GREMLIN Database
DUF3379 - Protein of unknown function (DUF3379)
PFAM: PF11859 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 232 (230)
Sequences: 1461 (1217)
Seq/√Len: 80.2
META: 0.856

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_H28_C5.2041.00
28_C31_C4.5971.00
24_H31_C4.3871.00
194_F201_G3.9571.00
3_C24_H3.9001.00
4_L8_R3.4771.00
41_L45_L3.4241.00
3_C31_C3.2071.00
3_C28_C3.1371.00
172_T219_E2.9901.00
10_L21_L2.8841.00
10_L35_A2.7241.00
13_D16_S2.6771.00
25_R35_A2.5721.00
172_T175_G2.5011.00
34_F38_L2.3461.00
35_A39_L2.2081.00
115_V214_V2.1601.00
153_T171_Q2.1061.00
83_L86_S2.0901.00
17_R21_L1.9821.00
116_Y196_E1.9161.00
6_F25_R1.8841.00
119_P122_A1.8841.00
46_A50_A1.8141.00
122_A125_T1.7951.00
42_D45_L1.7951.00
119_P123_L1.7941.00
114_H167_H1.7721.00
209_G212_A1.7561.00
56_G59_D1.7361.00
10_L38_L1.7331.00
151_L171_Q1.7141.00
120_P123_L1.6771.00
23_A27_S1.6721.00
2_N5_E1.6621.00
172_T177_V1.6511.00
5_E9_R1.6421.00
6_F35_A1.6101.00
11_L38_L1.5981.00
9_R18_D1.5761.00
6_F10_L1.5691.00
59_D64_R1.5581.00
64_R68_A1.5541.00
15_R46_A1.5360.99
123_L126_D1.4980.99
160_F180_L1.4950.99
29_P32_A1.4820.99
63_L67_L1.4790.99
129_V134_L1.4720.99
10_L34_F1.4720.99
6_F21_L1.4710.99
17_R22_L1.4670.99
118_E180_L1.4490.99
153_T176_P1.4200.99
160_F178_T1.3820.99
187_V213_I1.3820.99
182_L210_S1.3810.99
56_G60_R1.3780.99
215_G221_L1.3570.99
107_L161_R1.3350.98
200_R218_G1.3240.98
57_L60_R1.3180.98
138_L172_T1.3150.98
32_A36_D1.3150.98
57_L62_L1.3070.98
9_R21_L1.3020.98
15_R42_D1.3000.98
131_L135_N1.2980.98
58_A61_I1.2850.98
94_G98_W1.2700.98
67_L70_R1.2630.98
89_L94_G1.2590.98
115_V194_F1.2520.98
5_E8_R1.2500.98
66_S69_A1.2420.98
4_L7_R1.2410.98
94_G97_L1.2410.98
106_S109_A1.2320.97
205_P209_G1.2240.97
57_L61_I1.2200.97
25_R32_A1.2110.97
15_R39_L1.1900.97
111_V212_A1.1870.97
33_A37_E1.1820.97
157_S166_P1.1650.96
99_L102_P1.1580.96
16_S21_L1.1450.96
20_E23_A1.1400.96
121_A125_T1.1380.96
95_V98_W1.1300.96
1_M5_E1.1240.96
171_Q176_P1.1140.95
118_E154_Y1.1040.95
157_S164_R1.1020.95
182_L212_A1.0860.95
161_R185_E1.0580.94
114_H118_E1.0530.94
122_A154_Y1.0470.93
77_R80_W1.0460.93
83_L90_A1.0460.93
203_I212_A1.0330.93
112_V196_E1.0280.93
62_L65_Q1.0170.92
9_R16_S1.0160.92
154_Y178_T1.0120.92
169_V178_T1.0090.92
112_V198_G1.0050.92
96_G99_L1.0020.92
158_C167_H0.9990.92
65_Q69_A0.9900.91
198_G205_P0.9850.91
26_A32_A0.9810.91
89_L96_G0.9780.91
33_A36_D0.9700.91
93_L102_P0.9670.90
118_E160_F0.9630.90
159_P164_R0.9500.90
45_L230_Q0.9310.89
78_R81_L0.9280.89
114_H158_C0.9260.88
121_A124_A0.9190.88
141_F166_P0.9160.88
152_V170_V0.9140.88
39_L140_S0.9130.88
155_A201_G0.9030.87
115_V118_E0.9020.87
87_V92_G0.8910.86
122_A126_D0.8830.86
23_A26_A0.8810.86
225_A229_R0.8780.86
75_R79_R0.8780.86
27_S36_D0.8770.86
143_V166_P0.8620.85
187_V212_A0.8560.84
18_D21_L0.8550.84
97_L101_G0.8540.84
187_V210_S0.8540.84
81_L88_A0.8520.84
38_L41_L0.8500.84
16_S45_L0.8490.84
87_V90_A0.8460.83
155_A181_L0.8450.83
127_E130_S0.8370.83
165_V183_P0.8370.83
3_C7_R0.8330.83
82_A86_S0.8320.82
18_D134_L0.8260.82
90_A93_L0.8220.82
65_Q68_A0.8200.82
61_I65_Q0.8120.81
56_G61_I0.8110.81
184_H208_G0.8070.80
8_R11_L0.8040.80
215_G219_E0.8010.80
97_L103_S0.7980.80
90_A102_P0.7980.80
111_V180_L0.7970.80
33_A50_A0.7900.79
213_I225_A0.7810.78
41_L44_R0.7800.78
96_G100_A0.7790.78
14_P114_H0.7770.78
125_T129_V0.7720.77
2_N7_R0.7700.77
111_V203_I0.7670.77
137_V166_P0.7610.76
58_A63_L0.7600.76
89_L93_L0.7580.76
210_S213_I0.7560.76
66_S70_R0.7540.76
16_S22_L0.7530.76
10_L25_R0.7530.76
157_S165_V0.7530.76
204_V211_I0.7510.75
174_Q219_E0.7500.75
17_R35_A0.7500.75
39_L42_D0.7480.75
21_L34_F0.7440.75
58_A89_L0.7420.75
134_L168_L0.7410.75
92_G136_A0.7370.74
88_A105_D0.7340.74
56_G62_L0.7340.74
3_C30_A0.7290.73
99_L104_Y0.7280.73
31_C34_F0.7240.73
209_G214_V0.7230.73
194_F199_Y0.7210.73
81_L86_S0.7190.72
87_V216_E0.7190.72
61_I64_R0.7190.72
168_L179_V0.7180.72
60_R63_L0.7140.72
125_T134_L0.7120.72
222_D226_E0.7120.72
53_V66_S0.7120.72
79_R82_A0.7110.71
134_L170_V0.7110.71
191_R215_G0.7080.71
97_L102_P0.7070.71
125_T153_T0.7060.71
11_L42_D0.7030.71
145_L227_R0.7020.70
92_G217_S0.7000.70
112_V116_Y0.7000.70
155_A167_H0.6980.70
187_V203_I0.6950.70
22_L35_A0.6900.69
204_V207_G0.6900.69
224_V227_R0.6890.69
139_A142_G0.6840.69
22_L26_A0.6830.68
81_L163_H0.6830.68
75_R78_R0.6830.68
12_A143_V0.6820.68
19_P32_A0.6810.68
177_V215_G0.6790.68
30_A37_E0.6750.67
176_P182_L0.6750.67
111_V182_L0.6730.67
198_G216_E0.6680.67
47_R52_P0.6680.67
79_R170_V0.6660.66
125_T154_Y0.6620.66
116_Y198_G0.6620.66
168_L181_L0.6610.66
169_V176_P0.6590.66
139_A143_V0.6540.65
137_V155_A0.6530.65
51_V54_P0.6530.65
54_P57_L0.6520.65
3_C8_R0.6510.65
147_P150_G0.6500.65
33_A146_D0.6490.64
94_G207_G0.6480.64
45_L49_L0.6460.64
167_H178_T0.6430.64
91_V94_G0.6430.64
134_L155_A0.6420.64
175_G215_G0.6410.64
18_D22_L0.6400.63
140_S159_P0.6390.63
202_V222_D0.6380.63
154_Y169_V0.6370.63
180_L214_V0.6370.63
89_L92_G0.6370.63
78_R134_L0.6320.62
147_P152_V0.6310.62
90_A97_L0.6310.62
155_A168_L0.6290.62
114_H166_P0.6260.62
44_R180_L0.6250.62
160_F165_V0.6240.61
118_E178_T0.6220.61
114_H175_G0.6190.61
113_A174_Q0.6180.61
11_L41_L0.6180.61
196_E199_Y0.6170.61
135_N139_A0.6150.60
110_E113_A0.6150.60
74_R78_R0.6150.60
137_V156_N0.6100.60
34_F215_G0.6090.60
71_A75_R0.6040.59
110_E161_R0.6020.59
18_D113_A0.6020.59
122_A176_P0.6010.59
86_S92_G0.6010.59
156_N168_L0.5980.58
55_E74_R0.5960.58
154_Y157_S0.5960.58
163_H183_P0.5950.58
155_A212_A0.5940.58
124_A128_P0.5910.57
138_L179_V0.5910.57
95_V103_S0.5880.57
211_I214_V0.5840.56
19_P23_A0.5830.56
77_R81_L0.5830.56
161_R196_E0.5780.56
91_V190_A0.5760.55
42_D46_A0.5730.55
43_A87_V0.5720.55
165_V212_A0.5700.55
28_C205_P0.5700.55
149_L184_H0.5700.55
94_G100_A0.5690.54
226_E229_R0.5680.54
153_T168_L0.5640.54
218_G221_L0.5640.54
46_A195_S0.5630.54
58_A62_L0.5630.54
126_D130_S0.5620.54
92_G97_L0.5620.54
68_A71_A0.5600.53
64_R69_A0.5600.53
93_L97_L0.5580.53
173_E223_Q0.5550.53
154_Y185_E0.5520.52
61_I188_A0.5510.52
31_C205_P0.5510.52
129_V172_T0.5500.52
160_F182_L0.5500.52
20_E36_D0.5490.52
38_L134_L0.5490.52
91_V150_G0.5460.52
61_I89_L0.5460.52
154_Y160_F0.5450.51
196_E214_V0.5400.51
122_A127_E0.5390.51
12_A184_H0.5390.51
148_D170_V0.5340.50
26_A35_A0.5330.50
62_L111_V0.5330.50
52_P72_R0.5280.49
128_P136_A0.5270.49
60_R136_A0.5260.49
81_L229_R0.5260.49
182_L213_I0.5260.49
31_C209_G0.5250.49
36_D189_D0.5230.49
110_E163_H0.5220.48
44_R140_S0.5220.48
160_F196_E0.5210.48
161_R165_V0.5200.48
216_E227_R0.5200.48
60_R64_R0.5200.48
182_L185_E0.5200.48
111_V168_L0.5200.48
36_D39_L0.5180.48
115_V199_Y0.5170.48
92_G96_G0.5140.47
137_V209_G0.5120.47
10_L129_V0.5120.47
63_L72_R0.5110.47
98_W101_G0.5110.47
16_S32_A0.5110.47
154_Y171_Q0.5090.47
11_L34_F0.5090.47
111_V116_Y0.5080.47
9_R31_C0.5070.46
2_N24_H0.5020.46
89_L95_V0.5020.46
1_M37_E0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hugB 2 0.2198 95.6 0.897 Contact Map
2q1zB 1 0.7198 94.7 0.903 Contact Map
4nqwB 1 0.2629 93.5 0.908 Contact Map
1or7C 1 0.2759 33.1 0.947 Contact Map
2lcoA 1 0.0819 16.1 0.954 Contact Map
1qb3A 2 0.1293 11.1 0.957 Contact Map
2jz2A 1 0.2284 8.1 0.96 Contact Map
4nphA 1 0.4397 7.4 0.96 Contact Map
4v3iA 2 0.2328 7.2 0.961 Contact Map
3vmaA 1 0.6078 6.1 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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