GREMLIN Database
DUF3396 - Protein of unknown function (DUF3396)
PFAM: PF11876 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 206 (198)
Sequences: 979 (773)
Seq/√Len: 54.9
META: 0.577

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
81_R155_D3.9451.00
44_V109_F3.8101.00
79_A87_V3.4431.00
134_I168_V3.4001.00
105_N108_T3.0401.00
147_A168_V2.7251.00
202_W205_R2.6061.00
107_L146_Q2.5791.00
59_G105_N2.4901.00
62_L85_L2.4761.00
115_L124_L2.4441.00
115_L143_V2.4401.00
41_R146_Q2.4111.00
27_L43_L2.2081.00
135_V146_Q2.1581.00
139_Y142_G2.1281.00
146_Q149_E2.0171.00
43_L47_L2.0081.00
124_L171_L1.9891.00
49_E140_G1.9801.00
105_N147_A1.9451.00
112_D141_G1.9251.00
166_R169_A1.8670.99
101_I175_I1.8530.99
76_Y80_Q1.8320.99
173_K176_R1.8020.99
169_A176_R1.7830.99
83_P160_P1.7720.99
131_P167_A1.7720.99
100_G169_A1.7680.99
134_I164_A1.7440.99
168_V172_L1.6830.99
162_P166_R1.6500.99
20_L55_H1.6460.99
41_R45_L1.6320.99
83_P163_P1.6280.99
62_L78_L1.6130.98
105_N165_Y1.5780.98
176_R204_R1.5560.98
48_A139_Y1.5390.98
118_L174_P1.5340.98
45_L144_V1.5320.98
110_L115_L1.5210.98
100_G117_K1.5120.98
102_K108_T1.5020.97
11_E14_E1.5010.97
128_L145_I1.4820.97
121_L138_P1.4790.97
137_H146_Q1.4690.97
80_Q201_R1.4580.97
155_D158_R1.4520.97
32_L40_F1.4500.97
121_L125_R1.4320.97
48_A109_F1.4300.97
56_G109_F1.4290.97
169_A173_K1.3880.96
107_L144_V1.3850.96
22_Y90_P1.3800.96
48_A56_G1.3560.95
154_G168_V1.3230.95
148_G164_A1.3050.94
40_F44_V1.3010.94
110_L175_I1.2750.94
56_G145_I1.2660.93
86_D102_K1.2600.93
59_G101_I1.2460.93
31_F35_H1.2290.92
114_L118_L1.2260.92
115_L120_G1.2230.92
180_L183_L1.2160.92
12_W16_L1.1960.91
57_Y105_N1.1940.91
75_E87_V1.1920.91
25_F47_L1.1910.91
202_W206_F1.1910.91
134_I145_I1.1890.91
108_T147_A1.1740.90
8_G11_E1.1690.90
52_P139_Y1.1480.89
152_E163_P1.1430.89
32_L36_G1.1370.89
38_E41_R1.1340.89
55_H102_K1.1320.89
171_L174_P1.1300.89
100_G114_L1.1270.88
7_F10_R1.1240.88
115_L119_G1.1140.88
125_R128_L1.1050.87
77_A157_N1.0990.87
113_P116_E1.0960.87
10_R13_Q1.0850.86
147_A154_G1.0780.86
83_P120_G1.0760.86
127_A171_L1.0740.86
72_E75_E1.0670.86
84_G154_G1.0590.85
133_D136_V1.0590.85
101_I145_I0.9900.81
23_L49_E0.9810.80
87_V184_H0.9780.80
46_E49_E0.9660.79
103_G205_R0.9580.79
115_L136_V0.9430.78
59_G176_R0.9430.78
57_Y102_K0.9420.78
161_V166_R0.9380.77
7_F13_Q0.9280.77
8_G13_Q0.9260.76
182_S186_G0.9200.76
57_Y88_D0.9170.76
201_R204_R0.9150.75
81_R157_N0.9130.75
83_P86_D0.9090.75
149_E174_P0.9010.74
79_A198_E0.8970.74
9_R19_G0.8930.74
124_L143_V0.8910.74
53_P162_P0.8890.73
144_V147_A0.8850.73
39_R42_E0.8830.73
110_L174_P0.8810.73
182_S185_F0.8810.73
99_D117_K0.8800.73
128_L168_V0.8750.72
127_A167_A0.8740.72
41_R137_H0.8730.72
56_G105_N0.8730.72
64_L73_P0.8730.72
194_F197_E0.8700.72
178_E181_G0.8610.71
152_E162_P0.8540.70
64_L88_D0.8500.70
53_P139_Y0.8450.70
64_L75_E0.8420.69
104_V145_I0.8360.69
10_R14_E0.8340.68
40_F147_A0.8300.68
7_F14_E0.8300.68
79_A102_K0.8280.68
23_L50_R0.8280.68
53_P142_G0.8250.68
124_L172_L0.8180.67
51_L126_A0.8170.67
55_H63_N0.8100.66
111_G175_I0.8080.66
48_A53_P0.8010.65
58_A144_V0.8000.65
42_E46_E0.7980.65
152_E160_P0.7930.65
40_F183_L0.7930.65
53_P109_F0.7930.65
130_P133_D0.7920.64
8_G12_W0.7910.64
62_L75_E0.7840.64
147_A165_Y0.7660.62
39_R51_L0.7630.62
109_F144_V0.7600.61
169_A172_L0.7590.61
177_A181_G0.7590.61
83_P161_V0.7570.61
83_P166_R0.7570.61
41_R107_L0.7550.61
45_L49_E0.7540.61
37_P45_L0.7500.60
40_F162_P0.7420.59
120_G123_A0.7350.59
103_G177_A0.7320.58
43_L174_P0.7300.58
132_P201_R0.7270.58
119_G128_L0.7260.58
128_L171_L0.7220.57
121_L127_A0.7210.57
169_A177_A0.7200.57
52_P176_R0.7130.56
39_R85_L0.7130.56
185_F188_P0.7130.56
95_L143_V0.7120.56
11_E16_L0.7110.56
59_G144_V0.7010.55
157_N181_G0.7000.55
7_F18_D0.6990.55
123_A200_E0.6980.55
78_L176_R0.6960.55
190_G193_R0.6960.55
105_N168_V0.6950.54
149_E153_L0.6950.54
57_Y86_D0.6880.54
86_D105_N0.6880.54
47_L55_H0.6840.53
110_L172_L0.6830.53
76_Y184_H0.6820.53
88_D102_K0.6820.53
153_L161_V0.6730.52
31_F51_L0.6730.52
50_R53_P0.6710.52
9_R13_Q0.6700.52
44_V56_G0.6650.51
112_D122_E0.6590.51
148_G166_R0.6570.50
101_I104_V0.6570.50
61_A158_R0.6560.50
128_L134_I0.6560.50
74_L96_R0.6550.50
34_E116_E0.6490.50
23_L92_S0.6470.49
153_L168_V0.6430.49
93_T97_L0.6400.49
199_T203_L0.6400.49
55_H139_Y0.6370.48
136_V142_G0.6370.48
134_I139_Y0.6340.48
148_G162_P0.6300.47
7_F11_E0.6280.47
60_L77_A0.6250.47
104_V172_L0.6240.47
111_G114_L0.6240.47
103_G169_A0.6220.47
28_P56_G0.6180.46
56_G103_G0.6180.46
127_A143_V0.6180.46
200_E204_R0.6150.46
43_L58_A0.6140.46
101_I105_N0.6120.46
185_F201_R0.6110.45
174_P179_E0.6110.45
134_I148_G0.6110.45
112_D116_E0.6100.45
140_G173_K0.6040.45
59_G103_G0.6040.45
145_I172_L0.6040.45
152_E164_A0.6020.45
75_E169_A0.6010.44
78_L104_V0.6000.44
155_D160_P0.6000.44
121_L143_V0.6000.44
133_D138_P0.5990.44
36_G56_G0.5980.44
134_I138_P0.5980.44
149_E160_P0.5960.44
30_E34_E0.5920.43
109_F113_P0.5900.43
159_G162_P0.5850.43
69_E92_S0.5810.42
184_H187_S0.5810.42
7_F16_L0.5810.42
165_Y199_T0.5800.42
13_Q16_L0.5780.42
20_L109_F0.5750.42
82_Y153_L0.5690.41
187_S190_G0.5690.41
145_I168_V0.5680.41
159_G166_R0.5670.41
110_L149_E0.5670.41
132_P141_G0.5660.41
59_G165_Y0.5660.41
198_E201_R0.5650.41
14_E17_D0.5640.41
39_R122_E0.5600.40
94_S174_P0.5600.40
150_A160_P0.5560.40
162_P186_G0.5550.40
67_D79_A0.5550.40
138_P142_G0.5540.39
112_D138_P0.5490.39
23_L76_Y0.5490.39
31_F182_S0.5480.39
71_A75_E0.5450.39
8_G108_T0.5420.38
27_L40_F0.5410.38
53_P112_D0.5380.38
93_T96_R0.5370.38
79_A104_V0.5360.38
58_A199_T0.5340.37
54_E102_K0.5330.37
148_G163_P0.5320.37
180_L185_F0.5300.37
180_L187_S0.5290.37
29_L62_L0.5290.37
200_E203_L0.5270.37
110_L145_I0.5260.37
51_L102_K0.5250.37
65_P143_V0.5220.36
143_V171_L0.5210.36
131_P134_I0.5210.36
101_I166_R0.5170.36
56_G124_L0.5160.36
56_G168_V0.5150.36
59_G199_T0.5130.35
180_L203_L0.5130.35
26_T148_G0.5110.35
61_A118_L0.5100.35
138_P168_V0.5100.35
142_G146_Q0.5090.35
22_Y105_N0.5080.35
162_P173_K0.5060.35
162_P168_V0.5020.34
193_R197_E0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3i12A 2 0.5777 10.1 0.948 Contact Map
1rv3A 3 0.432 9.3 0.949 Contact Map
3tqtA 2 0.5874 8 0.951 Contact Map
3e5nA 2 0.5194 6.1 0.953 Contact Map
3bczA 1 0.8398 5.7 0.954 Contact Map
4c5cA 2 0.5243 5.6 0.954 Contact Map
3lwbA 2 0.5534 5.3 0.955 Contact Map
1ehiA 2 0.6117 4.5 0.956 Contact Map
3ck1A 4 0.2476 4.4 0.956 Contact Map
4uz0A 1 0.2816 3.7 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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