GREMLIN Database
DUF3381 - Domain of unknown function (DUF3381)
PFAM: PF11861 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 164 (157)
Sequences: 741 (546)
Seq/√Len: 43.6
META: 0.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_E66_C5.2271.00
65_E68_K4.1421.00
24_A43_I4.0191.00
21_E42_K3.5321.00
22_V36_I3.5261.00
67_C81_L3.1621.00
54_L64_K2.7381.00
33_P82_L2.6321.00
19_Y42_K2.5601.00
22_V40_A2.5501.00
114_E117_E2.4111.00
24_A45_F2.2941.00
12_E20_K2.2811.00
59_T84_W2.2001.00
15_D20_K2.1841.00
42_K68_K2.0720.99
61_E64_K2.0640.99
70_L78_F2.0220.99
74_G77_D1.9060.99
4_K7_K1.8730.99
59_T63_I1.8170.98
88_L91_E1.7330.98
66_C80_L1.7280.98
24_A63_I1.7270.98
137_E141_E1.7110.98
36_I77_D1.6610.97
145_A149_R1.6420.97
145_A148_K1.5470.96
28_I75_K1.5120.95
63_I81_L1.4700.94
53_L88_L1.4700.94
23_S46_D1.4550.94
24_A28_I1.4490.94
151_K155_N1.4390.94
19_Y41_N1.4390.94
147_K150_E1.4310.93
55_K64_K1.4280.93
132_I135_E1.4030.93
61_E65_E1.3960.93
60_T66_C1.3560.91
2_E6_R1.3320.91
21_E44_T1.3270.90
19_Y44_T1.2830.89
41_N71_K1.2780.89
12_E18_L1.2610.88
44_T67_C1.2590.88
130_E134_E1.2410.87
125_E131_Q1.2350.87
150_E154_E1.2110.86
134_E138_E1.2040.86
43_I50_D1.1950.85
60_T63_I1.1940.85
139_L142_E1.1940.85
17_T20_K1.1930.85
36_I43_I1.1890.85
12_E21_E1.1880.85
113_E116_E1.1630.84
8_R75_K1.1620.83
138_E142_E1.1560.83
54_L151_K1.1070.80
63_I80_L1.0990.80
152_K160_K1.0940.80
5_K35_A1.0930.80
147_K157_R1.0910.79
147_K154_E1.0810.79
83_K87_K1.0790.79
76_K143_E1.0540.77
36_I148_K1.0520.77
154_E161_E1.0450.76
45_F139_L1.0390.76
25_S50_D1.0330.76
133_Q136_L1.0320.75
89_R94_L1.0210.75
146_K149_R1.0200.75
117_E121_A1.0190.75
28_I33_P1.0110.74
59_T62_E1.0100.74
116_E119_E1.0080.74
30_S36_I0.9890.72
146_K151_K0.9770.71
63_I67_C0.9750.71
135_E139_L0.9740.71
33_P85_R0.9740.71
115_E124_E0.9400.68
25_S29_K0.9290.67
77_D133_Q0.9250.67
16_Y71_K0.9240.67
155_N159_Q0.9170.66
35_A39_S0.9160.66
123_V127_D0.9100.66
118_E125_E0.8980.65
155_N162_I0.8970.65
85_R89_R0.8890.64
50_D53_L0.8730.63
13_E33_P0.8690.62
141_E144_A0.8670.62
145_A164_R0.8660.62
145_A152_K0.8620.62
99_E102_E0.8580.61
66_C76_K0.8580.61
89_R92_L0.8560.61
68_K77_D0.8540.61
143_E163_E0.8470.60
125_E128_E0.8300.59
136_L143_E0.8220.58
8_R78_F0.8140.57
56_H59_T0.8090.57
15_D18_L0.8030.56
38_G70_L0.7930.55
5_K156_E0.7850.54
20_K40_A0.7850.54
17_T160_K0.7850.54
113_E117_E0.7780.54
5_K47_D0.7690.53
45_F67_C0.7690.53
82_L86_L0.7660.53
22_V43_I0.7590.52
16_Y20_K0.7500.51
46_D117_E0.7500.51
13_E25_S0.7490.51
24_A34_I0.7420.50
119_E123_V0.7400.50
45_F60_T0.7400.50
35_A160_K0.7390.50
12_E70_L0.7390.50
28_I53_L0.7390.50
99_E104_D0.7330.49
70_L103_E0.7290.49
51_A54_L0.7250.49
53_L76_K0.7230.48
75_K79_K0.7170.48
24_A59_T0.7170.48
146_K150_E0.7120.47
83_K147_K0.7100.47
24_A53_L0.7090.47
13_E18_L0.7080.47
77_D80_L0.6990.46
159_Q163_E0.6970.46
27_F164_R0.6940.46
88_L95_E0.6930.46
70_L83_K0.6890.45
12_E15_D0.6880.45
60_T79_K0.6880.45
34_I59_T0.6870.45
81_L84_W0.6860.45
76_K79_K0.6850.45
32_D155_N0.6760.44
9_E139_L0.6740.44
114_E118_E0.6700.43
34_I60_T0.6670.43
38_G78_F0.6660.43
120_V134_E0.6640.43
34_I160_K0.6630.43
90_E96_K0.6610.43
23_S43_I0.6600.43
37_L59_T0.6550.42
12_E77_D0.6540.42
131_Q143_E0.6540.42
154_E159_Q0.6490.41
32_D35_A0.6480.41
31_E134_E0.6430.41
12_E17_T0.6380.40
4_K41_N0.6360.40
138_E149_R0.6350.40
13_E16_Y0.6280.40
45_F58_E0.6280.40
121_A126_M0.6240.39
141_E157_R0.6220.39
33_P83_K0.6170.39
13_E20_K0.6160.38
26_E99_E0.6130.38
50_D58_E0.6130.38
102_E105_E0.6080.38
45_F84_W0.6070.38
158_K162_I0.6050.37
14_G41_N0.5990.37
38_G85_R0.5990.37
90_E155_N0.5950.37
62_E81_L0.5950.37
7_K143_E0.5920.36
25_S116_E0.5920.36
59_T72_V0.5910.36
42_K56_H0.5850.36
46_D52_A0.5840.36
154_E158_K0.5840.36
27_F158_K0.5840.36
8_R11_Y0.5820.35
28_I41_N0.5800.35
40_A70_L0.5800.35
21_E41_N0.5780.35
125_E133_Q0.5770.35
45_F68_K0.5770.35
18_L125_E0.5730.35
100_A104_D0.5710.34
121_A156_E0.5690.34
29_K153_K0.5660.34
150_E153_K0.5660.34
21_E71_K0.5580.33
98_K101_K0.5570.33
20_K41_N0.5520.33
43_I94_L0.5500.33
157_R161_E0.5490.33
139_L149_R0.5460.32
65_E71_K0.5460.32
34_I78_F0.5460.32
47_D50_D0.5440.32
115_E118_E0.5440.32
144_A149_R0.5440.32
33_P164_R0.5420.32
21_E64_K0.5420.32
14_G38_G0.5410.32
43_I67_C0.5410.32
132_I140_K0.5390.32
35_A118_E0.5390.32
58_E87_K0.5380.32
123_V152_K0.5370.32
87_K124_E0.5360.32
17_T35_A0.5270.31
39_S80_L0.5240.31
73_L89_R0.5240.31
89_R93_G0.5230.30
48_E142_E0.5220.30
144_A147_K0.5210.30
93_G97_K0.5180.30
34_I82_L0.5150.30
117_E120_V0.5150.30
76_K134_E0.5140.30
67_C151_K0.5140.30
6_R38_G0.5100.29
53_L98_K0.5100.29
50_D56_H0.5090.29
30_S40_A0.5020.29
56_H88_L0.5020.29
19_Y29_K0.5000.29
48_E96_K0.5000.29
33_P139_L0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j3wL 1 0.6159 21.2 0.932 Contact Map
2zjrI 1 0.6098 19.5 0.933 Contact Map
4tp9L 1 0.0122 13.3 0.938 Contact Map
4jwhA 1 0 11.5 0.94 Contact Map
4v0qA 2 0.7134 7.5 0.944 Contact Map
1l6wA 6 0.4329 5.9 0.947 Contact Map
4rb6P 1 0.628 5.8 0.947 Contact Map
1vx7O 1 0.6402 3.8 0.951 Contact Map
1vq8L 1 0.6463 3.7 0.952 Contact Map
4d10G 1 0.7134 3.5 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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