GREMLIN Database
DUF3382 - Domain of unknown function (DUF3382)
PFAM: PF11862 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 97 (95)
Sequences: 3599 (2458)
Seq/√Len: 252.1
META: 0.828

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_A49_F3.3321.00
21_I44_A2.9361.00
5_D56_S2.7361.00
5_D52_R2.7001.00
43_I47_I2.2331.00
39_G43_I2.2121.00
17_F41_L2.1151.00
27_N31_E2.0811.00
11_L15_G2.0091.00
14_L18_L1.9651.00
14_L45_V1.9481.00
13_A48_V1.8971.00
44_A48_V1.8911.00
86_L90_L1.8911.00
10_A45_V1.8741.00
23_L36_T1.8121.00
9_A48_V1.8101.00
37_R40_L1.7601.00
23_L34_L1.7021.00
28_I33_V1.6811.00
52_R55_L1.6201.00
85_W88_P1.6061.00
90_L94_A1.5951.00
22_G41_L1.5631.00
13_A17_F1.5081.00
21_I41_L1.4651.00
50_V54_L1.4611.00
42_A46_A1.3671.00
6_A49_F1.3671.00
51_G55_L1.3151.00
25_T35_E1.3121.00
26_Q35_E1.2891.00
85_W89_A1.2441.00
31_E34_L1.2341.00
36_T39_G1.2321.00
24_T27_N1.2231.00
82_L88_P1.2211.00
17_F22_G1.1951.00
19_P23_L1.1651.00
7_L11_L1.1161.00
19_P41_L1.0931.00
74_A77_A1.0401.00
52_R56_S1.0371.00
55_L60_Q1.0011.00
89_A93_F0.9931.00
77_A81_R0.9841.00
20_L36_T0.9701.00
88_P92_G0.9601.00
78_A81_R0.9581.00
55_L58_L0.9581.00
70_P73_P0.9531.00
25_T28_I0.9471.00
21_I40_L0.9411.00
27_N30_G0.9081.00
4_K8_L0.9031.00
61_P66_R0.8971.00
82_L86_L0.8961.00
76_A79_L0.8881.00
93_F96_L0.8861.00
17_F44_A0.8861.00
7_L10_A0.8721.00
8_L12_V0.8671.00
6_A9_A0.8650.99
41_L45_V0.8620.99
31_E35_E0.8510.99
73_P76_A0.8500.99
22_G38_W0.8420.99
17_F21_I0.8390.99
75_V80_A0.8350.99
14_L41_L0.8250.99
50_V53_L0.8240.99
2_A15_G0.8230.99
76_A80_A0.8140.99
53_L56_S0.7950.99
83_G86_L0.7870.99
87_A90_L0.7600.99
47_I51_G0.7590.99
38_W45_V0.7570.99
58_L62_W0.7510.99
24_T28_I0.7490.99
41_L44_A0.7450.98
48_V51_G0.7410.98
39_G42_A0.7380.98
62_W65_R0.7060.98
40_L43_I0.7040.98
55_L59_R0.7030.98
28_I31_E0.6910.98
83_G90_L0.6870.97
43_I46_A0.6870.97
70_P77_A0.6730.97
72_P79_L0.6710.97
2_A56_S0.6680.97
70_P74_A0.6640.97
69_R75_V0.6630.97
50_V57_L0.6620.97
8_L15_G0.6540.97
38_W56_S0.6400.96
27_N37_R0.6390.96
6_A53_L0.6350.96
88_P93_F0.6290.96
49_F53_L0.6270.96
60_Q64_A0.6080.95
10_A53_L0.6060.95
75_V78_A0.6030.95
27_N32_L0.6020.95
84_R88_P0.6000.94
83_G87_A0.6000.94
26_Q33_V0.5960.94
87_A91_L0.5960.94
69_R79_L0.5900.94
52_R58_L0.5890.94
40_L44_A0.5870.94
88_P91_L0.5850.94
69_R72_P0.5850.94
22_G25_T0.5830.94
85_W92_G0.5750.93
14_L20_L0.5730.93
9_A56_S0.5630.92
70_P78_A0.5610.92
23_L35_E0.5600.92
18_L22_G0.5580.92
73_P77_A0.5560.92
66_R75_V0.5470.91
20_L41_L0.5450.91
6_A12_V0.5380.91
83_G93_F0.5340.90
74_A79_L0.5310.90
68_A72_P0.5310.90
70_P76_A0.5280.90
65_R68_A0.5280.90
23_L38_W0.5200.89
25_T29_G0.5120.88
22_G45_V0.5110.88
19_P24_T0.5110.88
35_E40_L0.5110.88
38_W42_A0.5100.88
56_S60_Q0.5090.88
84_R90_L0.5080.88
16_L49_F0.5070.88
9_A17_F0.5060.88
30_G33_V0.5010.87
89_A92_G0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3aqpA 1 0.9691 4.9 0.893 Contact Map
2yevB 1 0.8144 4 0.897 Contact Map
3mk7C 2 0.6598 3.2 0.902 Contact Map
1fftB 1 0.7732 3.2 0.902 Contact Map
3hb3B 1 0.8144 3.1 0.903 Contact Map
2z73A 2 1 2.9 0.904 Contact Map
2xq2A 2 0.9278 2.8 0.905 Contact Map
3dh4A 3 0.9175 2.8 0.905 Contact Map
4us3A 1 1 2.4 0.908 Contact Map
2ks9A 1 0.9794 2.4 0.908 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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