
52_I111_G1.5950.98
5_I9_F1.5700.98
94_R97_F1.5700.98
19_V29_A1.5340.98
16_Y20_K1.5310.98
46_H50_N1.5250.98
62_L66_L1.5250.98
75_L79_K1.4020.96
37_T97_F1.4010.96
58_L62_L1.3970.96
42_I100_F1.3580.95
8_P12_F1.2810.94
35_D91_G1.2600.93
22_F109_I1.2370.92
3_F59_P1.2030.91
14_L86_K1.1990.91
36_V41_L1.1910.91
61_I64_L1.1830.90
21_K53_F1.1730.90
36_V60_Y1.1730.90
46_H58_L1.1020.87
8_P97_F1.0960.87
90_R97_F1.0410.84
92_F96_S1.0180.82
52_I100_F1.0160.82
66_L94_R1.0150.82
23_T54_G1.0100.82
41_L81_G1.0080.82
68_L92_F0.9950.81
16_Y21_K0.9890.81
44_S96_S0.9830.80
66_L101_F0.9730.79
13_I102_L0.9720.79
10_L39_P0.9700.79
66_L83_I0.9680.79
20_K67_L0.9470.78
77_W82_E0.9460.77
56_S106_L0.9430.77
68_L108_L0.9340.77
68_L99_L0.9340.77
37_T40_F0.9330.77
102_L106_L0.9300.76
34_M97_F0.9170.75
20_K26_K0.9080.75
60_Y64_L0.8970.74
56_S59_P0.8950.73
6_T83_I0.8740.72
4_L48_L0.8710.71
13_I20_K0.8510.70
68_L105_I0.8480.69
49_S57_F0.8400.69
103_L107_L0.8380.68
42_I68_L0.8360.68
97_F104_Y0.8240.67
61_I100_F0.8190.67
74_L79_K0.7900.64
12_F36_V0.7900.64
62_L86_K0.7900.64
16_Y76_Q0.7820.63
76_Q90_R0.7800.63
73_G92_F0.7790.63
57_F105_I0.7710.62
67_L89_F0.7710.62
6_T22_F0.7690.62
12_F26_K0.7680.62
3_F10_L0.7670.62
50_N74_L0.7610.61
19_V23_T0.7590.61
14_L39_P0.7580.61
44_S108_L0.7550.60
3_F71_L0.7530.60
65_L111_G0.7500.60
17_I21_K0.7400.59
10_L59_P0.7360.58
4_L80_K0.7230.57
99_L111_G0.7210.57
33_A53_F0.7190.57
39_P63_L0.7120.56
15_V30_F0.7080.55
18_I110_I0.6970.54
98_L109_I0.6950.54
78_R83_I0.6920.54
56_S99_L0.6820.53
34_M65_L0.6750.52
64_L99_L0.6720.52
67_L110_I0.6700.51
49_S59_P0.6680.51
13_I21_K0.6650.51
52_I112_I0.6630.51
16_Y32_L0.6620.51
4_L101_F0.6620.51
61_I95_L0.6470.49
80_K98_L0.6430.49
100_F111_G0.6390.48
44_S59_P0.6360.48
11_P48_L0.6350.48
18_I109_I0.6330.47
31_L61_I0.6310.47
73_G78_R0.6260.47
43_L63_L0.6250.47
85_Y106_L0.6240.46
48_L63_L0.6220.46
63_L78_R0.6200.46
82_E104_Y0.6130.45
47_F81_G0.6100.45
35_D97_F0.6030.44
8_P29_A0.5990.44
27_K30_F0.5970.44
13_I89_F0.5960.44
44_S104_Y0.5930.43
18_I21_K0.5830.42
105_I109_I0.5830.42
70_I73_G0.5800.42
12_F35_D0.5780.42
44_S100_F0.5760.41
9_F16_Y0.5720.41
44_S66_L0.5700.41
15_V36_V0.5670.41
49_S60_Y0.5540.39
18_I91_G0.5530.39
76_Q96_S0.5510.39
37_T45_V0.5500.39
65_L96_S0.5450.38
79_K106_L0.5450.38
33_A48_L0.5450.38
57_F89_F0.5420.38
18_I61_I0.5380.38
30_F88_F0.5370.37
35_D83_I0.5370.37
78_R87_K0.5270.36
24_K70_I0.5260.36
58_L74_L0.5250.36
90_R94_R0.5200.36
7_L22_F0.5180.36
35_D41_L0.5130.35
95_L103_L0.5120.35
72_L76_Q0.5110.35
72_L89_F0.5070.35
9_F102_L0.5060.34
10_L21_K0.5060.34
12_F16_Y0.5050.34
18_I23_T0.5010.34
24_K112_I0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kv5A 1 0.2679 3.6 0.91 Contact Map
3j9pD 4 0.625 2.5 0.917 Contact Map
4httA 1 0.9911 2 0.922 Contact Map
2l2tA 2 0.2589 2 0.922 Contact Map
4b19A 1 0.25 1.8 0.924 Contact Map
4xp4A 1 0.9643 1.8 0.924 Contact Map
4b4aA 1 0.9911 1.8 0.924 Contact Map
2ks1B 1 0.25 1.7 0.925 Contact Map
3ayfA 2 0.2321 1.6 0.926 Contact Map
3lb6C 1 0 1.3 0.929 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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