GREMLIN Database
DUF3387 - Domain of unknown function (DUF3387)
PFAM: PF11867 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 332 (325)
Sequences: 8326 (5011)
Seq/√Len: 277.9
META: 0.862

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
204_E208_R3.4701.00
177_K181_N3.2351.00
203_E207_E3.2251.00
225_K229_E3.1871.00
247_L251_D3.1241.00
26_R93_E3.1231.00
277_E281_K3.1031.00
296_K299_V2.8801.00
222_E225_K2.8401.00
201_R229_E2.7001.00
221_E225_K2.6501.00
316_E320_E2.6491.00
235_K238_E2.5961.00
42_T45_E2.5701.00
190_K244_E2.4721.00
200_E204_E2.4571.00
174_E177_K2.4121.00
191_N251_D2.3131.00
17_V21_K2.2771.00
52_A168_H2.2751.00
161_A164_K2.2731.00
215_T218_E2.2441.00
236_R247_L2.2361.00
17_V20_E2.2251.00
294_R327_E2.1441.00
22_L90_I2.1441.00
299_V303_R2.0921.00
36_K45_E2.0831.00
3_G8_A2.0791.00
218_E221_E2.0581.00
267_K270_E2.0241.00
13_E16_A2.0231.00
236_R251_D2.0071.00
232_E235_K1.9881.00
86_E89_E1.9771.00
69_D73_A1.9441.00
62_D65_K1.9331.00
218_E222_E1.8431.00
199_S203_E1.8371.00
21_K73_A1.8161.00
101_R105_R1.7851.00
320_E324_E1.7721.00
23_E27_D1.7631.00
22_L26_R1.7551.00
15_V84_H1.7551.00
278_T281_K1.7521.00
53_A96_F1.7501.00
286_D289_K1.7471.00
29_F67_F1.7341.00
33_D36_K1.7281.00
310_Y318_A1.7281.00
96_F100_V1.7161.00
60_L63_G1.7081.00
274_E307_K1.6981.00
208_R222_E1.6891.00
225_K228_K1.6701.00
54_V103_A1.6601.00
278_T300_L1.6511.00
257_D261_D1.6431.00
204_E207_E1.6271.00
55_E170_N1.5911.00
151_D154_I1.5711.00
311_P314_K1.5581.00
310_Y314_K1.5511.00
34_Y97_F1.5491.00
192_P328_L1.5391.00
207_E211_N1.5041.00
65_K69_D1.4991.00
235_K239_E1.4961.00
72_R76_K1.4571.00
24_V70_L1.4531.00
75_S98_Q1.4481.00
32_F53_A1.4401.00
217_A221_E1.4401.00
194_Q233_E1.4291.00
5_G8_A1.4131.00
315_Q318_A1.4101.00
20_E24_V1.4081.00
233_E237_G1.3861.00
282_N300_L1.3761.00
19_L90_I1.3701.00
45_E48_A1.3691.00
274_E277_E1.3681.00
68_L101_R1.3651.00
324_E327_E1.3641.00
64_K68_L1.3621.00
283_A297_L1.3551.00
315_Q319_T1.3451.00
18_L90_I1.3441.00
214_I218_E1.3361.00
21_K24_V1.3291.00
68_L105_R1.3191.00
90_I94_V1.3171.00
317_E320_E1.3071.00
196_R204_E1.3001.00
266_E270_E1.2971.00
74_L94_V1.2961.00
22_L93_E1.2961.00
197_K200_E1.2941.00
302_K306_R1.2941.00
36_K52_A1.2941.00
184_I202_L1.2931.00
153_S156_S1.2921.00
229_E232_E1.2841.00
232_E239_E1.2821.00
296_K300_L1.2771.00
28_L67_F1.2681.00
25_V97_F1.2611.00
291_E294_R1.2611.00
32_F52_A1.2601.00
9_I13_E1.2591.00
71_V97_F1.2591.00
254_A257_D1.2551.00
282_N285_I1.2491.00
282_N297_L1.2371.00
188_L195_S1.2351.00
207_E210_N1.2221.00
270_E274_E1.2151.00
308_Y311_P1.2121.00
34_Y37_F1.2071.00
18_L22_L1.1921.00
314_K318_A1.1891.00
21_K70_L1.1851.00
254_A261_D1.1851.00
34_Y93_E1.1781.00
36_K41_G1.1701.00
196_R200_E1.1611.00
103_A107_L1.1591.00
161_A165_K1.1501.00
37_F49_L1.1421.00
18_L74_L1.1401.00
278_T304_L1.1321.00
71_V75_S1.1311.00
16_A19_L1.1301.00
70_L73_A1.1181.00
182_D186_A1.1121.00
231_R235_K1.1121.00
158_E161_A1.1111.00
243_S246_E1.1061.00
317_E321_T1.1041.00
300_L304_L1.1001.00
32_F37_F1.0991.00
267_K308_Y1.0961.00
157_D161_A1.0951.00
223_L301_V1.0951.00
48_A52_A1.0901.00
11_Q83_P1.0901.00
6_D13_E1.0841.00
87_A90_I1.0831.00
63_G66_R1.0811.00
144_A147_L1.0781.00
273_R277_E1.0781.00
25_V74_L1.0691.00
57_I63_G1.0681.00
12_E86_E1.0641.00
3_G7_P1.0501.00
102_A106_K1.0491.00
276_L279_L1.0481.00
226_L230_L1.0481.00
162_E165_K1.0461.00
187_R234_E1.0411.00
55_E58_L1.0311.00
19_L89_E1.0281.00
25_V70_L1.0201.00
255_K260_V1.0161.00
213_A216_T1.0131.00
41_G49_L1.0101.00
311_P318_A1.0071.00
24_V27_D1.0021.00
310_Y313_D0.9961.00
157_D228_K0.9941.00
29_F53_A0.9811.00
26_R35_S0.9781.00
59_G63_G0.9711.00
15_V18_L0.9691.00
140_D145_A0.9661.00
298_R302_K0.9591.00
270_E273_R0.9521.00
201_R205_I0.9461.00
12_E16_A0.9431.00
227_A231_R0.9411.00
233_E236_R0.9361.00
104_L108_T0.9321.00
78_F94_V0.9311.00
104_L107_L0.9301.00
205_I226_L0.9281.00
10_D13_E0.9271.00
72_R101_R0.9271.00
260_V263_L0.9251.00
311_P315_Q0.9241.00
173_V219_V0.9171.00
143_A148_K0.9161.00
159_F162_E0.9161.00
256_N313_D0.9141.00
41_G45_E0.9131.00
94_V98_Q0.9101.00
11_Q81_C0.9031.00
36_K49_L0.9031.00
257_D314_K0.9021.00
282_N296_K0.9001.00
144_A148_K0.8971.00
97_F101_R0.8961.00
82_V87_A0.8961.00
44_F48_A0.8931.00
105_R108_T0.8931.00
25_V29_F0.8921.00
26_R34_Y0.8911.00
64_K174_E0.8861.00
6_D9_I0.8841.00
256_N259_A0.8831.00
270_E308_Y0.8811.00
62_D66_R0.8771.00
29_F100_V0.8761.00
260_V264_G0.8741.00
50_L53_A0.8741.00
156_S159_F0.8651.00
254_A260_V0.8621.00
246_E273_R0.8621.00
69_D186_A0.8601.00
22_L97_F0.8581.00
23_E26_R0.8511.00
49_L52_A0.8501.00
274_E278_T0.8501.00
98_Q102_A0.8481.00
174_E178_K0.8381.00
297_L304_L0.8371.00
127_Q131_E0.8331.00
237_G247_L0.8311.00
224_I228_K0.8301.00
156_S160_L0.8271.00
232_E236_R0.8251.00
318_A321_T0.8240.99
135_S138_V0.8240.99
99_A103_A0.8240.99
124_A127_Q0.8230.99
268_L272_A0.8200.99
127_Q130_D0.8170.99
93_E97_F0.8140.99
32_F49_L0.8130.99
319_T323_L0.8130.99
3_G10_D0.8130.99
16_A20_E0.8100.99
116_P120_E0.8090.99
303_R306_R0.8080.99
28_L66_R0.8000.99
278_T307_K0.7980.99
310_Y315_Q0.7950.99
140_D143_A0.7940.99
141_I145_A0.7930.99
159_F163_V0.7930.99
255_K261_D0.7900.99
228_K232_E0.7880.99
312_P318_A0.7860.99
196_R201_R0.7840.99
50_L99_A0.7800.99
50_L54_V0.7790.99
314_K319_T0.7740.99
229_E294_R0.7730.99
190_K245_E0.7720.99
145_A150_P0.7720.99
15_V19_L0.7710.99
121_I129_V0.7700.99
102_A105_R0.7690.99
290_R293_V0.7680.99
55_E59_G0.7670.99
228_K231_R0.7670.99
11_Q82_V0.7650.99
18_L87_A0.7610.99
124_A129_V0.7610.99
29_F32_F0.7600.99
264_G267_K0.7590.99
142_F145_A0.7580.99
196_R324_E0.7570.99
109_P113_G0.7560.99
301_V323_L0.7550.99
308_Y312_P0.7510.99
183_E186_A0.7500.99
29_F34_Y0.7490.99
19_L86_E0.7470.99
11_Q84_H0.7450.99
51_P54_V0.7430.99
123_A126_R0.7420.99
68_L72_R0.7370.99
297_L301_V0.7370.99
15_V86_E0.7360.99
214_I217_A0.7340.99
145_A149_K0.7340.99
264_G268_L0.7320.99
11_Q14_A0.7320.99
257_D260_V0.7320.99
271_I304_L0.7310.99
34_Y38_F0.7290.99
300_L303_R0.7270.99
95_A99_A0.7260.99
157_D160_L0.7240.99
123_A127_Q0.7230.99
17_V77_A0.7230.99
100_V104_L0.7200.99
21_K25_V0.7200.99
221_E224_I0.7180.99
24_V28_L0.7180.99
22_L29_F0.7170.99
29_F97_F0.7170.99
214_I219_V0.7140.99
309_G314_K0.7120.99
193_V321_T0.7110.99
24_V30_H0.7110.99
64_K108_T0.7080.98
8_A11_Q0.7080.98
54_V107_L0.7080.98
234_E244_E0.7070.98
267_K309_G0.7050.98
71_V101_R0.7040.98
141_I144_A0.7020.98
321_T324_E0.7020.98
55_E171_L0.7010.98
48_A51_P0.6960.98
51_P103_A0.6960.98
269_K273_R0.6950.98
71_V98_Q0.6930.98
18_L94_V0.6930.98
324_E328_L0.6930.98
83_P88_L0.6910.98
117_D120_E0.6900.98
55_E168_H0.6890.98
201_R204_E0.6870.98
259_A262_V0.6870.98
299_V302_K0.6870.98
283_A330_A0.6850.98
4_K8_A0.6840.98
233_E238_E0.6820.98
271_I274_E0.6810.98
318_A322_V0.6800.98
293_V297_L0.6790.98
316_E319_T0.6790.98
214_I222_E0.6770.98
19_L26_R0.6760.98
224_I227_A0.6750.98
36_K40_T0.6740.98
278_T282_N0.6710.98
187_R195_S0.6700.98
46_R50_L0.6670.98
153_S157_D0.6640.98
219_V222_E0.6630.98
67_F97_F0.6610.98
29_F57_I0.6610.98
310_Y319_T0.6580.98
280_R285_I0.6570.98
147_L150_P0.6540.97
133_I206_I0.6540.97
272_A282_N0.6530.97
236_R239_E0.6530.97
38_F49_L0.6530.97
294_R298_R0.6520.97
32_F35_S0.6520.97
101_R104_L0.6500.97
166_M172_A0.6500.97
4_K7_P0.6490.97
113_G116_P0.6470.97
47_L50_L0.6450.97
61_E64_K0.6430.97
24_V66_R0.6430.97
205_I219_V0.6360.97
311_P319_T0.6320.97
103_A106_K0.6310.97
309_G318_A0.6300.97
194_Q236_R0.6300.97
73_A76_K0.6280.97
244_E247_L0.6280.97
271_I278_T0.6270.97
312_P315_Q0.6250.97
279_L283_A0.6250.97
291_E298_R0.6250.97
290_R297_L0.6230.97
314_K317_E0.6220.97
200_E203_E0.6220.97
99_A102_A0.6220.97
255_K321_T0.6200.97
3_G6_D0.6190.96
61_E65_K0.6190.96
295_A298_R0.6180.96
275_L304_L0.6180.96
256_N260_V0.6160.96
69_D72_R0.6160.96
53_A100_V0.6160.96
57_I60_L0.6150.96
217_A220_I0.6150.96
41_G46_R0.6130.96
3_G9_I0.6130.96
250_Y254_A0.6130.96
88_L91_R0.6090.96
47_L51_P0.6090.96
18_L25_V0.6070.96
183_E187_R0.6050.96
68_L104_L0.6050.96
44_F47_L0.6020.96
299_V306_R0.6010.96
283_A288_T0.6010.96
192_P321_T0.6010.96
276_L280_R0.6000.96
98_Q101_R0.5990.96
96_F99_A0.5960.96
242_L246_E0.5960.96
48_A167_K0.5930.96
146_G149_K0.5910.95
90_I93_E0.5870.95
312_P316_E0.5870.95
308_Y313_D0.5860.95
163_V166_M0.5850.95
35_S38_F0.5840.95
142_F146_G0.5840.95
122_E125_I0.5810.95
277_E280_R0.5810.95
254_A317_E0.5800.95
157_D231_R0.5790.95
191_N233_E0.5780.95
262_V265_D0.5770.95
280_R284_T0.5770.95
285_I290_R0.5750.95
178_K182_D0.5740.95
315_Q323_L0.5730.95
309_G315_Q0.5710.95
54_V104_L0.5690.94
321_T328_L0.5680.94
70_L125_I0.5680.94
297_L330_A0.5640.94
234_E247_L0.5610.94
272_A279_L0.5610.94
269_K279_L0.5590.94
164_K224_I0.5590.94
187_R233_E0.5580.94
266_E269_K0.5580.94
318_A325_Q0.5580.94
140_D146_G0.5570.94
66_R70_L0.5550.94
208_R211_N0.5520.93
31_G34_Y0.5500.93
81_C84_H0.5490.93
28_L60_L0.5490.93
306_R315_Q0.5470.93
95_A98_Q0.5460.93
234_E237_G0.5450.93
297_L300_L0.5440.93
75_S79_A0.5430.93
32_F36_K0.5420.93
19_L23_E0.5420.93
276_L329_L0.5410.93
258_S313_D0.5400.93
308_Y315_Q0.5390.93
278_T283_A0.5350.92
320_E327_E0.5350.92
25_V28_L0.5340.92
130_D135_S0.5280.92
21_K28_L0.5280.92
216_T220_I0.5280.92
258_S261_D0.5270.92
183_E234_E0.5260.92
173_V214_I0.5260.92
52_A167_K0.5230.92
267_K274_E0.5220.91
72_R184_I0.5210.91
20_E23_E0.5210.91
109_P114_K0.5170.91
141_I149_K0.5160.91
183_E231_R0.5160.91
318_A323_L0.5160.91
58_L61_E0.5130.91
313_D318_A0.5110.91
216_T219_V0.5110.91
180_L202_L0.5100.91
28_L57_I0.5100.91
30_H35_S0.5090.90
128_L131_E0.5080.90
171_L175_L0.5070.90
22_L74_L0.5070.90
96_F101_R0.5070.90
37_F46_R0.5060.90
101_R106_K0.5060.90
313_D319_T0.5060.90
14_A21_K0.5050.90
74_L97_F0.5050.90
67_F105_R0.5040.90
206_I210_N0.5040.90
237_G240_L0.5020.90
35_S40_T0.5010.90
152_I155_L0.5010.90
97_F103_A0.5010.90
140_D144_A0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2w00A 1 0.3916 36.9 0.948 Contact Map
3evyA 1 0.2259 33.4 0.949 Contact Map
2cr7A 1 0.241 21.7 0.954 Contact Map
4uxvA 1 0.8404 17 0.956 Contact Map
1ug3A 1 0.5663 16.9 0.956 Contact Map
2o8pA 2 0.4307 16.7 0.956 Contact Map
1h99A 2 0.5361 12.2 0.959 Contact Map
2clyA 1 0.3133 10 0.96 Contact Map
4uosA 1 0.4488 9.6 0.961 Contact Map
2w9yA 1 0.3855 8.8 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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